Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal
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A central question in stem cell biology is the relationship between stem cells and their niche. Although previous reports have uncovered how signaling molecules released by niche cells support stem cell function, the role of the extra-cellular matrix (ECM) within the niche is unclear. Here, we show that upon activation, skeletal muscle stem cells (satellite cells) induce local remodeling of the ECM and the deposition of laminin-α1 and laminin-α5 into the basal lamina of the satellite cell niche. Genetic ablation of laminin-α1, disruption of integrin-α6 signaling or blocking matrix metalloproteinase activity impairs satellite cell expansion and self-renewal. Collectively, our findings establish that remodeling of the ECM is an integral process of stem cell activity to support propagation and self-renewal, and may explain the effect laminin-α1-containing supports have on embryonic and adult stem cells, as well as the regenerative activity of exogenous laminin-111 therapy.
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Deletion of collagen VI or laminin-α1 (ECM components) or myofiber-specific deletion of O-fucosyltransferase 1 gene (Pofut1) impairs the self-renewal of SCs, leading to the shrinkage of the SC pool after multiple muscle injuries.
“Deletion of collagen VI or laminin-α1 (ECM components) or myofiber-specific deletion of O-fucosyltransferase 1 gene (Pofut1) impairs the self-renewal of SCs36–38, leading to the shrinkage of the SC pool after multiple muscle injuries.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [36]
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- Authors
- Rayagiri, S. S., Ranaldi, D., Raven, A., Mohamad Azhar, N. I. F., Lefebvre, O., Zammit, P. S., & Borycki, A.-G.
- Affiliations
- University of Sheffield (GB)
- MRC Centre for Regenerative Medicine (GB)
- King's College London (GB)
- Corresponding author
- Borycki, Anne-Gaëlle
- Venue
- Nature Communications
- Published
- 2018-03-14
- Volume
- 9
- Issue
- 1
- Pages
- 1075-1075
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5852002
- OpenAlex
- W2791349152
- Cited by
- 218
- References
- 62
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 25 · 2023: 35 · 2022: 25 · 2021: 31 · 2020: 33 · 2019: 20 · 2018: 6 · 2013: 1
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Funders
- FSH Society
- Agence Nationale de la Recherche (ANR-10-LABX-0034)
- Majlis Amanah Rakyat
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- skeletal muscle stem cells, satellite cells, extracellular matrix, stem cell niche, stem cell self-renewal, laminin alpha1, laminin alpha5, matrix metalloproteinases, muscle regeneration
- MeSH terms
- Cell Self Renewal, Animals, Basement Membrane, Cell Differentiation, Extracellular Matrix, Humans, Mice, Inbred C57BL, Signal Transduction, Muscle, Skeletal, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle, Stem Cell Niche
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