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Endothelial function improvement in patients with familial hypercholesterolemia receiving PCSK-9 inhibitors on top of maximally tolerated lipid lowering therapy

Di Minno, Alessandro, Gentile, Marco, Iannuzzo, Gabriella, Calcaterra, Ilenia, Tripaldella, Maria, Porro, Benedetta, Cavalca, Viviana, Di Taranto, Maria Donata, Tremoli, Elena, Fortunato, Giuliana, Rubba, Paolo Osvaldo Federico, Di Minno, Matteo Nicola Dario·2020·Thrombosis Research
DOI 10.1016/j.thromres.2020.07.049
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Abstract

Background Treatment with protein convertase subtilisin kexin type 9 inhibitors (PCSK-9i) reduced cholesterol levels and cardiovascular events in patients with hypercholesterolemia. We assessed changes in lipid profile, oxidation markers and endothelial function in patients with familial hypercholesterolemia (FH) after a 12-week treatment with a PCSK-9i. Methods Patients with FH starting a treatment with PCSK-9i were included. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) (Lp(a)), small dense LDL (assessed by LDL score), 11-dehydro-thromboxane (11-TXB2), 8-isoprostaglandin-2alpha (8-iso-PGF2α), flow-mediated dilation (FMD) and reactive hyperaemia index (RHI) were evaluated before starting PCSK-9i treatment and after a 12-week treatment. Results Twenty-five subjects were enrolled (52% males, mean age 51.5 years). At the 12-week assessment, we observed a 38% median reduction in TC, 52% in LDL-C, 7% in Lp(a) and 46% in LDL score. In parallel, 11-TXB2 and 8-iso-PGF2α showed a reduction of 18% and 17%, respectively. FMD changed from 4.78% ± 2.27 at baseline to 10.6% ± 5.89 at 12 weeks (p Conclusions Small dense LDL reduction (assessed by LDL score) is related to changes in oxidation markers and endothelial function in patients with FH treated with PCSK-9i.

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Metadata

Authors
Di Minno, A., Gentile, M., Iannuzzo, G., Calcaterra, I., Tripaldella, M., Porro, B., Cavalca, V., Di Taranto, M. D., Tremoli, E., Fortunato, G., Rubba, P. O. F., & Di Minno, M. N. D.
ORCID
Venue
Thrombosis Research
Publisher
Elsevier BV
Published
2020-10
Volume
194
Pages
229-236
ISSN
0049-3848
DOI
10.1016/j.thromres.2020.07.049
Cited by
45
References
4
Language
en
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CoChat. (2026). Citation check: Endothelial function improvement in patients with familial hypercholesterolemia receiving PCSK-9 inhibitors on top of maximally tolerated lipid lowering therapy. https://app.cochat.ai/papers/10.1016/j.thromres.2020.07.049
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Di Minno, A., Gentile, M., Iannuzzo, G., Calcaterra, I., Tripaldella, M., Porro, B., Cavalca, V., Di Taranto, M. D., Tremoli, E., Fortunato, G., Rubba, P. O. F., & Di Minno, M. N. D. (2020). Endothelial function improvement in patients with familial hypercholesterolemia receiving PCSK-9 inhibitors on top of maximally tolerated lipid lowering therapy. Thrombosis Research. https://doi.org/10.1016/j.thromres.2020.07.049