The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells
Open accessAbstract
Genetic lesions that reduce telomerase activity inhibit stem cell replication and cause a range of incurable diseases, including dyskeratosis congenita (DC) and pulmonary fibrosis (PF). Modalities to restore telomerase in stem cells throughout the body remain unclear. Here, we describe small-molecule PAPD5 inhibitors that demonstrate telomere restoration in vitro, in stem cell models, and in vivo. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC). We identified BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells. When human blood stem cells engineered to carry DC-causing PARN mutations were xenotransplanted into immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length. These findings pave the way for developing systemic telomere therapeutics to counteract stem cell exhaustion in DC, PF, and possibly other aging-related diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Small-molecule inhibitors of PAPD5, a non-canonical poly(A) polymerase that destabilizes TERC RNA, have been shown to rescue TERC levels in induced pluripotent stem cells from patients with dyskeratosis congenita190.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [190]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
HISAT: a fast spliced aligner with low memory requirements
Kim, D., Langmead, B., & Salzberg, S. L. (2015) · Nature Methods · doi:10.1038/nmeth.3317 · Cited by 24,112
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Salmon provides fast and bias-aware quantification of transcript expression
Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 24×
“When primary fibroblasts were transduced with a retrovirus encoding TERT, both BCH001-treated and untreated cells were immortalized, but only cells treated with BCH001 showed telomere lengthening (Figure 4H).”
BackgroundInfluentialThe limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Improved vectors and genome-wide libraries for CRISPR screening
Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Flagged first, then by citations
Cited by
Sorted by citations
Telomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754
Telomeres: history, health, and hallmarks of aging
Chakravarti, D., LaBella, K. A., & DePinho, R. A. (2021) · Cell · doi:10.1016/j.cell.2020.12.028 · Cited by 637
Genetics of human telomere biology disorders
Revy, P., Kannengiesser, C., & Bertuch, A. A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00527-z · Cited by 250
Molecular mechanisms of telomere biology disorders
Grill, S., & Nandakumar, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014017 · Cited by 114
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation
Shukla, S., Bjerke, G. A., Muhlrad, D., Yi, R., & Parker, R. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.010 · Cited by 94
Inherited bone marrow failure in the pediatric patient
Dokal, I. S., Tummala, H., & Vulliamy, T. (2022) · Blood · doi:10.1182/blood.2020006481 · Cited by 88
Immunological factors linked to geographical variation in vaccine responses
van Dorst, M. M. A. R., Pyuza, J. J., Nkurunungi, G., Kullaya, V. I., Smits, H. H., Hogendoorn, P. C. W., Wammes, L. J., Everts, B., Elliott, A. M., Jochems, S. P., et al. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00941-2 · Cited by 87
Kam, M. L. W., Nguyen, T. T. T., & Ngeow, J. Y. Y. (2021) · npj Genomic Medicine · doi:10.1038/s41525-021-00198-5 · Cited by 84
Bountziouka, V., Musicha, C., Allara, E., Kaptoge, S. K., Wang, Q., Angelantonio, E. D., Butterworth, A. S., Thompson, J. R., Danesh, J., Wood, A., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00072-1 · Cited by 77
Ma, H., Wu, X., Li, Y., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.963054 · Cited by 79
Thymidine nucleotide metabolism controls human telomere length
Mannherz, W. P., & Agarwal, S. (2023) · Nature Genetics · doi:10.1038/s41588-023-01339-5 · Cited by 75
Self-citationThe biology and management of dyskeratosis congenita and related disorders of telomeres
Tummala, H., Walne, A. J., & Dokal, I. S. (2022) · Expert Review of Hematology · doi:10.1080/17474086.2022.2108784 · Cited by 71
