C-reactive protein Levels and Sleep Disturbances: Observations Based on The Northern Finland 1966 Birth Cohort Study
Abstract
OBJECTIVE: To investigate whether sleep disturbances are associated with C-reactive protein (CRP) levels at the population level. Elevated CRP levels have been found to accompany sleep disturbances, but evidence so far comes only from limited clinical and experimental studies; epidemiological studies are lacking. METHODS: We utilized the Northern Finland 1966 Birth Cohort, whose participants have been followed up to the age of 31 years. The hs-enzyme immunoassay method was used to measure highly sensitive-CRP (hs-CRP) concentrations (4011 participants). Self-reported sleep disturbances were ranked from 1 (no problem) to 5 (severe disturbances). RESULTS: Multivariate analyses, after adjusting for confounders, revealed that hs-CRP levels in men in the sleep disturbance category "moderate, considerable and severe" (i.e., self-reported sleep disturbances rated 3, 4, or 5), were >18% (18.2%, 95% Confidence Interval 3.0% to 36.3%) higher than those in men with "no" sleep disturbance. In women, hs-CRP levels did not significantly differ between different sleep disturbance categories. CONCLUSIONS: Our results support the hypothesis that moderate-to-severe sleep disturbances in men are associated with slightly increased CRP levels at the epidemiological level. Further investigations are called for to see whether our results can be replicated in other databases.
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In a cohort of more than 4,000 participants, self-reported indices of sleep disturbances were related to higher CRP levels among men only.
“A sex-specific association was also found in a cohort of more than 4,000 participants, where self-reported indices of sleep disturbances were related to higher CRP levels among men only”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [341]
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- Authors
- Liukkonen, T., Räsänen, P., Ruokonen, A., Laitinen, J., Jokelainen, J., Leinonen, M., Meyer-Rochow, V. B., & Timonen, M.
- Affiliations
- Savonlinna Central Hospital (FI)
- Corresponding author
- Liukkonen, Timo
- Venue
- Psychosomatic Medicine
- Published
- 2007-10
- Volume
- 69
- Issue
- 8
- Pages
- 756-761
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2050842258
- Cited by
- 83
- References
- 56
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 4 · 2012: 3
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- C-reactive protein, sleep disorders, high-sensitivity C-reactive protein, inflammation, sex differences, men, Northern Finland Birth Cohort 1966
- MeSH terms
- Adult, C-Reactive Protein, Female, Finland, Humans, Male, Sex Factors, Sleep Wake Disorders, Cohort Studies
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