COVID-19 versus HIT hypercoagulability

Warkentin, Theodore E.; Kaatz, Scott

doi:10.1016/j.thromres.2020.08.017

Cited by 57Heparin-Induced Thrombocytopenia and ThrombosisCOVID-19 Clinical Research StudiesVenous Thromboembolism Diagnosis and Management

COVID-19 versus HIT hypercoagulability

Open access

Warkentin, Theodore E., Kaatz, Scott·2020·Thrombosis Research

DOI 10.1016/j.thromres.2020.08.017PMC PMC7416717

Open this paper in CoChat — free account Open PDF

Abstract

A striking feature of COVID-19 is the high frequency of thrombosis, particularly in patients who require admission to intensive care unit because of respiratory complications (pneumonia/adult respiratory distress syndrome). The spectrum of thrombotic events is wide, including in situ pulmonary thrombosis, deep-vein thrombosis and associated pulmonary embolism, as well as arterial thrombotic events (stroke, myocardial infarction, limb artery thrombosis). Unusual thrombotic events have also been reported, e.g., cerebral venous sinus thrombosis, mesenteric artery and vein thrombosis. Several hematology abnormalities have been observed in COVID-19 patients, including lymphopenia, neutrophilia, thrombocytopenia (usually mild), thrombocytosis, elevated prothrombin time and partial thromboplastin times (the latter abnormality often indicating lupus anticoagulant phenomenon), hyperfibrinogenemia, elevated von Willebrand factor levels, and elevated fibrin d-dimer. Many of these abnormal hematologic parameters-even as early as the time of initial hospital admission-indicate adverse prognosis, including greater frequency of progression to severe respiratory illness and death. Progression to overt disseminated intravascular coagulation in fatal COVID-19 has been reported in some studies, but not observed in others. We compare and contrast COVID-19 hypercoagulability, and associated increased risk of venous and arterial thrombosis, from the perspective of heparin-induced thrombocytopenia (HIT), including the dilemma of providing thromboprophylaxis and treatment recommendations when available data are limited to observational studies. The frequent use of heparin-both low-molecular-weight and unfractionated-in preventing and treating COVID-19 thrombosis, means that vigilance for HIT occurrence is required in this patient population.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.thromres.2020.08.017