Adegunsoye, A., Kropski, J. A., Behr, J., Blackwell, T. S., Corte, T. J., Cottin, V., Glanville, A. R., Glassberg, M. K., Griese, M., Hunninghake, G. M., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202401-0238so · Cited by 82
Perspectives on scaling production of adipose tissue for food applications
Yuen, J. S. K., Stout, A. J., Kawecki, N. S., Letcher, S. M., Theodossiou, S. K., Cohen, J. M., Barrick, B. M., Saad, M. K., Rubio, N. R., Pietropinto, J. A., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121273 · Cited by 60
Telomerase RNA processing: Implications for human health and disease
Nagpal, N., & Agarwal, S. (2020) · Stem Cells · doi:10.1002/stem.3270 · Cited by 47
Self-citationShukla, S., Jeong, H., Sturgeon, C. M., Parker, R., & Batista, L. F. Z. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001848 · Cited by 42
Telomeres in Interstitial Lung Disease
Stock, C. J. W., & Renzoni, E. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071384 · Cited by 44
Telomere length and metabolic syndrome traits: A Mendelian randomisation study
Loh, N. Y., Noordam, R., & Christodoulides, C. (2021) · Aging Cell · doi:10.1111/acel.13445 · Cited by 39
Zhao, N., Yin, G., Liu, C., Zhang, W., Shen, Y., Wang, D., Lin, Z., Yang, J., Mao, J., Guo, R., et al. (2023) · Cell Discovery · doi:10.1038/s41421-023-00538-y · Cited by 34
TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly
Klump, B. M., Perez, G. I., Patrick, E. M., Adams-Boone, K., Cohen, S. B., Li, H., Yu, K., & Schmidt, J. C. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112577 · Cited by 38
Idiopathic pulmonary fibrosis and the role of genetics in the era of precision medicine
Alonso-González, A., Tosco-Herrera, E., Molina‐Molina, M., & Flores, C. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1152211 · Cited by 36
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita
Tummala, H., Walne, A. J., Badat, M., Patel, M., Walne, A. M., Alnajar, J., Chow, C. C., Albursan, I., Frost, J. M., Ballard, D., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00118-x · Cited by 31
The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis
Li, Y., Misumi, I., Shiota, T., Sun, L., Lenarcic, E. M., Kim, H., Shirasaki, T., Hertel-Wulff, A., Tibbs, T., Mitchell, J. E., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204511119 · Cited by 28
Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review
Xue, T., Zhu, Z., Wang, L., Li, C., Sun, L., Wang, W., & Gong, W. (2023) · Aging and Disease · doi:10.14336/ad.2023.00808-1 · Cited by 37
Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics
Shou, S., Maolan, A., Zhang, D., Jiang, X., Liu, F., Li, Y., Zhang, X., Geer, E., Pu, Z., Hua, B., et al. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00597-9 · Cited by 29
Regulation of human telomerase RNA biogenesis and localization
Jian, Q., & Autexier, C. (2020) · RNA Biology · doi:10.1080/15476286.2020.1809196 · Cited by 27
Vieri, M., Brümmendorf, T. H., & Beier, F. (2021) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2021.101282 · Cited by 23
Telomere biology disorders: time for moving towards the clinic?
Batista, L. F. Z., Dokal, I. S., & Parker, R. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.08.001 · Cited by 25
Telomeres: Dysfunction, Maintenance, Aging and Cancer
Liao, P., Yan, B., Wang, C., & Lei, P. (2023) · Aging and Disease · doi:10.14336/ad.2023.1128 · Cited by 22
Premature aging and metabolic diseases: the impact of telomere attrition
Jinesh, S., Özüpek, B., & Aditi, P. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1541127 · Cited by 24
Choo, S.-A. S., Lorbeer, F. K., Regalado, S. G., Short, S. B., Wu, S., Rieser, G., Bertuch, A. A., & Hockemeyer, D. F. (2022) · Blood · doi:10.1182/blood.2021013750 · Cited by 20
Bhoopalan, S. V., Włodarski, M. W., Reiss, U. M., Triplett, B. M., & Sharma, A. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.29177 · Cited by 20
Rolles, B., Tometten, M., Meyer, R., Kirschner, M., Beier, F., & Brümmendorf, T. H. (2024) · Transfusion Medicine and Hemotherapy · doi:10.1159/000540109 · Cited by 18
Nurturing longevity through natural compounds: Where do we stand, and where do we go?
