The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States
Open accessAbstract
SUMMARY Embryonic stem cells (ESC) are apparently homogeneous self-renewing cells, but Stella, a marker of preimplantation embryos and germ cells showed heterogeneous expression in ESCs. Here we show that the Stella-positive ESCs were like the inner cell mass (ICM) while the Stella-negative cells were like the epiblast cells, although these populations exhibited interchangeability that reflected an adherence to an inherent program. Thus, ESCs are in a metastable state since they shift between the ICM- and epiblast-like phenotypes, which provides an insight into their instability, plasticity and pluripotency. This equilibrium was skewed reversibly by environmental and epigenetic cues; for example, the absence of signals from feeder cells caused a shift towards an epiblast-like state while trichostatin A, an inhibitor of histone deactelylase, restored Stella-positive population. Consistently, the two populations showed different histone modifications but with hypomethylated DNA in stella locus, as well as functional differences when induced to undergo differentiation. The Stella-negative cells were apparently more like the post-implantation epiblast-derived stem cells (EpiSCs), except that the stella locus was hypermethylated and repressed in the latter, which denotes a robust boundary between ESCs and EpiSCs.
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Cites
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Metadata
- Authors
- Hayashi, K., Lopes, S. M. C. D. S., Tang, F., & Surani, M. A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 3
- Issue
- 4
- Pages
- 391-401
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2072806829
- Cited by
- 649
- References
- 3
- FWCI
- 24.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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