Cites

132 of 132 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works
Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-Infected pneumonia in Wuhan, China
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148 · see citing works
La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463 · see citing works
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Huang, H., Zhang, L., Zhou, X., Du, C., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.0994 · Cited by 8,249 · see citing works
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166 · see citing works
Endothelial cell infection and endotheliitis in COVID-19
Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30937-5 · Cited by 6,358 · see citing works
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
Ackermann, M., Verleden, S. E., Kuehnel, M., Haverich, A., Welte, T., Laenger, F., Vanstapel, A., Werlein, C., Stark, H., Tzankov, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2015432 · Cited by 5,613 · see citing works
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia
Tang, N., Li, D., Wang, X., & Sun, Z.-Y. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14768 · Cited by 5,527 · see citing works
Incidence of thrombotic complications in critically ill ICU patients with COVID-19
Klok, F. A., Kruip, M. J. H. A., van der Meer, N. J. M., Arbous, M. S., Gommers, D. A. M. P. J., Kant, K. M., Kaptein, F. H. J., van Paassen, J., Stals, M. A. M., Huisman, M. V., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.013 · Cited by 5,028 · see citing works
Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy
Tang, N., Bai, H., Chen, X., Gong, J., Li, D., & Sun, Z. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14817 · Cited by 3,554 · see citing works
COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up
Bikdeli, B., Madhavan, M. V., Jiménez, D., Chuich, T., Dreyfus, I., Driggin, E., Der-Nigoghossian, C. A., Ageno, W., Madjid, M., Guo, Y., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.04.031 · Cited by 2,902 · see citing works
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study
Helms, J., Tacquard, C. A., Séverac, F., Léonard-Lorant, I., Ohana, M., Delabranche, X., Merdji, H., Clère-Jehl, R., Schenck, M., Gandet, F. F., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06062-x · Cited by 2,818 · see citing works
Towards Definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation: On behalf of the Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH)
Taylor, F., Toh, C.-H., Hoots, K., Wada, H., & Levi, M. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1616068 · Cited by 2,285 · see citing works
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19
Wichmann, D., Sperhake, J., Lütgehetmann, M., Steurer, S. A., Edler, C., Heinemann, A., Heinrich, F., Mushumba, H., Kniep, I., Schröder, A. S., et al. (2020) · Annals of Internal Medicine · doi:10.7326/m20-2003 · Cited by 2,271 · see citing works
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases
MAGRO, C. M. J., Mulvey, J. J., Berlin, D., Nuovo, G. J., Salvatore, S., HARP, J. L., Baxter-Stoltzfus, A., & Laurence, J. C. (2020) · Translational research · doi:10.1016/j.trsl.2020.04.007 · Cited by 2,185 · see citing works
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
Oxley, T. J., Mocco, J., Majidi, S., Kellner, C. P., Shoirah, H., Singh, I. P., Leacy, R. A. D., Shigematsu, T., Ladner, T. R., Yaeger, K., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2009787 · Cited by 2,114 · see citing works
Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy
Lodigiani, C., Iapichino, G., Carenzo, L., Cecconi, M., Ferrazzi, P., Sebastian, T., Kucher, N., Studt, J.-D., Sacco, C., Bertuzzi, A., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.024 · Cited by 2,054 · see citing works
Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia
Cui, S., Chen, S., Li, X., Liu, S., & Wang, F. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14830 · Cited by 1,805 · see citing works
The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease
McGonagle, D., Sharif, K., O'Regan, A., & Bridgewood, C. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102537 · Cited by 1,654 · see citing works
Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis
Klok, F. A., Kruip, M. J. H. A., van der Meer, N. J. M., Arbous, M. S., Gommers, D., Kant, K. M., Kaptein, F. H. J., van Paassen, J., Stals, M. A. M., Huisman, M. V., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.041 · Cited by 1,601 · see citing works
Neutrophil extracellular traps in COVID-19
Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J. A., Blair, C., Weber, A. G., Barnes, B. J., Egeblad, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138999 · Cited by 1,598 · see citing works
Targeting potential drivers of COVID-19: Neutrophil extracellular traps
Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J. M., Daßler-Plenker, J., Guerci, P., Huynh, C., Knight, J. S., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20200652 · Cited by 1,486 · see citing works
Incidence of venous thromboembolism in hospitalized patients with COVID‐19
Middeldorp, S., Coppens, M., van Haaps, T. F., Foppen, M., Vlaar, A. P. J., Müller, M. C. A., Bouman, C. S. C., Beenen, L. F. M., Kootte, R. S., Heijmans, J., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14888 · Cited by 1,453 · see citing works
COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection
Al-Samkari, H. T., Leaf, R. K., Dzik, S., Carlson, J., Fogerty, A. E., Waheed, A., Goodarzi, K., Bendapudi, P. K., Bornikova, L., Gupta, S., et al. (2020) · Blood · doi:10.1182/blood.2020006520 · Cited by 1,342 · see citing works
Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction
Menter, T., Haslbauer, J. D., Nienhold, R., Savic, S., Hopfer, H., Deigendesch, N., Frank, S., Turek, D., Willi, N., Pargger, H., et al. (2020) · Histopathology · doi:10.1111/his.14134 · Cited by 1,207 · see citing works
High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients
Llitjos, J., Leclerc, M., Chochois, C., Monsallier, J.-M., Ramakers, M., Auvray, M., & Merouani, K. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14869 · Cited by 1,199 · see citing works
Pulmonary Embolism in Patients With COVID-19
Poissy, J., Goutay, J., Caplan, M., Parmentier-Decrucq, E., Duburcq, T., Lassalle, F., Jeanpierre, E., Rauch, A., Labreuche, J., Susen, S., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.047430 · Cited by 1,069 · see citing works
Risk of ischemic stroke in patients with coronavirus disease 2019 (COVID-19) vs patients with influenza.
Merkler, A. E., Parikh, N. S., Mir, S., Gupta, A., Kamel, H., Lin, E., Lantos, J., Schenck, E. J., Goyal, P., Bruce, S. S., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.2730 · Cited by 940 · see citing works
Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19
Paranjpe, I., Fuster, V., Lala, A., Russak, A. J., Glicksberg, B. S., Levin, M. A., Charney, A. W., Narula, J., Fayad, Z. A., Bagiella, E., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.05.001 · Cited by 918 · see citing works
A 14-year study of heparin-induced thrombocytopenia
Warkentin, T. E., & Kelton, J. G. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00258-6 · Cited by 899 · see citing works
Self-citation
Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis
Martel, N., Lee, J. C., & Wells, P. S. (2005) · Blood · doi:10.1182/blood-2005-04-1546 · Cited by 881 · see citing works
American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia
Cuker, A. C., Arepally, G. M., Chong, B. H., Cines, D. B., Greinacher, A., Gruel, Y., Linkins, L. A., Rodner, S. B., Selleng, S., Warkentin, T. E., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018024489 · Cited by 755 · see citing works
Self-citation
Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome
Lax, S., Skok, K., Zechner, P. M., Kessler, H. H., Kaufmann, N., Koelblinger, C., Vander, K., Bargfrieder, U., & Trauner, M. A. (2020) · Annals of Internal Medicine · doi:10.7326/m20-2566 · Cited by 730 · see citing works
Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID‐19
Spyropoulos, A. C., Levy, J. H., Ageno, W., Connors, J. M., Hunt, B. J., Iba, T., Levi, M. M., Samama, C. M., Thachil, J. V., Giannis, D., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14929 · Cited by 657 · see citing works
Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019
Moores, L. K., Tritschler, T., Brosnahan, S. B., Carrier, M., Collen, J. F., Doerschug, K. C., Holley, A. B., Jiménez, D., Gal, G. L., Rali, P. M., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.05.559 · Cited by 646 · see citing works
Coagulopathy in COVID‐19
Iba, T., Levy, J. H., Levi, M. M., & Thachil, J. V. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14975 · Cited by 594 · see citing works
Heparin‐induced thrombocytopenia: pathogenesis and management
Warkentin, T. E. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04334.x · Cited by 548 · see citing works
Self-citation
The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection
Pons, S., Fodil, S., Azoulay, É., & Zafrani, L. (2020) · Critical Care · doi:10.1186/s13054-020-03062-7 · Cited by 518 · see citing works
Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19
Bowles, L., Platton, S., Yartey, N., Dave, M., Lee, K., Hart, D. P., MacDonald, V., Green, L., Sivapalaratnam, S., Pasi, J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2013656 · Cited by 488 · see citing works
Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia
Warkentin, T., Hayward, C. P. M., Boshkov, L., Santos, A., Sheppard, J., Bode, A., & Kelton, J. (1994) · Blood · doi:10.1182/blood.v84.11.3691.bloodjournal84113691 · Cited by 478 · see citing works
Self-citation
Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum
Barnes, G. D., Burnett, A., Allen, A. L., Blumenstein, M. S., Clark, N. P., Cuker, A. C., Dager, W. E., Deitelzweig, S. B., Ellsworth, S., Garcia, D. A., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02138-z · Cited by 467 · see citing works
Self-citation
Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China
Zhang, L., Zhang, L., Feng, X., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.046702 · Cited by 441 · see citing works
Severe COVID-19 infection associated with endothelial activation
Escher, R., Breakey, N., & Lämmle, B. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.014 · Cited by 440 · see citing works
The pulmonary vascular lesions of the adult respiratory distress syndrome.
Tomashefski, J. F., Davies, P. A., Boggis, C. R. M., et al. (1983) · PubMed · Cited by 435 · see citing works
Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
