Cited by 405Bone Metabolism and DiseasesBone health and osteoporosis researchAlkaline Phosphatase Research Studies

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What old means to bone

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Manolagas, Stavros C., Parfitt, A. Michael·2010·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2010.01.010PMC PMC2880220

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Abstract

The adverse effects of aging of other organs (ovaries at menopause) on the skeleton are well known, but ironically little is known of skeletal aging itself. Evidence indicates that age-related changes, such as oxidative stress, are fundamental mechanisms of the decline of bone mass and strength. Unlike the short-lived osteoclasts and osteoblasts, osteocytes--former osteoblasts entombed in the mineralized matrix--live as long as 50 years, and their death is dependent on skeletal age. Osteocyte death is a major contributor to the decline of bone strength with age, and the likely mechanisms are oxidative stress, autophagy failure and nuclear pore "leakiness". Unraveling these mechanisms should improve understanding of the age-related increase in fractures and suggest novel targets for its prevention.

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Authors: Manolagas, S. C., & Parfitt, A. M.
Affiliations: Central Arkansas Veterans Healthcare System (US)
Corresponding author: Manolagas, Stavros C.
ORCID: Manolagas, Stavros C.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2010-06
Volume: 21
Issue: 6
Pages: 369-374
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2010.01.010
PMC: PMC2880220
OpenAlex: W2088789328
Cited by: 404
References: 74
Citations by year: 2026: 11 · 2025: 17 · 2024: 20 · 2023: 30 · 2022: 25 · 2021: 30 · 2020: 30 · 2019: 39 · 2018: 32 · 2017: 30 · 2016: 24 · 2015: 25 · 2014: 25 · 2013: 23 · 2012: 17
FWCI: 1.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
University of Arkansas for Medical Sciences
National Institutes of Health (P01 AG13918)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
Keywords: skeletal aging, osteocyte death, oxidative stress, bone loss, bone strength, osteoblasts, osteoclasts, menopause
MeSH terms: Aging, Animals, Bone and Bones, Bone Diseases, Humans, Menopause, Osteocytes, Cell Death

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