Therapeutic m 6 A Eraser ALKBH5 mRNA-Loaded Exosome–Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

Global patterns and trends in colorectal cancer incidence and mortality

Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2016) · Gut · doi:10.1136/gutjnl-2015-310912 · Cited by 5,250 · see citing works

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550 · see citing works

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huang, H., Weng, H., Sun, W., Qin, X., Shi, H., Wu, H., Zhao, B. S., Mesquita, A., Liu, C., Yuan, C. L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0045-z · Cited by 2,997 · see citing works

Time‐Dependent ROC Curves for Censored Survival Data and a Diagnostic Marker

Heagerty, P. J., Lumley, T., & PEPE, M. S. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00337.x · Cited by 2,870 · see citing works

Colorectal cancer

Brenner, H., Kloor, M., & Pox, C. P. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61649-9 · Cited by 2,854 · see citing works

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

Plaks, V., Kong, N., & Werb, Z. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.015 · Cited by 1,557 · see citing works

Cancer incidence and mortality in China, 2016

Zheng, R., Sun, K., Han, B., Li, L., Chen, R., Wang, S., Li, L., Zeng, H., He, J., Wei, W., et al. (2022) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2022.02.002 · Cited by 1,515 · see citing works

m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

Zhang, S., Zhao, B. S., Zhou, A., Lin, K., Zheng, S., Lu, Z., Chen, Y., Sulman, E. P., Xie, K., Bögler, O., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.013 · Cited by 1,453 · see citing works

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Gao, H., Korn, J. M., Ferretti, S., Monahan, J. E., Wang, Y., Singh, M., Zhang, C., Schnell, C., Yang, G., Zhang, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3954 · Cited by 1,393 · see citing works

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

Chen, M., Wei, L., Law, C., Tsang, F. H., Shen, J., Cheng, C. L., Tsang, L.-H., Ho, D. W., Chiu, D. K., Lee, J. M., et al. (2017) · Hepatology · doi:10.1002/hep.29683 · Cited by 1,381 · see citing works

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

Qu, L., Ding, J., Chen, C. Y., Wu, Z., Liu, B., Gao, Y., Chen, W., Liu, F., Sun, W. C., Li, X., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.03.004 · Cited by 1,116 · see citing works

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA

Zhang, C., Samanta, D., Lu, H., Bullen, J. W., Zhang, H., Chen, I., He, X., & Semenza, G. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602883113 · Cited by 977 · see citing works

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

Li, T., Hu, P.-S., Zuo, Z., Lin, J., Li, X., Wu, Q.-N., Chen, Z., Zeng, Z.-L., Wang, F., Zheng, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1038-7 · Cited by 797 · see citing works

Reading m6A in the Transcriptome: m6A-Binding Proteins

Patil, D. P., Pickering, B. F., & Jaffrey, S. R. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.10.001 · Cited by 631 · see citing works

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

Li, N., Kang, Y., Wang, L., Huff, S. E., Tang, R., Hui, H., Agrawal, K., Gonzalez, G. M., Wang, Y., Patel, S. P., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918986117 · Cited by 578 · see citing works

RNA nucleotide methylation

Motorin, Y., & Helm, M. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.79 · Cited by 441 · see citing works

Reversible RNA adenosine methylation in biological regulation

Jia, G., Fu, Y., & He, C. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.11.003 · Cited by 425 · see citing works

mRNA vaccine: a potential therapeutic strategy

Wang, Y., Zhang, Z., Luo, J., Han, X., Wei, Y., & Wei, X. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01311-z · Cited by 422 · see citing works

m6A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy

Wang, L., Hui, H., Agrawal, K., Kang, Y., Li, N., Tang, R., Yuan, J., & Rana, T. M. (2020) · The EMBO Journal · doi:10.15252/embj.2020104514 · Cited by 409 · see citing works

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

Chen, X., Xu, M., Xu, X., Zeng, K., Liu, X., Pan, B., Li, C., Sun, L., Qin, J., Xu, T., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01220-7 · Cited by 407 · see citing works

The folate receptor as a rational therapeutic target for personalized cancer treatment

Assaraf, Y. G., Leamon, C. P., & Reddy, J. A. (2014) · Drug Resistance Updates · doi:10.1016/j.drup.2014.10.002 · Cited by 399 · see citing works

mRNA therapeutics in cancer immunotherapy

Beck, J. D., Reidenbach, D., Salomon, N., Sahin, U., Türeci, Ö., Vormehr, M., & Kranz, L. M. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01348-0 · Cited by 385 · see citing works

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

Peng, W., Li, J., Chen, R., Gu, Q., Yang, P., Qian, W., Ji, D., Wang, Q., Zhang, Z., Tang, J., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1408-4 · Cited by 373 · see citing works

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

Jin, D., Guo, J., Wu, Y., Yang, L., Wang, X., Du, J., Dai, J., Chen, W., Gong, K., Miao, S., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01161-1 · Cited by 344 · see citing works

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

Islam, M. A., Xu, Y., Tao, W., Ubellacker, J. M., Lim, M., Aum, D., Lee, G. Y., Zhou, K., Zope, H., Yu, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0284-0 · Cited by 339 · see citing works

