Regulation of longevity by FGF21: interaction between energy metabolism and stress responses

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,283 · see citing works

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Mihaylova, M. M., & Shaw, R. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2329 · Cited by 2,923 · see citing works

The integrated stress response

Pakos‐Zebrucka, K., Koryga, I., Mnich, K., Ljujic, M., Samali, A., & Gorman, A. M. (2016) · The EMBO Reports · doi:10.15252/embr.201642195 · Cited by 2,659 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Sirtuins as regulators of metabolism and healthspan

Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008 · see citing works

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works

The mitochondrial basis of aging

Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441 · see citing works

miR-34a repression of SIRT1 regulates apoptosis

Yamakuchi, M., Ferlito, M., & Lowenstein, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801613105 · Cited by 1,344 · see citing works

Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works

Adipose tissue browning and metabolic health

Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177 · see citing works

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

B’chir, W., Maurin, A.-C., Carraro, V., Averous, J., Jousse, C., Muranishi, Y., Parry, L., Stepien, G., Fafournoux, P., & Bruhat, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt563 · Cited by 1,162 · see citing works

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works

Evolution of the Fgf and Fgfr gene families.

Itoh, N., & Ornitz, D. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.08.007 · Cited by 1,123 · see citing works

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

Senft, D., & Ronai, Z. A. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.01.002 · Cited by 1,121 · see citing works

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982 · see citing works

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Hulbert, A. J., Pamplona, R., Buffenstein, R., & Buttemer, W. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00047.2006 · Cited by 926 · see citing works

Body size, energy metabolism and lifespan

Speakman, J. R. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01556 · Cited by 914 · see citing works

Understanding the Physiology of FGF21

Fisher, F. M., & Maratos-Flier, E. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105339 · Cited by 912 · see citing works

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

Tazawa, H., Tsuchiya, N., Izumiya, M., & Nakagama, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707351104 · Cited by 902 · see citing works

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

Salminen, A., Hyttinen, J. M. T., & Kaarniranta, K. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0748-0 · Cited by 866 · see citing works

AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860 · see citing works

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

Verfaillie, T., Rubio, N., Garg, A. D., Bultynck, G., Rizzuto, R., Decuypere, J.-P., Piette, J. G., Linehan, C., Gupta, S., Afshin Samali, A., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.74 · Cited by 851 · see citing works

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00067-1 · Cited by 847 · see citing works

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A., Kharitonenkov, A., Flier, J. S., & Maratos-Flier, E. (2010) · Diabetes · doi:10.2337/db10-0193 · Cited by 830 · see citing works

MicroRNA-34a regulates cardiac ageing and function.

Boon, R. A., Iekushi, K., Lechner, S., Seeger, T., Fischer, A., Heydt, S., Kaluza, D., Tréguer, K., Carmona, G., Bonauer, A., et al. (2013) · Nature · doi:10.1038/nature11919 · Cited by 821 · see citing works

The Critical Role of Metabolic Pathways in Aging

Barzilai, N., Huffman, D. M., Muzumdar, R. H., & Bartke, A. (2012) · Diabetes · doi:10.2337/db11-1300 · Cited by 803 · see citing works

Mitonuclear communication in homeostasis and stress

Quirós, P. M., Mottis, A., & Auwerx, J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.23 · Cited by 787 · see citing works

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774 · see citing works

Stressing the role of FoxO proteins in lifespan and disease

van der Horst, A., & Burgering, B. M. T. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2190 · Cited by 759 · see citing works

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

Nogueiras, R., Habegger, K. M., Chaudhary, N., Finan, B., Banks, A. S., Dietrich, M. O., Horváth, T. L., Sinclair, D. A., Pfluger, P. T., & Tschöp, M. H. (2012) · Physiological Reviews · doi:10.1152/physrev.00022.2011 · Cited by 712 · see citing works

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704 · see citing works

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

Lin, Z., Tian, H., Lam, K. S. L., Lin, S., Hoo, R. C. L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S. R., Xu, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.005 · Cited by 691 · see citing works

Brown adipose tissue as a secretory organ

Villarroya, F., Cereijo, R., Villarroya, J., & Giralt, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.136 · Cited by 677 · see citing works

Adiponectin – a key adipokine in the metabolic syndrome

Whitehead, J. P., Richards, A. A., Hickman, I. J., Macdonald, G. A., & Prins, J. B. (2005) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00510.x · Cited by 640 · see citing works

Mitohormesis

Yun, J., & Finkel, T. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.011 · Cited by 626 · see citing works

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623 · see citing works

βKlotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617 · see citing works

Low methionine ingestion by rats extends life span.

Orentreich, N., Matias, J. R., Felice, A. D., & Zimmerman, J. (1993) · Journal of NutriLife · doi:10.1093/jn/123.2.269 · Cited by 608 · see citing works

PGC1α and mitochondrial metabolism – emerging concepts and relevance in ageing and neurodegenerative disorders

Austin, S., & St‐Pierre, J. (2012) · Journal of Cell Science · doi:10.1242/jcs.113662 · Cited by 606 · see citing works

FGF21 is an endocrine signal of protein restriction

Laeger, T., Henagan, T. M., Albarado, D. C., Redman, L. M., Bray, G. A., Noland, R. C., Münzberg, H., Hutson, S. M., Gettys, T. W., Schwartz, M. W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74915 · Cited by 593 · see citing works

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes · doi:10.2337/db14-0595 · Cited by 590 · see citing works

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581 · see citing works

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

Chau, M. D. L., Gao, J., Yang, Q., Wu, Z., & Gromada, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006962107 · Cited by 548 · see citing works

