The DOI matches its Crossref record; 96 of the 98 references it cites were found in a registry or an index.
CSF-1 regulation of the wandering macrophage: complexity in action
Abstract
Most tissue macrophages and osteoclasts are regulated by colony-stimulating factor-1 (CSF-1, also known as macrophage CSF). The effects of CSF-1 are mediated by the CSF-1 receptor tyrosine kinase (CSF-1R), through autophosphorylation of CSF-1R and the subsequent phosphorylation of downstream molecules. Triggering this phosphorylation cascade increases gene transcription and protein translation, and induces cytoskeletal remodeling by several signaling pathways, leading to the survival, proliferation and differentiation of target cells. CSF-1-regulated tissue macrophages are important for innate immunity and for tissue development and function. Because CSF-1 regulates the survival, proliferation and chemotaxis of macrophages and supports their activation, this factor is involved in the pathogenesis of several diseases.
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In the citing paper
“Microglia usually become heterogeneously distributed when they respond to an insult or stimulus [39].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [39]
In the citing paper
“Other studies have shown that the CSF-1 signaling pathway is required for microglial motility [39].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [39]
Citations
Cites
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Obesity-induced inflammatory changes in adipose tissue
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Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.727 · Cited by 1,594
Dai, X.-M., Ryan, G. R., Hapel, A. J., Dominguez, M. G., Russell, R. G., Kapp, S., Sylvestre, V., & Stanley, E. R. (2002) · Blood · doi:10.1182/blood.v99.1.111 · Cited by 1,184
Self-citationWiktor-Jedrzejczak, W., Bartocci, A., Ferrante, A. W., Ahmed-Ansari, A., Sell, K. W., Pollard, J. W., & Stanley, E. R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4828 · Cited by 1,031
Self-citationInvolvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis
Dranoff, G., Crawford, A. D., Sadelain, M., Neugeboren, B. I., Rashid, A., Bronson, R. T., Dickersin, G. R., Bachurski, C. J., Mark, E. L., Whitsett, J. A., et al. (1994) · Science · doi:10.1126/science.8171324 · Cited by 877
Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils
Xu, J., Wang, F., Keymeulen, A. V., Herzmark, P., Straight, A. F., Kelly, K., Takuwa, Y., Sugimoto, N., Mitchison, T. J., & Bourne, H. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00555-5 · Cited by 684
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2 of the 98 references couldn’t be matched to a known paper.
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Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,745
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0609385 · Cited by 1,456
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329
Colony-stimulating factors in inflammation and autoimmunity
Hamilton, J. A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2356 · Cited by 1,305
Metadata
- Authors
- Pixley, F. J., & Stanley, E. R.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Stanley, E. Richard
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 14
- Issue
- 11
- Pages
- 628-638
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2032410318
- Cited by
- 807
- References
- 98
- Citations by year
- 2026: 19 · 2025: 34 · 2024: 50 · 2023: 32 · 2022: 45 · 2021: 41 · 2020: 36 · 2019: 34 · 2018: 30 · 2017: 39 · 2016: 33 · 2015: 34 · 2014: 44 · 2013: 40 · 2012: 45
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- National Institutes of Health (KO8 CA097348, PO1 CA100324, RO1 CA 25604, RO1 CA32551)
- Albert Einstein Cancer Center (P30 CA13330)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- colony-stimulating factor 1, CSF-1 receptor, tissue macrophages, osteoclasts, macrophage chemotaxis, macrophage activation, signaling pathways, innate immunity, pathogenesis
- MeSH terms
- Animals, Humans, Macrophage Activation, Macrophages, Phosphorylation, Signal Transduction, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor
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