Cited by 33Complement system in diseasesRetinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

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Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants

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Tzoumas, Nikolaos, Hallam, Dean, Harris, Claire L., Lako, Majlinda, Kavanagh, David, Steel, David H.W.·2021·Survey of Ophthalmology

DOI 10.1016/j.survophthal.2020.10.008

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Abstract

Ophthalmologists are long familiar with the eye showing signs of systemic disease, but the association between age-related macular degeneration and abnormal complement activation, common to several renal disorders, has only recently been elucidated. Although complement activation products were identified in drusen almost three decades ago, it was not until the early 21st century that a single-nucleotide polymorphism in the complement factor H gene was identified as a major heritable determinant of age-related macular degeneration, galvanizing global efforts to unravel the pathogenesis of this common disease. Advances in proteomic analyses and familial aggregation studies have revealed distinctive clinical phenotypes segregated by the functional effects of common and rare genetic variants on the mature protein and its splice variant, factor H-like protein 1. The predominance of loss-of-function, N-terminal mutations implicate age-related macular degeneration as a disease of general complement dysregulation, offering several therapeutic avenues for its modulation. Here, we explore the molecular impact of these mutations/polymorphisms on the ability of variant factor H/factor H-like protein 1 to localize to polyanions, pentraxins, proinflammatory triggers, and cell surfaces across ocular and renal tissues and exert its multimodal regulatory functions and their clinical implications. Finally, we critically evaluate key therapeutic and diagnostic efforts in this rapidly evolving field.

