Myogenic progenitor cells control extracellular matrix production by fibroblasts during skeletal muscle hypertrophy
Open accessAbstract
Satellite cells, the predominant stem cell population in adult skeletal muscle, are activated in response to hypertrophic stimuli and give rise to myogenic progenitor cells (MPCs) within the extracellular matrix (ECM) that surrounds myofibers. This ECM is composed largely of collagens secreted by interstitial fibrogenic cells, which influence satellite cell activity and muscle repair during hypertrophy and aging. Here we show that MPCs interact with interstitial fibrogenic cells to ensure proper ECM deposition and optimal muscle remodeling in response to hypertrophic stimuli. MPC-dependent ECM remodeling during the first week of a growth stimulus is sufficient to ensure long-term myofiber hypertrophy. MPCs secrete exosomes containing miR-206, which represses Rrbp1, a master regulator of collagen biosynthesis, in fibrogenic cells to prevent excessive ECM deposition. These findings provide insights into how skeletal stem and progenitor cells interact with other cell types to actively regulate their extracellular environments for tissue maintenance and adaptation.
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This prevents excessive ECM deposition for optimal muscle remodeling in response to hypertrophic stimuli.
“This would prevent excessive ECM deposition for optimal muscle remodeling in response to hypertrophic stimuli”
From Skeletal Muscle-Released Extracellular Vesicles: State of the Art (2019) · cites this paper as Fry et al., 2017
MPCs secrete ELVs containing miR-206, which repress ribosomal binding protein 1 in fibrogenic recipient cells.
“MPCs secrete ELVs containing miR-206, which repressed the ribosomal binding protein 1, a master regulator of collagen biosynthesis, in fibrogenic recipient cells.”
From Skeletal Muscle-Released Extracellular Vesicles: State of the Art (2019) · cites this paper as Fry et al., 2017
Satellite cell depletion appears to cause dysregulation in the surrounding muscle environment leading to increased fibrosis with ageing and reduced muscle quality and function.
“While satellite cell depleted mice do not show signs of increased muscle loss, satellite cell depletion appears to cause a dysregulation in the surrounding muscle environment leading to increased fibrosis with ageing and a reduction in muscle quality and function.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [30]
Satellite cells play an important role in maintenance of muscle mass with age by regulating extracellular matrix production during hypertrophy and regeneration.
“Indeed, satellite cells have been implicated in regulating extracellular matrix production during hypertrophy and regenerative processes, and therefore do play an important role in the maintenance of muscle mass with age [26,30,31].”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [30]
Satellite cells play an integral role in regulating the extracellular matrix during remodeling.
“While satellite cells play an integral role in regulating the extracellular matrix during remodeling [26,30,31], it is yet to be determined whether excessive extracellular matrix (ECM) accumulation or a “myonuclear domain ceiling” limits prolonged hypertrophy in the absence of satellite cells.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [30]
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- Authors
- Fry, C. S., Kirby, T. J., Kosmac, K., McCarthy, J. J., & Peterson, C. A.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- University of Kentucky (US)
- Corresponding author
- McCarthy, John J.
- Peterson, Charlotte A.
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 20
- Issue
- 1
- Pages
- 56-69
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC5218963
- OpenAlex
- W2552505527
- Cited by
- 372
- References
- 53
- Citations by year
- 2026: 23 · 2025: 40 · 2024: 39 · 2023: 34 · 2022: 34 · 2021: 66 · 2020: 44 · 2019: 43 · 2018: 25 · 2017: 23 · 2016: 1
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UKnowledge (University of Kentucky) (submittedVersion, cc-by-nc-nd)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- NIH (AR065337, AG034453, AR060701, AG049806, UL1TR000117)
- Jeane B. Kempner Postdoctoral Scholar Award
- UTMB Claude D. Pepper Older Americans Independence Center NIH/NIA (P30 AG024832)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- myogenic progenitor cells, satellite cells, skeletal muscle hypertrophy, extracellular matrix deposition, interstitial fibroblasts, collagen synthesis, exosomes, miR-206, RRBP1, muscle remodeling, intercellular communication, muscle aging
- MeSH terms
- Animals, Carrier Proteins, Cell Differentiation, Cell Nucleus, Cell Survival, Collagen, Extracellular Matrix, Fibroblasts, Hypertrophy, Models, Biological, Stem Cells, Tamoxifen, Down-Regulation, Gene Deletion, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, Satellite Cells, Skeletal Muscle, MicroRNAs, NIH 3T3 Cells, Ribonuclease III, Mice, PAX7 Transcription Factor, Exosomes, Gene Knockdown Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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