Todorova, M. N., Savova, M. S., Mihaylova, L. V., & Georgiev, M. I. (2024) · Food Frontiers · doi:10.1002/fft2.350 · Cited by 17
Stem cells at odds with telomere maintenance and protection
Penev, A., Markiewicz-Potoczny, M., Sfeir, A., & Denchi, E. L. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.12.007 · Cited by 18
Recent advances in understanding telomere diseases
Carvalho, V. S., Gomes, W. R., & Calado, R. T. (2022) · Faculty Reviews · doi:10.12703/r/11-31 · Cited by 20
Li, X., Liu, Y., Yao, H., Wang, M., Gao, L., Lou, J., Mao, J., Wu, W., Zhou, Y., Tang, Y., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00094-22 · Cited by 15
RNA tailing machinery drives amyloidogenic phase transition
Bokros, M., Balukoff, N. C., Grunfeld, A. M., Sebastiao, M., Beurel, E., Bourgault, S., & Lee, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2316734121 · Cited by 15
Sande, C. M., Chen, S., Mitchell, D. V., Lin, P., Abraham, D. M., Cheng, J. M., Gebhard, T., Deolikar, R. J., Freeman, C. M., Zhou, M., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci181659 · Cited by 15
Self-citationInduced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
Adegunsoye, A., Gonzales, N. M., & Gilad, Y. (2023) · Annual Review of Genetics · doi:10.1146/annurev-genet-022123-090319 · Cited by 16
Host RNA quality control as a hepatitis B antiviral target
Block, T. M., Young, J. A. T., Javanbakht, H., Sofia, M. J., & Zhou, T. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104972 · Cited by 12
Choi, Y., Kim, M. S., Rhoades, J. H., Johnson, N. M., Berry, C. T., Root, S., Chen, Q., Tian, Y., Fernandez, R. J., Cramer, Z., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.06.003 · Cited by 11
A roadmap to precision treatments for familial pulmonary fibrosis
Hurley, K., Ozaki, M., Philippot, Q., Galvin, L., Crosby, D., Kirwan, M., Gill, D. R., Alysandratos, K., Jenkins, G. R., Griese, M., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105135 · Cited by 10
Chen, Z. S., Peng, S. I., Leong, L. I., Gall-Duncan, T., Wong, N., Li, T. H., Lin, X., Wei, Y., Koon, A. C., Huang, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58618-4 · Cited by 10
Telomere biology and ribosome biogenesis: structural and functional interconnections
Valeeva, L. R., Abdulkina, L. R., Аgabekian, I. A., & Shakirov, E. V. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2022-0383 · Cited by 12
Li, S., Qian, X., Fang, G., Deng, Y., Yang, F., Qiu, C., Yang, Y., & Lan, C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166859 · Cited by 9
Regulation of telomerase towards tumor therapy
Yan, S., Song, L., Qiu, H., Wang, X., He, Y., Wang, C., & Huang, Y. Y. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01181-6 · Cited by 9
A missense variant in the nuclear localization signal of DKC1 causes Hoyeraal-Hreidarsson syndrome
Chu, C.-M., Yu, H., Kao, T.-L., Chen, Y.-H., Lu, H., Wu, E., Yang, Y., Lin, C., Lin, S., Tsai, M.-J. M., et al. (2022) · npj Genomic Medicine · doi:10.1038/s41525-022-00335-8 · Cited by 8
Pediatric Bone Marrow Failure: A Broad Landscape in Need of Personalized Management
Vissers, L. T. W., van der Burg, M., Lankester, A. C., Smiers, F. J. W., Bartels, M., & Mohseny, A. B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227185 · Cited by 10
Small Molecules Restore Telomeres in Patient Stem Cells
Brenner, K. A., & Nandakumar, J. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.05.003 · Cited by 8
Nagpal, N., & Agarwal, S. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01429-1 · Cited by 8
Self-citationDomain specific mutations in dyskerin disrupt 3′ end processing of scaRNA13
Nagpal, N., Tai, A., Nandakumar, J., & Agarwal, S. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac706 · Cited by 7
Self-citationTavares-Marcos, C., Correia, M., & de Jesus, B. B. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102773 · Cited by 6
Galati, A., Scatolini, L., Micheli, E., Bavasso, F., Cicconi, A., Maccallini, P., Chen, L., Roake, C. M., Schoeftner, S., Artandi, S. E., et al. (2021) · FEBS Letters · doi:10.1002/1873-3468.14240 · Cited by 6
Inducible pluripotent stem cell models to study bone marrow failure and MDS predisposition syndromes
Sahoo, S. S., Khiami, M., & Włodarski, M. W. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104669 · Cited by 6
Maturation and shuttling of the yeast telomerase RNP: assembling something new using recycled parts
Bartle, L., Vasianovich, Y., & Wellinger, R. J. (2021) · Current Genetics · doi:10.1007/s00294-021-01210-2 · Cited by 6
