CoChat
Sign Up
Cited by 36

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington's disease

Wang, Yiqin, Guo, Xiaoxian, Ye, Kaixiong, Orth, Michael, Gu, Zhenglong·2021·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.2014610118PMC PMC8325154
Open this paper in CoChat — free account

Abstract

Significance: Decline of mitochondrial function may underlie the pathogenesis of many age-related diseases, such as Huntington’s disease (HD). Mitochondrial oxidative phosphorylation (OXPHOS) system is encoded partially by the mitochondrial genome (mtDNA). By investigating mtDNA in lymphoblast and blood samples of HD patients, we found that the expansion of OXPHOS-impairing mtDNA heteroplasmies (coexistence of mutated and wild-type mtDNA) is a molecular feature associated with the functional, motor, and cognitive aspects of HD progression, suggesting that improving mtDNA quality or restoring mitochondrial function could be a potential target for HD treatments.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.2014610118

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Accelerated expansion of mitochondrial mutations with age has been observed in primate oocytes and somatic tissues, and in lymphoblasts from patients with neurodegenerative diseases.

    “The accelerated expansion of mitochondrial mutations with age has also been observed in both primate oocytes and somatic tissues 20 , as well as in lymphoblasts from patients with neurodegenerative diseases 21 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [21]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 71

  1. 10.1016/S0140-6736(07)60111-1 · DOI
  2. 10.3389/fnana.2011.00055 · DOI
  3. 10.1038/nrneurol.2014.24 · DOI · Paper page
  4. 10.1038/s41593-018-0075-7 · DOI · Paper page
  5. 10.1007/978-3-319-71779-1_3 · DOI
  6. 10.1146/annurev.genet.39.110304.095751 · DOI · Paper page
  7. 10.1111/j.1471-4159.1985.tb07192.x · DOI
  8. 10.1002/ana.410390317 · DOI · Paper page
  9. 10.1093/hmg/ddi319 · DOI
  10. 10.1038/13518 · DOI
  11. 10.1002/ana.410430321 · DOI
  12. 10.1002/1531-8249(200007)48:1<72::AID-ANA11>3.0.CO;2-I · DOI
  13. 10.1016/S1474-4422(09)70178-4 · DOI
  14. 10.1212/NXG.0000000000000275 · DOI
  15. 10.1016/j.cell.2006.09.015 · DOI · Paper page
  16. 10.1074/jbc.M112.407726 · DOI
  17. 10.1093/hmg/ddq306 · DOI
  18. 10.1093/hmg/ddr475 · DOI
  19. 10.1038/nm.2313 · DOI
  20. 10.1038/cddis.2014.581 · DOI
  21. 10.15252/emmm.201505256 · DOI · Paper page
  22. 10.1073/pnas.1420103111 · DOI · Paper page
  23. 10.1111/ejn.12957 · DOI
  24. 10.1016/j.cub.2018.01.004 · DOI · Paper page
  25. 10.1016/j.nbd.2015.09.008 · DOI
  26. 10.1038/nrneurol.2014.228 · DOI
  27. 10.1101/cshperspect.a021220 · DOI
  28. 10.1016/j.cmet.2009.06.010 · DOI · Paper page
  29. 10.1038/ng.863 · DOI · Paper page
  30. 10.1038/nrg3966 · DOI
  31. 10.1073/pnas.1403521111 · DOI
  32. 10.1016/j.tcb.2018.11.004 · DOI
  33. 10.1093/nargab/lqaa065 · DOI
  34. M. Orth .; Investigators of the European Huntington’s Disease Network, Observing Huntington’s disease: The European Huntington’s Disease Network’s REGISTRY. PLoS Curr. 2, RRN1184 (2010).
  35. 10.1002/mds.870110204 · DOI
  36. 10.1212/WNL.31.10.1333 · DOI
  37. 10.1371/journal.pgen.1003929 · DOI
  38. 10.1371/journal.pgen.1003990 · DOI
  39. 10.1038/348651a0 · DOI · Paper page
  40. 10.1038/s41598-018-30255-6 · DOI
  41. 10.15252/emmm.201708262 · DOI
  42. 10.1073/pnas.1414028111 · DOI
  43. 10.1016/j.jns.2019.02.010 · DOI
  44. 10.1016/j.mad.2016.09.003 · DOI
  45. 10.1186/1750-1326-6-1 · DOI
  46. 10.1093/hmg/dds177 · DOI
  47. 10.1152/advan.00052.2006 · DOI
  48. 10.1016/j.cell.2019.06.036 · DOI
  49. 10.1007/978-1-4614-3722-2_11 · DOI
  50. 10.1016/j.bbadis.2011.11.014 · DOI
  51. 10.1172/JCI70911 · DOI
  52. 10.1016/j.bbadis.2015.08.012 · DOI
  53. 10.1038/srep44849 · DOI
  54. 10.1074/jbc.M111.309849 · DOI
  55. 10.1016/j.stem.2016.02.005 · DOI
  56. 10.15252/embj.201694892 · DOI
  57. 10.1016/j.cell.2019.01.022 · DOI
  58. 10.1093/bioinformatics/btp698 · DOI · Paper page
  59. E. Garrison G. Marth Haplotype-based variant detection from short-read sequencing arXiv [Preprint] (2012). https://arxiv.org/abs/1207.3907 (Accessed 7 June 2019). · arXiv
  60. 10.1093/bioinformatics/btp352 · DOI · Paper page
  61. 10.1093/nar/gkw233 · DOI
  62. 10.1093/nar/gkq603 · DOI
  63. 10.1093/nar/gkr1086 · DOI
  64. 10.1038/ng.2892 · DOI · Paper page
  65. 10.1093/nar/gkw046 · DOI
  66. 10.1002/0471250953.bi0123s44 · DOI
  67. 10.1093/nar/gkt1113 · DOI · Paper page
  68. I. Adzhubei, D. M. Jordan, S. R. Sunyaev, Predicting functional effect of human missense mutations using PolyPhen-2. Curr. Protoc. Hum. Genet. 76, 7–20 (2013).
  69. 10.1093/bioinformatics/btp528 · DOI
  70. 10.1371/journal.pcbi.1005867 · DOI
  71. 10.1186/s12864-017-4287-0 · DOI

Cited by

Sorted by citations

Metadata

Authors
Wang, Y., Guo, X., Ye, K., Orth, M., & Gu, Z.
Affiliations
  • Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853;
  • Department of Neurology, Ulm University Hospital, D-89081 Ulm, Germany
ORCID
Ye, Kaixiong
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2021-07-23
Volume
118
Issue
30
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.2014610118
PMC
PMC8325154
Cited by
36
References
14
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Funders
CHDI Foundation (NA)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review