Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China
Open accessPublished version of a preprint
Abstract
Background: In December 2019, coronavirus disease 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described. We described the clinical courses and prognosis in COVID-19 patients. Methods: Retrospective case series of COVID-19 patients from Zhongnan Hospital of Wuhan University in Wuhan and Xishui Hospital, Hubei Province, China, up to February 10, 2020. Epidemiological, demographic, and clinical data were collected. The clinical course of survivors and non-survivors were compared. Risk factors for death were analyzed. Results: A total of 107 discharged patients with COVID-19 were enrolled. The clinical course of COVID-19 presented as a tri-phasic pattern. Week 1 after illness onset was characterized by fever, cough, dyspnea, lymphopenia, and radiological multi-lobar pulmonary infiltrates. In severe cases, thrombocytopenia, acute kidney injury, acute myocardial injury, and adult respiratory distress syndrome were observed. During week 2, in mild cases, fever, cough, and systemic symptoms began to resolve and platelet count rose to normal range, but lymphopenia persisted. In severe cases, leukocytosis, neutrophilia, and deteriorating multi-organ dysfunction were dominant. By week 3, mild cases had clinically resolved except for lymphopenia. However, severe cases showed persistent lymphopenia, severe acute respiratory dyspnea syndrome, refractory shock, anuric acute kidney injury, coagulopathy, thrombocytopenia, and death. Older age and male sex were independent risk factors for poor outcome of the illness. Conclusions: A period of 7–13 days after illness onset is the critical stage in the COVID-19 course. Age and male gender were independent risk factors for death of COVID-19.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A review of 107 patients with COVID-19 showed that 7 to 13 days after illness onset is a critical stage in this disease.
“A review of 107 patients with COVID-19 showed that 7 to 13 days after illness onset is a critical stage in this disease (67).”
From Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 (2021) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Epidemiological and clinical features of the 2019 novel coronavirus outbreak in ChinaPreprint
Yang, Y., Lu, Q., Liu, M., Wang, Y.-X., Zhang, A., Jalali, N., Dean, N. E., Longini, I. M., Halloran, M. E., Xu, B., et al. (2020) · medRxiv · doi:10.1101/2020.02.10.20021675 · Cited by 523 · see citing works
Self-citationRetractedClinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works
A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244 · see citing works
Self-citationZhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969 · see citing works
Self-citationChen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415 · see citing works
Self-citationWang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148 · see citing works
Self-citationLa certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463 · see citing works
Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575 · see citing works
Self-citationLu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30251-8 · Cited by 11,907 · see citing works
Self-citationChen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works
Self-citationAcute Respiratory Distress Syndrome
Ards Definition Task Force (2012) · JAMA · doi:10.1001/jama.2012.5669 · Cited by 8,806 · see citing works
Chan, J., Yuan, S.-F., Kok, K.-H., To, K., Chu, H., Yang, J., Xing, F., Liu, J.-L., Yip, C., Poon, R., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30154-9 · Cited by 8,450 · see citing works
Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Hú, Z., Zhong, W., & Xiao, G. (2020) · Cell Research · doi:10.1038/s41422-020-0282-0 · Cited by 6,967 · see citing works
First case of 2019 novel coronavirus in the United States
Holshue, M. L., DeBolt, C., Lindquist, S., Lofy, K. H., Wiesman, J., Bruce, H., Spitters, C., Ericson, K., Wilkerson, S., Tural, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001191 · Cited by 6,030 · see citing works
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677 · see citing works
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
Cao, B., Wang, Y., Wen, D., Liu, W., Wang, J., Fan, G., Ruan, L., Song, B., Cai, Y., Wei, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001282 · Cited by 5,187 · see citing works
Self-citation(2012) · Kidney International Supplements · doi:10.1038/kisup.2012.1 · Cited by 4,326 · see citing works
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany
Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Thiel, V., Jänke, C., Guggemos, W., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001468 · Cited by 4,143 · see citing works
Letko, M., Marzi, A., & Munster, V. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0688-y · Cited by 3,109 · see citing works
Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam
Lan, P. T., Nguyễn, T. V., Lương, Q. C., Nguyen, T. V., Nguyen, H. T., Le, H. Q., Nguyen, T. T., Cao, T. M., & Pham, Q. D. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001272 · Cited by 1,139 · see citing works
Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2
Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., & Zuo, W. (2020) · doi:10.1101/2020.01.26.919985 · Cited by 860 · see citing works
Zhang, H., Kang, Z., Gong, H., Xu, D., Wang, J., Li, Z., Cui, X., Xiao, J., Meng, T., Zhou, W., et al. (2020) · doi:10.1101/2020.01.30.927806 · Cited by 658 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [16]Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury Kidney Int Suppl 2012; 2:1.