M6A demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia

Shen, C., Sheng, Y., Zhu, A., Robinson, S., Jiang, X., Dong, L., Chen, H., Su, R., Yin, Z., Li, W., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.04.009 · Cited by 321 · see citing works

Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy

Cheng, L., Zhang, X., Tang, J., Lv, Q., & Liu, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120964 · Cited by 307 · see citing works

Post-transcriptional regulons coordinate the initiation and resolution of inflammation

Anderson, P. (2009) · Nature reviews. Immunology · doi:10.1038/nri2685 · Cited by 285 · see citing works

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1

Chen, Y., Zhao, Y., Chen, J., Peng, C., Zhang, Y., Tong, R., Cheng, Q., Yang, B., Feng, X., Lu, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01239-w · Cited by 284 · see citing works

ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis

Yu, H., Yang, X. F., Tang, J., Si, S., Zhou, Z., Lu, J., Han, J., Yuan, B., Wu, Q., Lü, Q., et al. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.10.031 · Cited by 206 · see citing works

The Roles of Jumonji-Type Oxygenases in Human Disease

Johansson, C., Tumber, A., Che, K., Cain, P., Nowak, R. P., Gileadi, C., & Oppermann, U. C. T. (2014) · Epigenomics · doi:10.2217/epi.13.79 · Cited by 163 · see citing works

Prognostic and Predictive Role of JWA and XRCC1 Expressions in Gastric Cancer

Wang, S., Wu, X., Chen, Y., Zhang, J., Ding, J., Zhou, Y., He, S., Tan, Y., Qiang, F., Bai, J., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2863 · Cited by 129 · see citing works

Biomedical applications of mRNA nanomedicine

Xiong, Q., Lee, G. Y., Ding, J., Li, W., & Shi, J. (2018) · Nano Research · doi:10.1007/s12274-018-2146-1 · Cited by 125 · see citing works

Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

Ding, X., Pan, H., Li, J., Zhong, Q., Chen, X., Dry, S., & Wang, C. (2013) · Science Signaling · doi:10.1126/scisignal.2003884 · Cited by 120 · see citing works

Lysine Methylation Regulators Moonlighting outside the Epigenome

Cornett, E. M., Ferry, L., Defossez, P., & Rothbart, S. B. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.026 · Cited by 113 · see citing works

The essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma

Ma, L., Xue, X., Zhang, X., Yu, K., Xu, X., Tian, X., Miao, Y., Meng, F., Liu, X., Guo, S., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02200-5 · Cited by 113 · see citing works

ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer

Liu, H., Lyu, H., Jiang, G., Chen, D., Ruan, S., Liu, S., Zhou, L., Yang, M., Zeng, S., He, Z., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0800 · Cited by 109 · see citing works

Deregulated expression of selected histone methylases and demethylases in prostate carcinoma

Vieira, F. Q., Costa‐Pinheiro, P., Ramalho-Carvalho, J., Faria‐Pereira, A., Menezes, F. D., Antunes, L., Carneiro, I. C., Oliveira, J., Henrique, R., & Jerónimo, C. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0375 · Cited by 103 · see citing works

Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment

Li, F., Wang, Y., Chen, W., Wang, D., Zhou, Y., You, B., Liu, Y., Qu, C., Yang, S.-D., Chen, M., et al. (2019) · Theranostics · doi:10.7150/thno.32416 · Cited by 101 · see citing works

RNA-based pharmacotherapy for tumors: From bench to clinic and back

Liang, X., Li, D., Leng, S., & Zhu, X. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109997 · Cited by 96 · see citing works

An acetate switch regulates stress erythropoiesis

Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H. C., Moon, Y.-A., Gerard, R. D., Huang, C.-L., Comerford, S. A., Hammer, R. E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3587 · Cited by 87 · see citing works

Highly sensitive and specific cytosensing of HT 29 colorectal cancer cells using folic acid functionalized-KCC-1 nanoparticles

Soleymani, J., Hasanzadeh, M., Somi, M. H., Shadjou, N., & Jouyban, A. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.02.052 · Cited by 77 · see citing works

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis

Elkouris, M., Kontaki, H., Stavropoulos, A., Antonoglou, A., Nikolaou, K. C., Samiotaki, M. K., Szántai, E., Saviolaki, D., Brown, P. J., Sideras, P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.051 · Cited by 75 · see citing works

FIH Is an Oxygen Sensor in Ovarian Cancer for G9a/GLP-Driven Epigenetic Regulation of Metastasis-Related Genes

Kang, J., Shin, S.-H., Yoon, H., Huh, J., Shin, H., Chun, Y., & Park, J. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-2506 · Cited by 56 · see citing works

Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered

Zheng, S., Liu, Q., Liu, T., & Lu, X. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00813-0 · Cited by 54 · see citing works

Folate Receptor-Mediated siRNA Delivery: Recent Developments and Future Directions for RNAi Therapeutics

Gangopadhyay, S., Nikam, R. R., & Gore, K. R. (2021) · Nucleic Acid Therapeutics · doi:10.1089/nat.2020.0882 · Cited by 53 · see citing works

N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation

Zhang, Z., Wang, L., Zhao, L., Wang, Q., Yang, C., Zhang, M., Wang, B., Jiang, K., Ye, Y., Wang, S., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.940 · Cited by 53 · see citing works

JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells

Boeckel, J., Derlet, A., Glaser, S.-F., Luczak, A., Lucas, T., Heumüller, A. W., Krüger, M., Zehendner, C. M., Kaluza, D., Doddaballapur, A., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307695 · Cited by 51 · see citing works

Role of astrocyte activation in fine particulate matter-enhancement of existing ischemic stroke in Sprague-Dawley male rats

Zhang, C., Meng, Q., Zhang, X., Wu, S., Wang, S., Chen, R., & Li, X. (2016) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2016.1176615 · Cited by 45 · see citing works

MiR-873-5p suppresses cell proliferation and epithelial–mesenchymal transition via directly targeting Jumonji domain-containing protein 8 through the NF-κB pathway in colorectal cancer

Wang, L., Jiang, F., Ma, F., & Zhang, B. (2019) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-019-00522-w · Cited by 44 · see citing works

PRDM16 is associated with evasion of apoptosis by prostatic cancer cells according to RNA interference screening

Zhu, S., Xu, Y., Song, M. L., Chen, G., Wang, H., Zhao, Y., Wang, Z., & Li, F. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5605 · Cited by 42 · see citing works

Effect of Cationic Lipid Type in Folate-PEG-Modified Cationic Liposomes on Folate Receptor-Mediated siRNA Transfection in Tumor Cells

Hattori, Y., Shimizu, S., Ozaki, K., & Onishi, H. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11040181 · Cited by 36 · see citing works

Role of post‐transcriptional regulation of mRNA stability in renal pathophysiology: focus on chronic kidney disease

Feigerlová, E., & Battaglia-Hsu, S.-F. (2016) · The FASEB Journal · doi:10.1096/fj.201601087rr · Cited by 29 · see citing works

JMJD8 is a positive regulator of TNF-induced NF-κB signaling

Yeo, K. S., Tan, M. C., Wong, W. Y., Loh, S. W., Lam, Y. L., Tan, C. L., Lim, Y., & Ea, C.-K. (2016) · Scientific Reports · doi:10.1038/srep34125 · Cited by 26 · see citing works

Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells

Kim, I., Shin, S.-H., Lee, J. E., & Park, J. (2019) · Oncogene · doi:10.1038/s41388-019-0676-y · Cited by 22 · see citing works

PEGylated siRNA lipoplexes for silencing of BLIMP-1 in Primary Effusion Lymphoma: In vitro evidences of antitumoral activity

Belletti, D., Tosi, G., Forni, F., Lagreca, I., Barozzi, P., Pederzoli, F., Vandelli, M. A., Riva, G., Luppi, M., & Ruozi, B. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.11.007 · Cited by 20 · see citing works

MPO Promoter Polymorphism rs2333227 Enhances Malignant Phenotypes of Colorectal Cancer by Altering the Binding Affinity of AP-2α

Meng, Q., Wu, S., Wang, Y., Xu, J., Sun, H., Lu, R., Gao, N., Yang, H., Li, X., Tang, B., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2538 · Cited by 19 · see citing works

A novel mechanism of rs763110 polymorphism contributing to cervical cancer risk by affecting the binding affinity of C/EBPβ and OCT1 complex to chromatin

Wu, S., Wang, S., Fu, Y., Tang, W., Jin, H., Meng, Q., Zhang, C., Cui, M., Cao, X., Li, X., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30490 · Cited by 18 · see citing works

DR4 mediates the progression, invasion, metastasis and survival of colorectal cancer through the Sp1/NF1 switch axis on genomic locus

Wu, S., Meng, Q., Zhang, C., Sun, H., Lu, R., Gao, N., Yang, H., Li, X., Aschner, M., & Chen, R. (2018) · International Journal of Cancer · doi:10.1002/ijc.31318 · Cited by 18 · see citing works

Correlation between high expression levels of jumonji domain-containing 4 and short survival in cases of colon adenocarcinoma

Ho, Y., Shih, C., Yeh, K.-T., Shi, B., Gong, Z., Lin, Y.-M., & Lu, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.061 · Cited by 14 · see citing works

JMJD8 Functions as a Novel AKT1 Lysine Demethylase

Wang, Y., Zhang, Y., Li, Z., & Wang, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010460 · Cited by 10 · see citing works

Recent advances in extracellular vesicles for therapeutic cargo delivery

Kim, H. I., Park, J. B., Zhu, Y., Wang, X., Han, Y., & Zhang, D. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01201-6 · Cited by 504 · see citing works

Exosome for mRNA delivery: Strategies and therapeutic applications

Iqbal, Z., Rehman, K., Mahmood, A., Shabbir, M., Liang, Y., Duan, L., & Zeng, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02634-x · Cited by 144 · see citing works

Exosomes in Precision Oncology and Beyond: From Bench to Bedside in Diagnostics and Therapeutics

Youssef, E. M., Palmer, D., Fletcher, B., & Vaughn, R. (2025) · Cancers · doi:10.3390/cancers17060940 · Cited by 82 · see citing works

Biointerface‐Engineered Hybrid Nanovesicles for Targeted Reprogramming of Tumor Microenvironment

Zhen, X., Li, Y., Yuan, W., Zhang, T., Li, M., Huang, J., Kong, N., Xie, X., Wang, S., & Tao, W. (2024) · Advanced Materials · doi:10.1002/adma.202401495 · Cited by 71 · see citing works

