The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis
Open accessAbstract
SUMMARY Adult hippocampal neurogenesis is believed to maintain a range of cognitive functions, many of which decline with age. We recently reported that radial neural stem cells (rNSCs) in the hippocampus undergo activation-dependent conversion into astrocytes, a mechanism that over time contributes to a reduction in the rNSC population. Here, we injected low and high levels of kainic acid (KA) in the dentate gyrus to assess whether neuronal hyperexcitation, a hallmark of epileptic disorders, could accelerate this conversion. At low levels of KA, generating epileptiform activity without seizures, we indeed found increased rNSC activation and conversion into astrocytes. At high levels, generating sustained epileptic seizures, however, we find that rNSCs divide symmetrically and that both mother and daughter cells convert into reactive astrocytes. Our results demonstrate that a threshold response for neuronal hyperexcitation provokes a dramatic shift in rNSCs function, which impairs adult hippocampal neurogenesis in the long term.
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Cites
Astrocytes: Biology and pathology
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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
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Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
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Molecular dissection of reactive astrogliosis and glial scar formation
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Genomic analysis of reactive astrogliosis
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Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
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Self-citationAstrocytes give rise to new neurons in the adult mammalian hippocampus
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Cited by
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
Gonçalves, J. T., Schafer, S. T., & Gage, F. H. (2016) · Cell · doi:10.1016/j.cell.2016.10.021 · Cited by 1,122
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719
Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest
Urbán, N., Blomfield, I. M., & Guillemot, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.026 · Cited by 373
Microglia Actively remodel adult hippocampal neurogenesis through the phagocytosis secretome
Diaz-Aparicio, I., Paris, I., Sierra-Torre, V., Plaza-Zabala, A., Rodríguez-Iglesias, N., Márquez-Ropero, M., Beccari, S., Huguet, P., Abiega, O., Alberdi, E., et al. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0993-19.2019 · Cited by 333
Self-citationBao, H., Asrican, B., Li, W., Gu, B., Wen, Z., Lim, S.-A., Haniff, I., Ramakrishnan, C., Deisseroth, K., Philpot, B., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.10.003 · Cited by 151
Metadata
- Authors
- Sierra, A., Martín-Suárez, S., Valcárcel-Martín, R., Pascual-Brazo, J., Aelvoet, S.-A., Abiega, O., Deudero, J. J., Brewster, A. L., Bernales, I., Anderson, A. E., Baekelandt, V., Maletić-Savatić, M., & Encinas, J. M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 16
- Issue
- 5
- Pages
- 488-503
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1482674003
- Cited by
- 263
- References
- 14
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sierra, A., Martín-Suárez, S., Valcárcel-Martín, R., Pascual-Brazo, J., Aelvoet, S.-A., Abiega, O., Deudero, J. J., Brewster, A. L., Bernales, I., Anderson, A. E., Baekelandt, V., Maletić-Savatić, M., & Encinas, J. M. (2015). Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis. Cell Stem Cell. https://doi.org/10.1016/j.stem.2015.04.003
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
