Cited by 833Immune cells in cancerCytokine Signaling Pathways and InteractionsPhagocytosis and Immune Regulation

The DOI matches its Crossref record; 96 of the 98 references it cites were found in a registry or an index.

CSF-1 regulation of the wandering macrophage: complexity in action

Pixley, Fiona J., Stanley, E. Richard·2004·Trends in Cell Biology

DOI 10.1016/j.tcb.2004.09.016

Open this paper in CoChat — free account

Abstract

Most tissue macrophages and osteoclasts are regulated by colony-stimulating factor-1 (CSF-1, also known as macrophage CSF). The effects of CSF-1 are mediated by the CSF-1 receptor tyrosine kinase (CSF-1R), through autophosphorylation of CSF-1R and the subsequent phosphorylation of downstream molecules. Triggering this phosphorylation cascade increases gene transcription and protein translation, and induces cytoskeletal remodeling by several signaling pathways, leading to the survival, proliferation and differentiation of target cells. CSF-1-regulated tissue macrophages are important for innate immunity and for tissue development and function. Because CSF-1 regulates the survival, proliferation and chemotaxis of macrophages and supports their activation, this factor is involved in the pathogenesis of several diseases.

Integrity signals

Registry

Crossref · 10.1016/j.tcb.2004.09.016

Cites

96 of 96 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Rho GTPases in cell biology
Etienne-Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,965
Rho and Rac Take Center Stage
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,831
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.727 · Cited by 1,594
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
Dai, X.-M., Ryan, G. R., Hapel, A. J., Dominguez, M. G., Russell, R. G., Kapp, S., Sylvestre, V., & Stanley, E. R. (2002) · Blood · doi:10.1182/blood.v99.1.111 · Cited by 1,184
Self-citation
Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.
Wiktor-Jedrzejczak, W., Bartocci, A., Ferrante, A. W., Ahmed-Ansari, A., Sell, K. W., Pollard, J. W., & Stanley, E. R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4828 · Cited by 1,031
Self-citation
Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis
Dranoff, G., Crawford, A. D., Sadelain, M., Neugeboren, B. I., Rashid, A., Bronson, R. T., Dickersin, G. R., Bachurski, C. J., Mark, E. L., Whitsett, J. A., et al. (1994) · Science · doi:10.1126/science.8171324 · Cited by 877
Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils
Xu, J., Wang, F., Keymeulen, A. V., Herzmark, P., Straight, A. F., Kelly, K., Takuwa, Y., Sugimoto, N., Mitchison, T. J., & Bourne, H. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00555-5 · Cited by 684

Flagged first, then by citations

Show all 98 references

2 of the 98 references couldn’t be matched to a known paper.