Catecholaminergic systems in stress: structural and molecular genetic approaches

Kvetnansky, R., Sabban, E. L., & Palkovits, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2006 · Cited by 548 · see citing works

Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α

Yoon, M. J., Lee, G. Y., Chung, J.-J., Ahn, Y. H., Hong, S. H., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1322 · Cited by 546 · see citing works

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

Holland, W., Adams, A., Brozinick, J., Bui, H., Miyauchi, Y., Kusminski, C., Bauer, S., Wade, M., Singhal, E., Cheng, C. C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.019 · Cited by 525 · see citing works

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.012 · Cited by 523 · see citing works

The Effect of Age on Thymic Function

Palmer, D. B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00316 · Cited by 494 · see citing works

AMPK at the Nexus of Energetics and Aging

Burkewitz, K., Zhang, Y., & Mair, W. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.002 · Cited by 483 · see citing works

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

Baird, T. D., & Wek, R. C. (2012) · Advances in Nutrition · doi:10.3945/an.112.002113 · Cited by 470 · see citing works

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

Suomalainen, A., Elo, J. M., Pietiläinen, K. H., Hakonen, A. H., Sevastianova, K., Korpela, M., Isohanni, P., Marjavaara, S. K., Tyni, T., Kiuru-Enari, S., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70155-7 · Cited by 427 · see citing works

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420 · see citing works

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

Inagaki, T., Lin, V. Y., Goetz, R., Mohammadi, M., Mangelsdorf, D. J., & Kliewer, S. A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.006 · Cited by 409 · see citing works

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.002 · Cited by 403 · see citing works

Caloric restriction, SIRT1 and longevity

Cantó, C., & Auwerx, J. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.03.008 · Cited by 395 · see citing works

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

Liu, N., Landreh, M., Cao, K., Abe, M., Hendriks, G., Kennerdell, J. R., Zhu, Y., Wang, L., & Bonini, N. M. (2012) · Nature · doi:10.1038/nature10810 · Cited by 394 · see citing works

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., & Dillin, A. (2011) · Nature · doi:10.1038/nature09706 · Cited by 393 · see citing works

Regulation of autophagy by ATF4 in response to severe hypoxia

Rzymski, T., Milani, M., Pike, L., Buffa, F. M., Mellor, H. R., Winchester, L. M., Pires, I. M., Hammond, E. M., Ragoussis, J., & Harris, A. L. (2010) · Oncogene · doi:10.1038/onc.2010.191 · Cited by 387 · see citing works

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

Planavila, A., Redondo‐Angulo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L., Sitges, M., Giralt, M., van Bilsen, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms3019 · Cited by 371 · see citing works

Mitochondrial stress induces chromatin reorganization to promote longevity and UPR(mt)

Tian, Y., Garcia, G., Bian, Q., Steffen, K. K., Joe, L., Wolff, S., Meyer, B. J., & Dillin, A. (2016) · Cell · doi:10.1016/j.cell.2016.04.011 · Cited by 370 · see citing works

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., & Maratos-Flier, E. (2009) · Endocrinology · doi:10.1210/en.2009-0532 · Cited by 362 · see citing works

PPARα is a key regulator of hepatic FGF21

Lundåsen, T., Hunt, M., Nilsson, L.-M., Sanyal, S., Angelin, B., Alexson, S., & Rudling, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.068 · Cited by 361 · see citing works

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

Suzuki, M., Uehara, Y., Motomura-Matsuzaka, K., Oki, J., Koyama, Y., Kimura, M., Asada, M., Komi-Kuramochi, A., Oka, S., & Toru, T. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0313 · Cited by 345 · see citing works

Evolutionary conservation of the <i>clk-1</i> -dependent mechanism of longevity: loss of <i>mclk1</i> increases cellular fitness and lifespan in mice

Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., & Hekimi, S. (2005) · Genes &amp; Development · doi:10.1101/gad.1352905 · Cited by 345 · see citing works

MicroRNA-34a regulation of endothelial senescence

Ito, T., Yagi, S., & Yamakuchi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.012 · Cited by 336 · see citing works

FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho

Kharitonenkov, A., Dunbar, J. D., Bina, H. A., Bright, S. W., Moyers, J. S., Zhang, C., Ding, L., Micanovic, R., Mehrbod, S. F., Knierman, M. D., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21357 · Cited by 329 · see citing works

Adiponectin actions in the cardiovascular system

Hopkins, T. A., Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.009 · Cited by 326 · see citing works

The metabolic regulation of aging

Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works

Obesity accelerates thymic aging

Yang, H., Youm, Y., Vandanmagsar, B., Rood, J. C., Kumar, K. G., Butler, A. A., & Dixit, V. D. (2009) · Blood · doi:10.1182/blood-2009-03-213595 · Cited by 309 · see citing works

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

Woo, Y. C., Xu, A., Wang, Y., & Lam, K. S. L. (2012) · Clinical Endocrinology · doi:10.1111/cen.12095 · Cited by 302 · see citing works

Mitochondrial myopathy induces a starvation-like response

Tyynismaa, H., Carroll, C. J., Raimundo, N., Ahola-Erkkilä, S., Wenz, T., Ruhanen, H., Guse, K., Hemminki, A., Peltola-Mjøsund, K. E., Tulkki, V., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq310 · Cited by 300 · see citing works

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Liang, Q., Zhong, L., Zhang, J., Wang, Y., Bornstein, S. R., Triggle, C. R., Ding, H., Lam, K. S. L., & Xu, A. (2014) · Diabetes · doi:10.2337/db14-0541 · Cited by 299 · see citing works

AMPK as a mediator of hormonal signalling

Lim, C. T., Kola, B., & Korbonits, M. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0063 · Cited by 298 · see citing works

Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States

Muise, E. S., Azzolina, B., Kuo, D. W., El-Sherbeini, M., Tan, Y., Yuan, X., Mu, J., Thompson, J. R., Berger, J. P., & Wong, K. K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.044826 · Cited by 294 · see citing works

Calorie restriction and prevention of age‐associated chronic disease

Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293 · see citing works

Myokines and Adipokines: Involvement in the Crosstalk between Skeletal Muscle and Adipose Tissue

Li, F., Li, Y., Duan, Y., Hu, C.-A. A., Tang, Y., & Yin, Y. (2017) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.10.003 · Cited by 288 · see citing works

The multifaceted role of mTORC1 in the control of lipid metabolism

Ricoult, S. J. H., & Manning, B. D. (2013) · EMBO Reports · doi:10.1038/embor.2013.5 · Cited by 287 · see citing works

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity

Bartke, A., Sun, L. Y., & Longo, V. D. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2012 · Cited by 286 · see citing works

Adiponectin receptor signalling in the brain

Thundyil, J., Pavlovski, D., Sobey, C. G., & Arumugam, T. V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01560.x · Cited by 282 · see citing works

The fasting polypeptide FGF21 can enter brain from blood

Hsuchou, H., Pan, W., & Kastin, A. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.10.007 · Cited by 280 · see citing works

Regulation of the aging process by autophagy.

Salminen, A., & Kaarniranta, K. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.004 · Cited by 270 · see citing works

Fibroblast growth factor 21 protects the heart from oxidative stress

Planavila, A., Redondo‐Angulo, I., Ribas‐Aulinas, F., Garrabou, G., Casademont, J., Giralt, M., & Villarroya, F. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu263 · Cited by 265 · see citing works

Protein and amino acid restriction, aging and disease: from yeast to humans

Mirzaei, H., Suarez, J. A., & Longo, V. D. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.002 · Cited by 248 · see citing works

Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

Itoh, N. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1024-2 · Cited by 247 · see citing works

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

De Sousa-Coelho, A. L., Marrero, P. F., & Haro, D. (2012) · Biochemical Journal · doi:10.1042/bj20111748 · Cited by 246 · see citing works

Interplay between FGF21 and insulin action in the liver regulates metabolism

Emanuelli, B., Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, M., Michael, M. D., Adams, A. C., Kharitonenkov, A., & Kahn, C. R. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67353 · Cited by 243 · see citing works

The Th17/Treg balance is disturbed during aging

Schmitt, V., Rink, L., & Uciechowski, P. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.09.003 · Cited by 235 · see citing works

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.006 · Cited by 230 · see citing works

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

Camporez, J. P., Jornayvaz, F. R., Petersen, M. C., Pesta, D. H., Guigni, B. A., Serr, J., Zhang, D., Kahn, M., Samuel, V. T., Jurczak, M. J., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1191 · Cited by 226 · see citing works

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

Liu, Y., Palanivel, R., Rai, E., Park, M. S., Gabor, T. V., Scheid, M. P., Xu, A., & Sweeney, G. (2014) · Diabetes · doi:10.2337/db14-0267 · Cited by 223 · see citing works

Stress Biology and Aging Mechanisms: Toward Understanding the Deep Connection Between Adaptation to Stress and Longevity

Epel, E. S., & Lithgow, G. J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu055 · Cited by 223 · see citing works

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., van Schothorst, E. M., Keijer, J., & Klaus, S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2013 · Cited by 221 · see citing works

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

Douris, N., Stevanovic, D. M., Fisher, F. M., Cisu, T. I., Chee, M. J., Nguyen, N. L., Zarebidaki, E., Adams, A. C., Kharitonenkov, A., Flier, J. S., et al. (2015) · Endocrinology · doi:10.1210/en.2014-2001 · Cited by 215 · see citing works

Aging networks in Caenorhabditis elegans : AMP‐activated protein kinase ( aak‐2 ) links multiple aging and metabolism pathways

Curtis, R., O'Connor, G., & DiStefano, P. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00205.x · Cited by 215 · see citing works

FGF21 and the late adaptive response to starvation in humans

Fazeli, P. K., Lun, M., Kim, S. M., Bredella, M. A., Wright, S., Zhang, Y., Lee, H., Catana, C., Klibanski, A., Patwari, P., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83349 · Cited by 214 · see citing works

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients

Gallego-Escuredo, J. M., Gómez‐Ambrosi, J., Catalán, V., Domingo, P., Giralt, M., Frühbeck, G., & Villarroya, F. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.76 · Cited by 212 · see citing works

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Birkenfeld, A. L., Lee, H., Guebre‐Egziabher, F., Alves, T. C., Jurczak, M. J., Jornayvaz, F. R., Zhang, D., Hsiao, J. J., Martín‐Montalvo, A., Fischer‐Rosinsky, A., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.009 · Cited by 212 · see citing works

Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1

Li, N., Muthusamy, S., Liang, R., Sarojini, H., & Wang, E. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.12.004 · Cited by 211 · see citing works

The impact of low-protein high-carbohydrate diets on aging and lifespan

Le Couteur, D. G., Solon-Biet, S., Cogger, V. C., Mitchell, S. J., Senior, A., de Cabo, R., Raubenheimer, D., & Simpson, S. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2120-y · Cited by 209 · see citing works

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

Liu, L., Wise, D. R., Diehl, J. A., & Simon, M. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805056200 · Cited by 206 · see citing works

Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

Laeger, T., Albarado, D. C., Burke, S. J., Trosclair, L., Hedgepeth, J. W., Berthoud, H.-R., Gettys, T. W., Collier, J. J., Münzberg, H., & Morrison, C. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.044 · Cited by 206 · see citing works

