Sleep and cardiometabolic health in children and adults: examining sleep as a component of the 24-h day
Open accessAbstract
Study objectives Sleep, physical activity and sedentary time are all known to play a role in cardiometabolic health. Compositional data analysis (CoDA) enables us to examine associations between 24-h use of time and health outcomes.Methods Data were collected in the Child Health CheckPoint study, a one-off national population-cohort study conducted between February 2015 and March 2016. Wrist-worn actigraphy monitors (GENEActiv Original, Cambs, UK) were used to measure activity behaviours (sleep, physical activity and sedentary time) and sleep characteristics (sleep variability, midsleep, efficiency). CoDA was applied to determine the association between 24-h use of time and cardiometabolic risk markers (blood pressure; body mass index; apolipoprotein B/A1; glycoprotein acetyls; and composite metabolic syndrome score). Substitution modelling (one-for-remaining and one-for-one) examined the associations of reallocating sleep time with other activity behaviours.Results Data were available for 1073 Australian children aged 11-12 years (50% male) and 1337 adults (13% male). Strong association was found between 24-h use of time and all cardiometabolic health outcomes. Longer sleep was associated with more favourable cardiovascular health. Sleep characteristics other than duration (efficiency, timing, variability) were weakly and inconsistently associated with outcomes. Reallocating time from sleep to moderate-vigorous physical activity (MVPA) had favourable associations with cardiometabolic health, but reallocating from sleep to sedentary time was associated with less favourable cardiometabolic health.Conclusion The 24-h activity composition is strongly associated with cardiometabolic health in children and adults. Days with more sleep and MVPA are associated with improved cardiometabolic health.
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Among a sample of 644 children and 992 adults, actigraphy-measured sleep duration was not significantly associated with ApoB levels.
“In contrast, among a sample of 644 children and 992 adults, actigraphy-measured sleep duration was not significantly associated with ApoB levels (β = -0.50 in children, β = -0.05 in adults) where sleep duration was modelled continuously.45”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [45]
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How Much Time to Spend in Physical Activity, Sleep and be Sedentary in 24 h to Achieve Good Health?
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Sleep-Health Link: Newer Perspectives
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Recent Trends in Sleep Duration
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- Authors
- Matricciani, L., Dumuid, D., Paquet, C., Fraysse, F., Wang, Y., Baur, L. A., Juonala, M., Ranganathan, S., Lycett, K., Kerr, J. A., Burgner, D., Wake, M., & Olds, T.
- Affiliations
- University of South Australia (AU)
- The University of Melbourne (AU)
- The University of Sydney (AU)
- University of Turku (FI)
- Deakin University (AU)
- University of Auckland (NZ)
- Corresponding author
- Matricciani, Lisa
- ORCID
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 78
- Pages
- 63-74
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W3112538639
- Cited by
- 46
- References
- 67
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 17 · 2022: 7 · 2021: 3
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Update notices
- erratum (2021-10-01)
- Open access
- green
- figshare.com
- Licence
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council of Australia (1041352, 1109355)
- Royal Children's Hospital Foundation (2014-241)
- Murdoch Children's Research Institute
- The University of Melbourne
- National Heart Foundation of Australia (100660)
- Financial Markets Foundation for Children (2014-055, 2016-310)
- University of Auckland Faculty Development Research Fund (3712987)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep, cardiometabolic health, physical activity, sedentary time, sleep efficiency, sleep timing, sleep variability, metabolic syndrome, blood pressure, body mass index, apolipoproteins, children, adults, actigraphy
- MeSH terms
- Adult, Australia, Cardiovascular Diseases, Child, Cross-Sectional Studies, Female, Humans, Male, Sleep, Cohort Studies
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