The DOI matches its Crossref record; 101 of the 103 references it cites were found in a registry or an index.
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
Open accessAbstract
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms for controlling cell survival, differentiation, proliferation, metabolism, and motility in response to extracellular cues. Components of these pathways were among the first to be discovered when scientists began cloning proto-oncogenes and purifying cellular kinase activities in the 1980s. Ras-ERK and PI3K-mTOR were originally modeled as linear signaling conduits activated by different stimuli, yet even early experiments hinted that they might intersect to regulate each other and co-regulate downstream functions. The extent of this cross-talk and its significance in cancer therapeutics are now becoming clear.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“An additional layer of complexity is the cross-regulation between the two pathways with ERK signaling feeding into several nodes of PI3K/mTOR such as its phosphorylation of TSC236–38.”
From Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer (2024) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
Flaherty, K. T., Puzanov, I., Kim, K. B., Ribas, A., McArthur, G. A., Sosman, J. A., O'Dwyer, P. J., Lee, R. J., Grippo, J. F., Nolop, K., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002011 · Cited by 3,103
MAP kinase signalling pathways in cancer
Dhillon, A. S., Hagan, S., Rath, O., & Kolch, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210421 · Cited by 2,995
Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,578
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
Nazarian, R., Shi, H., Wang, Q., Kong, X., Koya, R. C., Lee, H., Chen, Z., Lee, M., Attar, N., Sazegar, H., et al. (2010) · Nature · doi:10.1038/nature09626 · Cited by 2,244
Phosphatidylinositol-3-OH kinase direct target of Ras
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
Johannessen, C. M., Boehm, J. S., Kim, S. Y., Thomas, S. R., Wardwell, L., Johnson, L. A., Emery, C. M., Stransky, N., Cogdill, A. P., Barretina, J., et al. (2010) · Nature · doi:10.1038/nature09627 · Cited by 1,460
Flagged first, then by citations
2 of the 103 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 701–800 of 1,004
Natural Modulators of Key Signaling Pathways in Skin Inflammageing
Ren, Q., Qu, L., Yuan, Y., & Wang, F. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s502252 · Cited by 29
Andreucci, M., Faga, T., Pisani, A., Sabbatini, M., Russo, D., Mattivi, F., Sarro, G. D., Navarra, M., & Michael, A. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.12.035 · Cited by 26
Lectin from Dioclea violacea induces autophagy in U87 glioma cells
Nascimento, A. P. M., Wolin, I. A. V., Welter, P. G., Heinrich, I. A., Zanotto‐Filho, A., Osterne, V. J. S., Lóssio, C. F., Silva, M. T. L., Nascimento, K. S., Cavada, B. S., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.203 · Cited by 26
Single-cell quantification of the concentrations and dissociation constants of endogenous proteins
Komatsubara, A. T., Goto, Y., Kondo, Y., Matsuda, M., & Aoki, K. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007685 · Cited by 24
Bjeije, H., Soltani, B. M., Behmanesh, M., & Zali, M. R. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz146 · Cited by 26
Melanoma Metabolism: Cell Survival and Resistance to Therapy
Luís, R., Brito, C., & Pojo, M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_11 · Cited by 26
Attenuation of allergen-mediated mast cell activation by rosemary extract (Rosmarinus officinalisL.)
Yousef, M., Crozier, R. W. E., Hicks, N. J., Watson, C. J. F., Boyd, T., Tsiani, E., & MacNeil, A. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0320-434r · Cited by 26
NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity
Haider, N., Dutt, P., van de Kooij, B., Ho, J., Palomero, L., Pujana, M. Á., Yaffe, M. B., & Stambolic, V. (2020) · Oncogene · doi:10.1038/s41388-020-1361-x · Cited by 26
Targeted Therapies for the Neurofibromatoses
Sanchez, L. D., Bui, A., & Klesse, L. J. (2021) · Cancers · doi:10.3390/cancers13236032 · Cited by 26
Kainthla, R., Kim, K. B., & Falchook, G. S. (2014) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-54490-3_14 · Cited by 27
Nutrient-Mediated Perception and Signalling in Human Metabolism: A Perspective of Nutrigenomics
Lal, M. K., Sharma, E., Tiwari, R. K., Devi, R., Mishra, U. N., Thakur, R., Gupta, R., Dey, A., Lal, P., Kumar, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911305 · Cited by 30
Kra, G., Daddam, J. R., Moallem, U., Kamer, H., Mualem, B., Levin, Y., Kočvarová, R., Nemirovski, A., Contreras, A. G., Tam, J., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32433-7 · Cited by 26
Lee, C. L., Cremona, M., Farrelly, A. M., Workman, J. A., Kennedy, S., Aslam, R., Carr, A., Madden, S. F., O’Neill, B., Hennessy, B. T., et al. (2023) · Cancer Biology & Therapy · doi:10.1080/15384047.2023.2223388 · Cited by 27
Dabrafenib for treatment of BRAF-mutant melanoma
Falchook, G. S., Kainthla, R., & Kim, K. (2013) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s37220 · Cited by 28
Martín, R., Córdova, C., & Nieto, M. L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-154 · Cited by 27
Coumestrol suppresses proliferation of ES2 human epithelial ovarian cancer cells
Lim, W., Jeong, W., & Song, G. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0418 · Cited by 26
Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis
Sontowska, I., Matyja, E., Malejczyk, J., & Grajkowska, W. (2017) · Folia Neuropathologica · doi:10.5114/fn.2017.66708 · Cited by 26
jo, R. D. A. ⁄., Pessoa, J. B., Cruz, L. J., Chan, A. B., Miguel, E. D. C., Cavalcante, R. ⁄. M., Brito, G. A. D. C., Silva, H. F., Gasparotto, L. H. S., Guedes, P. M. D. M., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4179 · Cited by 26
Zhao, X., Li, R., Jin, H., Jin, H., Wang, Y., Zhang, W., Wang, H., & Chen, W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192083 · Cited by 28
Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery
Simpson, L. J., Tzima, E., & Reader, J. S. (2020) · Cells · doi:10.3390/cells9030650 · Cited by 25
Kato, M., Onoyama, I., Yoshida, S., Cui, L., Kawamura, K., Kodama, K., Hori, E., Matsumura, Y., Yagi, H., Asanoma, K., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.32965 · Cited by 26
The Role of mTOR Inhibitors after Liver Transplantation for Hepatocellular Carcinoma
Todeschini, L., Cristin, L., Martinino, A., Mattia, A., Agnes, S., & Giovinazzo, F. (2023) · Current Oncology · doi:10.3390/curroncol30060421 · Cited by 27
Signaling pathways activated by the B-cell receptor in chronic lymphocytic leukemia
Scupoli, M. T., & Pizzolo, G. (2012) · Expert Review of Hematology · doi:10.1586/ehm.12.21 · Cited by 25
Isakovic, A. M., Dulović, M., Marković, I., Kravic‐Stevovic, T., Bumbasirevic, V. Z., Trajković, V., & Isaković, A. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.11.001 · Cited by 25
Smith-Cohn, M., Davidson, C. J., Colman, H., & Cohen, A. L. (2019) · CNS Oncology · doi:10.2217/cns-2019-0018 · Cited by 25
Lee, M.-H., Yanagawa, J., Tran, L. M., Walser, T. C., Bisht, B., Fung, E., Park, S. J., Zeng, G., Krysan, K., Wallace, W. D., et al. (2020) · PubMed Central · Cited by 25
Potential role of mTORC1 and the PI3K-Akt pathway in anti-acne properties of licorice flavonoids
Ruan, S.-F., Xiang, S., Wu, W., Cao, S., Du, Q., Wang, Z., Chen, T., Shen, Q., Liu, L., Chen, H., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103968 · Cited by 25
Strategic Combinations to Prevent and Overcome Resistance to Targeted Therapies in Oncology
Gümüşay, Ö., Vitiello, P. P., Wabl, C. A., Corcoran, R. B., Bardelli, A., & Rugo, H. S. (2020) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_280845 · Cited by 29
Ovarian transcriptomic analysis and follicular development of Leizhou black duck
Zou, K., Asiamah, C. A., Lü, L., Liu, Y., Pan, Y., Chen, T., Zhao, Z., & Su, Y. (2020) · Poultry Science · doi:10.1016/j.psj.2020.08.008 · Cited by 25
Wen, W., Wang, Y., Li, H., Xu, H., Xu, M., Frank, J. A., Ma, M., & Luo, J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.560020 · Cited by 25
A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance
Al‐Akhrass, H., Conway, J. R. W., Poulsen, A. S. A., Paatero, I., Kaivola, J., Padzik, A., Andersen, O. M., & Ivaska, J. (2021) · Oncogene · doi:10.1038/s41388-020-01604-5 · Cited by 25
Caratti, B., Fidan, M., Caratti, G., Breitenecker, K., Engler, M., Kazemitash, N., Traut, R., Wittig, R., Casanova, E., Ahmadian, M. R., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abm4452 · Cited by 26
He, T., Zhao, Y., Zhao, P., Zhao, L., Zakaria, J., & Wang, K. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108823 · Cited by 25
Wang, X., Yu, J., Liu, X., Luo, D., Li, Y., Song, L., Jiang, X. L., Yin, X., Wang, Y., Chai, L., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100741 · Cited by 25
Proteome diversification by mRNA translation in cancer
Kochavi, A., Lovecchio, D., Faller, W. J., & Agami, R. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.11.014 · Cited by 24
RAS‐targeted cancer therapy: Advances in drugging specific mutations
Liu, C., Ye, D., Yang, H., Chen, X., Su, Z., Li, X., Ding, M., & Liu, Y. (2023) · MedComm · doi:10.1002/mco2.285 · Cited by 25
Bailey, S. T., Zhou, B. R., Damrauer, J. S., Krishnan, B., Wilson, H. L., Smith, A. M., Li, M., Yeh, J. J., & Kim, W. Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104413 · Cited by 26
Yin, J., Hao, Z., Ma, Y., Liao, S., Li, X., Fu, J., Wu, Y., Shen, J., Ping, Z., Li, X., et al. (2013) · Cell Biology International · doi:10.1002/cbin.10235 · Cited by 25
Chen, K., Yang, J., Li, J., Wang, X., Chen, Y., Huang, S., & Chen, J. (2016) · Oncotarget · doi:10.18632/oncotarget.7164 · Cited by 26
Kwegyir‐Afful, A. K., Murigi, F. N., Purushottamachar, P., Ramamurthy, V. P., Martin, M. S., & Njar, V. C. O. (2016) · Oncotarget · doi:10.18632/oncotarget.14154 · Cited by 25
Fourneaux, B., Chaire, V., Lucchesi, C., Karanian, M., Pineau, R., Laroche‐Clary, A., & Italiano, A. (2016) · Oncotarget · doi:10.18632/oncotarget.13987 · Cited by 25
Peng, T., & Dou, Q. P. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25921 · Cited by 25
Bertucci, A., Pierron, F., Gourvès, P.-Y., Klopp, C., Lagarde, G., Pereto, C., Dufour, V., Gonzalez, P., Coynel, A., Budzinski, H., et al. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.08.090 · Cited by 25
van Montfort, T., van der Sluis, R. M., Darcis, G., Beaty, D. E., Groen, K., Pasternak, A. O., Pollakis, G. P., Vink, M. A., Westerhout, E. M., Hamdi, M., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2019.02.014 · Cited by 25
Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers
Mattox, T. E., Chen, X., Maxuitenko, Y. Y., Keeton, A. B., & Piazza, G. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010141 · Cited by 25
Ji, X., Hong, J., Yang, W., Yao, M., Wang, J., Jiang, G., Wang, Y., Li, C., Lin, J., Mou, H., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102635 · Cited by 25
Gordiienko, I. M., Shlapatska, L. M., Kholodniuk, V., Sklyarenko, L. M., Df, G., Clark, E. A., & Sidorenko, S. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185940 · Cited by 26
SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC
Ruiz, C. F., Montal, E. D., Haley, J. D., Bott, A. J., & Haley, J. D. (2020) · The FASEB Journal · doi:10.1096/fj.202000052r · Cited by 29
Ayaz, Z., Bibi, Z., Khan, S. A., Abbasi, A. M., Elshikh, M. S., Munir, A., Al‐Ghamdi, A. A., Alajmi, A. H., Alsubaie, Q. D., & Mustafa, A. E. M. A. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.06.041 · Cited by 24
Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
Yan, J., Xie, Y., Si, J., Gan, L., Li, H., Sun, C., Di, C., Zhang, J., Huang, G., Zhang, X., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020817 · Cited by 24
Khoshghamat, N., Jafari, N., Tolou, V., Azami, S., Mirnourbakhsh, S. H., Khazaei, M., Ferns, G. A., Rajabian, M., & Avan, A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119118 · Cited by 24
Sun, C., Cao, D., Ren, Q., Zhang, S., Zhou, N., Mai, S., Feng, B. C., & Wang, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.684243 · Cited by 24
Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression
Kotta, A. S., Kelling, A. S., Corleto, K. A., Sun, Y., & Giles, E. D. (2022) · Biomolecules · doi:10.3390/biom12040483 · Cited by 25
Structural insights into Ras regulation by SIN1
Zheng, Y., Ding, L., Meng, X., Potter, M., Kearney, A. L., Zhang, J., Sun, J., James, D. E., Yang, G., & Zhou, C. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119990119 · Cited by 25
Franke, K., Kirchner, M., Mertins, P., Zuberbier, T., & Babina, M. (2022) · Allergy · doi:10.1111/all.15396 · Cited by 24
Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.
Tai, C.-J., Chang, C.-C., Jiang, M.-C., Yeh, C., Su, T., Wu, P.-R., Chen, C., Yeh, K.-T., Lin, S.-H., & Chen, H.-C. (2012) · PubMed · Cited by 24
Estrogen receptor ESR1 mediates activation of ERK1/2, CREB, and ELK1 in the corpus of the epididymis
Cavalcanti, F. N., Lucas, T. F. G., Lazari, M. F. M., & Porto, C. S. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0086 · Cited by 24
Azad, A., Lawen, A., & Keith, J. M. (2015) · BMC Systems Biology · doi:10.1186/s12918-014-0135-x · Cited by 24
Dogan, T., Gnad, F., Chan, J., Phu, L., Young, A. E., Chen, J., Doll, S., Stokes, M. P., Belvin, M. P., Friedman, L. S., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.792754 · Cited by 25
Lu, F., Yin, D., Pu, Y., Liu, W., Li, Z., Shao, Q., He, C., & Cao, L. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-018-0322-7 · Cited by 25
Duan, H., Li, B., Zhuang, X. H., Wang, L., Cao, Q., Tan, L.-H., Qu, G.-F., & Xiao, S. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00264.2018 · Cited by 24
mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
Yang, J. Y., Madrakhimov, S. B., Ahn, D. H., Chang, H. S., Jung, S. J., Nah, S. K., Park, H. Y., & Park, T. K. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0380-0 · Cited by 24
Švajger, U., & Rožman, P. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02627 · Cited by 24
Cervi, F., Saletti, V., Turner, K., Peron, A., Bulgheroni, S., Taddei, M., Briola, F. L., Canevini, M. P., & Vignoli, A. (2020) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-020-01488-4 · Cited by 24
Rausch, M., Weiss, A., Zoetemelk, M., Piersma, S. R., Jiménez, C. R., B, J. R. V. B., & Nowak-Sliwinska, P. M. (2020) · Cancers · doi:10.3390/cancers12113172 · Cited by 24
The Targeted Therapies for Osteosarcoma via Six Major Pathways
Wang, S., Ren, Q., Li, G., Zhao, X., Zhao, X., & Zhang, Z. (2023) · Current Molecular Pharmacology · doi:10.2174/1874467217666230821142839 · Cited by 24
Therapeutic targeting of p90 ribosomal S6 kinase
Wright, E. B., & Lannigan, D. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1297292 · Cited by 26
Emerging roles of non-coding RNAs in modulating the PI3K/Akt pathway in cancer
Hashemi, M., Khosroshahi, E. M., Asadi, S., Tanha, M., Mohseni, F. G., Sagha, R. A., Taheri, E., Vazayefi, P., Shekarriz, H., Habibi, F., et al. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.08.002 · Cited by 24
Silvestre-Roig, C., Fernández, P., Esteban, V., Pello, Ó. M., Indolfi, C., Rodrı́guez, C., Rodríguez‐Calvo, R., López-Maderuelo, D., Bauriedel, G., Hutter, R., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300580 · Cited by 23
REV-ERBα alters circadian rhythms by modulating mTOR signaling
Dadon‐Freiberg, M., Chapnik, N., & Froy, O. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111108 · Cited by 23
Signal Transduction Regulators in Axonal Regeneration
Hausott, B., Glueckert, R., Schrott‐Fischer, A., & Klimaschewski, L. P. (2022) · Cells · doi:10.3390/cells11091537 · Cited by 24
PI 3K‐dependent multiple myeloma cell survival is mediated by the PIK 3 CA isoform
Hofmann, C., Stühmer, T., Schmiedl, N., Wetzker, R., Mottok, A., Rosenwald, A., Langer, C., Zovko, J., Chatterjee, M., Einsele, H., et al. (2014) · British Journal of Haematology · doi:10.1111/bjh.12920 · Cited by 23
Kim, S.-H., Kim, J.-H., & Song, J. J. (2013) · Cancer Gene Therapy · doi:10.1038/cgt.2012.88 · Cited by 23
Venkatakrishnan, K., & Ecsedy, J. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.544 · Cited by 23
And Akt‐ion! IQGAP1 in control of signaling pathways
Choi, S., & Anderson, R. A. (2017) · The EMBO Journal · doi:10.15252/embj.201796827 · Cited by 23
Sen, S., Meric‐Bernstam, F., Hong, D. S., Hess, K. R., & Subbiah, V. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx094 · Cited by 23
mTOR complexes differentially orchestrates eosinophil development in allergy
Zhu, C., Xia, L., Li, F., Zhou, L., Weng, Q., Li, Z., Wu, Y., Mao, Y., Zhang, C., Wu, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25358-z · Cited by 23
Kotula‐Balak, M., Górowska-Wójtowicz, E., Milon, A., Pawlicki, P., Tworzydlo, W., Płachno, B. J., Krakowska, I., Hejmej, A., Wolski, J. K., & Bilińska, B. (2020) · PROTOPLASMA · doi:10.1007/s00709-020-01488-y · Cited by 23
Kaur, H., & Moreau, R. F. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109842 · Cited by 24
Jeong, J., Mai, N. T. Q., Moon, B.-S., & Choi, J. K. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118228 · Cited by 23
Lucas, T. F. G., Amaral, L. S., Porto, C. S., & Quintas, L. E. M. (2012) · Reproduction · doi:10.1530/rep-12-0232 · Cited by 23
Hirschi, B., Gallmeier, E., Ziesch, A., Marschall, M. K., & Kolligs, F. T. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-122 · Cited by 22
Quantification of growth factor signaling and pathway cross talk by live-cell imaging
Gross, S. M., & Rotwein, P. S. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00312.2016 · Cited by 21
Chiang, Y.-J., Liao, W.-T., Ho, K.-C., Wang, S., Chen, Y., Ho, C., Huang, S.-F. K., Shih, L., Yang‐Yen, H., & Yen, J. J.-Y. (2018) · Oncogene · doi:10.1038/s41388-018-0507-6 · Cited by 22
Roles of microRNAs in Regulating Cancer Stemness in Head and Neck Cancers
Fitriana, M., Hwang, W., Chan, P.-Y., Hsueh, T.-Y., & Liao, T. (2021) · Cancers · doi:10.3390/cancers13071742 · Cited by 24
Carli, D., Kalantari, S., Manicone, R., Coppo, P., di Celle, P. F., Selva, R. L., Santoro, F., Ranieri, C., Cardaropoli, S., Fagioli, F., et al. (2021) · Clinical Genetics · doi:10.1111/cge.14047 · Cited by 22
Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury
Mohan, M., Mannan, A., & Singh, T. G. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00505-0 · Cited by 22
Molecular and functional insight into anti-EGFR nanobody: Theranostic implications for malignancies
Tripathy, R. K., & Pande, A. H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122593 · Cited by 23
Inhibition of Galectin-1 Sensitizes HRAS-driven Tumor Growth to Rapamycin Treatment
Michael, J. V., Wurtzel, J. G. T., & Goldfinger, L. E. (2016) · Anticancer Research · doi:10.21873/anticanres.11074 · Cited by 22
Modulation of oncogenic signaling networks by Kaposi’s sarcoma-associated herpesvirus
Wong, J. P., & Damania, B. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0101 · Cited by 22
Rubens, J. A., Wang, S. Z., Price, A. C., Weingart, M., Allen, S. J., Orr, B. A., Eberhart, C. G., & Raabe, E. H. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox067 · Cited by 23
London, S. E. (2017) · Behavioural Processes · doi:10.1016/j.beproc.2017.11.008 · Cited by 23
Citi, V., Re, M. D., Martelli, A., Calderone, V., Breschi, M. C., & Danesi, R. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3543-6 · Cited by 22
Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor
Lee, S., Na, Y. J., Jeong, Y. A., Kim, J. L., Oh, S. C., & Lee, D.-H. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.07.008 · Cited by 23
Bessis, D., Morice‐Picard, F., Bourrat, E., Abadie, C., Aouinti, S., Baumann, C., Best, M., Bursztejn, A. ‐., Capri, Y., Chiavérini, C., et al. (2018) · British Journal of Dermatology · doi:10.1111/bjd.17077 · Cited by 22
Yu, Z., Chen, Z., Su, Q., Ye, S., Yuan, H., Kuai, M., Lv, M., Tu, Z., Yang, X., Liu, R., et al. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.01.028 · Cited by 22
Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses
Akan, D. T., Howes, J. E., Sai, J., Arnold, A. L., Beesetty, Y., Phan, J., Olejniczak, E. T., Waterson, A. G., & Fesik, S. W. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.8b00869 · Cited by 22
Liu, Z., Jiang, L., Li, Y., Xie, B., Xie, J., Wang, Z., Zhou, X., Jiang, H., Fang, Y., Pan, H., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.019 · Cited by 22
Defining subpopulations of differential drug response to reveal novel target populations
Keshava, N., Toh, T. S., Yuan, H., Yang, B., Menden, M. P., & Wang, D. Y. Q. (2019) · npj Systems Biology and Applications · doi:10.1038/s41540-019-0113-4 · Cited by 22
Schulte, A., Ewald, F., Spyra, M., Smit, D. J., Jiang, W., Salamon, J., Jücker, M., & Mautner, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041548 · Cited by 22
Metadata
- Authors
- Mendoza, M. C., Er, E. E., & Blenis, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Blenis, John
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 36
- Issue
- 6
- Pages
- 320-328
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC3112285
- OpenAlex
- W1998203489
- Cited by
- 1,817
- References
- 103
- Citations by year
- 2026: 112 · 2025: 96 · 2024: 122 · 2023: 133 · 2022: 127 · 2021: 163 · 2020: 166 · 2019: 164 · 2018: 144 · 2017: 158 · 2016: 123 · 2015: 100 · 2014: 92 · 2013: 55 · 2012: 49
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- LAM Foundation
- Susan G. Komen
- National Cancer Institute (R37CA046595)
- National Institute of General Medical Sciences (R01GM051405)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- Ras/ERK signaling pathway, signaling crosstalk, cell survival, cell proliferation, cell differentiation, cellular metabolism, cell motility, proto-oncogenes, cancer therapeutics
- MeSH terms
- Humans, Signal Transduction, ras Proteins, Extracellular Signal-Regulated MAP Kinases, Phosphatidylinositol 3-Kinase, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review