Perdomo, J., Leung, H. H. L., Ahmadi, Z., Feng, Y., Chong, J. J. H., Passam, F. H., & Chong, B. H. (2019) · Nature Communications · doi:10.1038/s41467-019-09160-7 · Cited by 419 · see citing works
Heparin-induced thrombocytopenia: laboratory studies
Kelton, J., Sheridan, D. M., Santos, A., et al. (1988) · Blood · doi:10.1182/blood.v72.3.925.925 · Cited by 414 · see citing works
[Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia].
Zhang, Y., Cao, W., Xiao, M., Li, Y. J., Yang, Y., Zhao, J., Zhou, X., Jiang, W., Zhao, Y., Zhang, S., et al. (2020) · PubMed Central · doi:10.3760/cma.j.issn.0253-2727.2020.0006 · Cited by 398 · see citing works
Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China
Wang, D., Yin, Y., Hu, C., Liu, X., Zhang, X., Zhou, S., Jian, M., Xu, H., Prowle, J., Hu, B., et al. (2020) · Critical Care · doi:10.1186/s13054-020-02895-6 · Cited by 397 · see citing works
Acute limb ischemia in patients with COVID-19 pneumonia
Bellosta, R., Luzzani, L., Natalini, G., Pegorer, M. A., Attisani, L., Cossu, L. G., Ferrandina, C., Fossati, A., Conti, E., Bush, R. L., et al. (2020) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2020.04.483 · Cited by 392 · see citing works
Heparin-induced thrombocytopenia: laboratory studies
Kelton, J., Sheridan, D. M., Santos, A., et al. (1988) · Blood · doi:10.1182/blood.v72.3.925.bloodjournal723925 · Cited by 382 · see citing works
Pulmonary embolism in patients with COVID-19 pneumonia
Bompard, F., Monnier, H., Saab, I., Tordjman, M., Abdoul, H., Fournier, L. S., Sanchez, O., Lorut, C., Chassagnon, G., & Revel, M. (2020) · European Respiratory Journal · doi:10.1183/13993003.01365-2020 · Cited by 379 · see citing works
Association between ABO blood groups and risk of SARS‐CoV‐2 pneumonia
Li, J., Wang, X., Chen, J., Cai, Y., Deng, A., & Yang, M. (2020) · British Journal of Haematology · doi:10.1111/bjh.16797 · Cited by 372 · see citing works
Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels
Rodríguez, P. D., Cervilla‐Muñoz, E., Ordieres‐Ortega, L., Parra‐Virto, A., Toledano‐Macías, M., Samaniego, N. T., García-García, A., García-Fernández-Bravo, I., Ji, Z., de Miguel‐Díez, J., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.05.018 · Cited by 353 · see citing works
An Improved Definition of Immune Heparin-Induced Thrombocytopenia in Postoperative Orthopedic Patients
Warkentin, T. E., Roberts, R. S., Hirsh, J., & Kelton, J. G. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.20.2518 · Cited by 316 · see citing works
Self-citation
Special Article - Acute myocardial injury in patients hospitalized with COVID-19 infection: A review
Bavishi, C., Bonow, R. O., Trivedi, V., Abbott, J. D., Messerli, F. H., & Bhatt, D. L. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.05.013 · Cited by 298 · see citing works
Gender imbalance and risk factor interactions in heparin-induced thrombocytopenia
Warkentin, T. E., Sheppard, J. I., Sigouin, C. S., et al. (2006) · Blood · doi:10.1182/blood-2005-11-012450 · Cited by 294 · see citing works
Self-citation
The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China
Fu, J., Kong, J., Wang, W., Wu, M., Lin, Y., Wang, Z., Jin, J., Wu, D., & Yu, X. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.05.006 · Cited by 289 · see citing works
Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19
Whyte, C. S., Morrow, G. B., Mitchell, J. L., Chowdary, P., & Mutch, N. J. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14872 · Cited by 271 · see citing works
Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)
Nahum, J., Morichau-Beauchant, T., Daviaud, F., Echegut, P., Fichet, J., Maillet, J.-M., & Thierry, S. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.10478 · Cited by 260 · see citing works
Plasma P-selectin is increased in thrombotic consumptive platelet disorders
Chong, B., Murray, B., Berndt, M. C., Dunlop, L., Brighton, T., & Chesterman, C. (1994) · Blood · doi:10.1182/blood.v83.6.1535.1535 · Cited by 250 · see citing works
Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study
Fraissé, M., Logre, E., Pajot, O., Mentec, H., Plantefève, G., & Contou, D. (2020) · Critical Care · doi:10.1186/s13054-020-03025-y · Cited by 240 · see citing works
Acute Pulmonary Embolism and COVID-19
Poyiadji, N., Cormier, P., Patel, P., Hadied, M., Bhargava, P., Khanna, K., Nadig, J., Keimig, T., Spizarny, D., Reeser, N., et al. (2020) · Radiology · doi:10.1148/radiol.2020201955 · Cited by 228 · see citing works
Extremely High Incidence of Lower Extremity Deep Venous Thrombosis in 48 Patients With Severe COVID-19 in Wuhan
Ren, B., Yan, F., Deng, Z., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.047407 · Cited by 225 · see citing works
Induction of monocyte tissue factor expression by antibodies to heparin–platelet factor 4 complexes developed in heparin-induced thrombocytopenia
Pouplard, C., Iochmann, S., Renard, B., et al. (2001) · Blood · doi:10.1182/blood.v97.10.3300 · Cited by 200 · see citing works
A Comparison of Danaparoid and Lepirudin in Heparin-induced Thrombocytopenia
Farner, B., Eichler, P., Kroll, H., et al. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615946 · Cited by 192 · see citing works
Clinical and computed tomography characteristics of COVID-19 associated acute pulmonary embolism: A different phenotype of thrombotic disease?