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Wagner, E. K., Raychaudhuri, S., Villalonga, M. B., Java, A., Triebwasser, M. P., Daly, M. J., Atkinson, J. P., & Seddon, J. M. (2016) · Scientific Reports · doi:10.1038/srep31531 · Cited by 54
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Murinello, S., Mullins, R. F., Lotery, A. J., Perry, V. H., & Teeling, J. L. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-11821 · Cited by 51
Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians
Fan, Q., Cheung, C. M. G., Chen, L. J., Yamashiro, K., Ahn, J., Laude, A., Mathur, R., Chan, C. M., Yeo, I. Y. S., Lim, T. H., et al. (2017) · Journal of Human Genetics · doi:10.1038/jhg.2017.83 · Cited by 48
Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration
Assel, M. J., Li, F., Wang, Y., Allen, A. S., Baggerly, K. A., & Vickers, A. J. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2017.09.008 · Cited by 48
Population-Based Study of Early Age-Related Macular Degeneration
Tedeschi‐Blok, N., Buckley, J. D., Varma, R., Triche, T. J., & Hinton, D. R. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.07.043 · Cited by 47
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Caire, J., Recalde, S., Velázquez-Villoria, Á., García‐García, L., Reiter, N., Anter, J., Fernández‐Robredo, P., & García‐Layana, A. (2014) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2013.8175 · Cited by 47
Age-related Macular Degeneration and Modification of Systemic Complement Factor H Production Through Liver Transplantation
Khandhadia, S., Hakobyan, S., Heng, L. Z., Gibson, J., Adams, D. H., Alexander, G. J., Gibson, J. M., Martin, K. R., Menon, G., Nash, K., et al. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2013.01.004 · Cited by 47
Clinical Phenotypes Associated with the Complement Factor H Y402H Variant in Age-related Macular Degeneration
Brantley, M. A., Edelstein, S. L., King, J. M., Apte, R. S., Kymes, S. M., & Shiels, A. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.05.018 · Cited by 46
Phenotypic Characterization of Complement Factor H R1210C Rare Genetic Variant in Age-Related Macular Degeneration
Ferrara, D., & Seddon, J. M. (2015) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2015.0814 · Cited by 46
Association of Genetic Variants With Response to Anti–Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration
Lorés‐Motta, L., Riaz, M., Grunin, M. A., Corominas, J., van Asten, F., Pauper, M., Leenders, M., Richardson, A. J., Muether, P. S., Cree, A. J., et al. (2018) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2018.2019 · Cited by 45
Genotype–Phenotype Correlations for Exudative Age-Related Macular Degeneration Associated with Homozygous HTRA1 and CFH Genotypes
Leveziel, N., Zerbib, J., Richard, F., Querques, G., Morineau, G., Frémeaux‐Bacchi, V., COSCAS, G. J., Soubrane, G., Benlian, P., & Souied, E. H. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1540 · Cited by 43
Characterization of a Factor H Mutation That Perturbs the Alternative Pathway of Complement in a Family with Membranoproliferative GN
Wong, E. K. S., Anderson, H. E., Herbert, A. P., Challis, R. C., Brown, P., dos Reis, G. S., Tellez, J. O., Strain, L., Fluck, N., Humphrey, A., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013070732 · Cited by 43
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Schnabolk, G., Parsons, N., Obert, E., Annamalai, B., Nasarre, C., Tomlinson, S., Lewin, A. S., & Rohrer, B. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.11.003 · Cited by 43
Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
Warwick, A., Khandhadia, S., Ennis, S., & Lotery, A. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041234 · Cited by 42
Zinc Binding to the Tyr402 and His402 Allotypes of Complement Factor H: Possible Implications for Age-Related Macular Degeneration
Nan, R., Farabella, I., Schumacher, F. F., Miller, A., Gor, J., Martin, A. C. R., Jones, D. T., Lengyel, I., & Perkins, S. J. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.03.006 · Cited by 42
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Puche, N., Blanco-Garavito, R., Richard, F., Leveziel, N., Zerbib, J., Tilleul, J., Mimoun, G., Querques, G., Cohen, S. Y., & Souied, E. H. (2013) · Retina · doi:10.1097/iae.0b013e31827b6483 · Cited by 41
Joint Effect of Cigarette Smoking and CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy
Nakanishi, H., Yamashiro, K., Yamada, R., Gotoh, N., Hayashi, H., Nakata, I., Saito, M., Iida, T., Oishi, A., Kurimoto, Y., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4948 · Cited by 40
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Dedania, V. S., Grob, S., Zhang, K., & Bakri, S. J. (2015) · Retina · doi:10.1097/iae.0000000000000466 · Cited by 38
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Hong, N., Shen, Y., Yu, C., Wang, S., & Tong, J. (2016) · Acta Ophthalmologica · doi:10.1111/aos.13049 · Cited by 38
A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration
van Asten, F., Simmons, M., Singhal, A., Keenan, T. D. L., Ratnapriya, R., Agrón, E., Clemons, T. E., Swaroop, A., Lu, Z., & Chew, E. Y. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.09.023 · Cited by 38
