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Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling
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Repressive H3K27me3 is depleted only in enhancers that gain H3K4me2 toward a pluripotent state.
“By contrast, repressive H3K27me3 is depleted only in enhancers that gain H3K4me2 toward a pluripotent state.”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [86]
The Results section, “Repressive H3K27me3 is lost specifically at sites where H3K4 methylation is gained” (page unavailable), reports H3K27me3 depletion where H3K4me2 increases, but examines promoters, not enhancers. The enhancer Results section describes H3K4me2 changes toward an ES-cell-like state; it does not establish H3K27me3 depletion at those enhancers or the claim that depletion occurs only there. (LLM, conf=0.86)
Experimental — accuracy not yet measuredH3K4me3 levels at promoters remain largely stable and are correlated with transcriptional changes.
“At the same time, H3K4me3 levels at promoters remain largely stable and are correlated with transcriptional changes 86 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [86]
In Results, under “Activating chromatin marks are targeted to the promoters of pluripotent genes prior to transcriptional activation” (page unavailable), the de novo promoter set does not gain H3K4me3 during early reprogramming. But H3K4me3 increases at the enhanced promoter set, so the passage does not establish that promoter levels remain largely stable overall. The reported correlation with transcriptional repression concerns H3K4me2, not H3K4me3. (LLM, conf=0.82)
Experimental — accuracy not yet measuredOn nucleosomes, levels of H3K4me2 change rapidly at enhancers of pluripotency and development-related genes before gene expression changes are observed.
“On nucleosomes, levels of H3K4me2, a transcriptional activation mark, change rapidly at enhancers of pluripotency and development-related genes before gene expression changes are observed.”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [86]
The Results section reports rapid H3K4me2 changes at promoters of pluripotency and development-related genes before their transcriptional activation. Its enhancer section separately reports rapid H3K4me2 changes, but does not establish that those enhancers belong to the specified genes or that their changes precede gene-expression changes. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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Cites
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“Repressive factors are associated with actively transcribed loci in somatic cells, such as H3K4/36/79 methylation 21 – 23 , SUMOylation 24 , Facilitates Chromatin Transcription (FACT) 25 , and Poly (ADP-Ribose) Polymerase 1 (PARP1) 26 .”
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Metadata
- Authors
- Koche, R. P., Smith, Z. D., Adli, M., Gu, H., Ku, M., Gnirke, A., Bernstein, B. E., & Meissner, A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 8
- Issue
- 1
- Pages
- 96-105
- ISSN
- 1934-5909
- PMC
- PMC3220622
- Cited by
- 355
- References
- 4
- Language
- en
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