The role of mitochondrial dysfunction in age-related diseases

Lane, R. K., Hilsabeck, T., & Rea, S. L. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.021 · Cited by 205 · see citing works

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

Lees, E. K., Król, E., Grant, L., Shearer, K., Wyse, C. A., Moncur, E. M., Bykowska, A. S., Mody, N., Gettys, T. W., & Delibegović, M. (2014) · Aging Cell · doi:10.1111/acel.12238 · Cited by 203 · see citing works

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway

Vernia, S., Cavanagh, J., García-Haro, L., Sabio, G., Barrett, T., Jung, D. Y., Kim, J. K., Xu, J. L., Shulha, H. P., Garber, M. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.010 · Cited by 200 · see citing works

Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease

Yilmaz, Y. N., Eren, F., Yönal, O., Kurt, R., Aktaş, B., Çelikel, Ç., Özdogan, O. C., İmeryüz, N., Kalaycı, C., & Avşar, E. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02338.x · Cited by 196 · see citing works

Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution

Yang, H., Youm, Y.-H., & Dixit, V. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900562 · Cited by 196 · see citing works

TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway

Díaz-Delfín, J., Hondares, E., Iglesias, R., Giralt, M., Caelles, C., & Villarroya, F. (2012) · Endocrinology · doi:10.1210/en.2012-1193 · Cited by 195 · see citing works

Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors

Chow, W. S., Xu, A., Woo, Y. C., Tso, A. W. K., Cheung, S., Fong, C. H.-Y., Tse, H., Chau, M. T., Cheung, B. M. Y., & Lam, K. S. L. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301599 · Cited by 193 · see citing works

Longevity and stress in Caenorhabditis elegans

Zhou, K. I., Pincus, Z., & Slack, F. J. (2011) · Aging · doi:10.18632/aging.100367 · Cited by 189 · see citing works

MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

Fu, T., Seok, S., Choi, S.-E., Huang, Z., Suino-Powell, K., Xu, H., Kemper, B., & Kemper, J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00596-14 · Cited by 187 · see citing works

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

Wu, A.-L., Kolumam, G., Stawicki, S., Chen, Y., Li, J., Zavala-Solorio, J., Phamluong, K., Feng, B., Li, L., Marsters, S., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002669 · Cited by 184 · see citing works

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

Jiang, S., Cheng, Y., Fang, Q., Shao, M., Zhang, Y., Liu, Y., Deng, Y., Shan, B., Liu, J., Li, H., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.565960 · Cited by 183 · see citing works

Circulatory miR-34a as an RNA-based, noninvasive biomarker for brain aging

Li, X., Khanna, A., Li, N., & Wang, E. (2011) · Aging · doi:10.18632/aging.100371 · Cited by 183 · see citing works

Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway

Yu, Y.-H., He, J., Li, S., Song, L., Guo, X., Yao, W., Zou, D., Gao, X., Liu, Y., Bai, F., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.05.026 · Cited by 181 · see citing works

Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

Liu, S. Q., Roberts, D., Kharitonenkov, A., Zhang, B., Hanson, S., Li, Y. C., Zhang, L., & Wu, Y. (2013) · Scientific Reports · doi:10.1038/srep02767 · Cited by 179 · see citing works

MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression

Tabuchi, T., Satoh, M., Itoh, T., & Nakamura, M. (2012) · Clinical Science · doi:10.1042/cs20110563 · Cited by 174 · see citing works

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

Gong, Q., Hu, Z., Zhang, F., Cui, A., Chen, X., Jiang, H., Gao, J., Chen, X., Han, Y., Liang, Q., et al. (2016) · Hepatology · doi:10.1002/hep.28523 · Cited by 172 · see citing works

AMP‐activated protein kinase mediates glucocorticoid‐ induced metabolic changes: a novel mechanism in Cushing's syndrome

Christ‐Crain, M., Kola, B., Lolli, F., Fekete, C., Seboek, D., Wittmann, G., Feltrin, D., Igreja, S., Ajodha, S. J., Harvey-White, J. D., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-094144 · Cited by 170 · see citing works

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

Maida, A., Zota, A., Sjøberg, K. A., Schumacher, J., Sijmonsma, T. P., Pfenninger, A., Christensen, M. M., Gantert, T., Fuhrmeister, J., Rothermel, U., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85946 · Cited by 170 · see citing works

Mitochondrial uncoupling and lifespan

Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169 · see citing works

A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption

Wang, X., Wei, W., Krzeszinski, J. Y., Wang, Y., & Wan, Y. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.010 · Cited by 165 · see citing works

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress

Schaap, F. G., Kremer, A. E., Lamers, W. H., Jansen, P. L. M., & Gaemers, I. C. (2012) · Biochimie · doi:10.1016/j.biochi.2012.10.019 · Cited by 164 · see citing works

FGF21-based pharmacotherapy – potential utility for metabolic disorders

Gimeno, R. E., & Moller, D. E. (2014) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2014.03.001 · Cited by 163 · see citing works

Calorie restriction mimetics: Can you have your cake and eat it, too?

Ingram, D. K., & Roth, G. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.005 · Cited by 162 · see citing works

Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice

Zhang, J., Cheng, Y., Gu, J., Wang, S., Zhou, S., Wang, Y., Tan, Y., Feng, W., Fu, Y., Mellen, N. M., et al. (2016) · Clinical Science · doi:10.1042/cs20150623 · Cited by 158 · see citing works

MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9

Yang, J., Chen, D., He, Y., Meléndez, A., Feng, Z., Hong, Q., Bai, X., Li, Q., Cai, G., Wang, J., et al. (2011) · AGE · doi:10.1007/s11357-011-9324-3 · Cited by 157 · see citing works

Endocrine FGFs and Klothos: emerging concepts.

