Mechanisms of estrogen-induced venous thromboembolism
Abstract
The use of oral contraceptives (OC) is a well established risk factor for venous thrombosis. It has been known for many years that almost all haemostatic parameters i.e. plasma levels of coagulation factors, anticoagulant proteins and proteins involved in the fibrinolytic pathway change during OC use. The discovery of several risk factors of venous thrombosis in the 1990s shed new light on the association between the effects of OC on the haemostatic system and the increased risk of venous thrombosis. In this review, we summarize the current knowledge on the effects of different kinds of hormonal contraceptives (OC, transdermal contraceptives, vaginal ring and levonorgestrel-releasing intrauterine device) on haemostatic variables and the relationship between the changes of these variables and the risk of venous thrombosis.
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It is unclear whether the effect of CHCs on fibrinolysis has clinical implications on the risk of VTE secondary to estrogen therapy.
“Presently, it is unclear if this effect on fibrinolysis has clinical implications on the risk of VTE secondary to estrogen therapy [68]”
From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [68]
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- Authors
- Tchaikovski, S. N., & Rosing, J.
- Affiliations
- Maastricht University (NL)
- Corresponding author
- Rosing, Jan
- Venue
- Thrombosis Research
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 126
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0049-3848 (ISSN-L)
- OpenAlex
- W2133917486
- Cited by
- 219
- References
- 80
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 15 · 2023: 19 · 2022: 19 · 2021: 16 · 2020: 21 · 2019: 14 · 2018: 5 · 2017: 7 · 2016: 13 · 2015: 10 · 2014: 11 · 2013: 19 · 2012: 14
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis Research (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- estrogen, venous thromboembolism, oral contraceptives, hormonal contraception, vaginal ring, levonorgestrel-releasing intrauterine system, hemostasis, coagulation factors, anticoagulant proteins, fibrinolysis, thrombosis risk factors
- MeSH terms
- Blood Coagulation Factors, Contraception, Contraceptive Agents, Contraceptives, Oral, Estrogens, Female, Hemostasis, Humans, Risk, Risk Factors, Levonorgestrel, Venous Thrombosis, Venous Thromboembolism
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