Cited by 363Functional Brain Connectivity StudiesSleep and Work-Related FatigueSleep and Wakefulness Research

Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance

De Havas, Jack A., Parimal, Sarayu, Soon, Chun Siong, Chee, Michael W.L.·2012·NeuroImage

Abstract

Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function. However, its effects on intrinsic low-frequency connectivity within the Default Mode Network (DMN) and its related anti-correlated network (ACN) have not been well characterized. We investigated the effect of SD on functional connectivity within the DMN, and on DMN-ACN anti-correlation, both during the resting state and during performance of a visual attention task (VAT). 26 healthy participants underwent fMRI twice: once after a normal night of sleep in rested wakefulness (RW) and once following approximately 24h of total SD. A seed-based approach was used to examine pairwise correlations of low-frequency fMRI signal across different nodes in each state. SD was associated with significant selective reductions in DMN functional connectivity and DMN-ACN anti-correlation. This was congruent across resting state and VAT analyses, suggesting that SD induces a robust alteration in the intrinsic connectivity within and between these networks.

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Crossref · 10.1016/j.neuroimage.2011.08.026

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  • Sleep deprivation reduced resting functional connectivity within the default mode network (DMN) and between DMN and its anticorrelated network.

    “Both studies found that sleep deprivation reduced resting functional connectivity within the default mode network (DMN) and between DMN and its anticorrelated network”

    From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [254]

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Authors
De Havas, J. A., Parimal, S., Soon, C. S., & Chee, M. W. L.
Affiliations
National University of Singapore (SG)
Corresponding author
Chee, Michael W.L.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2012-01
Volume
59
Issue
2
Pages
1745-1751
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2102436032
Cited by
363
References
63
Citations by year
2026: 24 · 2025: 17 · 2024: 21 · 2023: 18 · 2022: 27 · 2021: 27 · 2020: 25 · 2019: 27 · 2018: 34 · 2017: 33 · 2016: 23 · 2015: 29 · 2014: 19 · 2013: 30 · 2012: 7
FWCI
9.26
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Funders
  • Defense Science and Technology Agency Singapore (POD0713897)
  • National Research Foundation Singapore
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
sleep deprivation, default mode network, functional connectivity, resting state, intrinsic brain connectivity, seed-based correlation analysis
MeSH terms
Attention, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Rest, Sleep Deprivation, Statistics as Topic, Task Performance and Analysis, Visual Perception, Young Adult

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