van Dam, L. F., Kroft, L. J. M., van der Wal, L. I., Cannegieter, S. C., Eikenboom, J. C. J., de Jonge, E., Huisman, M. V., & Klok, F. A. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.06.010 · Cited by 188 · see citing works
Dynamic relationship between D‐dimer and COVID‐19 severity
Li, Y., Zhao, K., Wei, H., et al. (2020) · British Journal of Haematology · doi:10.1111/bjh.16811 · Cited by 181 · see citing works
Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
Iba, T., Levy, J. H., Raj, A., & Warkentin, T. E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050728 · Cited by 180 · see citing works
Self-citation
COVID-19 related neuroimaging findings: A signal of thromboembolic complications and a strong prognostic marker of poor patient outcome
Jain, R., Young, M., Dogra, S., Kennedy, H., Nguyen, V., Jones, S., Bilaloglu, S., Hochman, K. A., Raz, E., Galetta, S. L., et al. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116923 · Cited by 180 · see citing works
Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom
Thomas, W., Varley, J., Johnston, A. J., Symington, E. M., Robinson, M., Sheares, K. K. K., Lavinio, A., & Besser, M. W. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.028 · Cited by 178 · see citing works
Cerebral Venous Sinus Thrombosis as a Presentation of COVID-19
Hughes, C., Nichols, T., Pike, M., Subbe, C. P., & Elghenzai, S. (2020) · European Journal of Case Reports in Internal Medicine · doi:10.12890/2020_001691 · Cited by 175 · see citing works
Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease 2019
Maatman, T. K., Jalali, F., Feizpour, C. A., Douglas, A., McGuire, S. P., Kinnaman, G., Hartwell, J. L., Maatman, B. T., Kreutz, R. P., Kapoor, R., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004466 · Cited by 174 · see citing works
Neutrophil accumulation and NET release contribute to thrombosis in HIT
Gollomp, K. L., Kim, M., Johnston, I., Hayes, V., Welsh, J. D., Arepally, G. M., Kahn, M. L., Lambert, M. P., Cuker, A. C., Cines, D. B., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99445 · Cited by 170 · see citing works
Drug-Induced Immune-Mediated Thrombocytopenia — From Purpura to Thrombosis
Warkentin, T. E. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068309 · Cited by 166 · see citing works
Self-citation
Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia
Hong, A. P., Cook, D. J., Sigouin, C. S., et al. (2003) · Blood · doi:10.1182/blood-2002-05-1448 · Cited by 166 · see citing works
Clinical picture of heparin-induced thrombocytopenia
Warkentin, T. E. (2012) · CRC Press eBooks · doi:10.3109/9781841848617-5 · Cited by 163 · see citing works
Self-citation
Spontaneous heparin-induced thrombocytopenia syndrome: 2 new cases and a proposal for defining this disorder
Warkentin, T. E., Basciano, P. A., Knopman, J., & Bernstein, R. A. (2014) · Blood · doi:10.1182/blood-2014-01-549741 · Cited by 159 · see citing works
Self-citation
Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia
Rauova, L., Hirsch, J. D., Greene, T. K., Zhai, L., Hayes, V. M., Kowalska, M. A., Cines, D. B., & Poncz, M. (2010) · Blood · doi:10.1182/blood-2010-03-276964 · Cited by 156 · see citing works
Heparin-Induced Thrombocytopenia in Critically Ill Patients
Warkentin, T. E. (2015) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1398381 · Cited by 118 · see citing works
Self-citation
Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation
Takemitsu, T., Hatada, T., Ohmori, Y., Ishikura, K., Takeda, T., Sugiyama, T., Yamada, N., Maruyama, K., Katayama, N., Isaji, S., et al. (2010) · Thrombosis and Haemostasis · doi:10.1160/th10-05-0293 · Cited by 112 · see citing works
Ischemic Limb Gangrene with Pulses
Warkentin, T. E. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1316259 · Cited by 112 · see citing works
Self-citation
A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis
Padmanabhan, A., Jones, C. G., Curtis, B. R., Bougie, D. W., Sullivan, M. J., Peswani, N., McFarland, J. G., Eastwood, D. C., Wang, D., & Aster, R. H. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.02.641 · Cited by 105 · see citing works
Arterial and venous abdominal thrombosis in a 79-year-old woman with COVID-19 pneumonia
de Barry, O., Mekki, A., Diffre, C., Seror, M., El Hajjam, M., & Carlier, R.-Y. (2020) · Radiology Case Reports · doi:10.1016/j.radcr.2020.04.055 · Cited by 102 · see citing works
Delayed-Onset Heparin-Induced Thrombocytopenia and Cerebral Thrombosis after a Single Administration of Unfractionated Heparin
Warkentin, T. E., & Bernstein, R. A. (2003) · New England Journal of Medicine · doi:10.1056/nejm200303133481120 · Cited by 100 · see citing works
Self-citation
Cerebral venous thrombosis: Atypical presentation of COVID-19 in the young
Klein, D. E., Libman, R., Kirsch, C., & Arora, R. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.104989 · Cited by 98 · see citing works
Incidence and consequences of systemic arterial thrombotic events in COVID-19 patients
Cantador, E., Núñez, A., Sobrino, P., Espejo, V., Fabia, L., Vela, L., de Benito, L., & Botas, J. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02176-7 · Cited by 97 · see citing works
Systemic arterial thrombosis and acute mesenteric ischemia in a patient with COVID-19
Azouz, E., Yang, S., Monnier-Cholley, L., & Arrivé, L. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06079-2 · Cited by 96 · see citing works
