Cited by 1,121Endoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyIon Channels and Receptors

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UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

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Senft, Daniela, Ronai, Ze’ev A.·2015·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2015.01.002PMC PMC4340752

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Abstract

Cellular stress, induced by external or internal cues, activates several well-orchestrated processes aimed at either restoring cellular homeostasis or committing to cell death. Those processes include the unfolded protein response (UPR), autophagy, hypoxia, and mitochondrial function, which are part of the global endoplasmic reticulum (ER) stress (ERS) response. When one of the ERS elements is impaired, as often occurs under pathological conditions, overall cellular homeostasis may be perturbed. Further, activation of the UPR could trigger changes in mitochondrial function or autophagy, which could modulate the UPR, exemplifying crosstalk processes. Among the numerous factors that control the magnitude or duration of these processes are ubiquitin ligases, which govern overall cellular stress outcomes. Here we summarize crosstalk among the fundamental processes governing ERS responses.

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Authors: Senft, D., & Ronai, Z. A.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Senft, Daniela
Ronai, Ze’ev A.
ORCID: Senft, Daniela
Ronai, Ze’ev A.
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2015-03
Volume: 40
Issue: 3
Pages: 141-148
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2015.01.002
PMC: PMC4340752
OpenAlex: W2019263782
Cited by: 1,121
References: 90
Citations by year: 2026: 84 · 2025: 116 · 2024: 113 · 2023: 148 · 2022: 130 · 2021: 107 · 2020: 105 · 2019: 95 · 2018: 72 · 2017: 70 · 2016: 61 · 2015: 20
FWCI: 7.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA128814, CA-128814, P30CA030199)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: unfolded protein response, autophagy, mitochondrial function, endoplasmic reticulum stress, ubiquitin ligase, cellular stress response, cell death, cellular homeostasis
MeSH terms: Animals, Autophagy, Cell Physiological Phenomena, Humans, Mitochondria, Stress, Physiological, Unfolded Protein Response, Endoplasmic Reticulum Stress

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UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

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