The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Mendoza, Michelle C., Er, E. Emrah, Blenis, John·2011·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2011.03.006

Cited by (1,004)

Items 101–200 of 1,004

Personalized Preclinical Trials in BRAF Inhibitor–Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies
Clemens Krepler, Min Xiao, Katrin Sproesser, Patricia A. Brafford, Batool Shannan, Marilda Beqiri, Qin Liu, Wei Xu, Bradley Garman, Katherine L. Nathanson et al. · 2015 · Clinical Cancer Research
Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors
Jun Sun, Daohai Zhang, Dong-Hun Bae, Sumit Sahni, Patric J. Jansson, Yang Zheng, Qian Zhao, Fei Yue, Minhua Zheng, Žaklina Kovačević et al. · 2013 · Carcinogenesis
25 Years of Small Molecular Weight Kinase Inhibitors: Potentials and Limitations
Doriano Fabbro · 2014 · Molecular Pharmacology
Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle
Han Yu, Chao Liu, Dongfang Zhang, Hongchao Men, Lifang Huo, Qiaowei Geng, Shengnan Wang, Yiting Gao, Wei Zhang, Yongjian Zhang et al. · 2019 · International Journal of Oncology
Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth
Clemens Heissenberger, Lisa Liendl, Fabian Nagelreiter, Yulia Gonskikh, Guohuan Yang, Elena Maria Stelzer, Teresa L. Krammer, Lucia Mičutková, Stefan Vogt, David Philip Kreil et al. · 2019 · Nucleic Acids Research
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer
Min-Sik Lee, Courtney Dennis, Insia Naqvi, Lucas Dailey, Alireza Lorzadeh, George Ye, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin et al. · 2023 · Nature
Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma
Gustavo Ferrín, Marta Guerrero Misas, Víctor Amado, Manuel Rodríguez‐Perálvarez, Manuel de la Mata · 2020 · International Journal of Molecular Sciences
The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings
Claude Robert Cloninger, Kevin M. Cloninger, Igor Jorge Sergio Zwir, Liisa Keltikangas‐Järvinen · 2019 · Translational Psychiatry
Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy
Chong Wang, Jin‐Tai Yu, Dan Miao, Zhong‐Chen Wu, Meng‐Shan Tan, Lan Tan · 2013 · Molecular Neurobiology
Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer
Triparna Sen, Pan Tong, Lixia Diao, Lerong Li, You-Hong Fan, Jennifer A. Hoff, John Victor Heymach, Jing Wang, Lauren A. Byers · 2017 · Clinical Cancer Research
Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes
Nishant Mohan, Yi Shen, Yukinori Endo, M. Khair ElZarrad, Wen Jin Wu · 2016 · Molecular Cancer Therapeutics
Nuclear PI3K signaling in cell growth and tumorigenesis
William J. Davis, Peter Z. Lehmann, Weimin Li · 2015 · Frontiers in Cell and Developmental Biology
Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence
Salihanur Darici, Hazem Alkhaldi, Gillian Abigail Horne, Heather G. Jørgensen, Sandra Marmiroli, Xu Huang · 2020 · Journal of Clinical Medicine
S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1
Vered Ben-Hur, Polina Denichenko, Zahava Siegfried, Avi Maimon, Adrian R. Krainer, Ben Davidson, Rotem Karni · 2012 · Cell Reports
Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment
Jialing Zhang, Stephan Stanislaw Späth, Sadie L. Marjani, Wengeng Zhang, Xinghua Pan · 2018 · Precision Clinical Medicine
An update on the central nervous system manifestations of neurofibromatosis type 1
James Stephen Nix, Jaishri O'Neill Blakeley, Fausto J. Rodríguez · 2019 · Acta Neuropathologica
Drugs that modulate aging: the promising yet difficult path ahead
Kennedy, Brian K., Pennypacker, Juniper K. · 2014 · Translational research
Colorectal Cancer and Metabolism
Rachel E. Brown, Sarah P. Short, Christopher S. Williams · 2018 · Current Colorectal Cancer Reports
Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts
Patel, Vanlata, Adya, Raghu, Chen, Jing, Ramanjaneya, Manjunath, Bari, Muhammad F., Bhudia, Sunil K., Hillhouse, Edward W., Tan, Bee K., Randeva, Harpal S. · 2014 · PLoS ONE
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
Xue Zheng, Daniël J. Vis, Alejandra Bruna, Tonći Šuštić, Sake van Wageningen, Ankita Sati Batra, Oscar M. Rueda, Evert Bosdriesz, Carlos Caldas, Lodewyk F.A. Wessels et al. · 2018 · Cell Research
Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance
Ethan B. Butler, Yuhua Zhao, Cristina Muñoz‐Pinedo, Jianrong Lu, Ming Tan · 2013 · Cancer Research
Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma
Francesco Spagnolo, Paola Ghiorzo, Paola Queirolo · 2014 · Oncotarget
Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma
Deborah J. L. Wong, Lídia Robert, Mohammad S. Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl V Avramis, Jennifer Tsoi, David S. Foulad, Thomas G. Graeber et al. · 2014 · Molecular Cancer
HER2/PI3K/AKT pathway in HER2-positive breast cancer: A review
Linghui Pan, Jinling Li, Qi Xu, Zili Gao, Mao Yang, Xiaoping Wu, Xuesen Li · 2024 · Medicine
mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse
Neasta, Jeremie, Barak, Segev, Hamida, Sami Ben, Ron, Dorit · 2014 · Journal of Neurochemistry
Uncovering the complex genetics of human temperament
Igor Jorge Sergio Zwir, Javier Arnedo, Coral del Val, Laura Pulkki-Råbäck, Bettina Konte, Sarah S. Yang, Rocío Romero‐Zaliz, Mirka Hintsanen, Kevin M. Cloninger, Danilo Garcia et al. · 2018 · Molecular Psychiatry
The Role of Natural Products and Their Multitargeted Approach to Treat Solid Cancer
Naoshad Muhammad, Darksha Usmani, Mohammad Tarique, Huma Naz, Mohammad Ashraf, Ramesh Raliya, Shams S. M. Tabrez, Torki A. Zughaibi, Ahdab Alsaieedi, Israa Jameel Hakeem et al. · 2022 · Cells
Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways
Dhanasekhar Reddy, Ranjith Kumavath, Preetam Ghosh, Debmalya Barh · 2019 · Biomolecules
Schwann cell autophagy counteracts the onset and chronification of neuropathic pain
Marinelli, Sara, Nazio, Francesca, Tinari, Antonella, Ciarlo, Laura, D'Amelio, Marcello, Pieroni, Luisa, Vacca, Valentina, Urbani, Andrea, Cecconi, Francesco, Malorni, Walter et al. · 2014 · Pain
The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
Ana Moreira, Joana Pereira, Soraia Melo, Maria Sofia Fernandes, Patrı́cia Carneiro, Raquel Seruca, Joana Figueiredo · 2020 · Cells
MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response
W. Wang, Meghan Corrigan-Cummins, J. Hudson, I. Maric, O. Simakova, Sattva Swarup Neelapu, Larry W. Kwak, John Edward Janik, Barry L. Gause, Elaine S. Jaffe et al. · 2011 · Haematologica
Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit
Daniel A. Ritt, Maria Teresa Abreu‐Blanco, Lakshman K. Bindu, David Durrant, Ming Zhou, Suzanne I. Specht, Andrew G. Stephen, Matthew T. Holderfield, Deborah K. Morrison · 2016 · Molecular Cell
Insight into the Role of the PI3K/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart
Walkowski, Bartosz, Kleibert, Marcin, Majka, Miłosz, Wojciechowska, Małgorzata · 2022 · Cells
Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling
Colin H. Beckwitt, Keisuke Shiraha, Alan H. Wells · 2018 · PLoS ONE
Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis
Mokgadi Violet Gwangwa, Anna Margaretha Joubert, Michelle Helen Visagie · 2018 · Cellular & Molecular Biology Letters
MEK and PI3K inhibition in solid tumors: rationale and evidence to date
Elina Jokinen, Jussi Pekka Koivunen · 2015 · Therapeutic Advances in Medical Oncology
Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks
Regina Samaga, Steffen Klamt · 2013 · Cell Communication and Signaling
Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease
William M. Pryor, Marta Biagioli, Neelam Shahani, Supriya Swarnkar, Wen‐Chin Huang, Damon T. Page, Marcy E. MacDonald, Srinivasa Subramaniam · 2014 · Science Signaling
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
Chan, Karina, Robert, Francis, Oertlin, Christian, Kapeller-Libermann, Dana, Avizonis, Daina, Gutierrez, Johana, Handly-Santana, Abram, Doubrovin, Mikhail, Park, Julia, Schoepfer, Christina et al. · 2019 · Nature Communications
Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells
Jiejie Dong, Bo Zhai, Weihua Sun, Fengli Hu, Hao Cheng, Jun Xu · 2017 · PLoS ONE
Phosphate toxicity and tumorigenesis
Ronald B. Brown, Mohammed Shawkat Razzaque · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling
Yi‐Hsuan Ho, Audrey P. Gasch · 2015 · Current Genetics
Macropinocytosis, mTORC1 and cellular growth control
Yoshida, Sei, Pacitto, Regina, Inoki, Ken, Swanson, Joel · 2018 · Cellular and Molecular Life Sciences
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
Vanesa Fernández‐Sáiz, Bianca‐Sabrina Targosz, Simone Lemeer, Ruth Eichner, Christian Langer, Lars Bullinger, Clemens Reiter, Julia Slotta‐Huspenina, Sonja Schroeder, Anna-Maria Knorn et al. · 2012 · Nature Cell Biology
A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens
Christopher L. Yankaskas, Keyata N. Thompson, Colin D. Paul, Michele I. Vitolo, Panagiotis Mistriotis, Ankit Mahendra, Vivek K. Bajpai, Daniel J. Shea, Kristen M. Manto, Andreas C. Chai et al. · 2019 · Nature Biomedical Engineering
The role of PI3k/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review
Emad Shamsan, Maged Almezgagi, Mohammed Gamah, Naveed Khan, Abdulkareem Qasem, Liu Chuanchuan, Fan Haining · 2024 · Frontiers in Medicine
BRAF inhibitors: resistance and the promise of combination treatments for melanoma
Merope Griffin, Daniele Scotto, Debra Hannah Josephs, Silvia Mele, Silvia Crescioli, Heather J. Bax, Giulia Pellizzari, Matthew D. Wynne, Mano Nakamura, Ricarda M. Hoffmann et al. · 2017 · Oncotarget
PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression
Shuo Deng, Hin Chong Leong, Arpita Datta, Vennila Gopal, Alan Prem Kumar, Celestial T. Yap · 2022 · Cancers
Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons
Sung Woo Park, Jung Goo Lee, Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Bong Ju Lee, Wongi Seol, Young Hoon Kim · 2014 · The International Journal of Neuropsychopharmacology
Influenza Virus Infections and Cellular Kinases
Robert Meineke, Guus F. Rimmelzwaan, Husni Elbahesh · 2019 · Viruses
Nongenomic effects of thyroid hormones on the immune system cells: New targets, old players
Paolo De Vito, Valentina Balducci, Stefano Leone, Zulema Antonia Percario, Giorgio Mangino, Paul J. Davis, Faith B. Davis, Elisabetta Affabris, Paolo Luly, Jens Zacho Pedersen et al. · 2012 · Steroids
Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling
Youichi Uda, Yuhei Goto, Shigekazu Oda, Takayuki Kohchi, Michiyuki Matsuda, Kazuhiro Aoki · 2017 · Proceedings of the National Academy of Sciences
Oncogenic PI3K/AKT promotes the step-wise evolution of combination BRAF/MEK inhibitor resistance in melanoma
Mal Irvine, Ashleigh Stewart, Bernadette Pedersen, Suzanah C. Boyd, Richard F. Kefford, Helen Rizos · 2018 · Oncogenesis
Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring
Roberta Cagnetta, Hovy Ho‐Wai Wong, Christian Karl Frese, Giovanna R. Mallucci, Jeroen Krijgsveld, Christine E. Holt · 2018 · Molecular Cell
Role of aldo‐keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential
Reza Khayami, Seyyed Reza Hashemi, Mohammad Amin Kerachian · 2020 · Journal of Cellular and Molecular Medicine
Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling
Ginetta Collo, Laura Cavalleri, Federica Bono, Cristina Mora, Stefania Fedele, Roberto William Invernizzi, Massimo Gennarelli, Giovanna Piovani, Tilo Kunath, Mark John Millan et al. · 2018 · Neural Plasticity
Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms
Inan Olmez, Breanna R. Brenneman, Aizhen Xiao, Vlad Serbulea, Mouadh Benamar, Ying Zhang, Laryssa C. Manigat, Tarek Abbas, Jeongwu Lee, Ichiro Nakano et al. · 2017 · Clinical Cancer Research
Mechanisms shaping the role of ERK1/2 in cellular sene scence (Review)
Junrong Zou, Tingting Lei, Pei Guo, Jason Yu, Qichao Xu, Yunfei Luo, Rong Ke, Deqiang Huang · 2018 · Molecular Medicine Reports
Dual PI3K/AKT/mTOR Inhibitor BEZ235 Synergistically Enhances the Activity of JAK2 Inhibitor against Cultured and Primary Human Myeloproliferative Neoplasm Cells
Warren C. Fiskus, Srđan Verstovšek, Taghi Manshouri, Jacqueline E. Smith, Karissa Peth, Sunil Abhyankar, Joseph P. McGuirk, Kapil N. Bhalla · 2013 · Molecular Cancer Therapeutics
PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data
Elena Piñeiro-Yáñez, Miguel Reboiro‐Jato, Gonzalo Goméz-López, Javier Perales-Patón, Kevin Troulé, José Manuel Rodrı́guez, Héctor Tejero, Takeshi Shimamura, Pedro Pablo Lopez-Casas, Julián Carretero et al. · 2018 · Genome Medicine
ERK signaling for cell migration and invasion
Shiela C. Samson, Akib M. Khan, Michelle C. Mendoza · 2022 · Frontiers in Molecular Biosciences
Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells
Heidrun Karlic, Roman Thaler, Christopher Gerner, Thomas W. Grunt, Katharina Proestling, Florian Haider, Franz Varga · 2015 · Cancer Genetics
Ca2+in quality control
Daniel A. East, Michelangelo Campanella · 2013 · Autophagy
AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve
Ekrem Emrah Er, Michelle C. Mendoza, Ashley M. Mackey, Lucia E. Rameh, John Blenis · 2013 · Science Signaling
Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways
Boris Rodenak‐Kladniew, Agustina Castro, Peter Stärkel, Christine De Saeger, Margarita María García de Bravo, Rosana Crespo · 2018 · Life Sciences
Translational control of aberrant stress responses as a hallmark of cancer
Amal M. El-Naggar, Poul H. B. Sorensen · 2018 · The Journal of Pathology
Ketamine for depression
Luke A. Jelen, James M. Stone · 2021 · International Review of Psychiatry
A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer
Wainberg, Zev A., Alsina, Maria, Soares, Heloisa P., Braña, Irene, Britten, Carolyn D., Del Conte, Gianluca, Ezeh, Patrick, Houk, Brett, Kern, Kenneth A., Leong, Stephen et al. · 2017 · Targeted Oncology
Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly
Dong Li, Tara Lynn Wenger, Christoph Seiler, Michael March, Álvaro Gutiérrez-Uzquiza, Charlly Kao, Elizabeth J. K. Bhoj, Lifeng Tian, Misha A. Rosenbach, Yichuan Liu et al. · 2018 · Human Molecular Genetics
Tyrosine Kinase Receptors in Oncology
Jorge Esteban-Villarrubia, J.J. Soto Castillo, Javier Pozas, María San Román, Inmaculada Orejana, Javier Torres-Jiménez, Alfredo Carrato, Teresa Alonso‐Gordoa, Javier Molina‐Cerrillo · 2020 · International Journal of Molecular Sciences
Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme
Manali Tilak, Jennifer Holborn, Laura A. New, Jasmin Lalonde, Nina Jones · 2021 · International Journal of Molecular Sciences
Enrichment of PI3K-AKT–mTOR Pathway Activation in Hepatic Metastases from Breast Cancer
Mariaelena Pierobon, Corinne Ramos, Shukmei Wong, Kimberley Alex Hodge, Jessica Aldrich, Sara Ann Byron, Stephen Patrick Anthony, Nicholas J. Robert, DW Northfelt, Mohammad Jahanzeb et al. · 2017 · Clinical Cancer Research
ERK reinforces actin polymerization to power persistent edge protrusion during motility
Michelle C. Mendoza, Marco Vilela, Jesus Eduardo Juarez, John Blenis, Gaudenz M. Danuser · 2015 · Science Signaling
Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway
Baiyu Han, Hanzhi Cui, Lei Kang, Xuelin Zhang, Zhitao Jin, Lanmin Lu, Zhongyi Fan · 2015 · Tumor Biology
SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors
Lu, Hengyu, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas Manuel, Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado, Eusebio, Brachmann, Saskia M. et al. · 2019 · Molecular Cancer Therapeutics
Investigational PI3K/AKT/mTOR inhibitors in development for endometrial cancer
Fabio Barra, Giulio Evangelisti, Lorenzo Ferro Desideri, Stefano Di Domenico, Domenico Ferraioli, Valerio Gaetano Vellone, Franco De Cian, Simone Ferrero · 2018 · Expert Opinion on Investigational Drugs
Phosphoregulation of the WAVE regulatory complex and signal integration
Mendoza, Michelle C. · 2013 · Seminars in Cell & Developmental Biology
Targeting the genetic alterations of the PI3K–AKT–mTOR pathway: Its potential use in the treatment of bladder cancers
Nadine Houédé, Philippe Pourquier · 2014 · Pharmacology & Therapeutics
Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis
Chengqian Yin, Bo Zhu, Ting Zhang, Tongzheng Liu, Shuyang Chen, Yu Liu, Xin Li, Xiao Miao, Shanshan Li, Xia Mi et al. · 2019 · Cell
Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice
Emanuela Santini, Thu N. Huynh, Francesco Longo, So Yeon Koo, Edward S. Mojica, Laura D’Andrea, Claudia Bagni, Eric Klann · 2017 · Science Signaling
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
Hema Adhikari, Christopher M. Counter · 2018 · Nature Communications
Conservative route to genome compaction in a miniature annelid
José María Martín-Durán, Bruno C. Vellutini, Ferdinand Marlétaz, Viviana Cetrangolo, Nevena Cvetešić, Daniel J. Thiel, Simon Henriet, Xavier Grau‐Bové, Allan M. Carrillo‐Baltodano, Wenjia Gu et al. · 2020 · Nature Ecology & Evolution
Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy
Xiaoli Pan, Junping Pei, Aoxue Wang, Shuai Wen, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang · 2022 · Acta Pharmaceutica Sinica B
The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders
Jesse L. Costales, Alexander Kolevzon · 2016 · Neuroscience & Biobehavioral Reviews
Morphologic Reproducibility, Genotyping, and Immunohistochemical Profiling Do Not Support a Category of Seromucinous Carcinoma of the Ovary
Peter Rambau, John B. McIntyre, Jennifer L. Taylor, Sandra Lee, Travis Ogilvie, Anna E. Sienko, Don G. Morris, Máire A. Duggan, Wilson Glenn McCluggage, Martin Köbel · 2017 · The American Journal of Surgical Pathology
NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3‐Kinase/Akt Serine/Threonine Kinase and Mitogen‐Activated Protein Kinase/Extracellular Signal‐Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma
Manali Dimri, Ashley Humphries, Archana Laknaur, Sawsan Elattar, Tae Jin Lee, Ashok Kumar Sharma, Ravindra B Kolhe, Satyanarayana Ande · 2019 · Hepatology
Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours
João M. Fernandes Neto, Ernest Nadal, Evert Bosdriesz, Salo Ooft, Lourdes Farré, Chelsea M. McLean, Sjoerd Klarenbeek, Anouk P. Jurgens, Hannes Hagen, Liqin Wang et al. · 2020 · Nature Communications
PTEN in osteosarcoma: Recent advances and the therapeutic potential
Chuanxi Zheng, Fan Tang, Li Min, Francis John Hornicek, Zhenfeng Duan, Chongqi Tu · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons
Jacob T. Beckley, Sophie Laguesse, Khanhky Phamluong, Nadège Morisot, Scott A. Wegner, Dorit Ron A · 2016 · Journal of Neuroscience
Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies
Monica Mossenta, Davide Busato, Michele Dal Bo, Giuseppe Toffoli · 2020 · Cancers
ERK-mediated NF-κB activation through ASIC1 in response to acidosis
Bin Chen, Jianjun Liu, T-T Ho, Xianfeng Ding, Y-Y Mo · 2016 · Oncogenesis
Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer
Pek, M, Yatim, S M J M, Chen, Y, Li, J, Gong, M, Jiang, X, Zhang, F, Zheng, J, Wu, X, Yu, Q · 2017 · Oncogene
Akt/mTOR signalling in myelination
Camilla Norrmén, Ueli Suter · 2013 · Biochemical Society Transactions
Animal Models for Human Polycystic Ovary Syndrome (PCOS) Focused on the Use of Indirect Hormonal Perturbations: A Review of the Literature
Youngjae Ryu, Sung Woo Kim, Yoon Young Kim, Seung‐Yup Ku · 2019 · International Journal of Molecular Sciences
Interdependent epidermal growth factor receptor signalling and trafficking
Sylwia Jones, Joshua Zachary Rappoport · 2014 · The International Journal of Biochemistry & Cell Biology
Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer
Shruti Setia, Bimla Nehru, Sankar Nath Sanyal · 2014 · Biomedicine & Pharmacotherapy
Autophagy: A Potential Therapeutic Target of Polyphenols in Hepatocellular Carcinoma
Chandramohan Kiruthiga, Kasi Pandima Devi, Seyed Mohammad Nabavi, Anupam Bishayee · 2020 · Cancers
Mechanisms of Resistance to CDK4/6 Blockade in Advanced Hormone Receptor–positive, HER2-negative Breast Cancer and Emerging Therapeutic Opportunities
Maxwell Roger Lloyd, Laura M. Spring, Aditya Bardia, Seth A. Wander · 2021 · Clinical Cancer Research
PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms
Franziska Briest, Patricia Grabowski · 2014 · Theranostics
Nutrient Signaling and Developmental Timing of Maturation
Erik Thomas Danielsen, Morten Erik Moeller, Kim Rewitz · 2013 · Current topics in developmental biology/Current Topics in Developmental Biology