Does the anti-β2-glycoprotein I antibody provide additional information in patients with thrombosis?
Abstract
Objective To investigate whether the anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibody may provide additional information in patients with thrombosis in conjunction with the lupus anticoagulant (LAC) or anticardiolipin (aCL) antibody.Methods We selected 235 patients whose plasma were tested for the presence of all three antiphospholipid (aPL) antibodies (LAC, aCL, and anti-beta(2)GPI) and were positive for at least one aPL antibody from January 2000 to December 2001. The LAC test was performed using dilute activated thromboplastin time reagent (dAPTT) and dilute Russell viper venom time reagent (dRVVT). ACL (IgG/IgM) and anti-beta(2)GPI (IgG/IgM) were detected by enzyme-linked immunosorbent assay (ELISA). Clinical data were collected and analysed in all patients with aPL antibody.Results Of the 235 patients with aPL, thrombosis was detected in 76 patients (28.0%). Of the 76 patients with thrombosis, 29 were positive for LAC, 9 for aCL, 7 for anti-beta(2)GPI, 3 for LAC+aCL, 9 for aCL+anti-beta(2)GPI, 11 for LAC+anti-beta(2)GPI, and 8 for LAC+aCL+anti-beta(2)GPI. The rate of thrombosis was significantly different (p=0.01) among single positive patients (45/163, 27.6%), double positive patients (23/60, 38.3%), and triple positive patients (8/12, 66.7%). In single positive patients, the rate of thrombosis was highest in LAC positive patients (29/85, 34.1%). In double positive patients, the LAC+anti-beta(2)GPI positive group (11/24, 45.8%) and aCL+anti-beta(2)GPI positive group (9/22, 40.9%) had higher rates of thrombosis than the LAC+aCL positive group (3/14, 21.4%).Conclusion Single positivity for anti-beta(2)GPI explained 9.2% of thrombotic events in the absence of LAC or aCL. Double or triple positivity for aPLs were associated with a higher rate of thrombosis than single positivity for aPL. Our results suggest that anti-beta(2)GPI provides additional information in patients with thrombosis in conjunction with LAC or aCL.
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Positivity for multiple antiphospholipid antibody tests is associated with thromboembolic events more frequently than positivity for a single test.
“multiple positivity in tests exploring the presence of antiphospholipid (aPL) antibodies (lupus anticoagulant [LA], anticardiolipin [aCL], and anti- 2 -glycoprotein I [anti- 2 GPI] antibodies) is associated with thromboembolic events (TEs) more frequently than single test positivity.[1][2][3][4][5]”
From Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study (2011) · cites this paper as [2]
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- Authors
- Lee, E. Y., Lee, C.-K., Lee, T. H., Chung, S. M., Kim, S. H., Cho, Y. S., Yoo, B., & Moon, H.-B.
- Affiliations
- Asan Medical Center (KR)
- Corresponding author
- Yoo, Bin
- Venue
- Thrombosis Research
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 111
- Issue
- 1-2
- Pages
- 29-32
- ISSN
- 0049-3848 (ISSN-L)
- OpenAlex
- W2030638382
- Cited by
- 47
- References
- 18
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis Research (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- anti-beta2-glycoprotein I antibodies, antiphospholipid antibodies, lupus anticoagulant, anticardiolipin antibodies, thrombosis, antiphospholipid syndrome, thrombosis risk, dilute Russell viper venom time, IgM and IgG antibodies
- MeSH terms
- Autoantibodies, Glycoproteins, Humans, Immunoglobulin G, Immunoglobulin M, Partial Thromboplastin Time, Thrombosis, Reproducibility of Results, Biomarkers, Lupus Coagulation Inhibitor, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, beta 2-Glycoprotein I
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