Semaphorin signaling: progress made and promises ahead
Abstract
Semaphorins were initially characterized according to their role in repulsive axon guidance but are now recognized as crucial regulators of morphogenesis and homeostasis over a wide range of organ systems. The pleiotropic nature of semaphorin signaling and its implication in human disease has triggered an enormous interest in the receptor and intracellular signaling mechanisms that direct the cell-type-specific and diverse biological effects of semaphorins. Recent breakthroughs in our understanding of semaphorin signaling link integrin and semaphorin signaling pathways, identify novel ligand-receptor interactions and provide insight into the cellular and molecular bases of bifunctional and reverse signaling events. These discoveries could lead to therapeutic advances in axonal regeneration, cancer and other diseases.
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Plexin-B1 binds to class 4 semaphorins, a family with six ligands expressed in diverse cell types.
“Plexin-B1 binds to class 4 semaphorins, a family with six ligands expressed in diverse cell types17, 60.”
From Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease (2024) · cites this paper as [60]
Cites
Semaphorins and their receptors in immune cell interactions
Suzuki, K., Kumanogoh, A., & Kikutani, H. (2008) · Nature Immunology · doi:10.1038/ni1553 · Cited by 400 · see citing works
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Dynamics of the skeletal muscle secretome during myoblast differentiation
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Semaphorins in Adult Nervous System Plasticity and Disease
Carulli, D., de Winter, F., & Verhaagen, J. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.672891 · Cited by 137 · see citing works
Inhibition of CNS Remyelination by the Presence of Semaphorin 3A
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Self-citationDecision making during interneuron migration in the developing cerebral cortex
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More than nervous: The emerging roles of plexins
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“Plexin-B1 binds to class 4 semaphorins, a family with six ligands expressed in diverse cell types 17,60 .”
- Authors
- Zhou, Y., Gunput, R.-A. F., & Pasterkamp, R. J.
- Affiliations
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Pasterkamp, R. Jeroen
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 33
- Issue
- 4
- Pages
- 161-170
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1987695717
- Cited by
- 307
- References
- 1
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 13 · 2021: 15 · 2020: 15 · 2019: 21 · 2018: 14 · 2017: 11 · 2016: 19 · 2015: 24 · 2014: 20 · 2013: 23 · 2012: 28
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- semaphorins, semaphorin signaling, axon guidance, integrin signaling, ligand-receptor interactions, reverse signaling, morphogenesis, homeostasis, axon regeneration, cancer, therapeutic target
- MeSH terms
- Animals, Axons, Cell Movement, Homeostasis, Humans, Ligands, Models, Biological, Neoplasms, Phosphorylation, Regeneration, Signal Transduction, Protein Structure, Tertiary, Semaphorins
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