Cited by
Sorted by citations
Risk factors for severe and critically ill COVID‐19 patients: A review
Gao, Y., Ding, M., Dong, X., Zhang, J., Azkur, A. K., Azkur, D., Gan, H. K., Sun, Y., Fu, W., Li, W., et al. (2020) · Allergy · doi:10.1111/all.14657 · Cited by 1,399 · see citing works
Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis
Langford, B. J., So, M., Raybardhan, S., Leung, V., Soucy, J.-P. R., Westwood, D. J., Daneman, N., & MacFadden, D. R. (2021) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.12.018 · Cited by 902 · see citing works
Izcovich, A., Ragusa, M. A., Tortosa, F. G., Marzio, M. A. L., Agnoletti, C., Bengolea, A., Ceirano, A., Espinosa, F., Saavedra, E., Sanguine, V., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241955 · Cited by 658 · see citing works
Booth, A., Reed, A. B., Ponzo, S., Yassaee, A., Aral, M., Plans, D., Labrique, A. B., & Mohan, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247461 · Cited by 553 · see citing works
The unique characteristics of COVID-19 coagulopathy
Iba, T., Levy, J. H., Connors, J. M., Warkentin, T. E., Thachil, J. V., & Levi, M. M. (2020) · Critical Care · doi:10.1186/s13054-020-03077-0 · Cited by 540 · see citing works
Biomarkers in COVID-19: An Up-To-Date Review
Samprathi, M., & Jayashree, M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2020.607647 · Cited by 297 · see citing works
Leung, J. M., Niikura, M., Yang, C. W. T., & Sin, D. D. (2020) · European Respiratory Journal · doi:10.1183/13993003.02108-2020 · Cited by 286 · see citing works
Hasan, S. S., Capstick, T., Ahmed, R., Kow, C. S., Mazhar, F., Merchant, H. A., & Zaidi, S. T. R. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1804365 · Cited by 283 · see citing works
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 283 · see citing works
Outcomes for Patients With COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis
Robbins-Juarez, S. Y., Qian, L., King, K. L., Stevens, J. S., Husain, S. A., Radhakrishnan, J., & Mohan, S. (2020) · Kidney International Reports · doi:10.1016/j.ekir.2020.06.013 · Cited by 264 · see citing works
D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237 · see citing works
Cutaneous signs in COVID ‐19 patients: A review
Wollina, U., Karadağ, A. S., Rowland‐Payne, C., Chiriac, A. E., & Lotti, T. (2020) · Dermatologic Therapy · doi:10.1111/dth.13549 · Cited by 231 · see citing works
Starke, K. R., Petereit-Haack, G., Schubert, M., Kämpf, D., Schliebner, A., Hegewald, J., & Seidler, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165974 · Cited by 230 · see citing works
Treskova, M., Haas, L., Reda, S. A., Pilic, A., Borodova, A., Karimi, K., Koch, J., Nygren, T. M., Scholz, S. M., Schönfeld, V., et al. (2021) · BMC Medicine · doi:10.1186/s12916-021-02058-6 · Cited by 219 · see citing works
Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions
Favas, T. T., Dev, P., Chaurasia, R. N., Chakravarty, K., Mishra, R., Joshi, D., Mishra, V. N., Kumar, A., Singh, V. K., Pandey, M., et al. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04801-y · Cited by 211 · see citing works
Renal complications in COVID-19: a systematic review and meta-analysis
Kunutsor, S. K., & Laukkanen, J. A. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1790643 · Cited by 209 · see citing works
Prevalence and impact of acute renal impairment on COVID-19: a systematic review and meta-analysis
