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Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation
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Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.
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“Self-renewal of SCs is maintained by the SC niche, including, but not limited to ECM components and myofibers34,35.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [34]
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Metadata
- Authors
- Kuang, S., Gillespie, M. A., & Rudnicki, M. A.
- Affiliations
- University of Ottawa (CA)
- Corresponding author
- Rudnicki, Michael A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 2
- Issue
- 1
- Pages
- 22-31
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2023200943
- Cited by
- 507
- References
- 99
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 17 · 2023: 11 · 2022: 30 · 2021: 17 · 2020: 27 · 2019: 23 · 2018: 27 · 2017: 27 · 2016: 27 · 2015: 35 · 2014: 42 · 2013: 47 · 2012: 45
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2024 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- satellite cells, self-renewal, asymmetric cell division, myogenic progenitor cells, muscle stem cells, cell fate determination, skeletal muscle regeneration, stem cell therapy, myopathy
- MeSH terms
- Animals, Cell Communication, Cell Differentiation, Gene Expression Regulation, Humans, Muscular Dystrophies, Regeneration, Signal Transduction, Muscle, Skeletal, Cell Cycle Proteins, Satellite Cells, Skeletal Muscle, Stem Cell Transplantation, Mice, PAX7 Transcription Factor, Myogenic Regulatory Factor 5, Stem Cell Niche
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