Acute aorto‐iliac and mesenteric arterial thromboses as presenting features of COVID‐19
Vulliamy, P., Jacob, S., & Davenport, R. A. (2020) · British Journal of Haematology · doi:10.1111/bjh.16760 · Cited by 93 · see citing works
First case of Covid-19 presented with cerebral venous thrombosis: A rare and dreaded case
Hemasian, H., & Ansari, B. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.04.013 · Cited by 90 · see citing works
Anticoagulant failure in coagulopathic patients: PTT confounding and other pitfalls
Warkentin, T. E. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.823946 · Cited by 87 · see citing works
Self-citation
Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation
Johnston, I., Sarkar, A., Hayes, V., et al. (2020) · Blood · doi:10.1182/blood.2018881607 · Cited by 80 · see citing works
ADAMTS13 activity, von Willebrand factor, factor VIII and D-dimers in COVID-19 inpatients
Escher, R., Breakey, N., & Lämmle, B. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.05.032 · Cited by 78 · see citing works
Thrombotic risk in COVID-19: a case series and case–control study
Stoneham, S. M., Milne, K. M., Nuttall, E., Frew, G. H., Sturrock, B. R., Sivaloganathan, H., Ladikou, E. E., Drage, S. M., Phillips, B., Chevassut, T. J. T., et al. (2020) · Clinical Medicine · doi:10.7861/clinmed.2020-0228 · Cited by 75 · see citing works
Performance characteristics of an automated latex immunoturbidimetric assay [HemosIL ® HIT-Ab (PF4-H) ] for the diagnosis of immune heparin-induced thrombocytopenia
Warkentin, T. E., Sheppard, J. I., Linkins, L., et al. (2017) · Thrombosis Research · doi:10.1016/j.thromres.2017.03.010 · Cited by 73 · see citing works
Self-citation
Involvement of ADAMTS13 and von Willebrand factor in thromboembolic events in patients infected with SARS‐CoV‐2
Huisman, A., Beun, R., Sikma, M. A., Westerink, J., & Kuşadasi, N. (2020) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.13244 · Cited by 73 · see citing works
Heparin-Induced Thrombocytopenia in Medical Surgical Critical Illness
Warkentin, T. E., Sheppard, J. I., Heels‐Ansdell, D., et al. (2013) · CHEST Journal · doi:10.1378/chest.13-0057 · Cited by 70 · see citing works
Self-citation
Differential diagnoses for sepsis‐induced disseminated intravascular coagulation: communication from the SSC of the ISTH
Iba, T., Levy, J. H., Wada, H., Thachil, J. V., Warkentin, T. E., & Levi, M. M. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14354 · Cited by 67 · see citing works
Self-citation
Beneficial effect of exogenous platelet factor 4 for detecting pathogenic heparin‐induced thrombocytopenia antibodies
Vayne, C., Guéry, E., Kizlik‐Masson, C., et al. (2017) · British Journal of Haematology · doi:10.1111/bjh.14955 · Cited by 66 · see citing works
Venous Thromboembolism Events Following Venovenous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Syndrome Coronavirus 2 Based on CT Scans
Parzy, G., Daviet, F., Puech, B., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004504 · Cited by 66 · see citing works
Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatmentPreprint
Liu, X., Zhang, X., Xiao, Y., Gao, T., Wang, G., Wang, Z., Zhang, Z., Hu, Y., Dong, Q., Zhao, S., et al. (2020) · medRxiv · doi:10.1101/2020.04.23.20076851 · Cited by 65 · see citing works
Arterial Mesenteric Thrombosis as a Complication of SARS-CoV-2 Infection
Beccara, L. A., Pacioni, C., Ponton, S., Francavilla, S., & Cuzzoli, A. (2020) · European Journal of Case Reports in Internal Medicine · doi:10.12890/2020_001690 · Cited by 65 · see citing works
Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia
Hayes, V., Johnston, I., Arepally, G. M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90958 · Cited by 63 · see citing works
Acute pulmonary embolism in COVID-19 disease: Preliminary report on seven patients
Faggiano, P. M., Bonelli, A., París, S. C., et al. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.04.028 · Cited by 63 · see citing works
Heparin‐induced thrombocytopenia with thrombosis in COVID‐19 adult respiratory distress syndrome
Riker, R. R., May, T., Fraser, G. L., Gagnon, D. J., Bandara, M., Zemrak, W. R., & Seder, D. B. (2020) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12390 · Cited by 61 · see citing works
Re The source of elevated plasma D‐dimer levels in COVID‐19 infection
Hunt, B. J., & Levi, M. M. (2020) · British Journal of Haematology · doi:10.1111/bjh.16907 · Cited by 60 · see citing works
Acute Thrombosis of an Aortic Prosthetic Graft in a Patient with Severe COVID-19–Related Pneumonia
Giacomelli, E., Dorigo, W., Fargion, A. T., Calugi, G., Cianchi, G., & Pratesi, C. (2020) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2020.04.040 · Cited by 59 · see citing works
Risk of peripheral arterial thrombosis in COVID-19
Mestres, G., Puigmacià, R., Blanco, C., et al. (2020) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2020.04.477 · Cited by 57 · see citing works
Serotonin‐release assay‐negative heparin‐induced thrombocytopenia
Warkentin, T. E., Nazy, I., Sheppard, J. I., Smith, J. W., Kelton, J. G., & Arnold, D. M. (2019) · American Journal of Hematology · doi:10.1002/ajh.25660 · Cited by 56 · see citing works
Self-citation
Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it?
