Semaphorin signaling: progress made and promises ahead
Abstract
Semaphorins were initially characterized according to their role in repulsive axon guidance but are now recognized as crucial regulators of morphogenesis and homeostasis over a wide range of organ systems. The pleiotropic nature of semaphorin signaling and its implication in human disease has triggered an enormous interest in the receptor and intracellular signaling mechanisms that direct the cell-type-specific and diverse biological effects of semaphorins. Recent breakthroughs in our understanding of semaphorin signaling link integrin and semaphorin signaling pathways, identify novel ligand-receptor interactions and provide insight into the cellular and molecular bases of bifunctional and reverse signaling events. These discoveries could lead to therapeutic advances in axonal regeneration, cancer and other diseases.
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Plexin-B1 binds to class 4 semaphorins, a family with six ligands expressed in diverse cell types.
“Plexin-B1 binds to class 4 semaphorins, a family with six ligands expressed in diverse cell types17, 60.”
From Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease (2024) · cites this paper as [60]
Cites
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Inhibition of CNS Remyelination by the Presence of Semaphorin 3A
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“Plexin-B1 binds to class 4 semaphorins, a family with six ligands expressed in diverse cell types 17,60 .”
- Authors
- Zhou, Y., Gunput, R.-A. F., & Pasterkamp, R. J.
- Affiliations
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Pasterkamp, R. Jeroen
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 33
- Issue
- 4
- Pages
- 161-170
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1987695717
- Cited by
- 307
- References
- 1
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 13 · 2021: 15 · 2020: 15 · 2019: 21 · 2018: 14 · 2017: 11 · 2016: 19 · 2015: 24 · 2014: 20 · 2013: 23 · 2012: 28
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- semaphorins, semaphorin signaling, axon guidance, integrin signaling, ligand-receptor interactions, reverse signaling, morphogenesis, homeostasis, axon regeneration, cancer, therapeutic target
- MeSH terms
- Animals, Axons, Cell Movement, Homeostasis, Humans, Ligands, Models, Biological, Neoplasms, Phosphorylation, Regeneration, Signal Transduction, Protein Structure, Tertiary, Semaphorins
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