Recent advances in extracellular vesicle engineering and its applications to regenerative medicine

Rhim, W.-K., Kim, J. Y., Lee, S. Y., Cha, S.-G., Park, J. M., Park, H. J., Park, C. G., & Han, D. K. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00468-6 · Cited by 60 · see citing works

RNA m6A modification in ferroptosis: implications for advancing tumor immunotherapy

Shi, J.-X., Zhang, Z., Yin, H.-Z., Piao, X.-J., Liu, C., Liu, Q.-J., Zhang, J.-C., Zhou, W.-X., Liu, F., Yang, F., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02132-6 · Cited by 54 · see citing works

Fusogenic lipid nanoparticles for rapid delivery of large therapeutic molecules to exosomes

Son, G., Song, J., Park, J. C., Kim, H. N., & Kim, H. (2025) · Nature Communications · doi:10.1038/s41467-025-59489-5 · Cited by 59 · see citing works

Small molecule inhibitors targeting m6A regulators

Feng, G., Wu, Y., Hu, Y., Wen, S., Yang, X. J., Li, Y., Ouyang, L., & Wang, G. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01546-5 · Cited by 50 · see citing works

Tumor Microenvironment-Derived Exosomes: A Double-Edged Sword for Advanced T Cell-Based Immunotherapy

Lu, Y., Zheng, J., Lin, P., Lin, Y., Zheng, Y., Mai, Z., Chen, X., Xia, T., Zhao, X., & Cui, L. (2024) · ACS Nano · doi:10.1021/acsnano.4c09190 · Cited by 46 · see citing works

Lipid Nanoparticle-Based Delivery SystemA Competing Place for mRNA Vaccines

Zhang, X., Li, Y., & Zhou, Z. (2024) · ACS Omega · doi:10.1021/acsomega.3c08353 · Cited by 43 · see citing works

Bioinspired cellular membrane-derived vesicles for mRNA delivery

Xu, X., Xu, L., Wang, J., Wen, C., Xia, J., Zhang, Y., & Liang, Y. (2024) · Theranostics · doi:10.7150/thno.93755 · Cited by 41 · see citing works

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Li, Q., Xing, H., Naeem, A., Zhang, K., Zheng, A., Huang, Y., & Lu, M. (2025) · Exploration · doi:10.1002/exp.20240109 · Cited by 42 · see citing works

The challenge and opportunity of gut microbiota‐targeted nanomedicine for colorectal cancer therapy

Wei, Y., Shen, F., Song, H., Zhao, R., Feng, W., Pan, Y., Li, X., Yu, H., Familiari, G., Relucenti, M., et al. (2024) · iMeta · doi:10.1002/imt2.213 · Cited by 39 · see citing works

Harnessing gut microbiota for colorectal cancer therapy: from clinical insights to therapeutic innovations

Chen, C., Su, Q., Zi, M., Hua, X., & Zhang, Z. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00818-3 · Cited by 41 · see citing works

Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer

Zhang, J., Ali, K., & Wang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s466490 · Cited by 38 · see citing works

Nanomedicine for colon-targeted drug delivery: strategies focusing on inflammatory bowel disease and colon cancer

Kumar, A., Vaiphei, K. K., Singh, N., Chigurupati, S. P. D., Paliwal, S. R., Paliwal, R., & Gulbake, A. (2024) · Nanomedicine · doi:10.1080/17435889.2024.2350356 · Cited by 34 · see citing works

Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment

Lahouty, M., Fadaee, M., Shanehbandi, D., & Kazemi, T. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10157-9 · Cited by 31 · see citing works

Omics‐Enhanced Nanomedicine for Cancer Therapy

Qi, L., Li, Z., Liu, J., & Chen, X. S. (2024) · Advanced Materials · doi:10.1002/adma.202409102 · Cited by 30 · see citing works

Interplay of m6A RNA methylation and gut microbiota in modulating gut injury

Wang, H., Han, J., & Zhang, X. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2467213 · Cited by 29 · see citing works

Exosome-Mediated Chemoresistance in Cancers: Mechanisms, Therapeutic Implications, and Future Directions

Liu, G., Liu, J., Li, S., Zhang, Y., & Ren, H. (2025) · Biomolecules · doi:10.3390/biom15050685 · Cited by 24 · see citing works

Nature’s carriers: leveraging extracellular vesicles for targeted drug delivery

Chen, Q., Zheng, Y., Jiang, X., Wang, Y., Chen, Z., & Wu, D. (2024) · Drug Delivery · doi:10.1080/10717544.2024.2361165 · Cited by 22 · see citing works

Mechanisms and clinical landscape of N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers

Zhu, D., Su, K., Ouyang, X., Zhang, Y., Yu, X.-P., Li, Z., Ahmadi-Nishaboori, S.-S., & Li, L. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05040-x · Cited by 22 · see citing works

Extracellular vesicles as modifiers of epigenomic profiles

Zhou, H., Hu, S. C., & Yan, W. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.05.005 · Cited by 21 · see citing works

Engineering exosomes for mRNA delivery: a review

Yao, T. S., Dong, X., Wang, X., Liu, X., Fu, L., & Li, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144662 · Cited by 23 · see citing works

Extracellular Vesicle Lipids and Their Role in Delivery

Brent, A., Shirmast, P., & McMillan, N. A. J. (2025) · Journal of Extracellular Biology · doi:10.1002/jex2.70064 · Cited by 20 · see citing works

Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications

Liu, S., Ma, Q., Zeng, C., Li, H., Su, J., Song, Z., Yan, R., Zhao, Z., Tian, S., & Huang, W. (2025) · Biomarker Research · doi:10.1186/s40364-025-00824-9 · Cited by 18 · see citing works

m6A-modified circXPO1 accelerates colorectal cancer progression via interaction with FMRP to promote WWC2 mRNA decay

Zhu, X., & Zhang, P. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05716-4 · Cited by 18 · see citing works

N6-Methyladenosine methylation modification in breast cancer: current insights

Zhang, G., Chen, C., Wang, X., & Wang, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05771-x · Cited by 18 · see citing works

Unveiling the Potential of Extracellular Vesicles as Biomarkers and Therapeutic Nanotools for Gastrointestinal Diseases

Arrè, V., Mastrogiacomo, R., Balestra, F., Serino, G., Viti, F., Rizzi, F. R., Curri, M. L., Giannelli, G., Depalo, N., & Scavo, M. P. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040567 · Cited by 17 · see citing works

Delivery of mRNA Using Biomimetic Vectors: Progress and Challenges

Yin, M., Sun, H., Li, Y., Zhang, J., Wang, J., Liang, Y., & Zhang, K. (2024) · Small · doi:10.1002/smll.202402715 · Cited by 17 · see citing works

Engineered exosomes as precision tools for brain-targeted drug delivery and treatment of central nervous system diseases

Jin, Y., Zhang, Y., Song, M., Zhou, J., Zhang, H., & Ding, Y. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100344 · Cited by 17 · see citing works

Orchestrating cancer therapy: Recent advances in nanoplatforms harmonize immunotherapy with multifaceted treatments

Xu, R., Lin, P., Zheng, J., Lin, Y., Mai, Z., Lu, Y., Xu, C., Zhou, Z., Li, C., & Zhao, X. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101386 · Cited by 16 · see citing works

Epigenetic reprogramming in gastrointestinal cancer: biology and translational perspectives

Wang, Y., Liu, H., Zhang, M., Xu, J., Zheng, L., Liu, P., Chen, J., Liu, H., & Chen, C. (2024) · MedComm · doi:10.1002/mco2.670 · Cited by 16 · see citing works

Cold atmospheric plasma as a novel “drug” for cancer therapy

Fu, D., Lin, S., Xu, Q., Cao, F., KHAN, I. A., Xu, S., Li, Z., Chen, Z., Fang, Q., Chen, G., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114118 · Cited by 15 · see citing works

Advances in hybrid exosome-liposome nanoparticles for enhanced cancer therapy

Dou, J., Wang, J., Zhang, G., Fu, X., Zhang, Y., & Sun, F. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115317 · Cited by 15 · see citing works

Demethylases in tumors and the tumor microenvironment: Key modifiers of N6-methyladenosine methylation

Guo, J., Zhao, L., Duan, M., Yang, Z., Zhao, H., Liu, B., Wang, Y., Deng, L., Wang, C., Jiang, X., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116479 · Cited by 15 · see citing works

Targeted Delivery of Exosome-Derived miRNA-185-5p Inhibitor via Liposomes Alleviates Apoptosis and Cuproptosis in Dilated Cardiomyopathy

Xu, S., Zeng, Y., Tan, X., Zhang, G., Xu, A., Fan, H., Yu, F., Qin, Z., Song, Y., Jiang, Y., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s522157 · Cited by 14 · see citing works

Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review

Ibrahim, I. S., Chellathurai, M. S., Mahmood, S., Azmi, A. H., Harun, N., Nazri, M. U. I. A., Mahat, M. M., & Sofian, Z. M. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123735 · Cited by 11 · see citing works

Membrane-modified lipid nanoparticles for RNA delivery

Chowdhury, C. R., Hoover, E. C., & Day, E. S. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101505 · Cited by 11 · see citing works

Targeting Ischemic Myocardium: Nanoparticles Loaded with Long Noncoding RNA AK156373 siRNA Alleviate Myocardial Infarction

Gao, M., Yin, L., Zhang, B., Dong, Z., Jiang, W., Bai, Z., Zhao, X., Xu, L., Wang, N., & Peng, J. (2025) · ACS Nano · doi:10.1021/acsnano.5c01641 · Cited by 9 · see citing works

Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases

Zhang, J., Ma, W., Liu, R., Li, X., Yuan, Z., & Cheng, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01648 · Cited by 10 · see citing works

Mechanistic insights into the role of RNA demethylase ALKBH5 in malignant tumor therapy

An, R., Shao, Y., & Gu, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06938-w · Cited by 9 · see citing works

DNA, RNA, and histone methylation regulation enzymes and their crosstalk in colorectal carcinogenesis and progression: a review of molecular mechanisms, clinical implications, and future perspectives

Qian, S., Song, H., Huang, L., Hua, H. M., Zhang, X., Li, Z., Pu, M., Huang, H., & Zhang, J. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00823-6 · Cited by 9 · see citing works

The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential

Wu, L., & Tang, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115398 · Cited by 9 · see citing works

Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis

Liu, Q., Ma, T., Zhang, Z., Nan, J., Liu, G., Yang, Y., Hu, Y., & Xie, J. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70028 · Cited by 9 · see citing works

A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma

Guo, C., Dou, R., Wang, L., Zhang, J., Cai, X., Tang, J., Huang, Z., Liu, M., Chen, J., & Chen, H. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.12.014 · Cited by 8 · see citing works

Multifaceted Applications of Nanomaterials in Colorectal Cancer Management: Screening, Diagnostics, and Therapeutics

He, X., Chang, Z., & Niu, M. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s520616 · Cited by 8 · see citing works

Engineered Exosomes as Programmable Nanocarriers for Targeted Theranostic and Translational Applications

Patil, J., Singh, A., Bhalerao, S., Ahmad, S. F., Rawal, R., Bhatia, D. D., & Solanki, R. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01251 · Cited by 8 · see citing works

A novel member of biomimetic nano vesicles: Functional properties and research progress of hybrid-membered nanovesicles

Zhang, C., Liu, Y., Bai, T., Shao, H., Xiong, Z., Epstein, M. M., Li, X., & Chen, H. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108637 · Cited by 7 · see citing works

N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential

Liu, S., Liu, M., Li, Y., & Song, Q. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104360 · Cited by 8 · see citing works

Advanced Targeted Therapy for Colorectal Cancer with Lipid Nanoparticles

Kedar, P., Bhattacharya, S., Sakore, P., & Prajapati, B. G. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673327576241201145252 · Cited by 7 · see citing works

The mechanism of m6A modification in cardiovascular diseases: A systematic review

Liu, H., Song, T., & Huang, Y. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101672 · Cited by 6 · see citing works

RNA‐Based Therapeutics: Cutting‐Edge Advances in Clinical Research

Ferreira, D., & Rodrigues, L. R. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500082 · Cited by 6 · see citing works

Potential of Exosomes as Multifunctional Nanocarriers for Targeted Drug Delivery

Al-Ani, S. A., Lee, Q. Y., Maheswaran, D., Sin, Y. M., Loh, J. S., Foo, J. B., Hamzah, S. B., Ng, J. F., & Tan, L. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01268-6 · Cited by 6 · see citing works

Advances in the design and application of glycolysis-related nanodelivery systems for anti-tumor

Zhou, Y., Liu, M., Lü, N., Deng, X., Chen, X., Tang, L., Xie, Z., Lei, X., Yang, X., Zhou, S., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114844 · Cited by 6 · see citing works

Investigation of the enhanced antitumour potency of CD46-specific chimeric antigen receptor-T cells in human colorectal cancer liver metastases after combination with nanotherapeutics

Meng, Q., Xu, J., Wang, J., Zhang, X., Yang, H., Sun, H. X., Wu, S., Aschner, M., Li, X., Zhang, L., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101985 · Cited by 6 · see citing works

Exosomes serve as molecular diagnostic biomarkers and carriers for tissue engineering applications

Zhang, Z., Cao, H., & Li, X. (2025) · Materials Today Communications · doi:10.1016/j.mtcomm.2025.112978 · Cited by 5 · see citing works

The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma

Du, X., Ma, C., Wang, Y., Xu, M., Kuang, Y., Li, M., Wen, S., He, P., Zhao, H., & Wang, Q. (2025) · Respiratory Research · doi:10.1186/s12931-025-03281-y · Cited by 5 · see citing works

Exploring m6A modifications in gastric cancer: from molecular mechanisms to clinical applications

Li, P., Fang, X., & Huang, D. (2025) · European journal of medical research · doi:10.1186/s40001-025-02353-5 · Cited by 5 · see citing works

Nanomedicine targeting the Warburg effect: Advanced strategies for cancer therapy

Wang, X., Yang, W., Shen, B., Jiang, B., Zhang, Z., & Wu, H. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104922 · Cited by 4 · see citing works

The role of m6A reader IGF2BPs in tumor metabolic reprogramming

Zhou, X., Li, G., Su, X., Wang, Y., Liu, L., Yang, C., Xu, Y., He, J., & Zhang, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117452 · Cited by 4 · see citing works

Recent advances in engineering approaches for delivery of mRNA-based therapeutics

Prinindya, K. N. N., Ashraf, G. M., Uddin, S., Mahdi, E., & Hasan, A. (2025) · Biomaterials Advances · doi:10.1016/j.bioadv.2025.214667 · Cited by 5 · see citing works

N6-methyladenosine RNA methylation regulators and their target SOX2 as circulating biomarkers of colorectal cancer: Insights towards early diagnosis and staging

Senousy, M. A., Shaker, O. G., Abdel‐Sattar, R., & Gibriel, A. A. (2026) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2026.111520 · Cited by 4 · see citing works

Complicated role of ALKBH5 in gastrointestinal cancer: an updated review

Shu, W., Huang, Q., Chen, R., Lan, H., Yu, L., Cui, K., He, W., Zhu, S., Chen, M., Li, L., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03480-5 · Cited by 4 · see citing works

Exosomes from Cancer Cells: Innovative Approach for Targeted Cancer Treatment

Hosseinpouri, A., Saberi, M., Yazdansetad, Z., Arabpour, Z., & Zarei‐Behjani, Z. (2025) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00393-1 · Cited by 4 · see citing works