Sorted by citations

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,745
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0609385 · Cited by 1,456
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329
Colony-stimulating factors in inflammation and autoimmunity
Hamilton, J. A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2356 · Cited by 1,305
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Origin of the Lamina Propria Dendritic Cell Network
Bogunovic, M., Ginhoux, F., Helft, J., Shang, L., Hashimoto, D., Greter, M., Liu, K., Jakubzick, C., Ingersoll, M. A., Leboeuf, M., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.010 · Cited by 859
Self-citation
Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
Budhu, A., Forgues, M., Ye, Q.-H., Jia, H.-L., He, P., Zanetti, K. A., Kammula, U. S., Chen, Y., Qin, L., Tang, Z., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.016 · Cited by 838
CSF-1 receptor signaling in myeloid cells.
Stanley, E. R., & Chitu, V. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021857 · Cited by 825
Self-citation
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells
Helft, J., Böttcher, J. P., Chakravarty, P., Zelenay, S., Huotari, J., Schraml, B. U., Goubau, D., & Sousa, C. R. E. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.018 · Cited by 845
Osteoclast–osteoblast communication
Matsuo, K., & Irie, N. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.027 · Cited by 780
The origin and development of nonlymphoid tissue CD103+ DCs
Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J. G., Yin, N., Bromberg, J. S., Lira, S. A., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091756 · Cited by 736
Self-citation
Langerhans cells arise from monocytes in vivo
Ginhoux, F., Tacke, F., Angeli, V., Bogunovic, M., Loubeau, M., Dai, X.-M., Stanley, E. R., Randolph, G. J., & Mérad, M. (2006) · Nature Immunology · doi:10.1038/ni1307 · Cited by 736
Self-citation
Glioma cancer stem cells induce immunosuppressive macrophages/microglia
Wu, A., Wei, J., Kong, L.-Y., Wang, Y., Priebe, W., Qiao, W., Sawaya, R. A., & Heimberger, A. B. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq082 · Cited by 705
Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors
Kumar, V., Donthireddy, L., Marvel, D., Condamine, T., Wang, F., Lavilla-Alonso, S., Hashimoto, A., Vonteddu, P., Behera, R., Goins, M. A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.10.005 · Cited by 653
Colony-stimulating factor-1 in immunity and inflammation
Chitu, V., & Stanley, E. R. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.006 · Cited by 635
Self-citation
Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach
Zeisberger, S. M., Odermatt, B., Marty, C., Zehnder-Fjällman, A. H. M., Ballmer‐Hofer, K., & Schwendener, R. A. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603240 · Cited by 622
Obesity‐induced inflammation: a metabolic dialogue in the language of inflammation
Ferrante, A. W. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01852.x · Cited by 627
Granulocyte-Macrophage Colony-Stimulating Factor (CSF) and Macrophage CSF-Dependent Macrophage Phenotypes Display Differences in Cytokine Profiles and Transcription Factor Activities: Implications for CSF Blockade in Inflammation
Fleetwood, A. J., Lawrence, T., Hamilton, J. A., & Cook, A. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5245 · Cited by 607
GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation
Becher, B., Tugues, S., & Greter, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.026 · Cited by 628
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids
Rademakers, R., Baker, M., Nicholson, A. M., Rutherford, N. J., Finch, N., Soto-Ortolaza, A., Lash, J., Wider, C., Wojtas, A., DeJesus-Hernandez, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.1027 · Cited by 571
Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage
Ushach, I., & Zlotnik, A. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru0316-144r · Cited by 551
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
Olmos-Alonso, A., Schetters, S. T. T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V. H., & Gomez-Nicola, D. (2016) · Brain · doi:10.1093/brain/awv379 · Cited by 532
Beyond stem cells: self-renewal of differentiated macrophages
Sieweke, M. H., & Allen, J. E. (2013) · Science · doi:10.1126/science.1242974 · Cited by 503
The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities
Neophytou, C. M., Panagi, M., Stylianopoulos, T., & Papageorgis, P. (2021) · Cancers · doi:10.3390/cancers13092053 · Cited by 489
Resveratrol: French Paradox Revisited
Catalgol, B., Batirel, S., Taga, Y., & Ozer, N. K. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00141 · Cited by 449
Origin of microglia: current concepts and past controversies
Ginhoux, F., & Prinz, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020537 · Cited by 446
Roles of microglia in brain development, tissue maintenance and repair
Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 435
Ca 2+ ‐NFATc1 signaling is an essential axis of osteoclast differentiation
Negishi‐Koga, T., & Takayanagi, H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00821.x · Cited by 415
Hematopoietic Cytokines Can Instruct Lineage Choice
Rieger, M. A., Hoppe, P. S., Smejkal, B. M., Eitelhuber, A. C., & Schroeder, T. (2009) · Science · doi:10.1126/science.1171461 · Cited by 404
Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms
van der Knaap, M. S., & Bugiani, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1739-1 · Cited by 403
Apoptotic cell removal in development and tissue homeostasis
Henson, P. M., & Hume, D. A. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.03.005 · Cited by 388
Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Köchert, K., Bouhlel, M. A., Richter, J., Soler, E., et al. (2010) · Nature Medicine · doi:10.1038/nm.2129 · Cited by 376
M-CSF instructs myeloid lineage fate in single haematopoietic stem cells
Mossadegh‐Keller, N., Sarrazin, S., Kandalla, P. K., Espinosa, L., Stanley, E. R., Nutt, S. L., Moore, J. T., & Sieweke, M. H. (2013) · Nature · doi:10.1038/nature12026 · Cited by 392
Self-citation
Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells
Wei, S., Nandi, S., Chitu, V., Yeung, Y.-G., Yu, W., Huang, M., Williams, L. T., Lin, H., & Stanley, E. R. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1209822 · Cited by 370
Self-citation
Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility
Solinas, G., Schiarea, S., Liguori, M., Fabbri, M., Pesce, S., Zammataro, L. A., Pasqualini, F., Nebuloni, M., Chiabrando, C., Mantovani, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000413 · Cited by 373
Dendritic Cell and Macrophage Heterogeneity In Vivo
Hashimoto, D., Miller, J. C., & Mérad, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.007 · Cited by 378
The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
Nandi, S., Gökhan, Ş., Dai, X.-M., Wei, S., Enikolopov, G., Lin, H., Mehler, M. F., & Stanley, E. R. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.026 · Cited by 356
Self-citation
Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
Martini, R., Fischer, S., López‐Vales, R., & David, S. (2008) · Glia · doi:10.1002/glia.20766 · Cited by 319
MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages
Aziz, A., Soucie, E., Sarrazin, S., & Sieweke, M. H. (2009) · Science · doi:10.1126/science.1176056 · Cited by 317
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin
Otero, K., Turnbull, I. R., Poliani, P. L., Vermi, W., Cerutti, E., Aoshi, T., Tassi, I., Takai, T., Stanley, S. L., Miller, M., et al. (2009) · Nature Immunology · doi:10.1038/ni.1744 · Cited by 315
αvβ3and macrophage colony‐stimulating factor: partners in osteoclast biology
Ross, F. P., & Teitelbaum, S. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00331.x · Cited by 312
Diverse macrophages polarization in tumor microenvironment
Rhee, I. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0820-y · Cited by 295
Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment
Ma, C., Yang, C., Peng, A. F., Sun, T., Ji, X., Mi, J., Li, W., Shen, S., & Feng, Q. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01876-x · Cited by 295
Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study
Summan, M., Warren, G. L., Mercer, R. R., Chapman, R., Hulderman, T., Van Rooijen, N., & Simeonova, P. P. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00465.2005 · Cited by 285
Tissue macrophage identity and self‐renewal
Gentek, R., Molawi, K., & Sieweke, M. H. (2014) · Immunological Reviews · doi:10.1111/imr.12224 · Cited by 288
Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils
Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., & Maxfield, F. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-10-0975 · Cited by 271
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
