The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
Abstract
In humans, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), 17beta-HSD and 5alpha-reductase activities in androgen target tissues, such as the prostate and skin, convert dehydroepiandrosterone, androstenedione and testosterone into the most potent natural androgen dihydrotestosterone (DHT). This androgen is converted mainly in situ into two phase I metabolites, androsterone (ADT) and androstane-3alpha,17beta-diol (3alpha-DIOL), which might be back converted to DHT. Here, we discuss the recent findings regarding the characterization of specific UDP-glucuronosyltransferases (UGTs), UGT2B7, B15 and B17, responsible for the glucuronidation of these metabolites. The tissue distribution and cellular localization of the UGT2B transcripts and proteins in humans clearly indicate that these enzymes are synthesized in androgen-sensitive tissues. It is postulated that the conjugating activity of UGT enzymes is the main mechanism for modulating the action of steroids and protecting the androgen-sensitive tissues from deleteriously high concentrations of DHT, ADT and 3alpha-DIOL.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The glucuronidation of C19 steroids is catalyzed by three members of the UGT2B subfamily, namely: UGT2B7, UGT2B15 and UGT2B17 [175].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [175]
In the citing paper
“As opposed to sulfation, glucuronidation is irreversible and ultimately inactivates the androgen and initiates its renal excretion by increasing polarity and water solubility of the molecule (Belanger et al., 2003).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Belanger et al., 2003
Citations
Cites
Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Bélanger, A., Fournel‐Gigleux, S., Green, M. D., Hum, D. W., Iyanagi, T., et al. (1997) · Pharmacogenetics · doi:10.1097/00008571-199708000-00001 · Cited by 1,185
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685
Self-citationLabrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
Role of Hormones in Pilosebaceous Unit Development
Deplewski, D., & Rosenfield, R. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.4.0404 · Cited by 443
Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437
Zhou, Z. X., Lane, M. V., Kemppainen, J., French, F. S., & Wilson, E. M. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.2.7776971 · Cited by 411
Labrie, F., Bélanger, A., Cusan, L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4161 · Cited by 350
Self-citationTurgeon, D., Carrier, J.-S., Lévesque, E., Hum, D. W., & Bélanger, A. (2001) · Endocrinology · doi:10.1210/endo.142.2.7958 · Cited by 333
Cutaneous androgen metabolism: basic research and clinical perspectives
Chen, W., Thiboutot, D., & Zouboulis, C. C. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.00613.x · Cited by 273
Azziz, R., Carmina, E., & Sawaya, M. E. (2000) · Endocrine Reviews · doi:10.1210/er.21.4.347 · Cited by 249
Flagged first, then by citations
1 of the 74 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Turgeon, 2001, Relative enzymatic activity, protein stability and tissue distribution of human steroid metabolizing UGT2B subfamily members, Endocrinology, 142, 778, 10.1210/en.142.2.778 · DOI · Paper page
Cited by
Sorted by citations
Items 201–235 of 235
Portman, D. J., Archer, D. F., Martel, C., & Labrie, F. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000638 · Cited by 3
Zheng, X., Chen, Z., Liang, M., Zhou, L., Wang, M., Zhang, S., Zhang, S., Ma, L., Yi, W., & Liu, X. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01598-2 · Cited by 2
Yin, H., Lv, X., Wang, Z., Xiao, S., Liang, J., Sun, J., Jiang, L., & Liu, Y. (2024) · Toxicology in Vitro · doi:10.1016/j.tiv.2024.105863 · Cited by 2
Zachár, G., Deshmukh, N., Petróczi, A., Székely, A. D., Shah, I., Barker, J., & Naughton, D. P. (2017) · Molecules · doi:10.3390/molecules22060976 · Cited by 2
GENETICS OF ANDROGEN DISPOSITION
Schulze, J. J. (2007) · Figshare · Cited by 2
Mullen, J. (2018) · Figshare · Cited by 2