Molecular insight of dyskeratosis congenita: Defects in telomere length homeostasis
Dorgaleleh, S., Naghipoor, K., Hajimohammadi, Z., Dastaviz, F., & Oladnabi, M. (2022) · Journal of Clinical and Translational Research · doi:10.18053/jctres.08.202201.002 · Cited by 5
Mechanistic insights into stem cell aging: Pathways and processes
Fauzi, A., Wong, C. Z. E., Tee, P. Y. E., Yau, A. W. N., Rashid, E. A., Tang, Y. Q., & Chia, A. Y. Y. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112160 · Cited by 6
Advances in understanding telomerase assembly
Klump, B. M., & Schmidt, J. C. (2023) · Biochemical Society Transactions · doi:10.1042/bst20230269 · Cited by 5
TCAB1 prevents nucleolar accumulation of the telomerase RNA to promote telomerase assemblyPreprint
Klump, B. M., Perez, G. I., Patrick, E. M., Adams-Boone, K., Cohen, S. B., Li, H., Yu, K., & Schmidt, J. C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.27.445986 · Cited by 5
Telomere biology disorders and hepatic disease
Pirzada, S. A., Aleyadeh, W., Fathma, S., Koh, C., Plessier, A., Kleiner, D. E., & Heller, T. (2025) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.05.004 · Cited by 4
Kuru, G., Üner, G., & Bedіr, E. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-022-09829-w · Cited by 4
Comparative transcriptomics analysis at the key stage of maize ear development dissect heterosis
Wang, L., Li, J., Lin, Y. Y., Dang, K., Wan, J., Meng, S., Qiu, X., Wang, Q., Mu, L., Ding, D., et al. (2022) · The Plant Genome · doi:10.1002/tpg2.20293 · Cited by 4
Telomeropathies in Interstitial Lung Disease and Lung Transplant Recipients
Southern, B. D., & Gadre, S. K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051496 · Cited by 6
Saad, F. A. (2024) · Current Gene Therapy · doi:10.2174/0115665232286489240320051925 · Cited by 5
Oppezzo, A., Sepe, S., Cicio, G., Cancila, V., Sasso, E., Conti, A., Marinelli, E., Cabrini, M., Pallavi, R., Iacomino, N., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01136-9 · Cited by 4
Klinaki, E., & Ogrodnik, M. B. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111929 · Cited by 3
Discovery, optimization and biological evaluation of novel HBsAg production inhibitors
Zhang, L., Ge, X., Jin, H., Lu, D., Chen, S., Zhang, Y., Wang, X., Xu, H., Ao, W., & Zhang, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115387 · Cited by 3
Therapeutic strategies targeting somatic stem cells: Chemical approaches
Chen, Y., & Ding, S. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115824 · Cited by 3
Ignatieva, E. V., Yudin, N. S., & Larkin, D. M. (2023) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-23-34 · Cited by 3
Samajdar, A., Amato, R., Jo, S., Cordes, E., Tai, A., Raffa, G. D., & Batista, L. F. Z. (2026) · Genes & Development · doi:10.1101/gad.353100.125 · Cited by 3
Self-citationEstablished and emerging non-cellular therapies in inherited bone marrow failure syndromes
Janczar, S., Urbański, B., Ussowicz, M., & Mlynarski, W. M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1773574 · Cited by 2
Primer- and template-independent RNA polymerization by terminal nucleotidyltransferase TENT4B
Nagpal, N., Tai, A., Fong, Y. W., & Agarwal, S. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag864 · Cited by 2
Self-citationTelomerase-Mediated Anti-Ageing Interventions
Dunn, P. L., Logeswaran, D., & Chen, J. J. ‐. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_1 · Cited by 2
Genetic aspects of telomere biology disorders
de Tocqueville, S., Morel, H., Ba, I., Revy, P., & Kannengiesser, C. (2025) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.03.011 · Cited by 2
Inherited Bone Marrow Failure Syndromes
Mangaonkar, A. A., Ferrer, A., Ali, A., Kohorst, M. A., & Patnaik, M. M. (2024) · Wiley eBooks · doi:10.1002/9781683674023.ch72 · Cited by 2
Telomere Shortening in Interstitial Lung Disease: Challenges and Promises
Jin, H., Song, J., Gao, R., Sha, B., Wang, S., Luo, P., Yu, L., Xu, X., & Wang, X. (2025) · The Clinical Respiratory Journal · doi:10.1111/crj.70103 · Cited by 1
circHERC1—A telomerase activator
Cui, Y., He, Y., Wu, X., Dong, Y., Li, Y., Man, W., Li, X., Chen, S., Pang, F., Li, Y., et al. (2025) · Science Advances · doi:10.1126/sciadv.adz3680 · Cited by 2
Extracellular vesicles for delivery of functional telomerase
He, Y., Cui, Y., Wang, L., Yang, W., Wang, R., Li, Y., Ma, Y., Lin, Y., Wu, X., Cheng, L., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02524-1 · Cited by 1