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Amadi‐Obi, A., Yu, C., Dambuza, I. M., Kim, S.-H., Marrero, B., & Egwuagu, C. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045801 · Cited by 37
Transcriptional control of genes for soluble complement cascade regulatory proteins
Fraczek, L., & Martin, B. K. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.08.016 · Cited by 36
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Taylor, R. L., Poulter, J. A., Downes, S. M., McKibbin, M., Khan, K. N., Inglehearn, C. F., Webster, A. R., Hardcastle, A. J., Michaelides, M., Bishop, P. N., et al. (2019) · Ophthalmology · doi:10.1016/j.ophtha.2019.03.013 · Cited by 36
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay
Sofat, R., Mangione, P. P., Gallimore, J. R., Hakobyan, S., Hughes, T. R., Shah, T., Goodship, T. H. J., D’Aiuto, F., Langenberg, C., Wareham, N. J., et al. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.01.009 · Cited by 34
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Leveziel, N., Puche, N., Richard, F., Somner, J., Zerbib, J., Bastuji‐Garin, S., Cohen, S. Y., Korobelnik, J., Sahel, J., Soubrane, G., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4423 · Cited by 33
Human retinal pigment epithelial cells express the long pentraxin PTX3.
Woo, J. M., Kwon, M., Shin, D.-Y., Kang, Y.-H., Hwang, N., & Chung, S. W. (2013) · Europe PMC (PubMed Central) · Cited by 33
Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases
Recalde, S., Tortajada, A., Subias, M., Anter, J., Blasco, M., Maranta, R., Coco, R., Pinto, S., Noris, M., García-Layana, A., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050580 · Cited by 32
Incidence and Risk Factors of Reticular Pseudodrusen Using Multimodal Imaging
Dutheil, C., Goff, M. L., Cougnard‐Grégoire, A., et al. (2020) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2020.0266 · Cited by 32
Complement Factor H Autoantibodies and Age-Related Macular Degeneration
Dhillon, B., Wright, A. F., Tufail, A., Pappworth, I. Y., Hayward, C., Moore, I., Strain, L., Kavanagh, D., Barlow, P. N., Herbert, A. P., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-5124 · Cited by 31
Self-citation
Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis
Chen, G., Tzekov, R., Li, W., Jiang, F., Mao, S., & Tong, Y. (2015) · Scientific Reports · doi:10.1038/srep14517 · Cited by 31
Association between Polymorphisms of Complement Pathway Genes and Age-Related Macular Degeneration in a Chinese Population
Wu, L., Tao, Q., Chen, W., Wang, Z., Song, Y., Sheng, S.-Y., Li, P., & Zhou, J. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10453 · Cited by 30
C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation
Swinkels, M., Zhang, J. H., Tilakaratna, V., Black, G. C. M., Perveen, R., McHarg, S., Inforzato, A., Day, A. J., & Clark, S. J. (2018) · Scientific Reports · doi:10.1038/s41598-017-18395-7 · Cited by 30
CFH Y402H and ARMS2 A69S Polymorphisms and Oral Supplementation with Docosahexaenoic Acid in Neovascular Age-Related Macular Degeneration Patients: The NAT2 Study
Merle, B. M. J., Richard, F., Benlian, P., Puche, N., Delcourt, C., & Souied, E. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130816 · Cited by 29
Analysis of rare variants in the CFH gene in patients with the cuticular drusen subtype of age-related macular degeneration.
Duvvari, M. R., Saksens, N. T. M., van de Ven, J. P. H., de Jong‐Hesse, Y., Schick, T., Nillesen, W. M., Fauser, S., Hoefsloot, L. H., Hoyng, C. B., de Jong, E. K., et al. (2015) · Europe PMC (PubMed Central) · Cited by 28
Different Hereditary Contribution of theCFHGene Between Polypoidal Choroidal Vasculopathy and Age-Related Macular Degeneration in Chinese Han People
Huang, L., Li, Y., Guo, S., et al. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13437 · Cited by 28
Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus
Sardell, R. J., Persad, P. J., Pan, S. S., Whitehead, P. G., Adams, L. D., Laux, R. A., Fortun, J. A., Brantley, M. A., Kovach, J. L., Schwartz, S. G., et al. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-19519 · Cited by 28
Electrophysiology of type II mesangiocapillary glomerulonephritis with associated fundus abnormalities.
O'Brien, C., Duvall-Young, J., Brown, M. M., et al. (1993) · British Journal of Ophthalmology · doi:10.1136/bjo.77.12.778 · Cited by 27
Complement factor H Y402H polymorphism and characteristics of exudative age‐related macular degeneration lesions
Seitsonen, S., Järvelä, I. E., Meri, S., Tommila, P. V., Ranta, P., & Immonen, I. J. R. (2007) · Acta Ophthalmologica · doi:10.1111/j.1600-0420.2007.01050.x · Cited by 25
The link between morphology and complement in ocular disease
Mohlin, C., Sandholm, K., Ekdahl, K. N., & Nilsson, B. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.05.028 · Cited by 25
THE ARMS2 A69S VARIANT AND BILATERAL ADVANCED AGE-RELATED MACULAR DEGENERATION
Schwartz, S. G., Agarwal, A., Kovach, J. L., Gallins, P. J., Cade, W., Postel, E. A., Wang, G., Ayala-Haedo, J., Spencer, K. M., Haines, J. L., et al. (2012) · Retina · doi:10.1097/iae.0b013e318240a540 · Cited by 23
Genotype‐phenotype correlations of low‐frequency variants in the complement system in renal disease and age‐related macular degeneration
Geerlings, M. J., Volokhina, E. B., de Jong, E. K., van de Kar, N. C. A. J., Pauper, M., Hoyng, C. B., van den Heuvel, L. P., & den Hollander, A. I. (2018) · Clinical Genetics · doi:10.1111/cge.13392 · Cited by 21
Association of Two Polymorphisms, rs1061170 and rs1410996, in Complement Factor H with Age-Related Macular Degeneration in an Asian Population: A Meta-Analysis
Wu, M., Guo, Y., Ma, Y., Zheng, Z., Wang, Q., & Zhou, X. (2016) · Ophthalmic Research · doi:10.1159/000442257 · Cited by 20
Release of complement regulatory proteins from ocular surface cells in infections
Cocuzzi, E. T., Guidubaldi, J. M., Bardenstein, D. S., et al. (2000) · Current Eye Research · doi:10.1076/ceyr.21.5.856.5539 · Cited by 19
Generation of complement membrane attack complex in normal human corneas.
Mondino, B. J., Chou, H. J., & Sumner, H. L. (1996) · PubMed · Cited by 18
Complement factor H and related proteins in age-related macular degeneration
Calippe, B., Guillonneau, X., & Sennlaub, F. (2014) · Comptes Rendus. Biologies · doi:10.1016/j.crvi.2013.12.003 · Cited by 18
The Contribution of Genetic Architecture to the 10-Year Incidence of Age-Related Macular Degeneration in the Fellow Eye
Miyake, M., Yamashiro, K., Tamura, H., Kumagai, K., Saito, M., Sugahara-Kuroda, M., Yoshikawa, M., Oishi, M., Akagi-Kurashige, Y., Nakata, I., et al. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16020 · Cited by 17
Genetics of Pigment Changes and Geographic Atrophy
Thompson, C. L., Jun, G., Klein, R., Klein, R., Capriotti, J., Lee, K. E., & Iyengar, S. K. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1325 · Cited by 17
Association Between Perifoveal Drusen Burden Determined by OCT and Genetic Risk in Early and Intermediate Age-Related Macular Degeneration
Seddon, J. M., Dossett, J. P., Widjajahakim, R., & ROSNER, B. A. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27475 · Cited by 17
Gene–gene interaction of CFH, ARMS2, and ARMS2/HTRA1 on the risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese population
Huang, L., Meng, Q., Zhang, C., Sun, Y., Bai, Y., Li, S., Deng, X., Wang, B., Yu, W., Zhao, M., et al. (2015) · Eye · doi:10.1038/eye.2015.32 · Cited by 12
COMPLEMENT FACTOR H POLYMORPHISM IN AGE-RELATED MACULOPATHY IN THE CHINESE POPULATION
Gao, Y., LI, Y., Xu, L., LI, Y., Zhang, H., Jonas, J. B., & Sun, B. (2010) · Retina · doi:10.1097/iae.0b013e3181c2e086 · Cited by 12
Genetic Predictors of Response to Photodynamic Therapy
Parmeggiani, F., Gemmati, D., Costagliola, C., Semeraro, F., Perri, P., D’Angelo, S., Romano, M., Nadai, K. D., Sebastiani, A., & Incorvaia, C. (2011) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256411 · Cited by 12
Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration
Saksens, N. T. M., Lechanteur, Y. T. E., Verbakel, S. K., Groenewoud, J. M. M., Daha, M. R., Schick, T., Fauser, S., Boon, C. J. F., Hoyng, C. B., & den Hollander, A. I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144367 · Cited by 12
Geographic distribution of rare variants associated with age-related macular degeneration.
Geerlings, M. J., Kersten, E., Groenewoud, J. M. M., et al. (2018) · PubMed · Cited by 12
Complement halts angiogenesis gone wild
Kahr, W. H. A. (2010) · Blood · doi:10.1182/blood-2010-08-297648 · Cited by 11
Rare CFH mutations and early‐onset age‐related macular degeneration
Hughes, A. E., Meng, W., Bridgett, S., et al. (2015) · Acta Ophthalmologica · doi:10.1111/aos.12822 · Cited by 10
Human Complement Factor H and Factor H-Like Protein 1 Are Expressed in Human Retinal Pigment Epithelial Cells
Weinberger, A. W. A., Eddahabi, C., Carstesen, D., Zipfel, P. F., Walter, P., & Skerka, C. (2013) · Ophthalmic Research · doi:10.1159/000351624 · Cited by 10
Genetics of Unilateral and Bilateral Age-Related Macular Degeneration Severity Stages
Schick, T., Altay, L., Viehweger, E., Hoyng, C. B., den Hollander, A. I., Felsch, M., & Fauser, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156778 · Cited by 9
CFH Y402H polymorphism in Italian patients with age-related macular degeneration, retinitis pigmentosa, and Stargardt disease
Sodi, A., Passerini, I., Bacherini, D., Boni, L., Palchetti, S., Murro, V., Caporossi, O., Mucciolo, D. P., Franco, F. G. S., Vannozzi, L., et al. (2018) · Ophthalmic Genetics · doi:10.1080/13816810.2018.1525753 · Cited by 6
Rapid Dissection of the Genetic Risk of Age-Related Macular Degeneration
Haines, J. L., & Pericak-Vance, M. A. (2007) · JAMA · doi:10.1001/jama.297.4.401 · Cited by 5
Lens Status Influences the Association between CFH Polymorphisms and Age-Related Macular Degeneration: Findings from Two Population-Based Studies in Singapore
Wong, C. W., Liao, J., Cheung, C. M. G., Khor, C. C., Vithana, E. N., Wang, J. J., Mitchell, P., Aung, T., Wong, T. Y., & Cheng, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119570 · Cited by 4
Factor H and Factor H-like Protein 1
Barlow, P. N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810420-0.00030-4 · Cited by 2