Criel, M., Falter, M., Jaeken, J., Kerrebroeck, M. V., Lefere, I., Meylaerts, L., Mesotten, D., Laenen, M. V., Fivez, T., Thomeer, M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.01201-2020 · Cited by 56 · see citing works
Heparin induced thrombocytopenia antibodies in Covid‐19
Patell, R. D., Khan, A. M., Bogue, T., Merrill, M. H., Koshy, A. G., Bindal, P., Joyce, R., Aird, W. C., Neuberg, D. S., Bauer, K. A., et al. (2020) · American Journal of Hematology · doi:10.1002/ajh.25935 · Cited by 54 · see citing works
Titre of anti-heparin/PF4-antibodies and extent of in vivo activation of the coagulation and fibrinolytic systems
Chilver-Stainer, L., Lämmle, B., & Alberio, L. (2003) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0454 · Cited by 50 · see citing works
Comparative Analysis of a French Prospective Series of 144 Patients with Heparin-Induced Thrombocytopenia (FRIGTIH) and the Literature
Gruel, Y., Vayne, C., Rollin, J., et al. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1712957 · Cited by 47 · see citing works
Heparin-Induced Thrombocytopenia in COVID-19
Lingamaneni, P., Gonakoti, S., Moturi, K. R., Vohra, I., & Zia, M. (2020) · Journal of Investigative Medicine High Impact Case Reports · doi:10.1177/2324709620944091 · Cited by 47 · see citing works
Sudden death due to acute pulmonary embolism in a young woman with COVID-19
Polat, V., & Alp, G. İ. B. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02132-5 · Cited by 37 · see citing works
Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT
Kowalska, M. A., Krishnaswamy, S., Rauova, L., Zhai, L., Hayes, V., Amirikian, K., Esko, J. D., Bougie, D. W., Aster, R. H., Cines, D. B., et al. (2011) · Blood · doi:10.1182/blood-2011-02-335208 · Cited by 36 · see citing works
Severe Acute Respiratory Syndrome Coronavirus 2 Infection and the Upper Limb Deep Vein Thrombosis Risk
Bozzani, A., Arici, V., Franciscone, M. M., et al. (2020) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2020.04.037 · Cited by 35 · see citing works
Complicaciones arteriales trombóticas en pacientes hospitalizados con COVID-19
Rey, J. R., Caro‐Codón, J., Pinedo, I. D. P., Merino, J. L., Iniesta, Á. M., & Lopez-Sendon, J. L. (2020) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.05.013 · Cited by 35 · see citing works
Is COVID Evolution Due to Occurrence of Pulmonary Vascular Thrombosis?
Saba, L., & Sverzellati, N. (2020) · Journal of Thoracic Imaging · doi:10.1097/rti.0000000000000530 · Cited by 30 · see citing works
Arterial thrombotic complications in hospitalized patients with COVID-19
Rey, J. R., Caro‐Codón, J., Pinedo, I. D. P., Merino, J. L., Iniesta, Á. M., & López-Sendón, J. L. (2020) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2020.05.008 · Cited by 30 · see citing works
Formation of anti–platelet factor 4/heparin antibodies after cardiac surgery: Influence of perioperative platelet activation, the inflammatory response, and histocompatibility leukocyte antigen status
Paparella, D., Scrascia, G., Galeone, A., et al. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.06.014 · Cited by 24 · see citing works
Role of monocytes and endothelial cells in heparin-induced thrombocytopenia
Madeeva, D. V., Cines, D. B., Poncz, M., & Rauova, L. (2016) · Thrombosis and Haemostasis · doi:10.1160/th16-02-0162 · Cited by 23 · see citing works
Frequency of lupus anticoagulant in COVID‐19 patients
Harzallah, I., Debliquis, A. P., & Drénou, B. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14937 · Cited by 21 · see citing works
The detection of d-dimer in plasma by enzyme immunoassay
Hart, R., Bate, I., Dinh, D., et al. (1994) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-199404000-00011 · Cited by 20 · see citing works
Occurrence of pulmonary embolism in a patient with mild clinical expression of COVID-19
Vitali, C., Minniti, A., Caporali, R. F., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.05.002 · Cited by 19 · see citing works
Microthrombotic Complications of COVID-19 Are Likely Due to Embolism of Circulating Endothelial Derived Ultralarge Von Willebrand Factor (eULVWF) Decorated-Platelet Strings
Varatharajah (2020) · Federal Practitioner · doi:10.12788/fp.0001 · Cited by 19 · see citing works
Ischemic Limb Gangrene with Pulses
Warkentin, T. E. (2015) · New England Journal of Medicine · doi:10.1056/nejmc1511750 · Cited by 18 · see citing works
Self-citation
Microthrombotic Complications of COVID-19 Are Likely Due to Embolism of Circulating Endothelial Derived Ultralarge Von Willebrand Factor (eULVWF) Decorated-Platelet Strings
Varatharajah, N. (2020) · Federal Practitioner · doi:10.12788//fp.0001 · Cited by 16 · see citing works
Neutrophil and Monocyte Counts in Heparin-Induced Thrombocytopenia
Hui, M., Sheppard, J. I., Li, N., et al. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-1683913 · Cited by 12 · see citing works
Incidence and consequences of systemic arterial thrombotic events in COVID-19 patientsPreprint
Cantador, E., Núñez, A., Sobrino, P., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-31168/v1 · Cited by 10 · see citing works
HIT: still stringing us along
Warkentin, T. E. (2020) · Blood · doi:10.1182/blood.2020005157 · Cited by 6 · see citing works
Self-citation
Heparin-Induced Thrombocytopenia
Bartholomew, J. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9560-4_14 · Cited by 4 · see citing works

