The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
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Early experiments in human cells provided evidence that some biomarkers of aging (telomere lengths) were responding to epigenetic reprogramming.
“Early experiments in human cells were somewhat encouraging as they provide evidence that some of the biomarkers of aging (that is telomere lengths) were responding to the epigenetic reprogramming”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [20]
The Results section (‘Telomere Elongation during Reprogramming-Induced Tissue Dedifferentiation’; page unavailable) reports longer telomeres in reprogrammed areas, supporting the claim that telomere length responds to reprogramming. But those experiments used mice, not human cells. The Introduction also discusses earlier in vitro findings without establishing the cited paper’s experiments as early human-cell experiments. (LLM, conf=0.88)
Experimental — accuracy not yet measuredEarly human cell reprogramming protocols relied upon rejuvenation through re-differentiation after iPS cell formation.
“but protocols relied upon rejuvenation through re-differentiation after iPS cell formation 20,26,28 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [20]
The Introduction reports that adult cells’ telomeres can lengthen during in vitro reprogramming into iPSCs, supporting an aspect of rejuvenation. It does not say that early human-cell protocols relied on re-differentiation after iPSC formation; the Results instead study in vivo reprogramming in mice. No page numbers are available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSubsequent studies showed induced pluripotent stem (iPS) cell induction in vivo, indicating the possibility of cell de-differentiation in living organisms.
“Subsequent studies showed induced pluripotent stem (iPS) cell induction in vivo, indicating the possibility of cell de-differentiation in living organisms [19][20][21] .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [20]
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Citations
Cites
Mediator and cohesin connect gene expression and chromatin architecture
Kagey, M. H., Newman, J. J., Bilodeau, S., Zhan, Y., Orlando, D. A., van Berkum, N. L., Ebmeier, C. C., Goossens, J., Rahl, P. B., Levine, S. S., et al. (2010) · Nature · doi:10.1038/nature09380 · Cited by 1,939
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
Marión, R. M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Serrano, M., & Blasco, M. A. (2009) · Nature · doi:10.1038/nature08287 · Cited by 1,028 · cited 5×
“Finally, in vitro reprogramming induces epigenetic changes at the telomeric chromatin, including decreased trimethylation of H3K9 and H4K20, indicative of a more ‘‘open’’ chromatin at telomeres (Marion et al., 2009b).”
InfluentialSelf-citationArmanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982
Maitra, A., & Hruban, R. H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154305 · Cited by 707
The longest telomeres: a general signature of adult stem cell compartments
Flores, I., Canela, A., Vera, E., Tejera, A., Cotsarelis, G., & Blasco, M. A. (2008) · Genes & Development · doi:10.1101/gad.451008 · Cited by 352
Self-citationTelomerase regulation and stem cell behaviour
Flores, I., Benetti, R., & Blasco, M. A. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.03.003 · Cited by 232
Self-citationMice with Pulmonary Fibrosis Driven by Telomere Dysfunction
Povedano, J. M., Martinez, P., Flores, J. M., Mulero, F., & Blasco, M. A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.028 · Cited by 225 · cited 4×
“…and inadult stemcell compartments (Schneider et al., 2013), where it is required for the induction and maintenance of pluripotency in iPSCs (Schneider et al., 2013) and for tissue homeostasis (Beier et al., 2012; Martinez et al., 2009; Povedano et al., 2015; Schneider et al., 2013), respectively.”
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Flagged first, then by citations
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Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Cipriano, A., Moqri, M., Maybury-Lewis, S. Y., Rogers-Hammond, R., de Jong, T. A., Parker, A., Rasouli, S., Schöler, H. R., Sinclair, D. A., & Sebastiano, V. (2023) · Nature Aging · doi:10.1038/s43587-023-00539-2 · Cited by 66
AAV vector-mediated in vivo reprogramming into pluripotency
Senís, E., Mosteiro, L., Wilkening, S., Wiedtke, E., Nowrouzi, A., Afzal, S., Fronza, R., Landerer, H., Abad, M., Niopek, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05059-x · Cited by 64
Self-citation
Metadata
- Authors
- Marión, R. M., López de Silanes, I., Mosteiro, L., Gamache, B., Abad, M., Guerra, C., Megías, D., Serrano, M., & Blasco, M. A.
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 8
- Issue
- 2
- Pages
- 460-475
- ISSN
- 2213-6711
- PMC
- PMC5312258
- Cited by
- 39
- References
- 7
- Language
- en
- Licence
- Funders
- Fundación Botín
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