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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

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The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells

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Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway

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Simultaneous inhibition of aberrant cancer kinome using rationally designed polymer-protein core-shell nanomedicine

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Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner

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Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations

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Vertical Pathway Targeting in Cancer Therapy

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Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis

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Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow–derived stromal stem cellsPreprint

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Unraveling the AKT/ERK cascade and its role in Parkinson disease

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Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib

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Association of Extracellular Signal-Regulated Kinase Genes With Myopia: A Longitudinal Study of Chinese Children

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Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling

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Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

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Marine fungus-derived alkaloid inhibits the growth and metastasis of gastric cancer via targeting mTORC1 signaling pathway

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phuEGO: A Network-Based Method to Reconstruct Active Signaling Pathways From Phosphoproteomics Datasets

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IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts

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Piezo1 Activation Drives Enhanced Collagen Synthesis in Aged Animal Skin Induced by Poly L-Lactic Acid Fillers

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Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovarian clear cell carcinoma

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Urotensin II Inhibits Doxorubicin-Induced Human Umbilical Vein Endothelial Cell Death by Modulating ATF Expression and via the ERK and Akt Pathway

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Control of FLIPL expression and TRAIL resistance by the extracellular signal-regulated kinase1/2 pathway in breast epithelial cells

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Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

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Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells

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Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization

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Possible Novel Therapeutic Targets in Lymphangioleiomyomatosis Treatment

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AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo

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Au2phen and Auoxo6, Two Dinuclear Oxo-Bridged Gold(III) Compounds, Induce Apoptotic Signaling in Human Ovarian A2780 Cancer Cells

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Multiple Metabolic Alterations Exist in Mutant PI3K Cancers, but Only Glucose Is Essential as a Nutrient Source

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Identification of differentially expressed genes associated with differential body size in mandarin fish (Siniperca chuatsi)

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Dissecting Cell-Fate Determination Through Integrated Mathematical Modeling of the ERK/MAPK Signaling Pathway

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Regulation of AGR2 expression via 3’UTR shortening

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Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CNA) analysis

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PDK1 promotes apoptosis of chondrocytes via modulating MAPK pathway in osteoarthritis

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C16‑ceramide and sphingosine�1‑phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation

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The vaccine adjuvant MPLA activates glycolytic metabolism in mouse mDC by a JNK-dependent activation of mTOR-signaling

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TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma

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Biological Function of PD-L2 and Correlation With Overall Survival in Type II Endometrial Cancer

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Challenges and Opportunities in Modeling Pancreatic CancerPreprint

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Functional impact and targetability of PI3KCA , GNAS , and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutationPreprint

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RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia

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The Role of HIV Infection in the Pathophysiology of Gestational Diabetes Mellitus and Hypertensive Disorders of Pregnancy

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Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

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PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma

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Pro-Oxidant Auranofin and Glutathione-Depleting Combination Unveils Synergistic Lethality in Glioblastoma Cells with Aberrant Epidermal Growth Factor Receptor Expression

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Steroidal saponins: Natural compounds with the potential to reverse tumor drug resistance (Review)

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Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy

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Molecular Association of Glia Maturation Factor with the Autophagic Machinery in Rat Dopaminergic Neurons: a Role for Endoplasmic Reticulum Stress and MAPK Activation

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Insulin-like growth factor 1 exhibits the pro-autophagic and anti-apoptotic activity on T cells of oral lichen planus

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Intrathecal injection of dexmedetomidine ameliorates chronic neuropathic pain via the modulation of MPK3/ERK1/2 in a mouse model of chronic neuropathic pain

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REV‐ERBα activates the mTOR signalling pathway and promotes myotubes differentiation

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Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats

Xiao, L., Shu, L., Ge, L., Qiu, S., Wan, H., Wu, S., Fei, J., Peng, S., & Zeng, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00530 · Cited by 15

Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma

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Cell Populations Expressing Stemness-Associated Markers in Vascular Anomalies

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The Marine Natural Product Furospinulosin 1 Induces Apoptosis in MDA-MB-231 Triple Negative Breast Cancer Cell Spheroids, But Not in Cells Grown Traditionally with Longer Treatment

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A patent review of mTOR inhibitors for cancer therapy (2011–2020)

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Recombinant human growth hormone improves the immune status of rats with septic encephalopathy: The role of VEGFR2 in the prevalence of endoplasmic reticulum stress repair module

Zaky, D. A., Eldehna, W. M., Kerdawy, A. M. E., Abdallah, D. M., El-Abhar, H. S., & Wadie, W. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108370 · Cited by 15

Call the Eckols: Present and Future Potential Cancer Therapies

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Bcl-xl and Mcl-1 are the major determinants of the apoptotic response to dual PI3K and MEK blockage

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Injury‐induced rapid activation of MAPK signaling in dechorionated eggs and larvae of the silkworm Bombyx mori

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Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

Nelson, N. C., & Clark, G. J. (2016) · Oncotarget · doi:10.18632/oncotarget.8447 · Cited by 15

A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST

Trairatphisan, P., Wiesinger, M., Bahlawane, C., Haan, S., & Sauter, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156223 · Cited by 15

Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast

Lee, C. Q. E., Bailey, A. J., López‐Tello, J., Sferruzzi-Perri, A. N., Okkenhaug, K., Moffett, A., Rossant, J., & Hemberger, M. (2019) · Stem Cells · doi:10.1002/stem.3052 · Cited by 15

eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors

Hijazi, M., Casado, P., Akhtar, N., Álvarez–Teijeiro, S., Rajeeve, V., & Cutillas, P. R. (2022) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2022.100240 · Cited by 14

mTORC1 syndrome (TorS): unified paradigm for diabetes/metabolic syndrome

Bar‐Tana, J. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.01.001 · Cited by 16

MiR-18a-5p attenuates HER2-positive breast cancer development by regulating PI3K/AKT pathway

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ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

Farmaki, E., Nath, A., Emond, R., Karimi, K. L., Grolmusz, V. K., Cosgrove, P. A., & Bild, A. (2023) · eLife · doi:10.7554/elife.85898 · Cited by 14

Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

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Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization

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Aldosterone induces myofibroblast EGF secretion to regulate epithelial colonic permeability

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Guanosine and GMP increase the number of granular cerebellar neurons in culture: dependence on adenosine A2A and ionotropic glutamate receptors

Decker, H., Piermartiri, T., Nedel, C. B., Romão, L. F., Francisco, S. S., Dal-Cim, T. A., Boeck, C. R., Moura‐Neto, V., & Tasca, C. I. (2019) · Purinergic Signalling · doi:10.1007/s11302-019-09677-y · Cited by 14

Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

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Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy

Jaiprasart, P., Dogra, S., Neelakantan, D., Devapatla, B. K., & Woo, S. (2020) · Oncotarget · doi:10.18632/oncotarget.27307 · Cited by 14

Novel Tyrosine Kinase Targets in Urothelial Carcinoma

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