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A Specialized Vascular Niche for Adult Neural Stem Cells
Open accessAbstract
Stem cells reside in specialized niches that regulate their self-renewal and differentiation. The vasculature is emerging as an important component of stem cell niches. Here, we show that the adult subventricular zone (SVZ) neural stem cell niche contains an extensive planar vascular plexus that has specialized properties. Dividing stem cells and their transit-amplifying progeny are tightly apposed to SVZ blood vessels both during homeostasis and regeneration. They frequently contact the vasculature at sites that lack astrocyte endfeet and pericyte coverage, a modification of the blood-brain barrier unique to the SVZ. Moreover, regeneration often occurs at these sites. Finally, we find that circulating small molecules in the blood enter the SVZ. Thus, the vasculature is a key component of the adult SVZ neural stem cell niche, with SVZ stem cells and transit-amplifying cells uniquely poised to receive spatial cues and regulatory signals from diverse elements of the vascular system.
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“They contact the cerebrospinal fluid in the ventricles at the center of pinwheels formed by ependymal cells and extend a long process to the vasculature (Mirzadeh et al., 2008; Shen et al., 2008; Tavazoie et al., 2008).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Tavazoie et al., 2008
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Metadata
- Authors
- Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., Garcia-Verdugo, J. M., & Doetsch, F.
- Affiliations
- Columbia University (US)
- Corresponding author
- Doetsch, Fiona
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 3
- Issue
- 3
- Pages
- 279-288
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC6864413
- OpenAlex
- W2108340830
- Cited by
- 1,033
- References
- 55
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 31 · 2023: 22 · 2022: 35 · 2021: 48 · 2020: 59 · 2019: 61 · 2018: 49 · 2017: 60 · 2016: 59 · 2015: 71 · 2014: 88 · 2013: 79 · 2012: 95
- FWCI
- 24.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008224, T32GM007367)
- National Institute of Neurological Disorders and Stroke (R01NS053884)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- neural stem cells, stem cell niche, subventricular zone, vascular system, blood-brain barrier, pericytes, astrocyte endfeet, transit amplifying cells, self-renewal, tissue regeneration
- MeSH terms
- Animals, Blood Vessels, Brain, Cell Differentiation, Cell Division, Humans, Mice, Inbred Strains, Lateral Ventricles, Mice, Adult Stem Cells
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