The DOI matches its Crossref record; 440 of the 440 references it cites were found in a registry or an index.
The family of the interleukin‐1 receptors
Open accessAbstract
Summary: The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand‐binding receptor chain. For signaling to take place, a non‐binding accessory chain is recruited into a heterotrimeric complex. The intracellular approximation of the Toll‐IL‐1‐receptor (TIR) domains of the 2 receptor chains is the event that initiates signaling. The family of IL‐1 receptors (IL‐1R) includes 10 structurally related members, and the distantly related soluble protein IL‐18 BP that acts as inhibitor of the cytokine IL‐18. Over the years the receptors of the IL‐1 family have been known with many different names, with significant confusion. Thus, we will use here a recently proposed unifying nomenclature. The family includes several ligand‐binding chains (IL‐1R1, IL‐1R2, IL‐1R4, IL‐1R5, and IL‐1R6), 2 types of accessory chains (IL‐1R3, IL‐1R7), molecules that act as inhibitors of signaling (IL‐1R2, IL‐1R8, IL‐18 BP), and 2 orphan receptors (IL‐1R9, IL‐1R10). In this review, we will examine how the receptors of the IL‐1 family regulate the inflammatory and anti‐inflammatory functions of the IL‐1 cytokines and are, more at large, involved in modulating defensive and pathological innate immunity and inflammation. Regulation of the IL‐1/IL‐1R system in the brain will be also described, as an example of the peculiarities of organ‐specific modulation of inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. (1997) · Nature · doi:10.1038/41131 · Cited by 5,590
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.-M., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,043
Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,710
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
O'Neill, L. A. J., & Bowie, A. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2079 · Cited by 2,667
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
Dinarello, C. A. (2011) · Blood · doi:10.1182/blood-2010-07-273417 · Cited by 2,248
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,041
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945
Cited by
Kinase inhibition in autoimmunity and inflammation
Zarrin, A. A., Bao, K., Lupardus, P., & Vucic, D. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0082-8 · Cited by 431
Ni, J., Wang, X., Stojanovic, A., Zhang, Q., Wincher, M., Bühler, L., Arnold, A., Correia, M. P., Winkler, M., Koch, P.-S., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.001 · Cited by 324
Impact of Age-, Cancer- and Treatment-Driven Inflammation on T Cell Function and Immunotherapy
Quinn, K. M., Kartikasari, A. E. R., Cooke, R. E., Koldej, R. M., Ritchie, D. S., & Plebanski, M. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr0520-466r · Cited by 31
Hu, B. D., He, H., Bose, S., Gour, D., Nandymazumdar, M., Zhou, J., Golla, A., del Duca, E., Beaziz, J., Avallone, G., et al. (2026) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2026.02.014 · Cited by 5
Metadata
- Authors
- Boraschi, D., Italiani, P., Weil, S., & Martin, M. U.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2017-12-16
- Volume
- 281
- Issue
- 1
- Pages
- 197-232
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2780744144
- Cited by
- 389
- References
- 440
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The family of the interleukin‐1 receptors. https://app.cochat.ai/papers/10.1111/imr.12606
- The paper
- Boraschi, D., Italiani, P., Weil, S., & Martin, M. U. (2018). The family of the interleukin‐1 receptors. Immunological Reviews. https://doi.org/10.1111/imr.12606
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