Exosomes in treating Eye Diseases: Targeting strategies

Ge, P., Wang, J., Xie, P., & Hu, Z. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123598 · Cited by 4 · see citing works

M6AREG 2.0: the landscape of m6A-centered crosstalk with diverse epigenetic regulation

Yang, M., Zhou, Y., Yang, L., Yu, X., Ge, Y., Zhou, X., Li, X., Chen, F., Zhang, Y., Dai, H., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf997 · Cited by 3 · see citing works

Engineered nanotechnology for epigenetic therapy in cancer treatment

Li, Y., Li, Y., Tan, Y., Cai, Y., Liu, X., Wei, C., Yu, W., Fu, Y., & Cao, H. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.170485 · Cited by 4 · see citing works

Liposome-chondroitin sulfate/chitosan hybrid system for combinational drug delivery of curcumin and dexamethasone: In vitro anti-cancer activities

Eldurini, S., Tolba, E., El‐Hady, B. M. A., Ibrahim, A. M., & Shafaa, M. W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148941 · Cited by 3 · see citing works

Colorectal Cancer Puzzle: m6A Modification and Its Intricate Relationship With Drug Resistance

Yang, M., Dai, Z., Han, Y., Shen, Y., & Wang, J. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45750 · Cited by 3 · see citing works

Precision Engineering of Extracellular Vesicles as Programmable Carriers for mRNA Therapeutics

Yoon, H., Lee, G., Jo, J., Koo, J., Kim, E., Choi, H. J., Jung, S., Shin, Y., Oh, K. T., & Lim, C. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s595161 · Cited by 3 · see citing works

Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer

Jiang, T.-Q., Wang, H., Cheng, W.-X., & Xie, C. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i38.4175 · Cited by 3 · see citing works

The dual mechanism of m6A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR

Sun, X., Tan, Q., Yang, Y., Jia, W. P., Zhou, X., Gao, S., & Yang, F. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07791-x · Cited by 3 · see citing works

Interactions between ALKBH5 and reader proteins in tumors: functions and molecular mechanisms

Ou, J., Liu, B., Yu, Y., He, Y., Gao, Y., Chen, L., Chen, X., & Tao, H. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1611007 · Cited by 2 · see citing works

Spatial Confinement–Accelerated DNAzyme Nanoassembly for Demethylase Imaging and Chemoresistance Evaluation in Living Cells

Yu, M., Bai, X., Shang, J., Xie, C., Wang, Y., Guo, Z., & Wang, F. (2026) · ACS Nano · doi:10.1021/acsnano.6c05918 · Cited by 2 · see citing works

Unraveling molecular and clinical aspects of ALKBH5 as dual role in colorectal cancer

Memon, F., Nadeem, M., Sulaiman, M., Arain, M. I., Hani, U.-E., & Yuan, S. (2024) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgae108 · Cited by 2 · see citing works

Role of the m6A demethylase ALKBH5 in gastrointestinal tract cancer (Review)

Zhang, L., Jing, M., Song, Q., Ouyang, Y., Pang, Y., Ye, X., Fu, Y., & Yan, W. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5463 · Cited by 2 · see citing works

Mapping the intellectual structure and emerging trends on nanomaterials in colorectal cancer: a bibliometric analysis from 2003 to 2024

Lu, M., Liu, Y., Zhu, J., Shang, J., Bai, L., Jin, Z., Li, W., Hu, Y., Zheng, X., & Qian, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2024.1514581 · Cited by 2 · see citing works

The functional extracellular vesicles target tumor microenvironment for gastrointestinal malignancies therapy

Li, D., Chu, X., Ning, Y., Yang, Y., Wang, C., Tian, X., & Yang, Y. (2025) · Extracellular Vesicle · doi:10.1016/j.vesic.2025.100077 · Cited by 2 · see citing works

Small extracellular vesicles-based drug delivery systems for therapies of gastrointestinal tumours

Luo, L., Wang, D., Xu, W., & Jiang, J. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2535375 · Cited by 2 · see citing works

Overexpression of HYOU1 is associated with cisplatin resistance and may depend on m6A modification in patients with cervical cancer

Wang, R., Deng, J., Zhang, M., Wang, Z., Wu, S., Liu, S., & Qi, L. (2024) · Oncology Letters · doi:10.3892/ol.2024.14823 · Cited by 1 · see citing works

Exosomes facilitate mRNA and siRNA delivery using cationic liposomes 2X3-DOPE to rat heart mesenchymal cells in vitro

Dovbysh, O. V., Vysochinskaya, V. V., Gavrilova, N. V., Docshin, P. M., Nikitina, E. G., Klochev, A. S., Elpaeva, E. A., Dobrovolskaya, O. A., Shmendel, E. V., Maslov, M. A., et al. (2025) · Medical academic journal · doi:10.17816/maj641910 · Cited by 1 · see citing works

MEX3A-mediated super-enhancer RNA m6A methylation promotes aggressiveness of breast cancer via regulating RBM15B/IGF2BP3/KMT2C signaling

Zhang, Y., Song, S., Yu, X., & Li, J. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102580 · Cited by 1 · see citing works

The Role of N 6 ‐Methyladenosine Modification in Health and Disease

Li, L., 孙元海, Zheng, W., Li, L., Feng, Y., Qi, M.-Y., & Li, H. (2026) · MedComm · doi:10.1002/mco2.70767 · Cited by 1 · see citing works

