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Cited by 693

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

The Structural Biology of Toll-like Receptors

Open access
Botos, Istvan, Segal, David M., Davies, David R.·2011·Structure
DOI 10.1016/j.str.2011.02.004
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Abstract

The membrane-bound Toll-like receptors (TLRs) trigger innate immune responses following recognition of a wide variety of pathogen-derived compounds. Despite the wide range of ligands recognized by TLRs, the receptors share a common structural framework in their extracellular, ligand-binding domains. These domains all adopt horseshoe-shaped structures built from leucine-rich repeat motifs. Typically, upon ligand binding, two extracellular domains form an “m”-shaped dimer sandwiching the ligand molecule bringing the transmembrane and cytoplasmic domains in close proximity and triggering a downstream signalling cascade. Although the ligand-induced dimerization of these receptors has many common features, the nature of the interactions of the TLR extracellular domains with their ligands varies markedly between TLR paralogs.

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Crossref · 10.1016/j.str.2011.02.004

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Metadata

Authors
Botos, I., Segal, D. M., & Davies, D. R.
Venue
Structure
Publisher
Elsevier BV
Published
2011-04
Volume
19
Issue
4
Pages
447-459
ISSN
0969-2126 (ISSN-L)
DOI
10.1016/j.str.2011.02.004
OpenAlex
W2001747259
Cited by
693
References
9
FWCI
13.87
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Structural Biology of Toll-like Receptors. https://app.cochat.ai/papers/10.1016/j.str.2011.02.004
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Botos, I., Segal, D. M., & Davies, D. R. (2011). The Structural Biology of Toll-like Receptors. Structure. https://doi.org/10.1016/j.str.2011.02.004

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.