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Blinded by the Light: The Growing Complexity of p53

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Cell-cycle checkpoints and cancer

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PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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An Oncogene-Induced DNA Damage Model for Cancer Development

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p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

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PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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When mutants gain new powers: News from the mutant p53 field

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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p53-Dependent apoptosis suppresses tumor growth and progression in vivo

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

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Bax suppresses tumorigenesis and stimulates apoptosis in vivo

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The mitochondrial p53 pathway

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Modulation of mammalian life span by the short isoform of p53

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PML is induced by oncogenic <i>ras</i> and promotes premature senescence

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Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

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Role of PML in Cell Growth and the Retinoic Acid Pathway

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Genomic instability in Gadd45a-deficient mice

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Dissecting p53 tumor suppressor functions in vivo

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A new mouse model to explore the initiation, progression, and therapy of BRAF V600E -induced lung tumorsPreprint

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p53 Transcriptional Activation Mediated by Coactivators TAF II 40 and TAF II 60

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PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 familyPreprint

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

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CD95 promotes tumour growth

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p53 at a glance

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bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

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Integral role of Noxa in p53-mediated apoptotic responsePreprint

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Bax Involvement in p53-Mediated Neuronal Cell Death

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Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

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PML Is a Direct p53 Target that Modulates p53 Effector Functions

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Perp Is a p63-Regulated Gene Essential for Epithelial Integrity

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Noxa: at the tip of the balance between life and death

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Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53.

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PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

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Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis.

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PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome

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Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

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In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

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Structure of the Tfb1/p53 Complex: Insights into the Interaction between the p62/Tfb1 Subunit of TFIIH and the Activation Domain of p53

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Enhanced and accelerated lymphoproliferation in Fas-null mice.

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CKIα ablation highlights a critical role for p53 in invasiveness control

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The Isoforms of the p53 Protein

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Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis

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Suppression of tumorigenesis by the p53 target PUMA

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TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

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Role of p53 Serine 46 in p53 Target Gene Regulation

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Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis

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Loss of Oncogenic H-ras-Induced Cell Cycle Arrest and p38 Mitogen-Activated Protein Kinase Activation by Disruption of <i>Gadd45a</i>

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Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression

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p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells

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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

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Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

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Uncoupling between Phenotypic Senescence and Cell Cycle Arrest in Aging p21-Deficient Fibroblasts

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Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

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Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis

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The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

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Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40‐TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

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Gadd45a Suppresses Ras-Driven Mammary Tumorigenesis by Activation of c-Jun NH2-Terminal Kinase and p38 Stress Signaling Resulting in Apoptosis and Senescence

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Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types

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Policing of oncogene activity by p53

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DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis

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p21 delays tumor onset by preservation of chromosomal stability

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Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

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Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

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Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

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Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

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Probing p53 biological functions through the use of genetically engineered mouse models

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Bax accelerates tumorigenesis in p53-deficient mice.

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Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis

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Specific Requirement for Bax, Not Bak, in Myc-induced Apoptosis and Tumor Suppression in Vivo

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BH3-Only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death

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Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

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The Role of Ninjurin1 and Its Impact beyond the Nervous System

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Proteomic Analyses Uncover a New Function and Mode of Action for Mouse Homolog of Diaphanous 2 (mDia2)*

Isogai, T., van der Kammen, R., Goerdayal, S. S., Heck, A. J. R., Altelaar, M. A. F., & Innocenti, M. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.043885 · Cited by 26 · see citing works

Ephedrine and cocaine cause developmental neurotoxicity and abnormal behavior in zebrafish

Ma, D.-D., Shi, W., Li, S., Zhang, J., Lu, Z., Long, X.-B., Liu, X., Huang, C.-S., & Ying, G. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106765 · Cited by 25 · see citing works

Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters

Mungamuri, S. K., Wang, S., Manfredi, J. J., Gu, W., & Aaronson, S. A. (2014) · Oncogene · doi:10.1038/onc.2014.198 · Cited by 24 · see citing works

PAX 3 in neuroblastoma: oncogenic potential, chemosensitivity and signalling pathways

Fang, W., Wang, Q., Li, H., Ahmed, M., Kumar, P., & Kumar, S. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12155 · Cited by 24 · see citing works

PLCE1 Suppresses p53 Expression in Esophageal Cancer Cells

Li, Y., An, J., Huang, S., Liao, H.-Y., Weng, Y., Cai, S., & Zhang, J. (2014) · Cancer Investigation · doi:10.3109/07357907.2014.905588 · Cited by 24 · see citing works

Anticancer Therapeutic Strategies Targeting p53 Aggregation

Ferretti, G. D. S., Quarti, J., dos Santos, G., Rangel, L. P., & Silva, J. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911023 · Cited by 22 · see citing works

Lymphocytes of Patients with Alzheimer’s Disease Display Different DNA Damage Repair Kinetics and Expression Profiles of DNA Repair and Stress Response Genes

