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Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs
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Cites
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570
DNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944
Laurent, L. C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., Lynch, C., Harness, J. V., Lee, S., Barrero, M. J., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.003 · Cited by 890
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Flint Beal, M., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng1292-324 · Cited by 890
Human mitochondrial DNA: roles of inherited and somatic mutations
Schon, E. A., DiMauro, S., & Hirano, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3275 · Cited by 757 · cited 4×
“While current evidence suggests that mtDNA mutations increase in frequency in a variety of aged human tissues, leading to a pathogenic loss of respiratory capacity (Yu and Bennett, 2014), the extent and role of detectable high-level heteroplasmic or homoplasmicmtDNAmutations remains uncertain (Schon et al., 2012).”
BackgroundInfluentialMitochondrial DNA mutations in human colonic crypt stem cells
Taylor, R. W., Barron, M. J., Borthwick, G. M., Gospel, A., Chinnery, P. F., Samuels, D. C., Taylor, G. A., Plusa, S. M., Needham, S. J., Greaves, L. C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19435 · Cited by 530
Bua, E., Johnson, J., Herbst, A., Delong, B., McKenzie, D., Salamat, S., & Aiken, J. M. (2006) · The American Journal of Human Genetics · doi:10.1086/507132 · Cited by 442
DNA damage and ageing: new-age ideas for an age-old problem
Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1108-1241 · Cited by 366
Greaves, L. C., Nooteboom, M., Elson, J. L., Tuppen, H. A. L., Taylor, G. A., Commane, D. M., Arasaradnam, R. P., Khrapko, K., Taylor, R. W., Kirkwood, T. B. L., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004620 · Cited by 172
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Ma, H., Marti-Gutierrez, N., Park, S.-W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., et al. (2017) · Nature · doi:10.1038/nature23305 · Cited by 992
Self-citationMeasuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781
Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics
Ludwig, L. S., Lareau, C. A., Ulirsch, J. C., Christian, E., Muus, C., Li, L. H., Pelka, K., Ge, W., Oren, Y., Brack, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.022 · Cited by 567
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Zhang, J., Liu, H., Luo, S., Lu, Z., Chávez-Badiola, A., Liu, Z., Yang, M., Merhi, Z., Silber, S. J., Munné, S., et al. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.01.013 · Cited by 361
Self-citationSharma, R., Khristov, V., Rising, A., Jha, B. S., Dejene, R., Hotaling, N., Li, Y., Stoddard, J., Stankewicz, C., Wan, Q., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat5580 · Cited by 359
Self-citationMassively parallel single-cell mitochondrial DNA genotyping and chromatin profiling
Lareau, C. A., Ludwig, L. S., Muus, C., Gohil, S. H., Zhao, T., Chiang, Z., Pelka, K., Verboon, J. M., Luo, W., Christian, E., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-0645-6 · Cited by 315
The role of mitochondria in stem cell fate and aging
Zhang, H., Menzies, K. J., & Auwerx, J. (2018) · Development · doi:10.1242/dev.143420 · Cited by 284
Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications
Yoshihara, M., Hayashizaki, Y., & Murakawa, Y. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9680-6 · Cited by 283
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.004 · Cited by 240
Iannielli, A., Bido, S., Folladori, L., Segnali, A., Cancellieri, C., Maresca, A., Massimino, L., Rubio, A., Morabito, G., Caporali, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.089 · Cited by 239
Deciphering cell states and genealogies of human haematopoiesis
Weng, C., Yu, F., Yang, D., Poeschla, M., Liggett, L. A., Jones, M. G., Qiu, X., Wahlster, L., Caulier, A., Hussmann, J. A., et al. (2024) · Nature · doi:10.1038/s41586-024-07066-z · Cited by 171
Molecular Obstacles to Clinical Translation of iPSCs
Tapia, N., & Schöler, H. R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.06.017 · Cited by 141
Kim, Y., Zheng, X., Ansari, Z., Bunnell, M. C., Herdy, J. R., Traxler, L., Lee, H., Paquola, A. C. M., Blithikioti, C., Ku, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.105 · Cited by 117
Immunological aspects of RPE cell transplantation
Sugita, S., Mandai, M., Kamao, H., & Takahashi, M. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100950 · Cited by 77
Peng, Y., Shinde, D. N., Valencia, C. A., Mo, J.-S., Rosenfeld, J., Truitt Cho, M., Chamberlin, A., Li, Z., Liu, J., Gui, B., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx377 · Cited by 60
Self-citationCell reprogramming shapes the mitochondrial DNA landscape
Wei, W., Gaffney, D. J., & Chinnery, P. F. (2021) · Nature Communications · doi:10.1038/s41467-021-25482-x · Cited by 47
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Wang, Y., Guo, X., Ye, K., Orth, M., & Gu, Z. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014610118 · Cited by 36
Mitochondrial mutation, drift and selection during human development and ageing
Campbell, P., Chapman, M. S., Przybilla, M., Lawson, A., Mitchell, E., Dawson, K., Williams, N., Harvey, L., Ranzoni, A. M., Cvejic, A., et al. (2023) · doi:10.21203/rs.3.rs-3083262/v1 · Cited by 27
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Kosanke, M., Davenport, C., Szepes, M., Wiehlmann, L., Kohrn, T., Dorda, M., Gruber, J., Menge, K., Sievert, M., Melchert, A., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.08.016 · Cited by 17
Metadata
- Authors
- Kang, E., Wang, X., Tippner-Hedges, R., Ma, H., Folmes, C. D. L., Gutierrez, N. M., Lee, Y., Van Dyken, C., Ahmed, R., Li, Y., Koski, A., Hayama, T., Luo, S., Harding, C. O., Amato, P., Jensen, J., Battaglia, D., Lee, D., Wu, D., Terzic, A., Wolf, D. P., Huang, T., & Mitalipov, S.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 18
- Issue
- 5
- Pages
- 625-636
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2339107526
- Cited by
- 215
- References
- 11
- FWCI
- 16.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.