Luo, J., Elwood, F., Britschgi, M., Villeda, S., Zhang, H., Ding, Z., Zhu, L., Alabsi, H., Getachew, R., Narasimhan, R., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20120412 · Cited by 262
Bcl-6 and NF-κB cistromes mediate opposing regulation of the innate immune responsePreprint
Barish, G. D., Yu, R. T., Karunasiri, M. S., Ocampo, C. B., Dixon, J. R., Benner, C. W., Dent, A. L., Tangirala, R. K., & Evans, R. M. (2010) · Genes & Development · doi:10.1101/gad.1998010 · Cited by 258
Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580
Conway, J. G., McDonald, B., Parham, J. H., Keith, B. R., Rusnak, D. W., Shaw, E., Jansen, M., Lin, P., Payne, A. J., Crosby, R. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502000102 · Cited by 249
The M-CSF receptor in osteoclasts and beyond
Mun, S. H., Park, P. S. U., & Park‐Min, K. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0484-z · Cited by 257
Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton
Rougerie, P., Miskolci, V., & Cox, D. (2013) · Immunological Reviews · doi:10.1111/imr.12118 · Cited by 237
Colony-Stimulating Factor-1 Antibody Reverses Chemoresistance in Human MCF-7 Breast Cancer Xenografts
Paulus, P., Stanley, E. R., Schäfer, R., Abraham, D., & Aharinejad, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3523 · Cited by 231
Self-citation
Hypoxia Potentiates Glioma-Mediated Immunosuppression
Wei, J., Wu, A., Kong, L. Y., Wang, Y., Fuller, G. N., Fokt, I., Melillo, G., Priebe, W., & Heimberger, A. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016195 · Cited by 220
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
Paniagua, R. T., Sharpe, O., Ho, P. P.-K., Chan, S. M., Chang, A., Higgins, J. P., Tomooka, B. H., Thomas, F. M., Song, J. J., Goodman, S. B., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28546 · Cited by 214
CSF‐1 Controls Cerebellar Microglia and Is Required for Motor Function and Social Interaction
Kana, V., Desland, F. A., Casanova-Acebes, M., Ayata, P., Badimon, A., Nabel, E., Yamamuro, K., Sneeboer, M., Tan, I.-L., Flanigan, M. E., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182037 · Cited by 220
Self-citation
Plasticity in Tumor-Promoting Inflammation: Impairment of Macrophage Recruitment Evokes a Compensatory Neutrophil Response
Pahler, J. C., Tazzyman, S. J., Erez, N., Chen, Y., Murdoch, C., Nozawa, H., Lewis, C. E., & Hanahan, D. (2008) · Neoplasia · doi:10.1593/neo.07871 · Cited by 211
Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity
Elliott, L., Doherty, G. A., Sheahan, K. D., & Ryan, E. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00086 · Cited by 219
Immunosurveillance of senescent cells: the bright side of the senescence program
Sagiv, A., & Krizhanovsky, V. (2013) · Biogerontology · doi:10.1007/s10522-013-9473-0 · Cited by 208
CSF1R -related leukoencephalopathy: A major player in primary microgliopathies
Konno, T., Kasanuki, K., Ikeuchi, T., Dickson, D. W., & Wszolek, Z. K. (2018) · Neurology · doi:10.1212/wnl.0000000000006642 · Cited by 208
Interleukin‐34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment
Ségaliny, A. I., Mohamadi, A., Dizier, B., Lokajczyk, A., Brion, R., Lanel, R., Amiaud, J., Charrier, C., Boisson‐Vidal, C., & Heymann, D. (2015) · International Journal of Cancer · doi:10.1002/ijc.29376 · Cited by 199
Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments
Wong, A. P., Perez‐Castillejos, R., Love, J. C., & Whitesides, G. M. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.044 · Cited by 194
MEK inhibitor resistance mechanisms and recent developments in combination trials
Kun, E., Tsang, Y. T. M., Ng, C. W., Gershenson, D. M., & Wong, K. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102137 · Cited by 198
Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
Baghdadi, M., Wada, H., Nakanishi, S., Abe, H., Han, N., Putra, W. E., Endo, D., Watari, H., Sakuragi, N., Hida, Y., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1170 · Cited by 188
Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1
Tagliani, E., Shi, C., Nancy, P., Tay, C.-S., Pamer, E. G., & Erlebacher, A. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110866 · Cited by 185
Macrophage-lineage TRAP+ cells recruit periosteum-derived cells for periosteal osteogenesis and regeneration
Gao, B., Deng, R., Chai, Y., Chen, H. H., Hu, B., Wang, X., Zhu, S., Cao, Y. B., Ni, S., Wan, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci98857 · Cited by 184
Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles
Cianciaruso, C., Beltraminelli, T., Duval, F., Nassiri, S., Hamelin, R., Mozes, A., Gallart‐Ayala, H., Ceada, G., Torchia, B., Ries, C. H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.008 · Cited by 181
Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation
Lee, K., Chung, Y. H., Ahn, H., Kim, H., Rho, J., & Jeong, D. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.13814 · Cited by 178
Green tea and bone metabolism
Shen, C., Yeh, J. K., Cao, J., & Wang, J.-S. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.06.008 · Cited by 181
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase
Owen, K. A., Pixley, F. J., Thomas, K. S., Vicente‐Manzanares, M., Ray, B. J., Horwitz, A. F., Parsons, J. T., Beggs, H. E., Stanley, E. R., & Bouton, A. H. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708093 · Cited by 178
Self-citation
MafB Restricts M-CSF-Dependent Myeloid Commitment Divisions of Hematopoietic Stem Cells
Sarrazin, S., Mossadegh‐Keller, N., Fukao, T., Aziz, A., Mourcin, F., Vanhille, L., Modis, L. K., Kastner, P., Chan, S. H., Duprez, E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.057 · Cited by 190
Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R
Ma, X., Lin, W., Chen, Y., Stawicki, S. S., Mukhyala, K., Wu, Y. R., Martin, F., Bazán, J. F., & Starovasnik, M. A. (2012) · Structure · doi:10.1016/j.str.2012.02.010 · Cited by 174
Invadopodia and podosomes in tumor invasion
Yamaguchi, H., Pixley, F. J., & Condeelis, J. S. (2005) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.10.004 · Cited by 175
Self-citation
Evolution of danio pigment pattern development
Parichy, D. M. (2006) · Heredity · doi:10.1038/sj.hdy.6800867 · Cited by 179
Receptor-type Protein-tyrosine Phosphatase ζ Is a Functional Receptor for Interleukin-34
Nandi, S., Cioce, M., Yeung, Y.-G., Nieves, E., Tesfa, L., Lin, H., Hsu, A. W., Halenbeck, R., Cheng, H.-Y., Gökhan, Ş., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442731 · Cited by 170
Self-citation
M‐CSF, c‐Fms, and Signaling in Osteoclasts and their Precursors
Ross, F. P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.014 · Cited by 179
Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis
Gruen, M. L., Hao, M., Piston, D. W., & Hasty, A. H. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00062.2007 · Cited by 183
CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice
Weinmann‐Menke, J., Iwata, Y., Rabacal, W., Basu, R., Yeung, Y.-G., Humphreys, B. D., Wada, T., Schwarting, A., Stanley, E. R., & Kelley, V. R. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39087 · Cited by 172
Self-citation
Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor
Chiţu, V., & Stanley, E. R. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.10.004 · Cited by 163
Self-citation
Efficient differentiation and function of human macrophages in humanized CSF-1 mice
Rathinam, C., Poueymirou, W. T., Rojas, J., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Rongvaux, A., Eynon, E. E., Manz, M. G., & Flavell, R. A. (2011) · Blood · doi:10.1182/blood-2010-12-326926 · Cited by 160
CSF1R mutations link POLD and HDLS as a single disease entity
Nicholson, A. M., Baker, M. C., Finch, N. A., Rutherford, N. J., Wider, C. W., Graff‐Radford, N. R., Nelson, P. T., Clark, H. B., Wszołek, Z. K., Dickson, D. W., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31828726a7 · Cited by 162
The enteric nervous system in gastrointestinal disease etiology
Holland, A. M., Bon‐Frauches, A. C., Keszthelyi, D., Melotte, V., & Boesmans, W. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03812-y · Cited by 172
Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation
Grubišić, V., McClain, J. L., Fried, D. E., Grants, I. S., Rajasekhar, P., Csizmadia, E., Ajijola, O. A., Watson, R. E., Poole, D. P., Robson, S. C., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108100 · Cited by 167
Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors
Wesolowski, R., Sharma, N., Reebel, L., Rodal, M. B., Alexandra, P., West, B. L., Marimuthu, A., Severson, P. L., Karlin, D. A., Dowlati, A., et al. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919854238 · Cited by 158
The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis
Muñoz-García, J., Cochonneau, D., Télétchéa, S., Moranton, E., Lanoé, D., Brion, R., Lézot, F., Heymann, M., & Heymann, D. (2020) · Theranostics · doi:10.7150/thno.50683 · Cited by 161
Macrophages and CSF-1
Jones, C. V., & Ricardo, S. D. (2013) · Organogenesis · doi:10.4161/org.25676 · Cited by 152
Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
Caescu, C. I., Guo, X., Tesfa, L., Bhagat, T. D., Verma, A. K., Zheng, D., & Stanley, E. R. (2015) · Blood · doi:10.1182/blood-2014-10-608000 · Cited by 157
Self-citation
Dendritic Cell-Specific ICAM-3–Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10
Domínguez‐Soto, Á., Sierra‐Filardi, E., Puig‐Kröger, A., Pérez-Maceda, B. T., Gómez, F., Corcuera, M. T., Sánchez‐Mateos, P., & Corbí, A. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000475 · Cited by 152
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity
Junttila, I., Mizukami, K., Dickensheets, H. L., Meier‐Schellersheim, M., Yamane, H., Donnelly, R. P., & Paul, W. E. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080452 · Cited by 148
Signaling pathways in macrophages: molecular mechanisms and therapeutic targets
Li, M., Wang, M., Wen, Y., Zhang, H., Zhao, G., & Gao, Q. (2023) · MedComm · doi:10.1002/mco2.349 · Cited by 165
Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease
Grosse, J., Chiţu, V., Marquardt, A., Hanke, P., Schmittwolf, C., Zeitlmann, L., Schropp, P., Barth, B., Yu, P., Paffenholz, R., et al. (2006) · Blood · doi:10.1182/blood-2005-09-3556 · Cited by 146
Self-citation
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Zhang, M., Liu, Z. Z., Aoshima, K., Cai, W. L., Sun, H., Xu, T., Zhang, Y., An, Y., Chen, J. F.-Y., Chan, L.-H., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abf5473 · Cited by 142
Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases
Takegahara, N., Kim, H., & Choi, Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01157-7 · Cited by 161
Macrophages and Renal Fibrosis
Vernon, M. A., Mylonas, K. J., & Hughes, J. (2010) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.03.004 · Cited by 142
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
Iavarone, A., King, E. R., Dai, X.-M., Leone, G. W., Stanley, E. R., & Lasorella, A. (2004) · Nature · doi:10.1038/nature03068 · Cited by 140
Self-citation
IL‐23 promotes osteoclast formation by up‐regulation of receptor activator of NF‐κB (RANK) expression in myeloid precursor cells
Chen, L., Wei, X., Evans, B. A. J., Jiang, W. G., & Aeschlimann, D. P. (2008) · European Journal of Immunology · doi:10.1002/eji.200838192 · Cited by 135
Osteoclast migration, differentiation and function: novel therapeutic targets for rheumatic diseases
Kikuta, J., & Ishii, M. (2012) · Rheumatology · doi:10.1093/rheumatology/kes259 · Cited by 139
Next frontier in tumor immunotherapy: macrophage-mediated immune evasion
Qiu, Y., Chen, T., Hu, R., Zhu, R., Li, C., Ruan, Y., Xie, X., & Li, Y. (2021) · Biomarker Research · doi:10.1186/s40364-021-00327-3 · Cited by 138
Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation
Guo, L., Bertola, D. R., Takanohashi, A., Saito, A., Segawa, Y., Yokota, T., Ishibashi, S., Nishida, Y., Yamamoto, G. L., Franco, J. F. D. S., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.03.004 · Cited by 133
Small molecule tools for functional interrogation of protein tyrosine phosphatases
He, R., Zeng, L., He, Y., Zhang, S., & Zhang, Z. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08718.x · Cited by 133

Authors: Pixley, F. J., & Stanley, E. R.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Stanley, E. Richard
ORCID: Pixley, Fiona J.
Stanley, E. Richard
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2004-11
Volume: 14
Issue: 11
Pages: 628-638
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2004.09.016
OpenAlex: W2032410318
Cited by: 807
References: 98
Citations by year: 2026: 19 · 2025: 34 · 2024: 50 · 2023: 32 · 2022: 45 · 2021: 41 · 2020: 36 · 2019: 34 · 2018: 30 · 2017: 39 · 2016: 33 · 2015: 34 · 2014: 44 · 2013: 40 · 2012: 45
FWCI: 2.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Funders: National Institutes of Health (KO8 CA097348, PO1 CA100324, RO1 CA 25604, RO1 CA32551)
Albert Einstein Cancer Center (P30 CA13330)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: colony-stimulating factor 1, CSF-1 receptor, tissue macrophages, osteoclasts, macrophage chemotaxis, macrophage activation, signaling pathways, innate immunity, pathogenesis
MeSH terms: Animals, Humans, Macrophage Activation, Macrophages, Phosphorylation, Signal Transduction, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

CSF-1 regulation of the wandering macrophage: complexity in action

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks