Cited by 83Sleep and related disordersSleep and Wakefulness ResearchSleep and Work-Related Fatigue

C-reactive protein Levels and Sleep Disturbances: Observations Based on The Northern Finland 1966 Birth Cohort Study

Liukkonen, Timo, Räsänen, Pirkko, Ruokonen, Aimo, Laitinen, Jaana, Jokelainen, Jari, Leinonen, Maija, Meyer-Rochow, V Benno, Timonen, Markku·2007·Psychosomatic Medicine

Abstract

OBJECTIVE: To investigate whether sleep disturbances are associated with C-reactive protein (CRP) levels at the population level. Elevated CRP levels have been found to accompany sleep disturbances, but evidence so far comes only from limited clinical and experimental studies; epidemiological studies are lacking. METHODS: We utilized the Northern Finland 1966 Birth Cohort, whose participants have been followed up to the age of 31 years. The hs-enzyme immunoassay method was used to measure highly sensitive-CRP (hs-CRP) concentrations (4011 participants). Self-reported sleep disturbances were ranked from 1 (no problem) to 5 (severe disturbances). RESULTS: Multivariate analyses, after adjusting for confounders, revealed that hs-CRP levels in men in the sleep disturbance category "moderate, considerable and severe" (i.e., self-reported sleep disturbances rated 3, 4, or 5), were >18% (18.2%, 95% Confidence Interval 3.0% to 36.3%) higher than those in men with "no" sleep disturbance. In women, hs-CRP levels did not significantly differ between different sleep disturbance categories. CONCLUSIONS: Our results support the hypothesis that moderate-to-severe sleep disturbances in men are associated with slightly increased CRP levels at the epidemiological level. Further investigations are called for to see whether our results can be replicated in other databases.

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Crossref · 10.1097/psy.0b013e318157cb96

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  • In a cohort of more than 4,000 participants, self-reported indices of sleep disturbances were related to higher CRP levels among men only.

    “A sex-specific association was also found in a cohort of more than 4,000 participants, where self-reported indices of sleep disturbances were related to higher CRP levels among men only”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [341]

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Authors
Liukkonen, T., Räsänen, P., Ruokonen, A., Laitinen, J., Jokelainen, J., Leinonen, M., Meyer-Rochow, V. B., & Timonen, M.
Affiliations
Savonlinna Central Hospital (FI)
Corresponding author
Liukkonen, Timo
Venue
Psychosomatic Medicine
Published
2007-10
Volume
69
Issue
8
Pages
756-761
ISSN
0033-3174 (ISSN-L)
OpenAlex
W2050842258
Cited by
83
References
56
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 4 · 2012: 3
FWCI
3.84
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
C-reactive protein, sleep disorders, high-sensitivity C-reactive protein, inflammation, sex differences, men, Northern Finland Birth Cohort 1966
MeSH terms
Adult, C-Reactive Protein, Female, Finland, Humans, Male, Sex Factors, Sleep Wake Disorders, Cohort Studies

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