Carbene-Catalyzed Asymmetric Synthesis of Thiophene-Fused Lactams
Shi, D., Zhang, H., Zhang, Y., & Fu, Z. (2026) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5c02874 · Cited by 1
Telomeres and telomerase: revealing the end game
Rivosecchi, J., Wu, G., & Cech, T. R. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.07.010 · Cited by 1
Telomere dysfunction in some pediatric congenital and growth-related diseases
Zheng, B., & Fu, J. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1133102 · Cited by 1
Wen, J. M., Gloude, N. J., & Ebens, C. L. (2025) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.03.002 · Cited by 1
End Products of Telomere Research
Reddel, R. R., MacKenzie, K. L., & Bryan, T. M. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.05.006
Fyn interrupts telomere maintenance in stem cells by phosphorylating menin at tyrosine 603Preprint
Paul, S., McCourt, P. M., Le, L. T. M., Ryu, J., Czaja, W., Bode, A. M., Contreras-Galindo, R., & Dong, Z. (2022) · Research Square · doi:10.21203/rs.3.rs-1425640/v1
Liu, S., Chen, T., Tan, Y., Qin, J., Han, Y., Fan, W., & Qu, S.-L. (2022) · Research Square · doi:10.21203/rs.3.rs-2146456/v1
Ma, H., Wu, X., Li, Y., & Xia, Y. (2022) · Kompass Neumología · doi:10.1159/000526906
Pulmonary Fibrosis: One Manifestation, Various Diseases
Ruaro, B., Matucci‐Cerinic, M., Baratella, E., Confalonieri, M., Salton, F., & Hughes, M. (2022) · Frontiers research topics · doi:10.3389/978-2-83250-654-7
The molecular basis of bone marrow failure syndromes and red cell enzymopathies
Iskander, D., Luzzatto, L., & Karadimitris, A. (2024) · Wiley eBooks · doi:10.1002/9781394180486.ch11
The Immune System and Hematopoietic Stem Cells
Elshimali, Y., Chatty, E. M., & Vadgama, J. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00094-9
Kannengiesser, C., & Revy, P. (2024) · Wiley eBooks · doi:10.1002/9781394300808.ch12
The Immunologic Complications and Genetic Origins of Telomere Biology Disorders
de Tocqueville, S., Touzot, F., & Revy, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00040-5
Stern, J. L., Rizzardi, L. F., & Gassman, N. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614488
Dyskeratosis congenita future: Hematopoietic stem cell transplantation or gene therapy?
Manoochehrabadi, S., Behfar, M., Ahmadvand, M., & Hamidieh, A. A. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.102072
Small molecule HBV RNA destabilizing drugs: Drugs of the future or compounds from the past?
Block, T. M., Gotchev, D., & Du, Y. (2025) · Antiviral Research · doi:10.1016/j.antiviral.2025.106288
Qu, L., Ding, S., Qian, L., & Yi, W. (2025) · Discover Oncology · doi:10.1007/s12672-025-03594-w
Glass, J., Groarke, E. M., & Young, N. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-02386-5_17
Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanismPreprint
Mannherz, W. P., Homfeldt, L., Lampl, N. M., & Agarwal, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.728939
Self-citationSenescence modulated cardiac repair with pluripotent stem cell-derived cardiomyocytes
Zhao, J., Kadota, S., Ichimura, H., Yang, X., Kusabuka, H., Kobayashi, H., Kitaori, Y., Takahashi, H., Omar, Z. G., Caruso, A., et al. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05062-w
Metadata
- Authors
- Nagpal, N., Wang, J., Zeng, J., Lo, E., Moon, D. H., Luk, K., Braun, R. O., Burroughs, L. M., Keel, S. B., Reilly, C., Lindsley, R. C., Wolfe, S. A., Tai, A. K., Cahan, P., Bauer, D. E., Fong, Y. W., & Agarwal, S.
- Affiliations
- Boston Children's Hospital (US)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Johns Hopkins University (US)
- University of Massachusetts Chan Medical School (US)
- Seattle Children's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Tufts University (US)
- Corresponding author
- Agarwal, Suneet
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 26
- Issue
- 6
- Pages
- 896-909.e8
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC7275922
- OpenAlex
- W3017218125
- Cited by
- 105
- References
- 89
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 17 · 2023: 17 · 2022: 22 · 2021: 10 · 2020: 8
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- telomerase activity, dyskeratosis congenita, pulmonary fibrosis, induced pluripotent stem cells, blood stem cells, xenotransplantation, stem cell exhaustion, age-related diseases
- MeSH terms
- Animals, Humans, Mutation, RNA, Telomere, Telomerase, Dyskeratosis Congenita, Mice, Induced Pluripotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review