Engineering Biomimetic 3D Microenvironments for Extracellular Vesicle Programming Toward Clinical Translation

Nabeta, E., Wang, A., Zhao, J., & Hao, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146121 · Cited by 1 · see citing works

Extracellular vesicles in targeted drug delivery: from biological functions to surface engineering

Duca, G., Tinnirello, V., Ganji, N. R., Alessandro, R., & Raimondo, S. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00578-2 · Cited by 1 · see citing works

Therapeutic mRNAs for cancer immunotherapy: From structure to delivery

Vishwakarma, M., Akram, W., & Haider, T. (2024) · Advances in immunology · doi:10.1016/bs.ai.2024.10.013

Comparative segmental molecular genetic assessment of colorectal cancer in the community of endoscopy and surgery of a multidisciplinary hospital

Короткевич, А. Г., Titov, S. E., Zhilina, N. M., Сергеевич, Д. П., Veryaskina, Y. A., & Маринич, Я. Я. (2025) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-237-5-79-88

Immunoregulatory roles of post-translational modifications in colorectal cancer: mechanisms and therapeutic implications

Liang, X., Yao, J., Jiao, W., Li, X., Yang, B., & Fan, H. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05992-3

Nanoformulated oxaliplatin reduces platinum accumulation in dermal fibroblasts to alleviate cold allodynia

Zhang, S., Liu, Z., Ma, X., Zu, M., Wang, M., Zheng, W., Yang, H., Huike, M. A., Zhao, R., Chen, Z., et al. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2026.100345

Vesicular Systems for Anticancer Drug Delivery

Garanin, A., Плевако, Д. С., Васильева, О. А., & Malek, A. V. (2025) · Nanobiotechnology Reports · doi:10.1134/s2635167625600506

Chemical Epigenetics: Small Molecules Targeting Chromatin Modifiers in Disease Modulation

Alum, B. N., Echegu, D. A., & Alum, E. U. (2026) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-026-02049-5

Fusion of magnetic fusogenic liposomes with model membranes for nanoparticle delivery

Sagastuy, M., Michel, A., Lam, F., Chaumeton, C., Fresnais, J., Wilhelm, C., & Ménager, C. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115708

A multifunctional nanotherapeutic strategy based on exosome-liposome hybrid nanoparticles for comprehensive periodontitis management

Qiao, X., Liu, K., Tang, J., Du, J., Sun, Q., Deng, S., & Yang, D. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04602-z

m6A RNA modification: a central epitranscriptomic switch orchestrating oncogenic signaling and glycolytic reprogramming in cancer

Guo, Y., Kou, R., Huang, Z., Chen, Z., & Yun, H. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1864321

RNA modifications in cancer: regulators of tumor evolution and therapeutic response

Gu, X., He, Y., Xu, Z., Zhang, S., Liu, Y., Yang, Z., Liu, H., Chen, W., Zhang, L., 謝英達, et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02745-z

Biomimetic delivery systems for overcoming drug resistance in gastrointestinal cancers

Wu, G., Li, A.-X., Gu, Y.-W., Cheng, X.-L., Mao, R.-C., Wang, X.-J., He, M.-Y., Chai, Q., Li, F.-N., Liu, H., et al. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101465

Crosstalk between m6A modification and metabolic reprogramming in colorectal cancer: from the immune microenvironment to clinical applications

Zhao, L., Yin, Z., Ji, C., Wu, Y., Gao, H., & Yuan, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1911067

Gut Microbiome Modulation for Colorectal Cancer Therapy: Biomolecule‐Integrated Nanotherapeutic Strategies

Sarkar, P., Shannigrahi, S., Sen, O., Adak, S., Jana, P., & Manna, S. (2026) · ChemistrySelect · doi:10.1002/slct.202507043

Extracellular Vesicle–Lipid Hybrid Systems for RNA Delivery in Cancer: Structural Classification, Functional Delivery, and Translational Challenges

Lu, L., Qiu, Y., Wu, J., Dou, W., Yang, J., & Zhang, B. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18091108

N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation

Zhang, Z., Wang, L., Zhao, L., Wang, Q., Yang, C., Zhang, M., Wang, B., Jiang, K., Ye, Y., Wang, S., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.940 · Cited by 53 · see citing works

RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner

Shen, D., Lin, J., Xie, Y., Zhuang, Z., Xu, G., Peng, S., Tang, G., Bai, L., Zhu, M., Zhang, Y., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1279 · Cited by 36 · see citing works

Targeting of the m6A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer

Zhou, H., Chen, H., Liu, W., Liang, C., Wang, S., Yuan, K., Cheung, A. H. K., Wu, Y., Kang, W., Cheung, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67502-0 · Cited by 10 · see citing works

IDDF2023-ABS-0166 ALKBH5 drives chemoresistance in colorectal cancer by promoting cancer stemness and is a therapeutic target

Zhou, H., Wong, C.-C., Chen, H., Cheung, H., Liu, W., & Yu, J. Q. (2023) · doi:10.1136/gutjnl-2023-iddf.85

ALKBH1 ‐mediated m 1 A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression

Chen, W., Wang, H., Mi, S., Shao, L., Xu, Z., & Xue, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13366 · Cited by 42 · see citing works