Effects of one night of sleep deprivation on whole brain intrinsic connectivity distribution using a graph theory neuroimaging approach
Abstract
Neuroimaging studies have revealed disturbances in brain functional connectivity (FC) after one night of sleep deprivation (SD). These researches explored the alterations of FC using classical regions of interest (ROI)-based analysis or functional connectivity density. However, these methods need for a priori information about the selected ROIs and a specific correlation threshold to define a connection between two ROIs or voxels, which may bring inconsistent results. In the present study, we adopted a data-driven, whole brain voxel-based graph-theoretical approach, intrinsic connectivity distribution (ICD) analysis, to examine changes of brain connectivity after SD in 52 normal young subjects without any prior knowledge. The cross-hemisphere ICD (ch-ICD) analysis was also performed to discover the effect of SD on cerebral lateralization. We found that sleep-deprived subjects showed significant reduced ICD in default mode network (DMN) and limbic network, and increased ICD in sensorimotor network. Furthermore, after SD, the ICD in the right precuneus showed significant correlation with psychomotor vigilance test (PVT) performance following the stepwise regression analysis after Bonferroni correction (ICD = 0.43 - 0.62∗10 % fast reaction time + 0.31∗the standard deviation of reaction time, p = 0.0012). Follow-up seed-based FC analyses in the right precuneus revealed decreased FC to regions in DMN, visual network, ventral attentional network and frontal-parietal network. Nevertheless, no striking difference of ch-ICD was found following SD. In conclusion, these findings suggested that DMN, especially precuneus may be hubs of FC disturbances associated with vigilance after SD, and may provide new insights into the intervention for SD.
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Zhao et al. reported significantly increased intrinsic connectivity following sleep-deprivation in the resting sensorimotor network.
“Regarding sensory networks, Zhao et al. 44 reported significantly increased intrinsic connectivity following sleep-deprivation in the resting sensorimotor network.”
From Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations (2025) · cites this paper as [44]
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- Authors
- Zhao, R., Wang, F.-M., Cheng, C., Li, X., Wang, Y., Zhang, F., Li, S.-G., Huang, Y.-H., Zhao, Z.-Y., Wei, W., Zhang, X.-D., Su, X.-P., Yang, X.-J., Qin, W., & Sun, J.-B.
- Affiliations
- Xi'an Polytechnic University (CN)
- Xidian University (CN)
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2025-01
- Volume
- 125
- Pages
- 89-99
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W4404170407
- Cited by
- 8
- References
- 62
- Citations by year
- 2026: 4 · 2025: 4
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, brain functional connectivity, default mode network, precuneus, sustained attention, psychomotor vigilance test, hemispheric lateralization, sensorimotor network, limbic network, graph theory, seed-based functional connectivity
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Sleep Deprivation, Young Adult, Neuroimaging
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