Flagged first, then by citations

Sorted by citations

Portal-splenic-mesenteric venous thrombosis in COVID-19 patients: a systematic review
Gomes, R. Z., Salina, M. V. J., Pironatto, V. H. M., Lepinski, J. K., Gueiber, T. D., Juliatto, B. M. S., Prestes, M. Z., & Martins, C. M. (2025) · Jornal Vascular Brasileiro · doi:10.1590/1677-5449.202301282 · Cited by 2 · see citing works

Особенности сахароснижающей фармакотерапии у пациентов с SARS-CoV-2 (COVID-19)
Кухнина, Л. С., Сахарова, К. В., & Elina, D. (2021) · ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ · doi:10.18411/lj-04-2021-51
ОПЫТ ИССЛЕДОВАНИЯ СЕРОПРЕВАЛЕНТНОСТИ К ВИРУСУ SARS-CoV-2 НАСЕЛЕНИЯ ИРКУТСКОЙ ОБЛАСТИ В ПЕРИОД ВСПЫШКИ COVID-19Preprint
Popova, A. Y., Ezhlova, E. B., Melnikova, A. A., Балахонов, С. В., Chesnokova, M. V., Dubrovina, V. I., Лялина, Л., Смирнов, В. С., Ag, T., Николаевич, П. А., et al. (2020) · doi:10.21055/preprints-3111809 · Cited by 2 · see citing works
Chilblain‐like lesions after BNT162b2 mRNA COVID‐19 vaccine: a case report suggesting that ‘COVID toes’ are due to the immune reaction to SARS‐CoV‐2
Lesort, C., Kanitakis, J., Donzier, L., et al. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17451 · Cited by 25 · see citing works
Спонтанний пневмоторакс у хворих на нову коронавірусну хворобу SARS-CoV-2 COVID-19
Горолюк, А. Ю. (2022) · Шпитальна хірургія Журнал імені Л Я Ковальчука · doi:10.11603/2414-4533.2022.1.12929
The Covid‐19 Pandemic Highlights Key Roles for Economists La pandémie de Covid‐19 met en évidence les rôles importants des économistes Die Covid‐19‐Pandemie unterstreicht die Schlüsselrolle von Ökonominnen und Ökonomen
Davis, J. S. (2020) · EuroChoices

Authors: Warkentin, T. E., & Kaatz, S.
Affiliations: Hamilton General Hospital (CA)
Henry Ford Hospital (US)
Corresponding author: Warkentin, Theodore E.
ORCID: Warkentin, Theodore E.
Kaatz, Scott
Venue: Thrombosis Research
Publisher: Elsevier BV
Published: 2020-12
Volume: 196
Pages: 38-51
ISSN: 0049-3848 (ISSN-L)
DOI: 10.1016/j.thromres.2020.08.017
PMC: PMC7416717
OpenAlex: W3048096829
Cited by: 57
References: 132
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 15 · 2021: 22 · 2020: 4
FWCI: 2.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Thrombosis Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Janssen Canada
Bristol-Myers Squibb Canada
Topics: Health Sciences › Medicine › Surgery › Heparin-Induced Thrombocytopenia and Thrombosis
Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Keywords: COVID-19 pandemic, heparin-induced thrombocytopenia, hypercoagulability, thrombosis, deep vein thrombosis, pulmonary embolism, disseminated intravascular coagulation, thromboprophylaxis, heparin, anticoagulation, SARS-CoV-2, intensive care unit patients, thrombocytopenia
MeSH terms: COVID-19, SARS-CoV-2, Disseminated Intravascular Coagulation, Heparin, Humans, Thrombocytopenia, Thrombosis, Thrombophilia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

COVID-19 versus HIT hypercoagulability

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks