Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract
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BACKGROUND: It was recently reported that dairy cows fed a polyphenol-rich grape seed and grape marc meal extract (GSGME) during the transition period had an increased milk yield, but the underlying reasons remained unclear. As polyphenols exert a broad spectrum of metabolic effects, we hypothesized that feeding of GSGME influences metabolic pathways in the liver which could account for the positive effects of GSGME in dairy cows. In order to identify these pathways, we performed genome-wide transcript profiling in the liver and lipid profiling in plasma of dairy cows fed GSGME during the transition period at 1 week postpartum. RESULTS: Transcriptomic analysis of the liver revealed 207 differentially expressed transcripts, from which 156 were up- and 51 were down-regulated, between cows fed GSGME and control cows. Gene set enrichment analysis of the 155 up-regulated mRNAs showed that the most enriched gene ontology (GO) biological process terms were dealing with cell cycle regulation and the most enriched Kyoto Encyclopedia of Genes and Genomes pathways were p53 signaling and cell cycle. Functional analysis of the 43 down-regulated mRNAs revealed that a great part of these genes are involved in endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) and inflammatory processes. Accordingly, protein folding, response to unfolded protein, unfolded protein binding, chemokine activity and heat shock protein binding were identified as one of the most enriched GO biological process and molecular function terms assigned to the down-regulated genes. In line with the transcriptomics data the plasma concentrations of the acute phase proteins serum amyloid A (SAA) and haptoglobin were reduced in cows fed GSGME compared to control cows. Lipidomic analysis of plasma revealed no differences in the concentrations of individual species of major and minor lipid classes between cows fed GSGME and control cows. CONCLUSIONS: Analysis of hepatic transcript profile in cows fed GSGME during the transition period at 1 week postpartum indicates that polyphenol-rich feed components are able to inhibit ER stress-induced UPR and inflammatory processes, both of which are considered to contribute to liver-associated diseases and to impair milk performance in dairy cows, in the liver of dairy cows during early lactation.
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RNA quality was checked (A260:A280 ratios and RNA integrity number values).
“After checking RNA quality [A260:A280 ratios and RNA integrity number values were 1.84 ± 0.05 (mean ± SD) and 7.4 ± 0.6, respectively], as described in [37]”
From Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats (2021) · cites this paper as [37]
The filter criteria FC > 1.3 and p < 0.05 were used for defining differentially expressed transcripts.
“transcripts with an FC > 1.3 and a Student’s t-test p-value < 0.05 were defined as upregulated, and those with aN FC < −1.3 and a Student’s t-test p-value < 0.05 as downregulated for the comparison OE vs. OC and LE vs. LC.”
From Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats (2021) · cites this paper as [37]
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Plant flavonoids to improve productivity of ruminants – A review
Olagaray, K. E., & Bradford, B. J. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.02.004 · Cited by 158 · see citing works
Kuhla, B. (2020) · animal · doi:10.1017/s1751731119003124 · Cited by 85 · see citing works
Meyer, S., Geßner, D. K., Braune, M. S., Friedhoff, T., Most, E., Höring, M., Liebisch, G., Zorn, H., Eder, K., & Ringseis, R. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-0425-7 · Cited by 77 · see citing works
Self-citationGessner, D. K., Schwarz, A., Meyer, S., Wen, G., Most, E., Zorn, H., Ringseis, R., & Eder, K. (2019) · The Journal of Nutrition · doi:10.1093/jn/nxy256 · Cited by 53 · see citing works
