The DOI matches its Crossref record; 236 of the 236 references it cites were found in a registry or an index.
Tissue Stem Cells: Architects of Their Niches
Open accessAbstract
Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation in tissue architecture and regenerative demands, SCs often follow similar paradigms in communicating with their microenvironmental "niche" to transition between quiescent and regenerative states. Here we use skin epithelium and skeletal muscle-among the most highly-stressed tissues in our body-to highlight similarities and differences in niche constituents and how SCs mediate natural tissue rejuvenation and perform regenerative acts prompted by injuries. We discuss how these communication networks break down during aging and how understanding tissue SCs has led to major advances in regenerative medicine.
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“Tissue regeneration requires coordination between resident stem cells and local niche cells1,2.”
From Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration (2023) · cites this paper as [1]
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SATELLITE CELL OF SKELETAL MUSCLE FIBERS
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Defining trained immunity and its role in health and disease
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Self-citationPaneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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PRDM16 controls a brown fat/skeletal muscle switch
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Macrophages as a therapeutic target to promote diabetic wound healing
Sharifiaghdam, M., Shaabani, E., Majidi, R. F., Smedt, S. C. D., Braeckmans, K., & Fraire, J. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.016 · Cited by 606
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
Moiseeva, V., Cisneros, A., Sica, V., Deryagin, O., Lai, Y., Jung, S., Andrés, E., An, J., Segalés, J., Ortet, L., et al. (2023) · Nature · doi:10.1038/s41586-022-05535-x · Cited by 423
Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 450
Macrophage Related Chronic Inflammation in Non-Healing Wounds
Li, M., Hou, Q., Zhong, L., Zhao, Y., & Fu, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681710 · Cited by 307
Metadata
- Authors
- Fuchs, E., & Blau, H. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Stanford Medicine (US)
- Corresponding author
- Fuchs, Elaine
- Blau, Helen M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 27
- Issue
- 4
- Pages
- 532-556
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC7861346
- OpenAlex
- W3090928815
- Cited by
- 332
- References
- 235
- Citations by year
- 2026: 48 · 2025: 80 · 2024: 76 · 2023: 46 · 2022: 48 · 2021: 34
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Li Ka Shing Foundation
- American Heart Association
- Foundation for the National Institutes of Health
- Baxter International Foundation
- California Institute for Regenerative Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- tissue stem cells, stem cell niche, tissue homeostasis, wound healing, skin epithelium, skeletal muscle, tissue rejuvenation, aging, regenerative medicine
- MeSH terms
- Rejuvenation, Stem Cells, Muscle, Skeletal, Regenerative Medicine
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