Kawai, Y. K., Sano, K., Ikenaka, Y., Nakayama, S. M. M., Kondo, M., Kubota, A., & Ishizuka, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.20.457063 · Cited by 2
Lokale Aktivierung und Inaktivierung der Steroidhormone, insbesondere der Sexualhormone
Adamski, J. (2006) · Springer eBooks · doi:10.1007/3-540-28782-5_23 · Cited by 1
Lee, S.-R., Ahn, M.-H., Choi, Y. H., & Leem, S. (2015) · Genes & Genomics · doi:10.1007/s13258-015-0379-x · Cited by 1
Expression of aldo-keto reductase family 1, member C14 during ovulation in the rat
Dam, P. T. M., Jang, Y.-J., Kim, J.-Y., Choi, S.-G., Park, J.-I., Seo, Y.-W., & Chun, S. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej17-0038 · Cited by 1
Zakharian, E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00024-9 · Cited by 1
Breakdown and clearance of steroids
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00001-2 · Cited by 1
Complexities of Working with UDP‐ Glucuronosyltransferases (UGTs): Focus on Enzyme Inhibition
Fisher, M. B. (2009) · doi:10.1002/9780470538951.ch12 · Cited by 1
Löbker, W. A. (2014) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-4305 · Cited by 1
The interrelationship of sex steroid levels, body composition and bone characteristics in men
Lapauw, B. (2009) · Ghent University Academic Bibliography (Ghent University)
Bichlmaier, I. (2008) · Työväentutkimus Vuosikirja
Sex steroid metabolism and body composition
Swanson, C. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
COMT Genotype, sex steroids, and bone phenotype in mice and men
Eriksson, A. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Exploration on atypical kinetics of UGT1A1 and UGT1A4
Zhou, J. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
The role of the prostate in androgen metabolism
Olsson, M. J. (2009) · Figshare
Schooling, C. M. (2015) · The Lancet HIV · doi:10.1016/s2352-3018(15)00152-6
An investigation into the catalytic activity of porcine cytochrome P450 17α-hydroxylase/17,20-lyase
Fox, C.-L. (2014) · SUNScholar (Stellenbosch University)
GENETICS OF ANDROGEN DISPOSITION
Schulze, J. J. (2007)
Deshmukh, N., Zachár, G., Petróczi, A., Székely, A. D., Barker, J., & Naughton, D. P. (2012)
Järvinen, E. (2016) · Työväentutkimus Vuosikirja
The metabolism of androstenone and other steroid hormone conjugates in relation to boar taint
Laderoute, H. (2015) · The Atrium (University of Guelph)
The role of sex steroid hormones in Crohn\'s disease
Silva, M. D. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2023.tde-30062023-093802
Dart, D. A. (2024) · Academia oncology. · doi:10.20935/acadonco7321
Microbiome matters: the hidden influence of gut flora on male reproductive health
Navas, F., Hynniewta, B. C., & Marbaniang, K. (2025) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20252374
Drug metabolism in cancer patients
Huang, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29289-7.00024-2
Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications
Braccagni, G., Branca, C., & Bortolato, M. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101272
Endocrine and diagnostic aspects of cognitive impairment
Johansson, P. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Metadata
- Authors
- Bélanger, A., Pelletier, G., Labrie, F., Barbier, O., & Chouinard, S.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Bélanger, Alain
- ORCID
- Barbier, Olivier
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 14
- Issue
- 10
- Pages
- 473-479
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W1988871942
- Cited by
- 235
- References
- 74
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 17 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 18 · 2012: 8
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- androgen metabolism, UDP-glucuronosyltransferase, UGT2B7, UGT2B15, UGT2B17, dihydrotestosterone, androstanediol, androstanediol glucuronide, glucuronidation, 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase, 5α-reductase, prostate, skin
- MeSH terms
- Androgens, Humans, Isoenzymes, Male, Prostate, Prostatic Neoplasms, Skin, Glucuronosyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review