Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis
Open accessAbstract
Endometriosis, defined as the presence of endometrial tissue outside the uterus, is a common gynecological disease with poorly understood pathogenesis. MicroRNAs are members of a class of small noncoding RNA molecules that have a critical role in posttranscriptional regulation of gene expression by repression of target mRNAs translation. We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium in 3 patients through microarray analysis. We identified 50 microRNAs differentially expressed and the differential expression of five microRNAs was validated by real-time RT-PCR in other 13 patients. We identified in silico their predicted targets, several of which match the genes that have been identified to be differentially expressed in ectopic versus eutopic endometrium in studies of gene expression. A functional analysis of the predicted targets indicates that several of these are involved in molecular pathways implicated in endometriosis, thus strengthening the hypothesis of the role of microRNAs in this pathology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups.
“Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups [120–124].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [122]
Ovarian endometriosis evidenced differential expression of miRNAs relative to paired eutopic endometrium in several studies.
“Similar to peritoneal disease, ovarian endometriosis evidenced differential expression of miRNAs relative to paired eutopic endometrium in several studies [122, 123].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Pan, Q., Luo, X., Toloubeydokhti, T., & Chegini, N. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam063 · Cited by 261 · see citing works
RetractedThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,185 · see citing works
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,592 · see citing works
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755 · see citing works
Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515 · see citing works
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852 · see citing works
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018 · see citing works
Brennecke, J., Hipfner, D. R., Stark, A., Russell, R. B., & Cohen, S. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00231-9 · Cited by 1,721 · see citing works
Fabbri, M., Garzon, R., Cimmino, A., Liu, Z., Zanesi, N. A. O., Callegari, E., Liu, S., Alder, H., Costinean, S., Fernandez-Cymering, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707628104 · Cited by 1,676 · see citing works
A systems biology approach for pathway level analysisPreprint
Drăghici, S., Khatri, P., Tarca, A. L., Amin, K., Done, A., Voichiţa, C., Georgescu, C., & Romero, R. J. (2007) · Genome Research · doi:10.1101/gr.6202607 · Cited by 1,250 · see citing works
The microRNAs of <i>Caenorhabditis elegans</i>
Lim, L. P., Lau, N. C., Weinstein, E. G., Abdelhakim, A., Yekta, S., Rhoades, M. W., Burge, C. B., & Bartel, D. P. (2003) · Genes & Development · doi:10.1101/gad.1074403 · Cited by 1,007 · see citing works
The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism
Xu, P., Vernooy, S. Y., Guo, M., & Hay, B. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00250-1 · Cited by 1,006 · see citing works
MicroRNA expression and function in cancer
Garzon, R., Fabbri, M., Cimmino, A., Calin, G. A., & Croce, C. M. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.006 · Cited by 782 · see citing works
Burney, R. O., Talbi, S., Hamilton, A. E., Vo, K. C., Nyegaard, M., Nezhat, C. R., Lessey, B. A., & Giudice, L. C. (2007) · Endocrinology · doi:10.1210/en.2006-1692 · Cited by 735 · see citing works
Computational identification of DrosophilamicroRNA genes
Lai, E. C., Tomančák, P., Williams, R. W., & Rubin, G. M. (2003) · Genome biology · doi:10.1186/gb-2003-4-7-r42 · Cited by 723 · see citing works
miR-148 targets human DNMT3b protein coding region
Duursma, A. M., Kedde, M., Schrier, M., le Sage, C., & Agami, R. (2008) · RNA · doi:10.1261/rna.972008 · Cited by 578 · see citing works
Pan, W. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.4.546 · Cited by 522 · see citing works
miRNAs and apoptosis: RNAs to die for
Jovanović, M., & Hengartner, M. O. (2006) · Oncogene · doi:10.1038/sj.onc.1209912 · Cited by 503 · see citing works
Heritable aspects of endometriosis
Simpson, J. L., Elias, S., Malinak, L. R., & Buttram, V. C. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90917-5 · Cited by 468 · see citing works
Principles and effects of microRNA-mediated post-transcriptional gene regulation
Engels, B., & Hutvágner, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209909 · Cited by 410 · see citing works
<i>Stem Cells and the Pathogenesis of Endometriosis</i>
Sasson, I. E., & Taylor, H. S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1434.014 · Cited by 371 · see citing works
MicroRNA-regulated pathways associated with endometriosis
Ohlsson Teague, E. M. C., Van der Hoek, K. H., Van der Hoek, M. B., Perry, N., Wagaarachchi, P., Robertson, S. A., Print, C. G., & Hull, L. M. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0387 · Cited by 357 · see citing works
Peritoneal fluid cell populations in infertility patients
Haney, A. F., Muscato, J. J., & Weinberg, J. B. (1981) · Fertility and Sterility · doi:10.1016/s0015-0282(16)45567-6 · Cited by 336 · see citing works
Semaphorin signaling: progress made and promises ahead
Zhou, Y., Gunput, R.-A. F., & Pasterkamp, R. J. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.01.006 · Cited by 307 · see citing works
Deficient cellular immunity in endometriosis
Dmowski, W. P., Steele, R. W., & Baker, G. F. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90598-6 · Cited by 302 · see citing works
Numerous microRNPs in neuronal cells containing novel microRNAs
DOSTIE, J., MOURELATOS, Z., YANG, M., SHARMA, A., & DREYFUSS, G. (2003) · RNA · doi:10.1261/rna.2141503 · Cited by 285 · see citing works
Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis
Rana, N., Braun, D. P., House, R., Gebel, H., Rotman, C., & Dmowski, W. P. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58262-4 · Cited by 264 · see citing works
The familial risk of endometriosis
Moen, M. H., & Magnus, P. (1993) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016349309058164 · Cited by 248 · see citing works
Khatri, P., Bhavsar, P., Bawa, G., & Drăghici, S. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh409 · Cited by 218 · see citing works
In situ synthesis of oligonucleotide microarrays
Gao, X., Gülari, E., & Zhou, X. (2004) · Biopolymers · doi:10.1002/bip.20005 · Cited by 208 · see citing works
Transcriptional characterizations of differences between eutopic and ectopic endometrium
Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W. (2006) · Endocrinology · doi:10.1210/en.2005-0426 · Cited by 208 · see citing works
Endometrial epithelial cells in peritoneal fluid during the early follicular phase
Kruitwagen, R. F. P. M., Poels, L. G., Willemsen, W. N. P., de Ronde, I. J. Y., Jap, P. H. K., & Rolland, R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54119-3 · Cited by 199 · see citing works
Wu, Y., Strawn, E., Basir, Z., Halverson, G., & Guo, S.-W. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.077 · Cited by 193 · see citing works
Eyster, K. M., Klinkova, O. V., Kennedy, V., & Hansen, K. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.056 · Cited by 192 · see citing works
Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment
Hull, M. L., Rangel‐Escareño, C., Godsland, J. M., Doig, J. R., Johnson, C. M., Phillips, S. C., Smith, S. K., Tavaré, S., Print, C. G., & Jones, D. S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071128 · Cited by 174 · see citing works
Antsiferova, Y. S., Sotnikova, N. Y., Посисеева, Л. В., & Shor, A. L. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.05.066 · Cited by 155 · see citing works
Matsuzaki, S., Canis, M. J., Vaurs‐Barrière, C., Boespflug‐Tanguy, O., Dastugue, B., & Mage, G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.041 · Cited by 151 · see citing works
Kyama, C. M., Overbergh, L., Debrock, S., Valckx, D., Perre, S. V., Meuleman, C., Mihalyi, A., Mwenda, J. M., Mathieu, C., & D’Hooghe, T. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.11.060 · Cited by 146 · see citing works
Tsudo, T., Harada, T., Iwabe, T., Tanikawa, M., Nagano, Y., Ito, M., Taniguchi, F., & Terakawa, N. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00496-3 · Cited by 124 · see citing works
Differentially expressed genes in eutopic and ectopic endometrium of women with endometriosis
Meola, J., Silva, J. C. R. E., Dentillo, D. B., Silva, W. A., Veiga-Castelli, L. C., Bernardes, L. Â. D. S., Ferriani, R. A., de Paz, C. C. P., Giuliatti, S., & Martelli, L. R. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.12.058 · Cited by 120 · see citing works
Kennedy, S. (1999) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(98)00213-9 · Cited by 110 · see citing works
Familial inheritance of endometriosis in a British population. A case control study
Coxhead, D., & Thomas, E. J. (1993) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443619309151773 · Cited by 97 · see citing works
Altered interleukin-6 production by peritoneal leukocytes from patients with endometriosis
Rier, S. E., Parsons, A. K., & Becker, J. L. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56520-0 · Cited by 88 · see citing works
Honda, H., Barrueto, F. F., Gogusev, J., Im, D. D., & Morin, P. J. (2008) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-6-59 · Cited by 84 · see citing works
μParaflo™ Biochip for Nucleic Acid and Protein Analysis
Zhu, Q., Hong, A., Sheng, N., Zhang, X., Matejko, A. A., Jun, K.-Y., Srivannavit, O., Gülari, E., Gao, X., & Zhou, X. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-304-2_19 · Cited by 78 · see citing works
Autoreactivity in women with endometriosis
Taylor, P. V., MALONEY, M. D., Campbell, J. M., SKERROW, S. M., NIP, M. M. C., Parmar, R., & TATE, G. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13455.x · Cited by 77 · see citing works
Age of onset of pain symptoms in non-twin sisters concordant for endometriosis
Kennedy, S., Hadfield, R., Mardon, H., & Barlow, D. (1996) · Human Reproduction · doi:10.1093/humrep/11.2.403 · Cited by 63 · see citing works
Badawy, S. Z. A., Cuenca, V., Freliech, H., & STEFANU, C. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53534-1 · Cited by 63 · see citing works
Increased Immunoreactivity to SLIT/ROBO1 in Ovarian Endometriomas
Shen, F., Liu, X., Geng, J.-G., & Guo, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090024 · Cited by 62 · see citing works
Hu, W.-P., Tay, S. K., & Zhao, Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1594 · Cited by 57 · see citing works
Responsiveness of Human Endometrial Stromal Cells to Cytokinesa
Semer, D. A., REISLER, K., MacDonald, P. C., & Casey, M. L. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb37854.x · Cited by 53 · see citing works
Magnetic resonance imaging to assess familial risk in relatives of women with endometriosis
Kennedy, S., Hadfield, R., Westbrook, C., Weeks, D. E., Barlow, D., & Golding, S. (1998) · The Lancet · doi:10.1016/s0140-6736(05)61262-7 · Cited by 49 · see citing works
Affected sib-pair analysis in endometriosis
Kennedy, S., Bennett, S. T., & Weeks, D. E. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.4.411 · Cited by 45 · see citing works
In vitro lymphocyte activity in women with endometriosis—an altered immune response?
Gilmore, S. M., Aksel, S., Hoff, C. J., & Peterson, R. D. A. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55560-5 · Cited by 42 · see citing works
The pattern of cytokine mRNA expression in ovarian endometriomata
Odukoya, O. A. (1997) · Molecular Human Reproduction · doi:10.1093/molehr/3.5.393 · Cited by 39 · see citing works
FOXO1 and c-jun transcription factors mRNA are modulated in endometriosis
Shazand, K., Baban, S., Privé, C., Malette, B., Croteau, P., Lagacé, M., Racine, J.-B., & Hugo, P. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah119 · Cited by 35 · see citing works
Interleukin-1 inhibits growth of normal human endometrial stromal cells.
Van Le, L., St, O., Ja, A., Ca, R., & Halme, J. K. (1992) · PubMed · Cited by 27 · see citing works
Kharfi, A., Labelle, Y., Mailloux, J. R., & Akoum, A. (2003) · American Journal of Reproductive Immunology · doi:10.1034/j.1600-0897.2003.00058.x · Cited by 24 · see citing works
Genetics and infertility II Affected sib-pair analysis in endometriosis
Kennedy, S., & Bennett, S. T. (2001) · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [33]Dostie J Mourelatos Z Yang M Sharma A Dreyfuss G Erratum: numerous microRNPs in neuronal cells containing novel microRNAs RNA 2003 9 5 631 632 PMC1370383 12554860
Cited by
Sorted by citations
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights
Laganà, A. S., Garzon, S., Götte, M., Viganò, P., Franchi, M. P., Ghezzi, F., & Martin, D. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225615 · Cited by 492 · see citing works
Functional MicroRNA Involved in Endometriosis
Hawkins, S. M., Creighton, C. J., Han, D. Y., Zariff, A., Anderson, M. L., Gunaratne, P. H., & Matzuk, M. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0371 · Cited by 264 · see citing works
Endometriosis and nuclear receptors
Yilmaz, B. D., & Bulun, S. E. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz005 · Cited by 243 · see citing works
Update on biomarkers for the detection of endometriosis
Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L. (2015) · BioMed Research International · doi:10.1155/2015/130854 · Cited by 195 · see citing works
“Similar to peritoneal disease, ovarian endometriosis evidenced differential expression of miRNAs relative to paired eutopic endometrium in several studies [122, 123].”
Wang, W.-T., Zhao, Y.-N., Han, B.-W., Hong, S.-J., & Chen, Y.-Q. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2415 · Cited by 193 · see citing works
Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis
Jia, S.-Z., Yang, Y., Lang, J., Sun, P., & Leng, J. (2013) · Human Reproduction · doi:10.1093/humrep/des413 · Cited by 172 · see citing works
MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors
Braza-Boïls, A., Marí-Alexandre, J., Gilabert, J., Sánchez-Izquierdo, D., España, F., Estellés, A., & Gilabert-Estellés, J. (2014) · Human Reproduction · doi:10.1093/humrep/deu019 · Cited by 164 · see citing works
Recent insights on the genetics and epigenetics of endometriosis
Borghese, B., Zondervan, K. T., Abrão, M. S., Chapron, C., & Vaiman, D. (2016) · Clinical Genetics · doi:10.1111/cge.12897 · Cited by 162 · see citing works
Cyclooxygenase-2 in Endometriosis
Lai, Z., Yang, H., Ha, S., Chang, K., Mei, J., Zhou, W.-J., Qiu, X., Wang, X.-Q., Zhu, R., Li, D., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.35128 · Cited by 165 · see citing works
Hsu, C., Hsieh, T., Tsai, C., Tsai, H., Chen, H., Chang, Y., Chuang, H., Lee, J.-N., Hsu, Y., & Tsai, E. (2013) · The Journal of Pathology · doi:10.1002/path.4295 · Cited by 157 · see citing works
Non-coding RNAs in endometriosis: a narrative review
Panir, K., Schjenken, J. E., Robertson, S. A., & Hull, M. L. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy014 · Cited by 151 · see citing works
Fassbender, A., Vodolazkaia, A., Saunders, P., Lebovic, D., Waelkens, E., De Moor, B., & D'Hooghe, T. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.01.097 · Cited by 150 · see citing works
Lin, S., Wang, C.-C., Wu, M., Yang, S., Li, Y.-H., & Tsai, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1450 · Cited by 131 · see citing works
MicroRNAs in endometriosis: biological function and emerging biomarker candidates†
Bjorkman, S. H., & Taylor, H. S. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz014 · Cited by 129 · see citing works
MicroRNA and gynecological reproductive diseases
Santamaría, X., & Taylor, H. S. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.04.044 · Cited by 124 · see citing works
Rekker, K., Saare, M., Roost, A. M., Kaart, T., Sõritsa, D., Karro, H., Sõritsa, A., Simón, C., Salumets, A., & Peters, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.06.029 · Cited by 118 · see citing works
microRNAs expression in endometriosis and their relation to angiogenic factors
Ramon, L. A., Braza-Boils, A., Gilabert-Estelles, J., Gilabert, J., Espana, F., Chirivella, M., & Estelles, A. (2011) · Human Reproduction · doi:10.1093/humrep/der025 · Cited by 117 · see citing works
Abe, W., Nasu, K., Nakada, C., Kawano, Y., Moriyama, M., & Narahara, H. (2013) · Human Reproduction · doi:10.1093/humrep/des446 · Cited by 114 · see citing works
Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis
Zhang, L., Li, H., Yuan, M., Li, D., Chang, S., & Wang, G. (2020) · Disease Markers · doi:10.1155/2020/2456340 · Cited by 113 · see citing works
Adammek, M., Greve, B., Kässens, N., Schneider, C., Brüggemann, K., Schüring, A. N., Starzinski‐Powitz, A., Kiesel, L., & Götte, M. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.11.055 · Cited by 107 · see citing works
Non-Coding RNAs in Endometrial Physiopathology
Ferlita, A. L., Battaglia, R., Andronico, F., Caruso, S., Cianci, A., Purrello, M., & Pietro, C. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072120 · Cited by 103 · see citing works
Nanoparticles in pregnancy: the next frontier in reproductive therapeutics
Pritchard, N., Kaitu’u‐Lino, T. J., Harris, L. K., Tong, S., & Hannan, N. J. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa049 · Cited by 101 · see citing works
Dai, L., Gu, L., & Di, W. J. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar066 · Cited by 99 · see citing works
MicroRNA signatures differentiate uterine cancer tumor subtypes
Ratner, E., Tuck, D. P., Richter, C. E., Nallur, S. V., Patel, R., Schultz, V., Hui, P., Schwartz, P. E., Rutherford, T., & Weidhaas, J. B. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.05.010 · Cited by 93 · see citing works
Analysis of Serum microRNA Profile by Solexa Sequencing in Women With Endometriosis
Wang, L., Huang, W., Ren, C., Zhao, M., Jiang, X., Fang, X., & Xia, X. (2016) · Reproductive Sciences · doi:10.1177/1933719116641761 · Cited by 89 · see citing works
Eggers, J. C., Martino, V., Reinbold, R. A., Schäfer, S. D., Kiesel, L., Starzinski‐Powitz, A., Schüring, A. N., Kemper, B., Greve, B., & Götte, M. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.12.013 · Cited by 88 · see citing works
Hirakawa, T., Nasu, K., Abe, W., Aoyagi, Y., Okamoto, M., Kai, K., Takebayashi, K., & Narahara, H. (2016) · Human Reproduction · doi:10.1093/humrep/dew217 · Cited by 87 · see citing works
Panda, H., Pelakh, L., Chuang, T., Luo, X., Bükülmez, O., & Chegini, N. (2012) · Reproductive Sciences · doi:10.1177/1933719112438448 · Cited by 86 · see citing works
Zhao, L., Gu, C., Ye, M., Zhang, Z., Li, L., Fan, W., & Meng, Y. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-017-0319-5 · Cited by 84 · see citing works
New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments
Brichant, G., Laraki, I., Henry, L., Munaut, C., & Nisolle, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910498 · Cited by 85 · see citing works
Bakhtiarizadeh, M. R., Hosseinpour, B., Shahhoseini, M., Korte, A., & Gifani, P. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00453 · Cited by 78 · see citing works
Challenges in endometriosis miRNA studies — From tissue heterogeneity to disease specific miRNAs
Saare, M., Rekker, K., Laisk, T., Rahmioğlu, N., Zondervan, K. T., Salumets, A., Götte, M., & Peters, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.06.018 · Cited by 76 · see citing works
Okamoto, M., Nasu, K., Abe, W., Aoyagi, Y., Kawano, Y., Kai, K., Moriyama, M., & Narahara, H. (2014) · Human Reproduction · doi:10.1093/humrep/deu332 · Cited by 73 · see citing works
miRNAs Regulation and Its Role as Biomarkers in Endometriosis
Marí‐Alexandre, J., Sánchez-Izquierdo, D., Gilabert–Estellés, J., Barceló‐Molina, M., Braza‐Boïls, A., & Sandoval, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010093 · Cited by 71 · see citing works
Tissue and circulating microRNA influence reproductive function in endometrial disease
Louise Hull, M., & Nisenblat, V. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.07.012 · Cited by 69 · see citing works
MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis
Nothnick, W. B. (2017) · Seminars in Reproductive Medicine · doi:10.1055/s-0037-1599089 · Cited by 69 · see citing works
Wu, J., Huang, H., Huang, W. J., Wang, L., Xia, X., & Fang, X. (2020) · Epigenomics · doi:10.2217/epi-2020-0084 · Cited by 68 · see citing works
Nothnick, W. B., Falcone, T., Joshi, N., Fazleabas, A. T., & Graham, A. R. (2016) · Reproductive Sciences · doi:10.1177/1933719116681519 · Cited by 68 · see citing works
Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer
Neto, J. S., Kho, R. M., Siufi, D., Baracat, E. C., Anderson, K. S., & Abrão, M. S. (2013) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2013.07.021 · Cited by 67 · see citing works
Plasma miRNAs Display Limited Potential as Diagnostic Tools for Endometriosis
Nisenblat, V., Sharkey, D. J., Wang, Z., Evans, S., Healey, M., Teague, E., Print, C. G., Robertson, S. A., & Hull, M. L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01464 · Cited by 63 · see citing works
Pateisky, P., Pils, D., Szabo, L., Kuessel, L., Husslein, H., Schmitz, A. A. P., Wenzl, R. J., & Yotova, I. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.05.007 · Cited by 61 · see citing works
Forte, A., Cipollaro, M., & Galderisi, U. (2013) · Clinical Science · doi:10.1042/cs20130099 · Cited by 63 · see citing works
Graham, A. R., Falcone, T., & Nothnick, W. B. (2015) · Human Reproduction · doi:10.1093/humrep/dev005 · Cited by 61 · see citing works
Estrogen Induces Distinct Patterns of MicroRNA Expression Within the Mouse Uterus
Nothnick, W. B., & Healy, C. (2010) · Reproductive Sciences · doi:10.1177/1933719110377472 · Cited by 59 · see citing works
Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance
Steinbuch, S. C., Lüß, A.-M., Eltrop, S., Götte, M., & Kiesel, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084306 · Cited by 63 · see citing works
Shen, L., Yang, S., Huang, W., Xu, W., Wang, Q., Song, Y., & Liu, Y. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3010 · Cited by 57 · see citing works
Lam, E. W. ‐., Shah, K., & Brosens, J. J. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0480 · Cited by 57 · see citing works
Molecular signatures of ovarian diseases: Insights from network medicine perspective
Kori, M., Göv, E., & Arğa, K. Y. (2016) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2016.1197982 · Cited by 55 · see citing works
Logan, P. C., Yango, P., & Tran, N. D. (2017) · Reproductive Sciences · doi:10.1177/1933719117704905 · Cited by 54 · see citing works
Saare, M., Rekker, K., Laisk, T., Sõritsa, D., Roost, A. M., Simm, J., Velthut‐Meikas, A., Samuel, K., Metsalu, T., Karro, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112630 · Cited by 50 · see citing works
Liu, S., Gao, S., Wang, X. Y., & Wang, D. B. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-2112-6 · Cited by 49 · see citing works
Schneider, C., Kässens, N., Greve, B., Hassan, H., Schüring, A. N., Starzinski‐Powitz, A., Kiesel, L., Seidler, D. G., & Götte, M. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.10.051 · Cited by 46 · see citing works
Yang, P., Wu, Z., Ma, C., Pan, N., Wang, Y., & Yan, L. (2018) · Reproductive Sciences · doi:10.1177/1933719118799199 · Cited by 44 · see citing works
Rekker, K., Tasa, T., Saare, M., Samuel, K., Kadastik, Ü., Karro, H., Götte, M., Salumets, A., & Peters, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123789 · Cited by 43 · see citing works
Joshi, N., Su, R., Chandramouli, G. V. R., Khoo, S. K., Jeong, J., Young, S. L., Lessey, B. A., & Fazleabas, A. T. (2015) · Human Reproduction · doi:10.1093/humrep/dev229 · Cited by 42 · see citing works
microRNAs and angiogenesis in endometriosis
Marí‐Alexandre, J., García-Oms, J., Barceló‐Molina, M., Gilabert-Aguilar, J., Estellés, A., Braza‐Boïls, A., & Gilabert–Estellés, J. (2015) · Thrombosis Research · doi:10.1016/s0049-3848(15)50439-8 · Cited by 42 · see citing works
MicroRNA expression pattern differs depending on endometriosis lesion type†
Haikalis, M. E., Wessels, J. M., Leyland, N. A., Agarwal, S. K., & Foster, W. G. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy019 · Cited by 41 · see citing works
Wu, M. Y., & Zhang, Y. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03986-2 · Cited by 39 · see citing works
Redox regulation of microRNAs in endometriosis-associated pain
Wright, K. R., Mitchell, B. L., & Santanam, N. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.037 · Cited by 38 · see citing works
Minireview: The Roles of Small RNA Pathways in Reproductive Medicine
Hawkins, S. M., Buchold, G. M., & Matzuk, M. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0099 · Cited by 37 · see citing works
Non-coding RNAs in Uterine Development, Function and Disease
Nothnick, W. B. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7417-8_9 · Cited by 37 · see citing works
Hidalgo, G. D. S., Meola, J., Silva, J. C. R. E., de Paz, C. C. P., & Ferriani, R. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.06.052 · Cited by 38 · see citing works
Mortlock, S., Houshdaran, S., Kosti, I., Rahmioğlu, N., NEZHAT, C. R., Vitonis, A. F., Andrews, S. V., Grosjean, P., Paranjpe, M. D., Horne, A. W., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05070-z · Cited by 38 · see citing works
Nothnick, W. B., Graham, A. R., Holbert, J., & Weiss, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100336 · Cited by 36 · see citing works
Monnaka, V. U., Hernandes, C., Heller, D., & Podgaec, S. (2021) · Einstein (São Paulo) · doi:10.31744/einstein_journal/2021rw5704 · Cited by 33 · see citing works
Bhattacharyya, M., & Bandyopadhyay, S. (2012) · Molecular BioSystems · doi:10.1039/c2mb25434d · Cited by 32 · see citing works
Yang, H., Hu, T., Hu, P., Qi, C., & Lin, Q. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11995 · Cited by 32 · see citing works
The differential expression of microRNA-143,145 in endometriosis.
Zheng, B., Xue, X., Zhao, Y., Chen, J., Xu, C., & Duan, P. (2014) · Europe PMC (PubMed Central) · Cited by 32 · see citing works
Wang, Y., Lv, Y., Gao, S., Zhang, Y., Sun, J., Gong, C., Chen, X., & Li, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0143116 · Cited by 31 · see citing works
Hwang, J. Y., Oh, J., Wang, T., Jin, Y., Lee, J., Choi, J.-R., LEE, K.-S., JOO, J.-K., & Lee, H. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1469 · Cited by 29 · see citing works
Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise
Nothnick, W. B., Al-Hendy, A. A., & Lue, J. (2015) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2015.02.021 · Cited by 29 · see citing works
MicroRNAs in Endometriosis: Insights into Inflammation and Progesterone Resistance
Hon, J.-X., Wahab, N. A., Karim, A., Mokhtar, N. M., & Mokhtar, M. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241915001 · Cited by 33 · see citing works
Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis
He, J., Chang, W., Feng, C., Cui, M., & Xu, T. (2018) · International Journal of Genomics · doi:10.1155/2018/1465348 · Cited by 28 · see citing works
miRNAs and lncRNAs: Potential Non-Invasive Biomarkers for Endometriosis
Maier, I. M., & Maier, A. C. (2021) · Biomedicines · doi:10.3390/biomedicines9111662 · Cited by 27 · see citing works
Aoyagi, Y., Nasu, K., Kai, K., Hirakawa, T., Okamoto, M., Kawano, Y., Abe, W., Tsukamoto, Y., Moriyama, M., & Narahara, H. (2016) · Reproductive Sciences · doi:10.1177/1933719116657894 · Cited by 27 · see citing works
Zubrzycka, A., Migdalska‐Sęk, M., Jędrzejczyk, S., & Brzeziańska‐Lasota, E. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43020064 · Cited by 26 · see citing works
TNFα-Induced Altered miRNA Expression Links to NF-κB Signaling Pathway in Endometriosis
Banerjee, S., Xu, W., Doctor, A., Driss, A., Nezhat, C., Sidell, N., Taylor, R. N., Thompson, W. E., & Chowdhury, I. (2023) · Inflammation · doi:10.1007/s10753-023-01862-x · Cited by 26 · see citing works
A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
Tsai, E., Wang, Y., Lin, C., Lin, W.-Y., Hsi, E., Wu, M., & Juo, S. H. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.1 · Cited by 26 · see citing works
Diagnostic value of the combination of circulating serum miRNAs and CA125 in endometriosis
Chen, G., Guo, J., Li, W., Zheng, R., Shang, H., & Wang, Y. (2023) · Medicine · doi:10.1097/md.0000000000036339 · Cited by 25 · see citing works
Evaluation of miR‑135a/b expression in endometriosis lesions
Petracco, R. G., Dias, A., Taylor, H. S., Petracco, �., Badalotti, M., Michelon, J., Marinowic, D. R., Hentschke, M. R., de Azevedo, P., Zanirati, G., et al. (2019) · Biomedical Reports · doi:10.3892/br.2019.1237 · Cited by 25 · see citing works
Roles of microRNAs in Regulating Apoptosis in the Pathogenesis of Endometriosis
Azam, I. N. A., Wahab, N. A., Mokhtar, M. H., Shafiee, M. N., & Mokhtar, N. M. (2022) · Life · doi:10.3390/life12091321 · Cited by 26 · see citing works
Sohler, F., Sommer, A., Wachter, D. L., Agaimy, A., Fischer, O. M., Renner, S. P., Burghaus, S., Fasching, P. A., Beckmann, M. W., Fuhrmann, U., et al. (2012) · Reproductive Sciences · doi:10.1177/1933719112451147 · Cited by 25 · see citing works
Wang, Y., Chen, H., Fu, Y., Ai, A., Xue, S., Lyu, Q., & Kuang, Y. (2013) · Europe PMC (PubMed Central) · Cited by 24 · see citing works
de Oliveira, R. Z., Buono, F. D. O., Cressoni, A. C. L., Penariol, L. B. C., Padovan, C. C., Tozetti, P. A., Poli‐Neto, O. B., Ferriani, R. A., Orellana, M. D., Silva, J. C. R. E., et al. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00860-y · Cited by 24 · see citing works
DNA microarray analysis in endometriosis for development of more effective targeted therapies
Matsuzaki, S. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/e317 · Cited by 24 · see citing works
Tang, X.-L., Zhang, F.-L., Jiang, X., & Yang, X. (2019) · Europe PMC (PubMed Central) · Cited by 23 · see citing works
Xu, X., Li, Z.-Z., Liu, J., Yu, S., & Wei, Z. (2017) · Journal of X-Ray Science and Technology · doi:10.3233/xst-17286 · Cited by 23 · see citing works
Wang, F., & Liu, Y. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2019.1680622 · Cited by 23 · see citing works
Sadłocha, M., Toczek, J., Major, K., Staniczek, J., & Stojko, R. (2024) · Pharmaceuticals · doi:10.3390/ph17070827 · Cited by 31 · see citing works
Gao, S., Liu, S., Gao, Z., Deng, P., & Wang, D. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i16.2155 · Cited by 21 · see citing works
Fassbender, A., Dorien, O., Moor, B. D., Waelkens, E., Meuleman, C., Tomassetti, C., Peeraer, K., & D’Hooghe, T. M. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_20 · Cited by 22 · see citing works
MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology
Nothnick, W. B. (2022) · Cells · doi:10.3390/cells11071096 · Cited by 22 · see citing works
Mirabutalebi, S. H., Karami, N., Montazeri, F., Fesahat, F., Sheikhha, M. H., Hajimaqsoodi, E., Karimi‐Zarchi, M., & Kalantar, S. M. (2018) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.16.8.501 · Cited by 19 · see citing works
Zevallos, H. B. V., McKinnon, B. D., Tokushige, N., Mueller, M. D., Fraser, I. S., & Bersinger, N. A. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3379-1 · Cited by 18 · see citing works
Uterine microRNA signature and consequence of their dysregulation in uterine disorders.
Chegini, N. (2010) · PubMed · Cited by 18 · see citing works
Nothnick, W. B., Swan, K., Flyckt, R. L., Falcone, T., & Graham, A. R. (2019) · Scientific Reports · doi:10.1038/s41598-019-45243-7 · Cited by 18 · see citing works
LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction
Jiang, L., Zhang, M., Wang, S., Xiao, Y., Wu, J., Zhou, Y., & Fang, X. (2020) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738420976309 · Cited by 16 · see citing works
Antônio, L. G. L., Meola, J., Silva, A. C. J. D. S. R. E., Nogueira, A. A., dos Reis, F. J. C., Poli‐Neto, O. B., & Silva, J. C. R. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054434 · Cited by 16 · see citing works
Liu, L., Chen, H., Jiang, T., & He, D. (2021) · Modern Rheumatology · doi:10.1093/mr/roab108 · Cited by 16 · see citing works
Abdelkareem, A. O., Alotaibi, F. T., AlKusayer, G. M., Ait-Allah, A. S., Rasheed, S. M., Helmy, Y. A., Allaire, C., Peng, B., Yong, P. J., & Bedaiwy, M. A. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00167-w · Cited by 15 · see citing works
- Authors
- Filigheddu, N., Gregnanin, I., Porporato, P. E., Surico, D., Perego, B., Galli, L., Patrignani, C., Graziani, A., & Surico, N.
- Affiliations
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Corresponding author
- Filigheddu, Nicoletta
- ORCID
- Venue
- Journal of Biomedicine and Biotechnology
- Publisher
- Hindawi Limited
- Published
- 2010
- Volume
- 2010
- Pages
- 1-29
- ISSN
- 1110-7243 (ISSN-L)
- 1110-7251
- PMC
- PMC2837904
- OpenAlex
- W2044038984
- Cited by
- 162
- References
- 63
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 12 · 2015: 7 · 2014: 11 · 2013: 13 · 2012: 8
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- endometrioma, microRNA, ectopic endometrium, eutopic endometrium, differential gene expression, post-transcriptional regulation, miRNA target prediction, endometriosis pathogenesis
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Middle Aged, Ovarian Diseases, Gene Expression, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review