Cited by 332Mesenchymal stem cell researchHair Growth and DisordersHematopoietic Stem Cell Transplantation

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Tissue Stem Cells: Architects of Their Niches

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Fuchs, Elaine, Blau, Helen M.·2020·Cell Stem Cell

DOI 10.1016/j.stem.2020.09.011PMC PMC7861346

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Abstract

Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation in tissue architecture and regenerative demands, SCs often follow similar paradigms in communicating with their microenvironmental "niche" to transition between quiescent and regenerative states. Here we use skin epithelium and skeletal muscle-among the most highly-stressed tissues in our body-to highlight similarities and differences in niche constituents and how SCs mediate natural tissue rejuvenation and perform regenerative acts prompted by injuries. We discuss how these communication networks break down during aging and how understanding tissue SCs has led to major advances in regenerative medicine.

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Authors: Fuchs, E., & Blau, H. M.
Affiliations: Howard Hughes Medical Institute (US)
Stanford Medicine (US)
Corresponding author: Fuchs, Elaine
Blau, Helen M.
ORCID: Fuchs, Elaine
Blau, Helen M.
Venue: Cell Stem Cell
Publisher: Elsevier BV
Published: 2020-10
Volume: 27
Issue: 4
Pages: 532-556
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2020.09.011
PMC: PMC7861346
OpenAlex: W3090928815
Cited by: 332
References: 235
Citations by year: 2026: 48 · 2025: 80 · 2024: 76 · 2023: 46 · 2022: 48 · 2021: 34
FWCI: 4.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Li Ka Shing Foundation
American Heart Association
Foundation for the National Institutes of Health
Baxter International Foundation
California Institute for Regenerative Medicine
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: tissue stem cells, stem cell niche, tissue homeostasis, wound healing, skin epithelium, skeletal muscle, tissue rejuvenation, aging, regenerative medicine
MeSH terms: Rejuvenation, Stem Cells, Muscle, Skeletal, Regenerative Medicine

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Tissue Stem Cells: Architects of Their Niches

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