Yang, X., Jin, Y., Li, R., Zhang, Z., Sun, R., & Chen, D. (2020) · Critical Care · doi:10.1186/s13054-020-03065-4 · Cited by 198 · see citing works
Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy
Chedid, M., Waked, R., Haddad, É., Chetata, N., Saliba, G., & Choucair, J. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.02.001 · Cited by 182 · see citing works
Impact of Corticosteroids in Coronavirus Disease 2019 Outcomes
Cevallos, E. C., Fuentes, X. F., Campioli, C. C., O’Horo, J. C., Saleh, O. A., Odeyemi, Y., Yadav, H., & Temesgen, Z. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.10.054 · Cited by 172 · see citing works
Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis
Hessami, A., Shamshirian, A., Heydari, K., Pourali, F., Alizadeh‐Navaei, R., Moosazadeh, M., Abrotan, S., Shojaie, L., Sedighi, S., Shamshirian, D., et al. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.10.022 · Cited by 179 · see citing works
Chidambaram, V., Tun, N. L., Haque, W. Z., Majella, M. G., Sivakumar, R. K., Kumar, A., Hsu, A. T., Ishak, I. A., Nur, A. A., Ayeh, S. K., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241541 · Cited by 176 · see citing works
Incidence of acute kidney injury in COVID-19 infection: a systematic review and meta-analysis
Chen, Y.-T., Shao, S., Hsu, C.-K., Wu, I., Hung, M., & Chen, Y. (2020) · Critical Care · doi:10.1186/s13054-020-03009-y · Cited by 157 · see citing works
Du, Y., Zhou, N., Zha, W., & Lv, Y. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.12.009 · Cited by 153 · see citing works
COVID-19 and its cardiovascular effects: a systematic review of prevalence studies
Pellicori, P., Doolub, G., Wong, C. M., Lee, K. S., Mangion, K., Ahmad, M., Berry, C., Squire, I. B., Lambiase, P. D., Lyon, A. R., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013879 · Cited by 147 · see citing works
Clinical and laboratory features of COVID-19: Predictors of severe prognosis
Baştuğ, A., Bodur, H., Erdoğan, S., Gökçınar, D., Kazancıoğlu, S., Kosovalı, B. D., Özbay, B. O., Gök, G., Turan, İ. Ö., Yılmaz, G., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106950 · Cited by 143 · see citing works
Clinical course and outcomes of critically ill patients with COVID-19 infection: a systematic review
Serafim, R. B., Póvoa, P. M. S. R., de Souza-Dantas, V. C., Kalil, A. C., & Salluh, J. I. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.10.017 · Cited by 137 · see citing works
Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury
Andargie, T. E., Tsuji, T., Seifuddin, F., Jang, M. K., Yuen, P. S. T., Kong, H., Tunc, I., Singh, K., Charya, A. V., Wilkins, K. J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.147610 · Cited by 137 · see citing works
Early estimation of the risk factors for hospitalization and mortality by COVID-19 in Mexico
Carrillo-Vega, M. F., Escudero, G. S., García‐Peña, C., Gutiérrez‐Robledo, L. M., & Parra‐Rodríguez, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238905 · Cited by 123 · see citing works
Fu, E. L., Janse, R. J., de Jong, Y., van der Endt, V. H. W., Milders, J., van der Willik, E. M., de Rooij, E. N. M., Dekkers, O. M., Rotmans, J. I., & van Diepen, M. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa160 · Cited by 119 · see citing works
Shah, A., Donovan, K., McHugh, A., Pandey, M. K., Aaron, L., Bradbury, C. A., Stanworth, S. J., Alikhan, R., Kier, S. V., Maher, K., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03260-3 · Cited by 121 · see citing works
Narasaraju, T., Tang, B. M. P., i, M. H., Muller, S., Chow, V. T. K., & Radic, M. Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00870 · Cited by 114 · see citing works
Rheumatic manifestations of COVID-19: a systematic review and meta-analysis
Ciaffi, J., Melicòni, R., Ruscitti, P., Berardicurti, O., Giacomelli, R., & Ursini, F. (2020) · BMC Rheumatology · doi:10.1186/s41927-020-00165-0 · Cited by 106 · see citing works
Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States
Molnar, M. Z., Bhalla, A., Azhar, A., Tsujita, M., Talwar, M., Balaraman, V., Sodhi, A., Kadaria, D., Eason, J. D., Hayek, S. S., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16280 · Cited by 103 · see citing works
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
Ostaszewski, M., Niarakis, A., Mazein, A., Kuperstein, I., Phair, R. D., Resendiz, A. O., Singh, V., Aghamiri, S. S., Acencio, M. L., Glaab, E., et al. (2021) · Molecular Systems Biology · doi:10.15252/msb.202110387 · Cited by 100 · see citing works
Shao, M., Li, X.-M., Liu, F., Tian, T., Luo, J., & Yang, Y. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105107 · Cited by 100 · see citing works
Immunological imprint of COVID‐19 on human peripheral blood leukocyte populations
Kratzer, B., Trapin, D., Ettel, P., Körmöczi, U., Rottal, A., Tuppy, F., Feichter, M., Gattinger, P., Borochova, K., Dorofeeva, Y., et al. (2020) · Allergy · doi:10.1111/all.14647 · Cited by 97 · see citing works
Mortality in chronic kidney disease patients with COVID-19: a systematic review and meta-analysis
Cai, R., Zhang, J., Zhu, Y., Liu, L., Liu, Y., & He, Q. (2021) · International Urology and Nephrology · doi:10.1007/s11255-020-02740-3 · Cited by 99 · see citing works
Geng, J., Yu, X., Bao, H., Feng, Z., Yuan, X., Zhang, J., Chen, X., Chen, Y., Li, C., & Hao, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.588013 · Cited by 103 · see citing works
Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19
Shah, A., Frost, J. N., Aaron, L., Donovan, K., Drakesmith, H., Collaborators, McKechnie, S., & Stanworth, S. J. (2020) · Critical Care · doi:10.1186/s13054-020-03051-w · Cited by 94 · see citing works
COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-Analysis
Fabrizi, F., Alfieri, C., Cerutti, R., Lunghi, G., & Messa, P. (2020) · Pathogens · doi:10.3390/pathogens9121052 · Cited by 90 · see citing works
SARS-CoV-2 and Oral Manifestation: An Observational, Human Study
Sinjari, B., D’Ardes, D., Santilli, M., Rexhepi, I., D’Addazio, G., Carlo, P. D., Chiacchiaretta, P., Caputi, S., & Cipollone, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103218 · Cited by 89 · see citing works
Huang, C., Soleimani, J., Herasevich, S., Pinevich, Y., Pennington, K. M., Dong, Y., Pickering, B. W., & Barwise, A. K. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.10.022 · Cited by 90 · see citing works
Li, Y., Ashcroft, T., Chung, A., Dighero, I., Dozier, M., Horne, M., McSwiggan, E., Shamsuddin, A., & Nair, H. (2021) · Journal of Global Health · doi:10.7189/jogh.11.10001 · Cited by 88 · see citing works
Self-citationDu, P., Li, D., Wang, A., Shen, S., Ma, Z., & Li, X. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/6660930 · Cited by 86 · see citing works
Micco, P. D., Russo, V., Carannante, N., Imparato, M., Rodolfi, S., Cardillo, G., & Lodigiani, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051371 · Cited by 84 · see citing works
Luo, L., Fu, M., Li, Y., Hu, S., Luo, J., Chen, Z., Yu, J., Li, W., Dong, R., Yang, Y., et al. (2020) · Clinical Cardiology · doi:10.1002/clc.23465 · Cited by 84 · see citing works
Self-citationCOVID-19 gender susceptibility and outcomes: A systematic review
Lakbar, I., Paz, D. L., Mège, J., Einav, S., & Léone, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241827 · Cited by 84 · see citing works
Kastora, S. L., Patel, M., Carter, B., Delibegović, M., & Myint, P. K. (2022) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.338 · Cited by 81 · see citing works
Clinical characteristics and risk factors for mortality in hematologic patients affected by COVID‐19
Cattaneo, C. M., Daffini, R., Pagani, C., Salvetti, M., Mancini, V., Borlenghi, E., D’Adda, M., Oberti, M., Paini, A., Ciuceis, C. D., et al. (2020) · Cancer · doi:10.1002/cncr.33160 · Cited by 79 · see citing works
Shang, L., Shao, M., Guo, Q., Shi, J. H., Zhao, Y., Xiaokereti, J., & Tang, B. (2020) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.07.005 · Cited by 75 · see citing works
Liang, X., Shi, L., Wang, Y., Xiao, W., Duan, G., Yang, H., & Wang, Y. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.06.060 · Cited by 75 · see citing works
Sego, T. J., Aponte-Serrano, J. O., Gianlupi, J. F., Heaps, S. R., Breithaupt, K., Brusch, L., Crawshaw, J. R., Osborne, J. M., Quardokus, E. M., Plemper, R. K., et al. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008451 · Cited by 69 · see citing works
Thromboinflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 Patients
Chaudhary, R., Garg, J., Houghton, D. E., Murad, M. H., Kondur, A., Chaudhary, R., Wysokiński, W. E., & McBane, R. D. (2021) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2021.01.009 · Cited by 73 · see citing works
Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age
O’Brien, J. A., Du, K. Y., & Peng, C. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00734-4 · Cited by 68 · see citing works
A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results
Pecly, I. M. D., Azevedo, R. B., Muxfeldt, E. S., Botelho, B. G., de Albuquerque, G. G., Diniz, P. H. P., Silva, R., & Rodrigues, C. I. S. (2021) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2020-0204 · Cited by 75 · see citing works
Wei, Y., Zeng, W., Huang, X., Li, J., Qiu, X., Li, H., Liu, D., He, Z., Yao, W., Huang, P. C., et al. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05252-8 · Cited by 66 · see citing works
Charytan, D. M., Parnia, S., Khatri, M., Petrilli, C. M., Jones, S., Benstein, J. A., & Horwitz, L. I. (2021) · Kidney International Reports · doi:10.1016/j.ekir.2021.01.036 · Cited by 66 · see citing works
Kiss, S., Gede, N., Hegyi, P. J., Németh, D. I., Földi, M., Dembrovszky, F., Nagy, B., Juhász, M. F., Ocskay, K., Zádori, N., et al. (2020) · Medical Microbiology and Immunology · doi:10.1007/s00430-020-00696-w · Cited by 67 · see citing works
Deb, S., & Arrighi, S. (2021) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-020-00668-8 · Cited by 65 · see citing works
The Spectrum of Antibiotic Prescribing During COVID-19 Pandemic: A Systematic Literature Review
Al-Hadidi, S. H., Alhussain, H., Hadi, H. A., Johar, A.-R. A., Yassine, H. M., Thani, A. A. A., & Eltai, N. O. (2021) · Microbial Drug Resistance · doi:10.1089/mdr.2020.0619 · Cited by 66 · see citing works
Linssen, J., Ermens, A. A. M., Berrevoets, M. A. H., Seghezzi, M., Previtali, G., der Brugge, S. V. D. S., Russcher, H., Verbon, A., Gillis, J., Riedl, J., et al. (2020) · eLife · doi:10.7554/elife.63195 · Cited by 64 · see citing works
Katzenschlager, S., Zimmer, A., Gottschalk, C., Grafeneder, J., Schmitz, S., Kraker, S., Ganslmeier, M., Muth, A., Seitel, A., Maier‐Hein, L., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255154 · Cited by 58 · see citing works
A systematic meta‐analysis of immune signatures in patients with COVID‐19
Liu, K., Yang, T., Peng, X., Lv, S., Ye, X., Zhao, T., Li, J., Shao, Z., Lu, Q., Li, J., et al. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2195 · Cited by 63 · see citing works
Yang, X., Tian, S., & Guo, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107159 · Cited by 60 · see citing works
Discharge characteristics and care transitions of hospitalized patients with COVID-19
Loerinc, L. B., Scheel, A. M., Evans, S. T., Shabto, J. M., O’Keefe, G. A. D., & O’Keefe, J. B. (2020) · Healthcare · doi:10.1016/j.hjdsi.2020.100512 · Cited by 59 · see citing works
Santus, P., Tursi, F., Croce, G., Simone, C. D., Frassanito, F., Gaboardi, P., Airoldi, A., Pecis, M., Negretto, G., & Radovanovic, D. (2020) · Multidisciplinary Respiratory Medicine · doi:10.4081/mrm.2020.713 · Cited by 60 · see citing works
COVID-19 versus HIT hypercoagulability
Warkentin, T. E., & Kaatz, S. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.08.017 · Cited by 57 · see citing works
Risk factors for predicting mortality of COVID-19 patients: A systematic review and meta-analysis
Yang, L., Jin, J., Luo, W., Gan, Y., Chen, B., & Li, W. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243124 · Cited by 58 · see citing works
Predictors of the prolonged recovery period in COVID-19 patients: a cross-sectional study
SeyedAlinaghi, S., Abbasian, L., Solduzian, M., Yazdi, N. A., Jafari, F., Adibimehr, A., Farahani, A., Khaneshan, A. S., Alavijeh, P. E., Jahani, Z., et al. (2021) · European journal of medical research · doi:10.1186/s40001-021-00513-x · Cited by 58 · see citing works
Saleem, F., ALGhamdi, A. S. A.-M., Alassafi, M. O., & AlGhamdi, S. A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095099 · Cited by 57 · see citing works
Xu, Z., Tang, Y., Huang, Q., Fu, S., Li, X., Lin, B., Xu, A., & Chen, J. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02244-x · Cited by 56 · see citing works
Platelets in Coronavirus Disease 2019
Larsen, J. B., Pasalic, L., & Hvas, A. (2020) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1710006 · Cited by 54 · see citing works
The role of androgens in COVID-19
Moradi, F., Enjezab, B., & Ghadiri‐Anari, A. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.10.014 · Cited by 54 · see citing works
Li, J., Liao, X., Zhou, Y., Wang, L., Yang, H., Zhang, W., Zhang, Z., & Kang, Y. (2021) · Shock · doi:10.1097/shk.0000000000001738 · Cited by 54 · see citing works
Xiang, G., Xie, L., Chen, Z., Hao, S., Fu, C., Wu, Q., Liu, X., & Li, S. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-1278 · Cited by 53 · see citing works
Self-citationConverging pathways in pulmonary fibrosis and Covid-19 - The fibrotic link to disease severity
Wigén, J., Löfdahl, A., Bjermer, L. H., Elowsson, L., & Westergren‐Thorsson, G. (2020) · Respiratory Medicine X · doi:10.1016/j.yrmex.2020.100023 · Cited by 54 · see citing works
Novel coronavirus disease (COVID-19) pandemic: A recent mini review
Rehman, M. F. U., Fariha, C., Anwar, A., Shahzad, N., Ahmad, M., Mukhtar, S., & Haque, M. F. U. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.12.033 · Cited by 51 · see citing works
Zhang, Z., Guo, L., Huang, L., Zhang, C., Luo, R., Zeng, L., Liang, H., Li, Q., Lü, X., Wang, X., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1911 · Cited by 51 · see citing works
Self-citationAwortwe, C., & Cascorbi, I. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105250 · Cited by 50 · see citing works
Bellocchio, L., Bordea, I. R., Ballini, A., Lorusso, F., Hazballa, D., Isacco, C. G., Malcangi, G., Inchingolo, A. D., Dipalma, G., Inchingolo, F., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218049 · Cited by 50 · see citing works
Renal changes and acute kidney injury in covid-19: a systematic review
Nogueira, S. Á. R., de Oliveira, S. C. S., Carvalho, A. F., Neves, J. M. C., da Silva, L. S. V., da Silva, G. B., & Nobre, M. E. P. (2020) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.66.s2.112 · Cited by 49 · see citing works
Chen, Y.-T., Shao, S., Lai, E. C., Hung, M., & Chen, Y.-C. (2020) · Critical Care · doi:10.1186/s13054-020-03134-8 · Cited by 49 · see citing works
Diagnósticos de enfermagem para pacientes com COVID-19
Dantas, T. P., de Aguiar, C. A. D. S., Rodrigues, V. R. T., da Silva, R. R. G., da Silva, M. I. C., Sampaio, L. R. L., & Pinheiro, W. R. (2020) · Journal Health NPEPS · doi:10.30681/252610104575 · Cited by 48 · see citing works
Plasma exchange in critically ill COVID-19 patients
Morath, C. P., Weigand, M. A., Zeier, M., Speer, C., Tiwari‐Heckler, S., & Merle, U. (2020) · Critical Care · doi:10.1186/s13054-020-03171-3 · Cited by 48 · see citing works
Screening and testing for COVID ‐19 before surgery
Kovoor, J. G., Tivey, D. R., Williamson, P., Tan, L., Kopunic, H. S., Babidge, W., Collinson, T. G., Hewett, P. J., Hugh, T. J., Padbury, R. T. A., et al. (2020) · ANZ Journal of Surgery · doi:10.1111/ans.16260 · Cited by 48 · see citing works
Hachim, M. Y., Hachim, I. Y., Naeem, K., Hannawi, H., Salmi, I. A., & Hannawi, S. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.585003 · Cited by 48 · see citing works
Menon, T., Gandhi, S. A. Q., Tariq, W., Sharma, R. K., Sardar, S., Arshad, A. M., Adhikari, R., Ata, F., Kataria, S., & Singh, R. (2021) · Cureus · doi:10.7759/cureus.14279 · Cited by 48 · see citing works
Karadaş, Ö., Öztürk, B., Sonkaya, A. R., Taşdelen, B., Özge, A., & Bolay, H. (2021) · Neurological Sciences · doi:10.1007/s10072-020-04978-2 · Cited by 46 · see citing works
Incidence and Outcomes of Acute Kidney Injury in COVID-19: A Systematic Review
Raina, R., Mahajan, Z., Vasistha, P., Chakraborty, R., Mukunda, K., Tibrewal, A. O., & Neyra, J. A. (2021) · Blood Purification · doi:10.1159/000514940 · Cited by 46 · see citing works
Analysis of sex-specific risk factors and clinical outcomes in COVID-19
Jun, T. W., Nirenberg, S., Weinberger, T., Sharma, N., Pujadas, E., Cordon‐Cardo, C., Kovatch, P., & Huang, K. (2021) · Communications Medicine · doi:10.1038/s43856-021-00006-2 · Cited by 46 · see citing works
Mejia-Vilet, J. M., Córdova‐Sánchez, B. M., Fernández-Camargo, D. A., Méndez‐Pérez, R. A., Morales-Buenrostro, L. E., & Hernández‐Gilsoul, T. (2020) · Salud Pública de México · doi:10.21149/11684 · Cited by 45 · see citing works
Bels, J. L. M., van Kuijk, S. M. J., Ghossein‐Doha, C., Tijssen, F. H., van Gassel, R. J. J., Tas, J., Collaborators, M., Schnabel, R. M., Aries, M. J. H., van der Horst, I. C. C., et al. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.11.006 · Cited by 44 · see citing works
COVID-19 and acute kidney injury
Ertuğlu, L. A., Kanbay, A., Afşar, B., Afşar, R. E., & Kanbay, M. (2020) · Tuberkuloz ve Toraks · doi:10.5578/tt.70010 · Cited by 44 · see citing works
Hemostatic Changes in Patients with COVID-19: A Meta-Analysis with Meta-Regressions
Minno, M. N. D. D., Calcaterra, I. L., Lupoli, R., Storino, A., Spedicato, G. A., Maniscalco, M., Minno, A. D., & Ambrosino, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072244 · Cited by 43 · see citing works
Skibba, M. E., Drelich, A. J., Poellmann, M. J., Hong, S., & Brasier, A. R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.607689 · Cited by 42 · see citing works
Biomarkers during COVID-19: Mechanisms of Change and Implications for Patient Outcomes
Chen, C., Lin, S.-W., Shen, C., Hsieh, K., & Cheng, C. (2022) · Diagnostics · doi:10.3390/diagnostics12020509 · Cited by 41 · see citing works
Wang, B., Luo, Q., Zhang, W., Yu, S., Cheng, X., Wang, L., Chen, X., & Chen, Y. (2020) · Kidney & Blood Pressure Research · doi:10.1159/000512211 · Cited by 40 · see citing works
COVID-19 vaccines: Immune correlates and clinical outcomes
Mahrokhian, S. H., Tostanoski, L. H., Vidal, S. J., & Barouch, D. H. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2324549 · Cited by 40 · see citing works
Lung ventilation function characteristics of survivors from severe COVID-19: a prospective study
Li, X., Wang, C., Kou, S., Luo, P., Zhao, M., & Yu, K. (2020) · Critical Care · doi:10.1186/s13054-020-02992-6 · Cited by 39 · see citing works
Dalia, T., Lahan, S., Ranka, S., Acharya, P., Gautam, A. S., Goyal, A., Mastoris, I., Sauer, A. J., & Shah, Z. I. (2020) · Indian Heart Journal · doi:10.1016/j.ihj.2020.12.002 · Cited by 38 · see citing works
- Authors
- Wang, D., Yin, Y., Hu, C., Liu, X., Zhang, X., Zhou, S., Jian, M., Xu, H., Prowle, J., Hu, B., Li, Y., & Peng, Z.
- Affiliations
- Zhongnan Hospital of Wuhan University (CN)
- Barts Health NHS Trust (GB)
- Corresponding author
- Li, Yirong
- Peng, Zhiyong
- ORCID
- Venue
- Critical Care
- Published
- 2020-04-30
- Volume
- 24
- Issue
- 1
- Pages
- 188-188
- ISSN
- 1364-8535 (ISSN-L)
- PMC
- PMC7192564
- OpenAlex
- W3023796702
- Cited by
- 397
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 16 · 2023: 21 · 2022: 59 · 2021: 134 · 2020: 161
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Critical Care (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (81701941, 81772046, 81971816)
- National Major Science and Technology Projects of China (2020ZX09201007)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, SARS-CoV-2, clinical course, prognosis, mortality risk factors, lymphopenia, acute respiratory distress syndrome, acute kidney injury, thrombocytopenia, multiple organ failure, old age, male sex, Wuhan
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Age Factors, Aged, Aged, 80 and over, China, Cough, Female, Fever, Heart, Humans, Lymphopenia, Male, Middle Aged, Patient Discharge, Pneumonia, Viral, Prognosis, Respiratory Distress Syndrome, Retrospective Studies, Risk Factors, Sex Factors, Thrombocytopenia, Coronavirus Infections, Young Adult, Acute Kidney Injury, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
