Cited by 1,070Iron Metabolism and DisordersTrace Elements in HealthHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.

Iron metabolism and toxicity

Papanikolaou, G., Pantopoulos, K.·2005·Toxicology and Applied Pharmacology

DOI 10.1016/j.taap.2004.06.021

Open this paper in CoChat — free account

Abstract

Iron is an essential nutrient with limited bioavailability. When present in excess, iron poses a threat to cells and tissues, and therefore iron homeostasis has to be tightly controlled. Iron's toxicity is largely based on its ability to catalyze the generation of radicals, which attack and damage cellular macromolecules and promote cell death and tissue injury. This is lucidly illustrated in diseases of iron overload, such as hereditary hemochromatosis or transfusional siderosis, where excessive iron accumulation results in tissue damage and organ failure. Pathological iron accumulation in the liver has also been linked to the development of hepatocellular cancer. Here we provide a background on the biology and toxicity of iron and the basic concepts of iron homeostasis at the cellular and systemic level. In addition, we provide an overview of the various disorders of iron overload, which are directly linked to iron's toxicity. Finally, we discuss the potential role of iron in malignant transformation and cancer.

Integrity signals

Registry

Crossref · 10.1016/j.taap.2004.06.021

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · cited 1×
“This modification is required for the recognition of HIF-1a by the von Hippel–Lindau protein (pVHL), which is a component of an E3 ubiquitin ligase complex (Ivan et al., 2001; Jaakkola et al., 2001).”
Background
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 2×
“Hepcidin expression is increased in inflammation (Nemeth et al., 2004) and secondary iron overload (Adamsky et al.”
Background
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168

Flagged first, then by citations

Show all 101 references

1 of the 101 references couldn’t be matched to a known paper.

