Sleep and future cardiovascular risk: prospective analysis from the English Longitudinal Study of Ageing
Abstract
Study objectives Hypertension and inflammation may contribute to the increased risk of cardiovascular disease in individuals with suboptimal sleep, but large prospective studies are lacking. This study tested whether sleep duration and disturbance were predictive of incident hypertension and inflammation four years later.Methods Participants were men and women aged 50 years and older from the English Longitudinal Study of Ageing. Sleep was assessed by self-report, incident hypertension (N = 3068) was defined by clinical examination and C-reactive protein and fibrinogen (N = 3768) were measures of inflammation.Results Both men (odds ratio, OR:1.73, confidence interval, C.I. 1.08-2.76) and women (OR: 1.44, C.I. 1.00-2.07) reporting short sleep at baseline had increased odds of incident hypertension 4 years later, after adjustment for covariates. Age-stratified analyses revealed that short sleep was predictive of incident hypertension in men (OR: 2.27, C.I. 1.01-5.11) and women (OR: 2.10, C.I. 1.08-4.09) younger than 60 years but not in older people. Disturbed sleep also predicted incident hypertension in men (OR: 1.20, C.I. 1.02-1.41). In women, disturbed sleep was associated with elevated C-reactive protein (B = 0.030, C.I. 0.00-0.06) and fibrinogen (B = 0.030, C.I. 0.01-0.05) at follow-up controlling for baseline inflammation and other covariates. Sleep duration was unrelated to inflammatory markers in either sex.Conclusions This study of older men and women adds to growing evidence that aberrant sleep patterns may increase the risk of cardiovascular outcomes through its adverse impact on blood pressure and inflammation.
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Several, though not all, PSG studies reported increased sleep onset latency, increased number of nocturnal awakenings, and reduced sleep efficiency in ME/CFS patients compared with healthy control participants.
“several, though not all, studies reported increased sleep onset latency, increased number of nocturnal awakenings, and reduced sleep efficiency in ME/CFS patients compared with healthy control participants (for review, see Ref. 269).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [269]
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- Authors
- Jackowska, M., & Steptoe, A.
- Affiliations
- University College London (GB)
- Corresponding author
- Jackowska, Marta
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 16
- Issue
- 6
- Pages
- 768-774
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2086702258
- Cited by
- 56
- References
- 53
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 10 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 2
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- British Heart Foundation (PG/13/65/30440)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep duration, sleep disorders, short sleep duration, hypertension incidence, cardiovascular risk, inflammation, C-reactive protein, fibrinogen, older adults, sex differences, English Longitudinal Study of Ageing
- MeSH terms
- Aged, C-Reactive Protein, Cardiovascular Diseases, England, Female, Fibrinogen, Humans, Hypertension, Inflammation, Longitudinal Studies, Male, Middle Aged, Risk Factors, Sex Factors, Sleep Wake Disorders, Incidence, Odds Ratio
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