Self-citationLysophosphatidylcholine: Potential Target for the Treatment of Chronic Pain
Ren, J., Lin, J., Yu, L., & Yan, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158274 · Cited by 52 · see citing works
Sun, H., Plastow, G. S., & Guan, L. L. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-16126 · Cited by 27 · see citing works
Ringseis, R., Zeitz, J. O., Weber, A., Koch, C., & Eder, K. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-15232 · Cited by 26 · see citing works
Self-citationUse of grape by-products in aquaculture: New frontiers for a circular economy application
Quagliardi, M., Frapiccini, E., Marini, M., Panfili, M., Santanatoglia, A., Nguefang, M. L. K., Roncarati, A., Vittori, S., & Borsetta, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27443 · Cited by 21 · see citing works
Gerardi, G., Cavia-Sáiz, M., & Múñiz, P. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1914542 · Cited by 20 · see citing works
Can anthocyanins replace antibiotics in food and animal feed? A review
Guo, F., & Shahidi, F. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104219 · Cited by 18 · see citing works
Eder, K., Ringseis, R., & Geßner, D. K. (2025) · Animals · doi:10.3390/ani15111536 · Cited by 17 · see citing works
Self-citationRingseis, R., Geßner, D. K., Loewenstein, F., Kuehling, J., Becker, S., Willems, H., Lechner, M., Eder, K., & Reiner, G. (2021) · Animals · doi:10.3390/ani11030772 · Cited by 17 · see citing works
Self-citationGeßner, D. K., Brock, C., Hof, L. M., Most, E., Koch, C., & Eder, K. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-020-00465-y · Cited by 17 · see citing works
Self-citationFibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
Eder, K., Geßner, D. K., & Ringseis, R. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00621-y · Cited by 17 · see citing works
Self-citationGrundmann, S. M., Ress, K., Zimmermann, L., Höring, M., Liebisch, G., Most, E., Ringseis, R., & Eder, K. (2023) · Nutrients · doi:10.3390/nu15173734 · Cited by 16 · see citing works
Self-citationLi, L., Bai, S., Zhao, H., Tan, J., Wang, Y., Zhang, A., Jiang, L., & Zhao, Y. (2024) · Antioxidants · doi:10.3390/antiox13060638 · Cited by 16 · see citing works
Maheshwari, G., Geßner, D. K., Meyer, S., Ahlborn, J., Wen, G., Ringseis, R., Zorn, H., & Eder, K. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000591 · Cited by 16 · see citing works
Self-citationGhaffari, M. H., Alaedin, M., Sadri, H., Hofs, I., Koch, C., & Sauerwein, H. (2021) · Journal of Dairy Science · doi:10.3168/jds.2021-20237 · Cited by 15 · see citing works
Self-citationMarschall, M. J. M., Ringseis, R., Gessner, D. K., Grundmann, S. M., Most, E., Wen, G., Maheshwari, G., Zorn, H., & Eder, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105241 · Cited by 13 · see citing works
Self-citationAnthocyanins in Dairy Cow Nutrition: A Review
Tian, X., & Qi, L. (2022) · Agriculture · doi:10.3390/agriculture12111806 · Cited by 13 · see citing works
Yonekura, S. (2024) · Animal Science Journal · doi:10.1111/asj.13935 · Cited by 12 · see citing works
Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome
Gerhards, K., Becker, S., Kuehling, J., Lechner, M., Willems, H., Ringseis, R., & Reiner, G. (2025) · BMC Veterinary Research · doi:10.1186/s12917-024-04469-y · Cited by 11 · see citing works
Self-citationFoodomics technology: promising analytical methods of functional activities of plant polyphenols
Yang, F., Xie, C. Y., Li, J., Ma, R., Dang, Z., Wang, C., & Wang, T. (2021) · European Food Research and Technology · doi:10.1007/s00217-021-03781-3 · Cited by 10 · see citing works
Geßner, D. K., Sandrock, L. M., Most, E., Koch, C., Ringseis, R., & Eder, K. (2022) · Animals · doi:10.3390/ani13010131 · Cited by 10 · see citing works
Self-citationZhang, H., Tong, J., Wang, Z., Xiong, B., & Jiang, L. (2019) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.19.0226 · Cited by 10 · see citing works
