The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network
Open accessAbstract
The molecular mechanisms of neurogenic fate determination are of particular importance in light of the need to regenerate neurons. Here we define the mechanisms of installing neurogenic fate by the transcription factor Pax6 acting together with the Brg1-containing BAF chromatin remodeling complex. We show that Pax6 physically interacts with Brg1-containing BAF complex and genetic deletion of either Pax6 or Brg1, in the neural stem cells in the adult mouse subependymal zone results in a strikingly similar fate conversion from neuronal progenitors to glia. The Pax6-BAF complex drives neurogenesis by directly activating transcription factors Sox11, Nfib and Pou3f4, which form a cross-regulatory network that maintains neurogenic fate downstream of the Pax6-BAF complex in neuroblasts. Our work identifies a novel concept of stratification in neural fate commitment with a strikingly specific role of the Pax6-BAF complex in initiating a cross-regulatory network essential for maintenance of the neurogenic lineage in the adult brain.
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Cites
Direct conversion of fibroblasts to functional neurons by defined factors
Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
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Self-citationMicroRNA-mediated switching of chromatin-remodelling complexes in neural development
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“, 2006) by tamoxifen (TM) inducible Cre-based excision in Glast mice, mediating genomic recombination in astrocytes and NSCs (Mori et al., 2006; Ninkovic et al., 2007).”
Self-citationChromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
Singhal, N., Graumann, J., Wu, G., Araúzo-Bravo, M. J., Han, D. W., Greber, B., Gentile, L., Mann, M., & Schöler, H. R. (2010) · Cell · doi:10.1016/j.cell.2010.04.037 · Cited by 378 · cited 1×
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Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation
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Self-citationThe Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
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H3K4me3 breadth is linked to cell identity and transcriptional consistency
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Metadata
- Authors
- Ninkovic, J., Steiner-Mezzadri, A., Jawerka, M., Akinci, U., Masserdotti, G., Petricca, S., Fischer, J., von Holst, A., Beckers, J., Lie, C. D., Petrik, D., Miller, E., Tang, J., Wu, J., Lefebvre, V., Demmers, J., Eisch, A., Metzger, D., Crabtree, G., Irmler, M., Poot, R., & Götz, M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 13
- Issue
- 4
- Pages
- 403-418
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1974203453
- Cited by
- 214
- References
- 15
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ninkovic, J., Steiner-Mezzadri, A., Jawerka, M., Akinci, U., Masserdotti, G., Petricca, S., Fischer, J., von Holst, A., Beckers, J., Lie, C. D., Petrik, D., Miller, E., Tang, J., Wu, J., Lefebvre, V., Demmers, J., Eisch, A., Metzger, D., Crabtree, G., . . . Götz, M. (2013). The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network. Cell Stem Cell. https://doi.org/10.1016/j.stem.2013.07.002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
