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Cited by 221Mitochondrial Function and PathologyAutophagy in Disease and TherapyNerve injury and regeneration

The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring

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Sheng, Zu-Hang·2017·Trends in Cell Biology
DOI 10.1016/j.tcb.2017.01.005PMC PMC5440189
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Abstract

Mitochondria are key cellular power plants essential for neuronal growth, survival, function, and regeneration after injury. Given their unique morphological features, neurons face exceptional challenges in maintaining energy homeostasis at distal synapses and growth cones where energy is in high demand. Efficient regulation of mitochondrial trafficking and anchoring is critical for neurons to meet altered energy requirements. Mitochondrial dysfunction and impaired transport have been implicated in several major neurological disorders. Thus, research into energy-mediated regulation of mitochondrial recruitment and redistribution is an important emerging frontier. In this review, I discuss new insights into the mechanisms regulating mitochondrial trafficking and anchoring, and provide an updated overview of how mitochondrial motility maintains energy homeostasis in axons, thus contributing to neuronal growth, regeneration, and synaptic function.

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  • Proper balance between motile and stationary mitochondria is crucial for maintaining high ATP levels required for proper axonal growth and branching.

    “Several studies over the last years suggest that a proper balance between motile and stationary mitochondria is crucial for maintaining the high ATP levels required for proper axonal growth and branching105,106.”

    From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [105]

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Authors
Sheng, Z.-H.
Affiliations
National Institutes of Health (US)
Corresponding author
Sheng, Zu-Hang
ORCID
Sheng, Zu-Hang
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2017-06
Volume
27
Issue
6
Pages
403-416
ISSN
0962-8924 (ISSN-L)
DOI
10.1016/j.tcb.2017.01.005
PMC
PMC5440189
OpenAlex
W2589816720
Cited by
221
References
5
Citations by year
2026: 18 · 2025: 18 · 2024: 22 · 2023: 26 · 2022: 37 · 2021: 28 · 2020: 29 · 2019: 20 · 2018: 13 · 2017: 10
FWCI
1.84
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (Z01NS003029, Z01NS002946, ZIANS003029, ZIANS002946)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
mitochondrial trafficking, mitochondrial motility, axons, neurons, neuronal growth, axon regeneration, synaptic function, mitochondrial dysfunction, neurological disorders
MeSH terms
Animals, Axons, Energy Metabolism, Homeostasis, Humans, Mitochondria, Synapses, Protein Transport

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