Decreased thalamocortical functional connectivity after 36 hours of total sleep deprivation: evidence from resting state fMRI
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OBJECTIVES: The thalamus and cerebral cortex are connected via topographically organized, reciprocal connections, which hold a key function in segregating internally and externally directed awareness information. Previous task-related studies have revealed altered activities of the thalamus after total sleep deprivation (TSD). However, it is still unclear how TSD impacts on the communication between the thalamus and cerebral cortex. In this study, we examined changes of thalamocortical functional connectivity after 36 hours of total sleep deprivation by using resting state function MRI (fMRI). MATERIALS AND METHODS: Fourteen healthy volunteers were recruited and performed fMRI scans before and after 36 hours of TSD. Seed-based functional connectivity analysis was employed and differences of thalamocortical functional connectivity were tested between the rested wakefulness (RW) and TSD conditions. RESULTS: We found that the right thalamus showed decreased functional connectivity with the right parahippocampal gyrus, right middle temporal gyrus and right superior frontal gyrus in the resting brain after TSD when compared with that after normal sleep. As to the left thalamus, decreased connectivity was found with the right medial frontal gyrus, bilateral middle temporal gyri and left superior frontal gyrus. CONCLUSION: These findings suggest disruptive changes of the thalamocortical functional connectivity after TSD, which may lead to the decline of the arousal level and information integration, and subsequently, influence the human cognitive functions.
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Shao et al. showed reduced thalamocortical functional connectivity after prolonged (36 hours) wakefulness.
“Shao et al. 45 showed reduced thalamocortical functional connectivity after prolonged (36 hours) wakefulness.”
From Towards an Integrative Account of Potential Mechanisms Mediating the Path From Sleep Dysfunction to Hallucinations (2025) · cites this paper as [45]
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- Authors
- Shao, Y., Wang, L., Ye, E., Jin, X., Ni, W., Yang, Y., Wen, B., Hu, D., & Yang, Z.
- Affiliations
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
- National University of Defense Technology (CN)
- Chinese People's Liberation Army (CN)
- Corresponding author
- Hu, Dewen
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-10-25
- Volume
- 8
- Issue
- 10
- Pages
- e78830
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3808277
- OpenAlex
- W1973936611
- Cited by
- 110
- References
- 36
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 7 · 2014: 4
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- total sleep deprivation, thalamus, resting state, parahippocampal gyrus, middle temporal gyrus, superior frontal gyrus, medial frontal gyrus, arousal, information integration, cognitive impairment
- MeSH terms
- Adolescent, Adult, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Nerve Net, Rest, Sleep Deprivation, Thalamus, Time Factors, Young Adult
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