Zhao, Y., Zhao, H., Li, L., Yu, S., Liu, M. R., & Jiang, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1321597 · Cited by 9 · see citing works
Cheema, U. B., Most, E., Eder, K., & Ringseis, R. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519000709 · Cited by 9 · see citing works
Self-citationGao, X., Tang, F., Zhang, F., Jia, C., Yang, Z., Liu, C., & Wei, G. (2019) · Archives of Animal Nutrition · doi:10.1080/1745039x.2019.1590142 · Cited by 8 · see citing works
Hu, H., Wang, L., Zhang, R., Tian, M., Zhang, S., Li, H., Cai, C., Yao, J., Wang, J., & Cao, Y. (2025) · Stress Biology · doi:10.1007/s44154-024-00206-5 · Cited by 6 · see citing works
Hepatic Transcriptome Reveals Potential Key Genes Contributing to Differential Milk Production
Du, C., La, A. L. T. Z., Gao, S., Gao, W., Ma, L., Bu, D., & Zhang, W. (2024) · Genes · doi:10.3390/genes15091229 · Cited by 6 · see citing works
Ringseis, R., Wächter, S., Cohrs, I., Eder, K., & Grünberg, W. (2024) · Journal of Dairy Science · doi:10.3168/jds.2023-24099 · Cited by 4 · see citing works
Self-citationRingseis, R., Grundmann, S. M., Schuchardt, S., Most, E., & Eder, K. (2021) · Metabolites · doi:10.3390/metabo11090573 · Cited by 4 · see citing works
Self-citationGenetic parameters and QTL mapping for novel metabolic traits in early-lactation Holsteins
Liu, R., Hailemariam, D., Baes, C. F., Miglior, F., Stothard, P., Colazo, M. G., & Plastow, G. S. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf359 · Cited by 2 · see citing works
Liver transcriptome dynamics in Holstein cows during the periparturient transition
Bhowmik, N., da Silva, M., Castaneda, A., Miles, A. M., Li, C., Tassell, C. P. V., Baldwin, R. L., Rico, J. E., & Liu, G. E. (2026) · Scientific Reports · doi:10.1038/s41598-026-46925-9 · Cited by 2 · see citing works
Häussler, S., Ghaffari, M. H., Seibt, K. D., Sadri, H., Alaedin, M., Huber, K., Frahm, J., Dänicke, S., & Sauerwein, H. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23556 · Cited by 2 · see citing works
Shao, Q., Li, X., Li, G., Cai, L., Usman, M. A., Loor, J. J., Fang, Z., Chen, M., Li, C., Ju, L., et al. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.04.009 · Cited by 2 · see citing works
Shao, Q., Feng, H., Li, G., Usman, M., Loor, J. J., Fang, Z., Chen, M., Li, C., Yu, H., Hao, X., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4724997/v1
Rahmatzadeh, M., Shokri-Gharelo, R., Derakhti-Dizaji, M., Bazzaz, A., & Mahmoudi, B. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102090
Geßner, D. K., Brock, C., Hof, L. M., Most, E., Koch, C., & Eder, K. (2020) · Figshare · doi:10.6084/m9.figshare.12432251
Self-citation
- Authors
- Gessner, D. K., Winkler, A., Koch, C., Dusel, G., Liebisch, G., Ringseis, R., & Eder, K.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Lehr- und Versuchsanstalt für Viehhaltung Hofgut Neumühle (DE)
- TH Bingen University of Applied Sciences (DE)
- University Hospital Regensburg (DE)
- Corresponding author
- Eder, Klaus
- Venue
- BMC Genomics
- Published
- 2017-03-23
- Volume
- 18
- Issue
- 1
- Pages
- 253-253
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC5364584
- OpenAlex
- W2599471025
- Cited by
- 39
- References
- 94
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 2
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Genomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University writing server of the Justus Liebig University Giessen (Justus-Liebig-Universität Gießen) (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- polyphenols, dairy cattle, transition period, liver transcriptome, plasma lipid profile, endoplasmic reticulum stress, unfolded protein response, inflammation, serum amyloid A, haptoglobin, acute phase proteins, milk yield, hepatic metabolism
- MeSH terms
- Animals, Animal Feed, Cattle, Dairying, Female, Lactation, Lipids, Liver, RNA, Messenger, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Grape Seed Extract
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