Leandro, G. D. S., Lôbo, R. R., Oliveira, D. V. N. P., Moriguti, J. C., & Sakamoto‐Hojo, E. T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612380 · Cited by 23 · see citing works

p53 mRNA Metabolism Links with the DNA Damage Response

Gnanasundram, S. V., Bonczek, O., Wang, L., Chen, S., & Fåhræus, R. (2021) · Genes · doi:10.3390/genes12091446 · Cited by 23 · see citing works

Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis

Halaby, M., Hakem, A., Li, L., Ghamrasni, S. E., Venkatesan, S., Hande, M. P., Sanchez, O. H., & Hakem, R. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003259 · Cited by 21 · see citing works

MDM2 and mitochondrial function: One complex intersection

Rubio‐Patiño, C., Trotta, A. P., & Chipuk, J. E. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.10.032 · Cited by 20 · see citing works

Phosphorylation Regulates the Bound Structure of an Intrinsically Disordered Protein: The p53-TAZ2 Case

Ithuralde, R. E., & Turjanski, A. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144284 · Cited by 19 · see citing works

Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy

Klimovich, B., Mutlu, S., Schneikert, J., Elmshäuser, S., Klimovich, M., Nist, A., Mernberger, M., Timofeev, O. N., & Stiewe, T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910255116 · Cited by 17 · see citing works

Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease

Chen, H.-Y., Lin, C., & Teng, S. (2020) · Aging · doi:10.18632/aging.103998 · Cited by 19 · see citing works

Coordination between p21 and DDB2 in the Cellular Response to UV Radiation

Li, H., Zhang, X., & Liu, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080111 · Cited by 19 · see citing works

Bioinformatics and Gene Network Analyses of the Swine Mammary Gland Transcriptome during Late Gestation

WangSheng, Z., Shahzad, K., Jiang, M., Graugnard, D. E., Rodriguez‐Zas, S. L., Luo, J., Loor, J. J., & Hurley, W. L. (2013) · Bioinformatics and Biology Insights · doi:10.4137/bbi.s12205 · Cited by 19 · see citing works

Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways

Torres, T. E. P., Russo, L. C., dos Santos, A., Marques, G. R., Magalhães, Y. T., Tabassum, S., & Forti, F. L. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.04.004 · Cited by 19 · see citing works

Molecular dynamics-based computational investigations on the influence of tumor suppressor p53 binding protein against other proteins/peptides

Abdalla, M., Abdelkhalig, S. M., Edet, U. O., Zothantluanga, J. H., Umoh, E. A., Moglad, E. H. O., Nkang, N. A., Hader, M. M., Alanazi, T. M. R., Al‐Shouli, S. T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-81499-4 · Cited by 17 · see citing works

Genome-wide association and sequencing studies on colorectal cancer

Wong, S. H., Sung, J. J. �., Chan, F. K. L., To, K. F., Ng, S. S. M., Wang, X., Yu, J. Q., & Wu, W. K. K. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.09.005 · Cited by 17 · see citing works

Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy

Nguyen, D., YANG, K. Y., Chiao, L. J., Deng, Y., Zhou, X. Y., Zhang, Z., Zeng, S. X., & Lu, H. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa017 · Cited by 17 · see citing works

A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines

Visagie, M. H., Birkholtz, L., & Joubert, A. M. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0010-5 · Cited by 16 · see citing works

A case of concha pyocele (concha bullosa mucocele) mimicking intranasal mass.

Yuca, K., Kiris, M., Kıroğlu, A. F., Bayram, İ., & Çankaya, H. (2008) · PubMed · Cited by 16 · see citing works

Abstract PR07: Deconstructing p53 transcriptional networks in pancreatic cancer suppression

Attardi, L. D., Mello, S. S., Valente, L. J., Mazur, P. K., Raj, N., Bieging-Rolett, K. T., & Vogel, H. S. (2016) · Cancer Research · doi:10.1158/1538-7445.panca16-pr07

Abstract IA07: Deconstructing p53 pathways in tumor suppression

Mello, S. S., Bieging-Rolett, K. T., Kaiser, A. M., Valente, L. J., Raj, N., McClendon, J., Flowers, B. M., Morgens, D. W., Bassik, M. C., & Attardi, L. D. (2018) · Cancer Research · doi:10.1158/1538-7445.mousemodels17-ia07

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

Jiang, D., Brady, C. A., Johnson, T. M., Lee, E. Y., Park, E. J., Scott, M. P., & Attardi, L. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111245108 · Cited by 86 · see citing works

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

Brady, C. A., Jiang, D., Mello, S. S., Johnson, T. M., Jarvis, L. A., Kozak, M. M., Broz, D. K., Basak, S., Park, E. J., McLaughlin, M. E., et al. (2011) · Cell · doi:10.1016/j.cell.2011.03.035 · Cited by 533 · see citing works

Deconstructing networks of p53-mediated tumor suppression in vivo

Kaiser, A. M., & Attardi, L. D. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.171 · Cited by 227 · see citing works