Sorted by citations

Items 701–800 of 1,000

Effect of iron and nitrogen on the development ofHelminthosporium solaniand potato silver scurf
Mimee, B., Avis, T. J., Boivin, S., Jabaji, S., & Tweddell, R. J. (2011) · Canadian Journal of Plant Pathology · doi:10.1080/07060661.2011.610826 · Cited by 4
Role of Iron in the Pathogenesis of Endometriosis
Gupta, S., Harlev, A., Agarwal, A. K., Gokul, S. R., & Kumaresan, D. (2015) · SpringerBriefs in reproductive biology · doi:10.1007/978-3-319-18308-4_5 · Cited by 4
Design and synthesis of a novel rhodamine-based chemosensor and recognition study to Fe 3+
Zhang, F., Gao, Q., Zhao, J., Ge, M., & Bai, Y. (2016) · Heterocyclic Communications · doi:10.1515/hc-2015-0139 · Cited by 4
PHARMACEUTICAL EVALUATION AND TOXICOLOGICAL QUANTIFICATION OF HEAVY METALS AND ADULTERATED ALLOPATHIC CONTENTS IN RAWAND FINISHED DOSAGE FORM OF ANTIHYPERTENSIVE HERBAL PRODUCTS
Khan, M. A., Badshah, A., & Shahid, M. M. (2016) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.21010/ajtcam.v13i6.9 · Cited by 4
Assessing the spatial pattern of iron in well water from a small central Florida community
Hudgins, J., Lambert, N., Duranceau, S. J., & Butler, J. R. (2017) · Journal of Water and Health · doi:10.2166/wh.2017.157 · Cited by 4
Disorders of Iron Overload
Pietrangelo, A., & Torbenson, M. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00004-2 · Cited by 4
BCc1 Nanomedicine Therapeutic Effects in Streptozotocin and High-Fat Diet Induced Diabetic Kidney Disease
Fakharzadeh, S., Argani, H., Dadashzadeh, S., Kalanaky, S., Torbati, P. M., Nazaran, M. H., & Basiri, A. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s240757 · Cited by 4
Nanotoxicity and regulatory aspects in musculoskeletal regeneration
Du, R., Niu, W., Hong, H., & Huo, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820262-3.00007-4 · Cited by 4
Iron Metabolism and Related Disorders
Ginzburg, Y. Z., & Finberg, K. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-812535-9.00012-1 · Cited by 4
Maternal Physiology during Pregnancy
Chambers, D., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.085 · Cited by 4
The modulation of iron metabolism affects the Rhabdomyosarcoma tumor growth in vitro and in vivo
Asperti, M., Cantamessa, L., Gryzik, M., Bugatti, M., Codenotti, S., Denardo, A., Vermi, W., Fanzani, A., & Poli, M. (2023) · Clinical and Experimental Medicine · doi:10.1007/s10238-023-01012-5 · Cited by 4
Interaction of ApoMyoglobin with Heme-hIAPP complex
Pal, I., Roy, M., & Dey, S. G. (2020) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2020.111348 · Cited by 4
Microcalorimetric Investigation of the Toxic Effect of Iron Species onEscherichia coli
Wang, F., Yao, J., Wang, Y., Tian, L., Chen, H., Djak, A., Choi, M. M. F., & Štupar, J. (2007) · Toxicology Mechanisms and Methods · doi:10.1080/15376510601069992 · Cited by 4
Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication
Lu, N., Chen, W., Zhu, J., & Peng, Y. (2011) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.10.014 · Cited by 4
Fibrogenesis & Tissue Repair
Parola, M., & Pinzani, M. (2009) · Cited by 4
INVESTIGATION OF PERIODONTAL PARAMETERS, TOTAL ANTIOXIDANT STATUS AND FERRITIN LEVELS IN PATIENTS WITH THALASSEMIA MAJOR
Günay, A., Doğru, A. G., Işık, B., Söker, M., & Günay, A. (2015) · Journal of international dental and medical research · Cited by 4
RESPONSE OF LEMNA MINOR AND SALNINIA NATANS AS PHYROREMEDIATION AGENTS TOWARDS FE, CU AND ZN TOXICITIES VIA IN VIVO MODEL SYSTEM
Othman, R., Ramya, R., Baharuddin, Z. M. H., Hashim, K. S. H., & Yaman, M. M. (2015) · Jurnal Teknologi · doi:10.11113/jt.v77.6873 · Cited by 4
Iron Load and Liver Enzymes in 10‐ and 13‐year‐olds
Okuda, M., Sasaki, S., Kunitsugu, I., Sakurai, R., Yoshitake, N., & Hobara, T. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318201aecc · Cited by 4
Circulating ferritin concentrations are differentially associated with serum adipokine concentrations in Japanese men and premenopausal women
Kimura, Y., Yasuda, K., Kurotani, K., Akter, S., Kashino, I., Hayabuchi, H., Sato, M., & Mizoue, T. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1285-y · Cited by 4
Lethal Gastric Mucosal Necrosis due to Administration of Oral Ferrous Bisglycinate Chelate to Suckling Piglets
Stokar‐Regenscheit, N., Sydler, T., Bürgi, E., Lippuner, A., Naegeli, H., & Sidler, X. (2017) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2017.04.004 · Cited by 4
Mortality and co-morbidity among patients with Hemochromatosis and their first-degree relatives
Elmberg, M. (2010) · Figshare · Cited by 4
Toxicity Evaluations of Nanoclays and an Associated Nanocomposite throughout their Life Cycle
Wagner, A. (2018) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.7270 · Cited by 4
Two-Month In Vitro Degradation of 3D-Printed Biodegradable FeMnC Alloys for Biomedical Applications
Cherqaoui, A., Cao, Q. N., Paternoster, C., Gélinas, S., Bieda, M., Jarzębska, A., Blais, C., & Mantovani, D. (2025) · JOM · doi:10.1007/s11837-025-07274-6 · Cited by 3
Development of DFO chelator-attached adsorptive membranes for selective removal of Fe3+ ions to obtain clean drinking water
Karakoç, V., Tan, T. G., Küçük, V. A., & Odabaşı, M. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.142458 · Cited by 3
An integrated analytical approach for biomarker discovery in esophageal cancer: Combining trace element and oxidative stress profiling with machine learning
Koçak, Ö. F., Yaman, M. E., & Eroglu, A. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127678 · Cited by 3
Effect of Multi-axial Forging on Microstructure and Functional Properties of Bioresorbable Fe–30Mn–5Si (Wt Pct) Alloy
Kadirov, P., Zhukova, Y., Sheremetyev, V., Antipina, M., Sadykova, Y., Викторович, Ч. В., Zavodov, A. V., & Дмитриевич, П. С. (2025) · Metallurgical and Materials Transactions A · doi:10.1007/s11661-025-08010-0 · Cited by 3
Biocontrol, plant growth-promoting, and bioremediation potential of Aeromonas veronii CMF from the gut of Chrysomya megacephala
Banerjee, S., Saha, K. K., Pramanik, K., Biswas, R., Parveen, M., Balachandran, S., Roubík, H., & Mandal, N. C. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01622-25 · Cited by 3
Visual Recovery and Prognosis in the Treatment of Submacular Hemorrhage due to Polypoidal Choroidal Vasculopathy and Retinal Arterial Macroaneurysm: A Retrospective Study
Wu, J., Yan, T., Zhang, R., Feng, C., Xu, C., Xu, T., Li, Y., Wang, S., & He, J. (2023) · International Journal of Clinical Practice · doi:10.1155/2023/3880297 · Cited by 3
Chloride converts lead slag into a bifunctional material to remove heavy metals
Zhi, G., Qi, X., Yan, G., Li, Y., Wang, J., Huang, P., Wang, H., Shi, J., & Wang, J. (2023) · Journal of Environmental Management · doi:10.1016/j.jenvman.2023.118631 · Cited by 3
Evaluation of iron metabolism in hospitalized COVID-19 patients
Lefèbvre, T., Boutten, A., Raulet-Bussian, C., Raynor, A., Manceau, H., Puy, H., Moulouel, B., Schmitt, C., Timsit, J., Lefort, A., et al. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117509 · Cited by 2
Transferrin Receptor 2 in Canine Testicular Tumors: An Emerging Key Role in Seminomas
Leandri, R., Buonocore, S., & Power, K. (2025) · Animals · doi:10.3390/ani15020264 · Cited by 3
Physicians' practices regarding management of antituberculosis drug-induced hepatotoxicity.
Thongraung, W., Lertphongpiroon, W., Pungrassami, P., & Ratanajamit, C. (2012) · PubMed · Cited by 3
Tipping the balance: Haemoglobinopathies and the risk of diabetes
Baldwin, H. J. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i1.8 · Cited by 3
Iron, Oxidative Stress and Diabetes
Marcus, S. R., & Dharmalingam, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-405885-9.00006-1 · Cited by 3
The effect of iron sulfate nanoparticles and their fortified bread on Wistar rats and human cell lines
Bonyadian, M., Moeini, E., Ebrahimnejad, H., Askari, N., & Karimi, I. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127005 · Cited by 3
Glycoproteomics meets thermodynamics: A calorimetric study of the effect of sialylation and synergistic anion on the binding of iron to human serum transferrin
Borko, V., Friganović, T., & Weitner, T. (2023) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2023.112207 · Cited by 4
The Relationship between Body Mass Index, Metal Elements, and Antioxidant Capacity of Semen on The Human Sperm Chromatin.
Roshankhah, S., Barani, N., Salahshoor, M. R., Rezakhani, L., & Khazaei, M. (2023) · PubMed Central · doi:10.22074/ijfs.2023.563577.1379 · Cited by 3
Evaluation of spray-dried blood meal for application in commercial-like feed for juvenile swimming crab (Portunus trituberculatus)
Yang, Y., Jin, M., Li, X., Xie, S., Guo, C., Zhang, X., Yang, Z., Zhu, T., Luo, J., Cui, Y., et al. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102043 · Cited by 3
Exposure of Escherichia coli to human hepcidin results in differential expression of genes associated with iron homeostasis and oxidative stress
Pascoe, M. J., Lueangsakulthai, J., Ripley, D. A., Morris, R. H., & Maddocks, S. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny089 · Cited by 3
Association between hepcidin and type 2 diabetes markers in indigenous Argentinean children living at high altitude
Hirschler, V., González, C. D., Rica, I., Urrutia, I., Zalazar, R. M., Aguayo, A., & Castaño, L. A. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.08.021 · Cited by 3
Metallic Biodegradable Coronary Stent: Degradation Study
Hermawan, H. (2012) · SpringerBriefs in materials · doi:10.1007/978-3-642-31170-3_5 · Cited by 3
Iron toxicity
Barton, J. C., Edwards, C. Q., Phatak, P. D., Britton, R. S., & Bacon, B. R. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777035.005 · Cited by 3
N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats
Matijević-Sosa, J., Samaržija, I., Honović, L., & Jurišić, B. (2008) · Acta Pharmaceutica · doi:10.2478/v10007-008-0010-7 · Cited by 3
Altered serum enzymes and biochemical levels in Arabian racing camels with bone fractures.
Alshamsi, N. S., Ksiksi, T. S., & Ashraf, S. M. (2015) · The Journal of Animal and Plant Sciences · Cited by 3
Risk factors for stomatitis in patients with lymphangioleiomyomatosis during treatment with sirolimus: A multicenter investigator‐initiated prospective study
Kitamura, N., Seyama, K., Inoue, Y., Nagai, K., Suzuki, M., Moriyama, H., Takada, T., Tazawa, R., Hirai, T., Mishima, M., et al. (2017) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4259 · Cited by 3
Designing of alternative polymeric nano-chelator for treatment in acute iron poisoning by molecular imprinting approach
Karakoç, V. (2020) · Hacettepe Journal of Biology and Chemistry · doi:10.15671/hjbc.723455 · Cited by 3
Serum prohepcidin levels in premature newborns with oxygen radical diseases
Çelik, H. T., Yurdakök, M., Korkmaz, A., & Yiğit, Ş. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.983064 · Cited by 3
THE EFFECT OF 2,4-D ON GENE EXPRESSION IN CULTURED CELLS
Gunness, P. F. (2007) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 3
Toxic Geogenic Contaminants in Serpentinitic Geological Systems: Occurrence, Behavior, Exposure Pathways, and Human Health Risks
Gwenzi, W. (2021) · Geochemistry · doi:10.1002/9781119710134.ch1 · Cited by 3
Lipid peroxidation intrinsically induces mitochondrial iron overload via Bach1-HO-1 signaling to promote cardiac ferroptosisPreprint
Guo, X., Chen, Y., Zeng, Y., Mo, X., Hong, S., He, H., Li, J., Zhang, K. S., & Liu, Q. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.15.682717 · Cited by 4
New reports on iron related proteins: Molecular characterization of two ferroportin genes in common carp (Cyprinus carpio L.) and its expression pattern
Kamińska-Gibas, T., Szczygieł, J., Blasweiler, A., Gajda, Ł., Yılmaz, E., Jurecka, P., Kolek, L., Ples, M., & Irnazarow, I. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109087 · Cited by 2
Ferroptosis in space: How microgravity alters iron homeostasis
Sivasubramanian, N., Mumbrekar, K. D., & Prabhu, S. (2025) · Acta Astronautica · doi:10.1016/j.actaastro.2025.01.049 · Cited by 2
A turn off fluorescent ionic liquid with carbazole fluorophore for sensing Fe2+ ions
Vyas, S., Pandya, K. A., Singh, N., & Mishra, R. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.142732 · Cited by 2
Transplanted Iron Oxide Nanoparticle-Labeled Mesenchymal Stem Cells Exhibit ex vivo Neuronal Firing Activity in Ischemic Stroke Rats
Huang, D., Lu, C., & Hsiao, J. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s518933 · Cited by 2
Ferroptosis-new avenues for the treatment of multidrug-resistant bacteria: A review
Chen, Y., Bi, X., Fu, G., & Wen, L. (2025) · Medicine · doi:10.1097/md.0000000000045002 · Cited by 1
The association between dietary iron intake and the incidence of cardiometabolic multimorbidity: the mediating role of biological age
Chen, N., Yang, D., Qiao, G., Ke, Z., Tang, Y., Zhou, J. W., & Zhu, X. (2025) · BMC Public Health · doi:10.1186/s12889-025-25256-w · Cited by 2
A toxicological comparison of tire and road wear particles emitted on rural and urban roads, alone or with the co-exposed pollutant benzo[a]pyrene: Size and origin as key factors in controlling the in vitro proinflammatory response
Bouredji, A., Lumière, L., Lakhmi, R., Muresan, B., Pourchez, J., & Forest, V. (2025) · Environment International · doi:10.1016/j.envint.2025.109920 · Cited by 2
Iron deficiency aggravates hepatic inflammation in suckling piglets via endoplasmic reticulum stress-driven NF-κB pathway activation
Qi, J., Liang, Y., Yu, D., Li, W., Long, F., Yuan, M., Lou, Z., Liu, C., Wang, G., Wu, B., et al. (2026) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-026-01356-4 · Cited by 2
Manipulating redox active metal metabolism to enhance cancer therapy
Petronek, M. S., & Allen, B. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817868-3.00010-x · Cited by 2
Pneumatic displacement for management of traumatic macular hole with submacular hemorrhage
Mishra, M., Ramanjulu, R., Shanmugam, M. P., Mishra, D. K. C., & Sridharan, P. (2020) · Oman Journal of Ophthalmology · doi:10.4103/ojo.ojo_267_2019 · Cited by 2
Venous Pressure Waveforms
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.041 · Cited by 2
Effects of Feeding 5-Aminolevulinic Acid on Iron Status in Weaned Rats from the Female Rats during Gestation and Lactation
Li, J., Xie, Y., Li, M., Zhang, S., Cheng, Q., & Yang, W. (2022) · Animals · doi:10.3390/ani12202869 · Cited by 2
Concentrations of iron and chromium in free-ranging common marmosets (Callithrix jacchus) from Pernambuco, Brazil
Barretto, M. L. D. M., de Albuquerque, P. P. F., Costa, J. B. D. S., Leal, S. G., Paim, A. P. S., & Oliveira, A. A. D. F. (2023) · Environmental Monitoring and Assessment · doi:10.1007/s10661-023-11508-y · Cited by 2
CAN WE PREDICT INCIPIENT DIABETES MELLITUS IN PATIENTS WITH TRANSFUSION DEPENDENT β-THALASSEMIA (β-TDT) REFERRED WITH A HISTORY OF PREDIABETES?
Sanctis, V. D., Soliman, A. T., Daar, S., Tzoulis, P., & KATTAMIS, C. A. (2024) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2024.005 · Cited by 2
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Inai, Y., Izawa, T., Kamei, T., Fujiwara, S., Tanaka, M., Yamate, J., & Kuwamura, M. (2024) · Toxicologic Pathology · doi:10.1177/01926233241235623 · Cited by 2
Efficacy of anti-VEGF intravitreal injection in traumatic submacular hemorrhage: a retrospective study
Wang, J., Huang, L., Chen, L., Chen, S., & Liu, S. (2024) · International Ophthalmology · doi:10.1007/s10792-024-03168-9 · Cited by 2
Effect of a magnetic field on the production of Monascus pigments and citrinin via regulation of intracellular and extracellular iron content
Yang, Y., Liao, Q., Zhang, J., Liu, Y., Li, L., Chen, S., & Gao, M. (2025) · Food Physics · doi:10.1016/j.foodp.2025.100070 · Cited by 3
The effect of extremely low frequency magnetic field on heart tissue iron density
Soker, S. I., Sert, C., Deniz, M., Ayaz, E., Tunik, S., & Nergız, Y. (2011) · Journal of Clinical and Experimental Investigations · doi:10.5799/ahinjs.01.2011.02.0228 · Cited by 4
Modulating LC-PUFA biosynthesis in freshwater farmed fish
Senadheera, S. D. (2012) · Cited by 2
Modulation of Iron Metabolism and Hepcidin Release by HFE Mutations in Chronic Hemodialysis Patients: Pathophysiological and Therapeutic Implications
Canavesi, E., & Valenti, L. V. C. (2011) · InTech eBooks · doi:10.5772/22735 · Cited by 2
Equilibrium Study of Complex Formation Among Trivalent Metals, Glycine Peptides and Phenolates in Aqueous Solution
Angkawijaya, A. E., Santoso, S. P., Soetaredjo, F. E., Ismadji, S., & Ju, Y. (2015) · Journal of Solution Chemistry · doi:10.1007/s10953-015-0397-y · Cited by 2
Changes of iron concentrations in skin and plasma of patients with hemochromatosis along therapy
Pinheiro, T., Barreiros, M. A., Alves, L. C., Neres, M., Fleming, R., Silva, J. M., Filipe, P., & Silva, R. (2009) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-009-0125-4 · Cited by 2
Desempenho ponderal, função hepática e hemograma de borregos naturalmente infectados por helmintos gastrointestinais suplementados com ferro oral ou parenteral
da Rocha, R. X., Filappi, A., Rodrigues, A., Soares, E., Fernandes, G., Leal, M. L. D. R., & Cecim, M. (2013) · Revista Brasileira de Ciência Veterinária · doi:10.4322/rbcv.2014.007 · Cited by 2
Antioxidant Therapy and Neuroprotection in the Newborn
Perrone, S., Turrisi, G., & Buonocore, G. (2008) · Pediatric Health · doi:10.2217/17455111.2.6.715 · Cited by 2
The role of anaemia in oxidative and genotoxic damage in transfused β-thalassaemic patients
Ferro, E., Visalli, G., Rosa, M. A. L., Civa, R., Papa, G. R., D’Ascola, D. G., Roccamo, G., Piraino, B., Salpietro, C. D., & Pietro, A. D. (2016) · Hematology · doi:10.1080/10245332.2016.1244034 · Cited by 2
Hubungan Kadar Feritin dan Ion Kalsium Serum pada Penyandang Thalassemia Mayor Anak yang Mendapat Transfusi Berulang
Amelia, M., Gurnida, D. A., & Reniarti, L. (2016) · Sari Pediatri · doi:10.14238/sp16.1.2014.1-4 · Cited by 2
Hubungan Kadar Feritin Serum dengan Gangguan Fungsi Paru Pasien Thalassemia Mayor Anak
Sani, M. R., Kartasasmita, C. B., & Reniarti, L. (2016) · Sari Pediatri · doi:10.14238/sp16.3.2014.210-4 · Cited by 2
EFFECT OF CHRONIC IRON OVERLOADING ON CARDIOVASCULAR SYSTEM IN ADULT MALE ALBINO RATS
Asalah, A. K., Soliman, N. A., Moursi, S. M. M., & Taiser, W. (2017) · Al-Azhar Medical Journal · doi:10.12816/0035552 · Cited by 2
The “Little Iron Waltz”: The Ternary Response of Paracoccidioides spp. to Iron Deprivation
de Souza, A. F., de Paula, M. S., Lima, R. M., Silva, M. G., de Curcio, J. S., Pereira, M., & Soares, C. M. D. A. (2020) · Journal of Fungi · doi:10.3390/jof6040221 · Cited by 2
Cardiac Pressure–Volume Loops
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.034 · Cited by 2
Oxygen Transport
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.011 · Cited by 2
SPD_0090 Negatively Contributes to Virulence of Streptococcus pneumoniae
Cao, L., Li, N., Dong, Y., Yang, X.-Y., Liu, J., He, Q., Ge, R., & Sun, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.896896 · Cited by 2
Resting Membrane Potential
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.054 · Cited by 2
The influence of ferric (III) citrate on ATP-hydrolases of Desulfuromonas acetoxidans ІМV В-7384
Maslovska, O., & Hnatush, S. О. (2013) · Biosystems Diversity · doi:10.15421/011301 · Cited by 2
Hemoglobina reticulocitaria: un nuevo parámetro del hemograma de gran valor en el diagnóstico y manejo de la eritropoyesis deficiente en hierro
Campuzano‐Maya, G., & Arismendy, N. M. G. (2015) · Medicina y Laboratorio · doi:10.36384/01232576.107 · Cited by 2
Iron-related immune cell function in sepsis
Thorburn, T. (2019) · DalSpace (Dalhousie University) · Cited by 2
Pulmonary Circulation
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.026 · Cited by 2
Efeito do citrato e taurina em meio CR2aa no desenvolvimento de embriões bovinos fecundados in vitro
Camargo, L. S. A., de Sá, W. F., Viana, J. H. M., Ramos, A. A., & Ferreira, A. M. (2009) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/s0102-09352009000100013 · Cited by 2
Les hémochromatoses héréditaires
Bouizegarène, P., Coulhon, M.-P., Deybach, J., Tchernitchko, D., & Lamoril, J. (2006) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/j.immbio.2005.10.002 · Cited by 2
Serum Ferritin: Deceptively Simple or Simply Deceptive? Lessons Learned From Iron Therapy in Patients With Chronic Kidney Disease
Kovesdy, C. P., Lee, G. H., & Kalantar‐Zadeh, K. (2008) · Journal of Pharmacy Practice · doi:10.1177/0897190008318915 · Cited by 2
Cadmium, Iron and Zinc Uptake Individually and as a Mixture by Limnodrillus hoffmeisteri and Impact on Adenosin-Triphosphate Content
y Ortega, M. D. L. A. G., López‐López, E., Favari, L., Garduño‐Siciliano, L., & Galar‐Martínez, M. (2007) · Environmental Toxicology and Chemistry · doi:10.1897/06-632.1 · Cited by 2
Timing of complementary feeding : its association with growth, diet, iron status, and eating behaviours in infants and toddlers
Ntouva, A. (2014) · University of Brighton Repository (University of Brighton) · Cited by 2
Iron stress affects the survival of Toxoplasma gondiiPreprint
Ying, Z., Yin, M., Zhu, Z., Shang, Z., Pei, Y., Liu, J., & Liu, Q. (2023) · Research Square · doi:10.21203/rs.3.rs-3240882/v1 · Cited by 2
Valsalva Manoeuvre
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.044 · Cited by 1
Altitude
Chambers, D. J., Huang, C. L.-H., & Matthews, G. D. K. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108565011.090 · Cited by 1
Ferrocenyl β‐Diketonate Compounds: Extended Ring Systems for Improved Anticancer Activity
Hofmann, B. J., Aljohani, E. T., Cicovacki, N., Lee, I., Warren, D. T., Sobolewski, A., Stringer, T., & Lord, R. M. (2024) · ChemBioChem · doi:10.1002/cbic.202400759 · Cited by 1
Azo dye-based on-site assay paper kit for rapid and selective naked-eye and smartphone-assisted detection of deferoxamine drug
Koç, Ö. K. (2025) · Talanta · doi:10.1016/j.talanta.2025.128333 · Cited by 1
Association between iron homeostasis and prognosis in patients with chronic obstructive pulmonary disease: a retrospective analysis from MIMIC-IV database
Dong, Z., Xu, C., Yu, S., Zhang, X., Yuan, J., Tang, L., Xie, L., Zhang, J., Li, Q., & Wang, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1610681 · Cited by 1
The Effect of Iron Deficiency Anemia and Serum Ferritin Deficiency on Cognitive Functions in Children 1 to 5 Years Old
Duran, B. C., Ay, Y., Imancli, H., & Akçay, G. (2025) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000003090 · Cited by 1
Thin films of biodegradable metals and their application in transient electronic devices
Zheng, Y. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22133-0.00015-1 · Cited by 1

Authors: Papanikolaou, G., & Pantopoulos, K.
Affiliations: National and Kapodistrian University of Athens (GR)
Jewish General Hospital (CA)
Corresponding author: Pantopoulos, K.
ORCID: Papanikolaou, G.
Pantopoulos, K.
Venue: Toxicology and Applied Pharmacology
Publisher: Elsevier BV
Published: 2005-01
Volume: 202
Issue: 2
Pages: 199-211
ISSN: 0041-008X (ISSN-L)
DOI: 10.1016/j.taap.2004.06.021
OpenAlex: W2077328361
Cited by: 1,070
References: 101
Citations by year: 2026: 35 · 2025: 46 · 2024: 59 · 2023: 71 · 2022: 62 · 2021: 52 · 2020: 52 · 2019: 140 · 2018: 48 · 2017: 44 · 2016: 48 · 2015: 63 · 2014: 53 · 2013: 57 · 2012: 44
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Toxicology and Applied Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Fonds De La Recherche Scientifique - FNRS
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords: iron metabolism, iron homeostasis, iron toxicity, iron overload, hereditary hemochromatosis, oxidative stress, free radicals, hepatocellular carcinoma, malignant transformation, iron bioavailability
MeSH terms: Animals, Free Radicals, Humans, Iron, Liver, Oxidative Stress, Iron Overload

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Iron metabolism and toxicity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks