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mTOR: from growth signal integration to cancer, diabetes and ageing

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

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Phosphatidylinositol-3-OH kinase direct target of Ras

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Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

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Pharmacologic inhibition of Akt in combination with chemotherapeutic agents effectively induces apoptosis in ovarian and endometrial cancer cell lines

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Overexpression of sortilin is associated with 5‐FU resistance and poor prognosis in colorectal cancer

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The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma

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Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux

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MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma

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Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells

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Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling

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Genetic and Environmental Contributions to Autism Spectrum Disorder Through Mechanistic Target of Rapamycin

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Ruminant Placental Adaptation in Early Maternal Undernutrition: An Overview

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Multidisciplinary Management of Costello Syndrome: Current Perspectives

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Molecular Mechanism of Tanshinone against Prostate Cancer

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Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression

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Optogenetic manipulation identifies the roles of ERK and AKT dynamics in controlling mouse embryonic stem cell exit from pluripotency

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PI3K/AKT signaling controls ICM maturation and proper epiblast and primitive endoderm specification in mice

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Dual PI3K/ERK inhibition induces necroptotic cell death of Hodgkin Lymphoma cells through IER3 downregulation

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Anti-tumor activity of PI3K-δ inhibitor in hematologic malignant cells: Shedding new light on resistance to Idelalisib

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Heterogeneous Reciprocal Graphical Models

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Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling

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CCR6 Is a Predicting Biomarker of Radiosensitivity and Potential Target of Radiosensitization in Rectal Cancer

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Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons

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Bruton’s tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma

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Dual inhibition of ERK1/2 and AKT pathways is required to suppress the growth and survival of endometriotic cells and lesions

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SQSTM1/p62 loss reverses the inhibitory effect of sunitinib on autophagy independent of AMPK signaling

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Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

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Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis

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Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling

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Neuroprotection by Phytoestrogens in the Model of Deprivation and Resupply of Oxygen and Glucose In Vitro: The Contribution of Autophagy and Related Signaling Mechanisms

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Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions

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Current developments in PI3K-based anticancer agents: Designing strategies, biological activity, selectivity, structure-activity correlation, and docking insight

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Research progress on traditional Chinese medicine-induced apoptosis signaling pathways in ovarian cancer cells

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Convergent and Divergent Pathways Decoding Hierarchical Additive Mechanisms in Treating Cerebral Ischemia–Reperfusion Injury

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Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells

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Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

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Breast Cancer: A Molecular and Redox Snapshot

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Mice Deficient in lysophosphatidic acid acyltransferase delta ( Lpaat δ)/ acylglycerophosphate acyltransferase 4 ( Agpat4 ) Have Impaired Learning and Memory

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NRAS -Mutated Rhabdomyosarcoma Cells Are Vulnerable to Mitochondrial Apoptosis Induced by Coinhibition of MEK and PI3K α

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Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse

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A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics

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The Secret Life of Translation Initiation in Prostate Cancer

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NFκB- and MAP-Kinase Signaling Contribute to the Activation of Murine Myeloid Dendritic Cells by a Flagellin A: Allergen Fusion Protein

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Neuroprotective Effect of CR-777, a Glutathione Derivative of Withaferin A, Obtained through the Bioconversion of Withania somnifera (L.) Dunal Extract by the Fungus Beauveria bassiana

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Anti‐angiogenic effects of the blue‐green alga Arthrospira platensis on pancreatic cancer

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BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer

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The two sides of HER2/neu: immune escape versus surveillance

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A Systems-Level Interrogation Identifies Regulators of Drosophila Blood Cell Number and Survival

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Decoding the crosstalk between mevalonate metabolism and T cell function

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Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition

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Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent manner

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Ras subfamily GTPases regulate development, aflatoxin biosynthesis and pathogenicity in the fungus Aspergillus flavus

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Pramipexole regulates depression-like behavior via dopamine D3 receptor in a mouse model of Parkinson’s disease

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Fatty acid synthase as a feasible biomarker for triple negative breast cancer stem cell subpopulation cultured on electrospun scaffolds

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Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer's Disease APP/PS1 Mouse Model

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VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection

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The combined anticancer of peanut skin procyanidins and resveratrol to CACO ‐2 colorectal cancer cells

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Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions

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Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation

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Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells

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Fluoxetine Modulates the Activity of Hypothalamic POMC Neurons via mTOR Signaling

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Endoplasmic reticulum-localized ECM1b suppresses tumor growth and regulates MYC and MTORC1 through modulating MTORC2 activation in esophageal squamous cell carcinoma

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The malignancy of liver cancer cells is increased by IL-4/ERK/AKT signaling axis activity triggered by irradiated endothelial cells

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Pan-RAF Inhibition Shows Anti-Leukemic Activity in RAS-Mutant Acute Myeloid Leukemia Cells and Potentiates the Effect of Sorafenib in Cells with FLT3 Mutation

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Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent.

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Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation

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mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio

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Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling

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mTOR inhibitor temsirolimus and MEK1/2 inhibitor U0126 promote chromosomal instability and cell type-dependent phenotype changes of glioblastoma cells

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Validation of efficacy and mechanism of Sanwei-Tanxiang powder in improving myocardial ischemia reperfusion injuries

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An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy

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Genetically Encoded Aminocoumarin Lysine for Optical Control of Protein–Nucleotide Interactions in Zebrafish Embryos

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MEK inhibitors: a promising targeted therapy for cardiovascular disease

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S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

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PI3K and MEK1/2 molecular pathways are involved in the erythropoietin-mediated regulation of the central respiratory command

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mTOR is involved in 17β‐estradiol‐induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1

Yang, W., Wang, Y., Wang, Y., Zhang, J., Zhang, J., Lu, C., & Wang, X. (2015) · Molecular Reproduction and Development · doi:10.1002/mrd.22473 · Cited by 18

Regulation of therapeutic resistance in cancers by receptor tyrosine kinases.

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Ras-Raf-MAPK signaling promotes nuclear localization of FOXA transcription factor SGF1 via Ser91 phosphorylation

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Adult Neural Stem Cells: Basic Research and Production Strategies for Neurorestorative Therapy

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