The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Epigenomic Comparison Reveals Activation of “Seed” Enhancers during Transition from Naive to Primed Pluripotency
Open accessAbstract
SUMMARY Naïve mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs) represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and epigenomic mapping we show that a small fraction of transcripts are differentially expressed between mESCs and mEpiSCs and these genes show expected changes in chromatin at their promoters and enhancers. Unexpectedly, the cis-regulatory circuitry of genes that are expressed at identical levels between these cell states also differs dramatically. In mESCs, these genes are associated with dominant proximal enhancers and dormant distal enhancers, which we term seed enhancers. In mEpiSCs, the naïve-dominant enhancers are lost, and the seed enhancers take up primary transcriptional control. Seed enhancers have increased sequence conservation and show preferential usage in downstream somatic tissues, often expanding into super enhancers. We propose that seed enhancers ensure proper enhancer utilization and transcriptional fidelity as mammalian cells transition from naïve pluripotency to a somatic regulatory program.
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Super-enhancers in the control of cell identity and disease
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Self-citationDevelopmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality
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Metadata
- Authors
- Factor, D. C., Corradin, O., Zentner, G. E., Saiakhova, A., Song, L., Chenoweth, J. G., McKay, R. D., Crawford, G. E., Scacheri, P. C., & Tesar, P. J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 14
- Issue
- 6
- Pages
- 854-863
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1992788426
- Cited by
- 159
- References
- 12
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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