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Authors: Tzoumas, N., Hallam, D., Harris, C. L., Lako, M., Kavanagh, D., & Steel, D. H. W.
Affiliations: Newcastle University (GB)
Royal Victoria Infirmary (GB)
Sunderland Eye Infirmary (GB)
Corresponding author: Tzoumas, Nikolaos
ORCID: Tzoumas, Nikolaos
Hallam, Dean
Harris, Claire L.
Lako, Majlinda
Kavanagh, David
Steel, David H.W.
Venue: Survey of Ophthalmology
Publisher: Elsevier BV
Published: 2021-03
Volume: 66
Issue: 2
Pages: 378-401
ISSN: 0039-6257 (ISSN-L)
DOI: 10.1016/j.survophthal.2020.10.008
OpenAlex: W3095970076
Cited by: 33
References: 266
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 5 · 2021: 7
FWCI: 0.46
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Survey of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Macular Society
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: complement factor H, age-related macular degeneration, complement activation, complement dysregulation, factor H-like protein 1, single nucleotide polymorphisms, rare variants, loss-of-function mutations, drusen, pentraxins, polyanions, complement regulation, therapeutic target, diagnosis
MeSH terms: Complement System Proteins, Humans, Macular Degeneration, Phenotype, Complement Factor H, Proteomics

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Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants

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