Kuro-o, M. (2008) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2008.06.002 · Cited by 154 · see citing works

Tipping the metabolic scales towards increased longevity in mammals

Riera, C. E., & Dillin, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3107 · Cited by 153 · see citing works

The somatotropic axis in human aging: framework for the current state of knowledge and future research

Milman, S., Huffman, D. M., & Barzilai, N. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.014 · Cited by 150 · see citing works

Adiponectin signaling in the liver

Combs, T. P., & Marliss, E. B. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9280-6 · Cited by 149 · see citing works

Mitochondria and PGC-1α in Aging and Age-Associated Diseases

Wenz, T. (2011) · Journal of Aging Research · doi:10.4061/2011/810619 · Cited by 149 · see citing works

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L., & Hall, M. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412047111 · Cited by 148 · see citing works

Visions & Reflections¶Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?

Longo, V. D., & Fabrizio, P. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8477-8 · Cited by 147 · see citing works

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

Pike, L., Singleton, D. C., Buffa, F. M., Abramczyk, O., Phadwal, K., Li, J., Simon, A. K., Murray, J. T., & Harris, A. L. (2012) · Biochemical Journal · doi:10.1042/bj20120972 · Cited by 147 · see citing works

Fibroblast growth factor-21, energy balance and obesity

Giralt, M., Gavaldà‐Navarro, A., & Villarroya, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.018 · Cited by 146 · see citing works

Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism

Liu, Q., Yuan, B., Lo, K. A., Patterson, H. C., Sun, Y., & Lodish, H. F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211611109 · Cited by 144 · see citing works

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho

Fu, T., Choi, S.-E., Kim, D.-H., Seok, S., Suino-Powell, K., Xu, H., & Kemper, J. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1205951109 · Cited by 143 · see citing works

Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

Chen, W., Hoo, R. L. C., Konishi, M., Itoh, N., Lee, P.-C., Ye, H., Lam, K. S. L., & Xu, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.285965 · Cited by 141 · see citing works

Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

Wang, L., Ishihara, T., Ibayashi, Y., Tatsushima, K., Setoyama, D., Hanada, Y., Takeichi, Y., Sakamoto, S., Yokota, S., Mihara, K., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3704-7 · Cited by 139 · see citing works

FGF21 Is an Exocrine Pancreas Secretagogue

Coate, K. C., Hernandez, G., Thorne, C. A., Sun, S., Le, T. D. V., Vale, K., Kliewer, S. A., & Mangelsdorf, D. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.004 · Cited by 136 · see citing works

MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors

Badi, I., Burba, I., Ruggeri, C., Zeni, F., Bertolotti, M., Scopece, A., Pompilio, G., & Raucci, A. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu180 · Cited by 134 · see citing works

DEC1, a Basic Helix-Loop-Helix Transcription Factor and a Novel Target Gene of the p53 Family, Mediates p53-dependent Premature Senescence

Qian, Y., Zhang, J., Yan, B., & Chen, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708624200 · Cited by 132 · see citing works

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Youm, Y.-H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A., & Dixit, V. D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514511113 · Cited by 129 · see citing works

Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress

Kim, S. H., Kim, K. H., Kim, H.-K., Kim, M.-J., Back, S. H., Konishi, M., Itoh, N., & Lee, M.-S. (2015) · Diabetologia · doi:10.1007/s00125-014-3475-6 · Cited by 124 · see citing works

Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts

Patel, V., Adya, R., Chen, J., Ramanjaneya, M., Bari, M. F., Bhudia, S. K., Hillhouse, E. W., Tan, B. K., & Randeva, H. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087102 · Cited by 124 · see citing works

Fibroblast growth factor 21 protects mouse brain against d-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation

Yu, Y., Bai, F., Wang, W., Liu, Y., Yuan, Q., Qu, S., Zhang, T., Tian, G., Li, S., Li, D., et al. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.020 · Cited by 119 · see citing works

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes

Minard, A. Y., Tan, S., Yang, P., Fazakerley, D. J., Domanova, W., Parker, B. L., Humphrey, S. J., Jothi, R., Stöckli, J., & James, D. E. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.086 · Cited by 118 · see citing works

FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1477-1 · Cited by 117 · see citing works

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1

Mäkelä, J., Tselykh, T. V., Maiorana, F., Eriksson, O., Thi, H., Mudò, G., Korhonen, L., Belluardo, N., & Lindholm, D. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-2 · Cited by 116 · see citing works

ER stress and hormetic regulation of the aging process

Salminen, A., & Kaarniranta, K. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.003 · Cited by 115 · see citing works

Adenosine Monophosphate-activated Protein Kinase Induces Cholesterol Efflux from Macrophage-derived Foam Cells and Alleviates Atherosclerosis in Apolipoprotein E-deficient Mice*

Li, D., Wang, D., Wang, Y., Ling, W., Feng, X., & Xia, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159772 · Cited by 115 · see citing works

Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21

Domouzoglou, E. M., Naka, K. Κ., Vlahos, A. P., Papafaklis, M. I., Michalis, L. K., Tsatsoulis, A., & Maratos–Flier, E. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00527.2015 · Cited by 115 · see citing works

FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism

Joki, Y., Ohashi, K., Yuasa, D., Shibata, R., Ito, M., Matsuo, K., Kambara, T., Uemura, Y., Hayakawa, S., Hiramatsu‐Ito, M., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.081 · Cited by 114 · see citing works

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

Kharitonenkov, A., & DiMarchi, R. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.007 · Cited by 114 · see citing works

Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway

Zhang, C., Huang, Z., Gu, J., Yan, X., Lu, X., Zhou, S., Wang, S., Shao, M., Zhang, F., Cheng, P., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3630-8 · Cited by 113 · see citing works

Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease

Gates, A. C., Bernal‐Mizrachi, C., Chinault, S. L., Chu, F., Schneider, J. G., Coleman, T., Malone, J. P., Townsend, R. R., Chakravarthy, M. V., & Semenkovich, C. F. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.010 · Cited by 113 · see citing works

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

Kim, K. H., Jeong, Y. T., Kim, S. H., Jung, H. S., Park, K. S., Lee, H.-Y., & Lee, M.-S. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.09.026 · Cited by 112 · see citing works

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

Singhal, G., Fisher, F. M., Chee, M. J. S., Tan, T. G., Ouaamari, A. E., Adams, A. C., Najarían, R. M., Kulkarni, R., Benoist, C. O., Flier, J. S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148252 · Cited by 112 · see citing works

High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets

So, W. Y., Cheng, Q., Chen, L., Evans‐Molina, C., Xu, A., Lam, K. S. L., & Leung, P. S. (2013) · Diabetes · doi:10.2337/db13-0645 · Cited by 109 · see citing works

ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress

Wan, X., Lu, X., Xiao, Y.-C., Lin, Y., Zhu, H., Ding, T., Yang, Y., Huang, Y., Zhang, Y., Liu, Y., et al. (2014) · BioMed Research International · doi:10.1155/2014/807874 · Cited by 105 · see citing works

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals

Hanks, L. J., Gutiérrez, O. M., Bamman, M. M., Ashraf, A., McCormick, K. L., & Casazza, K. (2015) · Journal of Clinical &amp; Translational Endocrinology · doi:10.1016/j.jcte.2015.02.001 · Cited by 104 · see citing works

FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice

Zhao, C., Liu, Y., Xiao, J., Liu, L., Chen, S., Mohammadi, M., McClain, C. J., Li, X., & Feng, W. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m058610 · Cited by 103 · see citing works

Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop

Patel, R., Bookout, A. L., Magomedova, L., Owen, B. M., Consiglio, G. P., Shimizu, M., Zhang, Y., Mangelsdorf, D. J., Kliewer, S. A., & Cummins, C. L. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1259 · Cited by 102 · see citing works

The FGF21–adiponectin axis in controlling energy and vascular homeostasis

Hui, X. H., Feng, T., Liu, Q., Gao, Y., & Xu, A. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw013 · Cited by 102 · see citing works

The Paradox of Mitochondrial Dysfunction and Extended Longevity

Munkácsy, E., & Rea, S. L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.016 · Cited by 101 · see citing works

Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage Apoptosis and Late-Stage Renal Dysfunction via Administration of Fibroblast Growth Factor-21 Is Associated with Suppression of Renal Inflammation

Zhang, C., Shao, M., Yang, H., Chen, L., Yu, L., Cong, W., Tian, H., Zhang, F., Cheng, P., Jin, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082275 · Cited by 100 · see citing works

Mechanisms of Aging-Related Impairment of Brown Adipocyte Development and Function

Graja, A., & Schulz, T. J. (2014) · Gerontology · doi:10.1159/000366557 · Cited by 99 · see citing works

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

Guridi, M., Tintignac, L. A. J., Lin, S., Kupr, B., Castets, P., & Rüegg, M. A. (2015) · Science Signaling · doi:10.1126/scisignal.aab3715 · Cited by 99 · see citing works

Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways

Xu, P., Zhang, Y., Liu, Y., Yuan, Q., Song, L., Liu, M., Liu, Z., Yang, Y., Li, J., Li, D., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.11.012 · Cited by 97 · see citing works

Circulating Fibroblast Growth Factor 21 Levels Are Closely Associated with Hepatic Fat Content: A Cross-Sectional Study

Yan, H., Xia, M., Chang, X., Xu, Q., Bian, H., Zeng, M., Rao, S., Yao, X., Tu, Y., Jia, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024895 · Cited by 95 · see citing works

Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway

Ji, K., Zheng, J., Lv, J., Xu, J., Ji, X., Luo, Y., Li, W. S., Zhao, Y., & Yan, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.020 · Cited by 95 · see citing works

Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate

Wu, S., Levenson, A. E., Kharitonenkov, A., & Luca, F. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.343707 · Cited by 94 · see citing works

Adiponectin Increases Skeletal Muscle Mitochondrial Biogenesis by Suppressing Mitogen-Activated Protein Kinase Phosphatase-1

Qiao, L., Kinney, B., Yoo, H. S., Lee, B., Schaack, J. B., & Shao, J. (2012) · Diabetes · doi:10.2337/db11-1475 · Cited by 94 · see citing works

Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice

Rusli, F., Deelen, J., Andriyani, E., Boekschoten, M. V., Lute, C., van den Akker, E. B., Müller, M. M., Beekman, M., & Steegenga, W. T. (2016) · Scientific Reports · doi:10.1038/srep30484 · Cited by 93 · see citing works

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

Wang, S., Chen, M.-S., Chou, Y., Ueng, Y., Yin, P., Yeh, T.-S., & Lee, H. (2016) · Oncotarget · doi:10.18632/oncotarget.12356 · Cited by 93 · see citing works

Anti-Inflammatory Mechanisms of Dietary Restriction in Slowing Aging Processes

Morgan, T. E., Wong, A., & Finch, C. E. (2006) · KARGER eBooks · doi:10.1159/000096557 · Cited by 92 · see citing works

Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle

Vandanmagsar, B., Warfel, J. D., Wicks, S. E., Ghosh, S., Salbaum, J. M., Burk, D., Dubuisson, O. S., Mendoza, T. M., Zhang, J., Noland, R. C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.057 · Cited by 92 · see citing works

Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRα Signaling in THP-1 Macrophage-Derived Foam Cells

Lin, X., Liu, M., Hu, H.-J., Feng, H., Fan, X., Zou, W.-W., Pan, Y., Hu, X., & Wang, Z. (2015) · DNA and Cell Biology · doi:10.1089/dna.2015.2866 · Cited by 86 · see citing works

FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology

Murata, Y., Konishi, M., & Itoh, N. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/981315 · Cited by 85 · see citing works

Fibroblast growth factor-21 protects human skeletal muscle myotubes from palmitate-induced insulin resistance by inhibiting stress kinase and NF-κB

Lee, M. S., Choi, S., Ha, E. S., An, S.-Y., Kim, T. H., Han, S. J., Kim, H. J., Kim, D. J., KANG, Y. Y., & Lee, K. W. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.012 · Cited by 79 · see citing works

Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway

Yu, Y.-H., Li, S., Liu, Y., Tian, G., Yuan, Q., Bai, F., Wang, W., Zhang, Z., Ren, G., Zhang, Y., et al. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.01.005 · Cited by 78 · see citing works

FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1

Kwon, M. M., O’Dwyer, S. M., Baker, R. K., Covey, S. D., & Kieffer, T. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.021 · Cited by 77 · see citing works

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

Perrone, C. E., Malloy, V. L., Orentreich, D. S., & Orentreich∥, N. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.005 · Cited by 76 · see citing works

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

Ren, J. T., & Zhang, Y. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.10.005 · Cited by 269 · see citing works

Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration

Li, R., Li, D.-H., Zhang, H., Wang, J., Li, X., & Xiao, J. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0338-1 · Cited by 256 · see citing works

Human Aging and Longevity Are Characterized by High Levels of Mitokines

Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., et al. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly153 · Cited by 219 · see citing works

LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging

Yang, Z. P., Jiang, S., Shang, J., Jiang, Y., Dai, Y., Xu, B., Yu, Y., Liang, Z., & Yang, Y. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.04.001 · Cited by 219 · see citing works

Brown and Beige Adipose Tissue and Aging

Zoico, E., Rubele, S., Caro, A. D., Nori, N., Mazzali, G., Fantin, F., Rossi, A. P., & Zamboni, M. M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00368 · Cited by 206 · see citing works

Mitohormesis, an Antiaging Paradigm

Bárcena, C., Mayoral, P., & Quirós, P. M. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.002 · Cited by 167 · see citing works

Mitochondrial stress and mitokines in aging

Burtscher, J., Soltany, A., Visavadiya, N. P., Burtscher, M., Millet, G. P., Khoramipour, K., & Khamoui, A. V. (2023) · Aging Cell · doi:10.1111/acel.13770 · Cited by 116 · see citing works

Inflammaging, hormesis and the rationale for anti-aging strategies

Santoro, A., Martucci, M., Conte, M., Capri, M., Franceschi, C., & Salvioli, S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101142 · Cited by 114 · see citing works

Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Lü, H., Jia, C., Wu, D., Jin, H., Zeng, L., Pan, J., Li, X., & Wang, W. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04157-x · Cited by 114 · see citing works

Mitochondria, immunosenescence and inflammaging: a role for mitokines?

Conte, M., Martucci, M., Chiariello, A., Franceschi, C., & Salvioli, S. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00813-0 · Cited by 104 · see citing works

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.009 · Cited by 97 · see citing works

Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia

Wang, C., Tan, Z., Niu, B., Tsang, K. Y., Tai, A. C. P., Chan, W. C. W., Lo, R. L. K., Leung, K. K. H., Dung, N. W. F., Itoh, N., et al. (2018) · eLife · doi:10.7554/elife.37673 · Cited by 87 · see citing works

The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases

Zhou, Z., Fan, Y., Zong, R., & Tan, K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101702 · Cited by 99 · see citing works

Myokines and Heart Failure: Challenging Role in Adverse Cardiac Remodeling, Myopathy, and Clinical Outcomes

Berezin, A. Е., Berezin, A. A., & Lichtenauer, M. (2021) · Disease Markers · doi:10.1155/2021/6644631 · Cited by 93 · see citing works

Decoding aging clocks: New insights from metabolomics

Huang, H., Chen, Y., Xu, W., Cao, L., Qian, K., Bischof, E. Y., Kennedy, B. K., & Pu, J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.007 · Cited by 91 · see citing works

Pathological mechanisms of kidney disease in ageing

Yamamoto, T., & Isaka, Y. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00868-4 · Cited by 94 · see citing works

Mitochondrial uncoupling and longevity – A role for mitokines?

Klaus, S., & Ost, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110796 · Cited by 79 · see citing works

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging

Conte, M., Sabbatinelli, J., Chiariello, A., Martucci, M., Santoro, A., Monti, D., Arcaro, M., Galimberti, D., Scarpini, E. A., Bonfigli, A. R., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00287-w · Cited by 82 · see citing works

Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

Fu, X., Wang, Y., Zhao, F., Cui, R., Xie, W., Liu, Q., & Yang, W. (2023) · Aging · doi:10.18632/aging.204847 · Cited by 76 · see citing works

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

Latko, M., Czyrek, A. A., Porębska, N., Kucińska, M. K., Otlewski, J., Zakrzewska, M., & Opaliński, Ł. (2019) · Cells · doi:10.3390/cells8050455 · Cited by 74 · see citing works

Effect of Cellular and ECM Aging on Human iPSC-derived Cardiomyocyte Performance, Maturity and Senescence

Ozcebe, S. G., Bahçecioğlu, G., Yue, X. S., & Zorlutuna, P. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120554 · Cited by 74 · see citing works

Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity

Çakır, I., Hadley, C. K., Pan, P. L., Bagchi, R. A., Ghamari‐Langroudi, M., Porter, D. T., Wang, Q., Litt, M. J., Jana, S., Hagen, S. E., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00515-3 · Cited by 74 · see citing works

PGC‐1α, a potential therapeutic target against kidney aging

Lee, G.-Y., Uddin, M. J., Kim, Y., Ko, M., Yu, I., & Ha, H. (2019) · Aging Cell · doi:10.1111/acel.12994 · Cited by 71 · see citing works

Nutrients and Pathways that Regulate Health Span and Life Span

Pignatti, C., D’Adamo, S., Stefanelli, C., Flamigni, F., & Cetrullo, S. (2020) · Geriatrics · doi:10.3390/geriatrics5040095 · Cited by 64 · see citing works

Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation

Hamstra, S. I., Roy, B. D., Tiidus, P., MacNeil, A. J., Klentrou, P., MacPherson, R. E. K., & Fajardo, V. A. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302151224 · Cited by 60 · see citing works

Increased Expression of the Mitochondrial Derived Peptide, MOTS-c, in Skeletal Muscle of Healthy Aging Men Is Associated with Myofiber Composition

D’Souza, R. F., Woodhead, J. S. T., Hedges, C. P., Zeng, N., Wan, J., Kumagai, H., Lee, C., Cohen, P., Cameron-Smith, D., Mitchell, C. J., et al. (2020) · Aging · doi:10.18632/aging.102944 · Cited by 55 · see citing works

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue

Villarroya, J., Gallego-Escuredo, J. M., Delgado‐Anglés, A., Cairó, M., Moure, R., Mateo, M. G., Domingo, J. C., Domingo, P., Giralt, M., & Villarroya, F. (2018) · Aging Cell · doi:10.1111/acel.12822 · Cited by 56 · see citing works

Skeletal Muscle and Bone – Emerging Targets of Fibroblast Growth Factor-21

Sun, H., Sherrier, M. C., & Li, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.625287 · Cited by 54 · see citing works

The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases

Yan, J., Nie, Y., Cao, J., Luo, M., Yan, M., Chen, Z., & He, B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.655575 · Cited by 53 · see citing works

FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice

Zhang, K., Gan, J., Wang, B., Lei, W., Dong, Z., Yang, J., Wang, N., Wen, C., Gao, X., Li, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56885-9 · Cited by 52 · see citing works

Genes and Longevity of Lifespan

Bin-Jumah, M. N., Nadeem, M. S., Gilani, S. J., Al-Abbasi, F. A., Ullah, I., Alzarea, S. I., Ghoneim, M. M., Alshehri, S., Ud-Din, A., Murtaza, B. N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031499 · Cited by 50 · see citing works

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

de Urturi, D. S., Buqué, X., Porteiro, B., Folgueira, C., Mora, A., Delgado, T. C., Prieto‐Fernández, E., Olaizola, P., Gómez‐Santos, B., Apodaka‐Biguri, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28749-z · Cited by 48 · see citing works

Veganism, aging and longevity: new insight into old concepts

Norman, K., & Klaus, S. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000625 · Cited by 45 · see citing works

Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats

Zheng, W., Matei, N., Pang, J., Luo, X., Song, Z. Q., Tang, J., & Zhang, J. H. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113007 · Cited by 44 · see citing works

Alginate self-adhesive hydrogel combined with dental pulp stem cells and FGF21 repairs hemisection spinal cord injury via apoptosis and autophagy mechanisms

Zhu, S., Ying, Y., Wu, Q., Ni, Z., Huang, Z., Cai, P., Tu, Y., Ying, W., Ye, J., Zhang, R., et al. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130827 · Cited by 41 · see citing works

FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity

Minami, S., Sakai, S., Yamamoto, T., Takabatake, Y., Namba‐Hamano, T., Takahashi, A., Matsuda, J., Yonishi, H., Nakamura, J., Maeda, S., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2259282 · Cited by 39 · see citing works

Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure

McCarty, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073321 · Cited by 40 · see citing works

Hypothalamus-pituitary-adrenal Axis in Glucolipid metabolic disorders

Lin, Y., Zhang, Z., Wang, S., Cai, J., & Guo, J. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09586-1 · Cited by 38 · see citing works

The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition

Liao, C., Kummert, O. M. P., Bair, A. M., Alavi, N., Alavi, J., Miller, D. M., Bagga, I., Schempf, A. M., Hsu, Y.-M., Woods, B. D., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab145 · Cited by 34 · see citing works

The integrated stress response as a key pathway downstream of mitochondrial dysfunction

Bilen, M., Benhammouda, S., Slack, R. S., & Germain, M. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100555 · Cited by 31 · see citing works

Mechanisms of ageing: growth hormone, dietary restriction, and metformin

Khan, J., Pernicova, I., Nisar, K., & Korbonits, M. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00001-3 · Cited by 32 · see citing works

The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity

Wang, X., & Zhang, G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102603 · Cited by 29 · see citing works

Mechanistical retinal drug targets and challenges

Kaarniranta, K., Xu, H., & Kauppinen, A. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.016 · Cited by 28 · see citing works

Obesity is a common soil for premature cardiac aging and heart diseases - Role of autophagy

Sun, M., Tan, Y., Rexiati, M., Dong, M., & Guo, W. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.004 · Cited by 29 · see citing works

FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling

Kong, Y., Zhao, C., Tan, P., Liu, S., Huang, Y., Zeng, F., Ma, P., Guo, Y., Zhao, B., & Wang, J. (2022) · Animals · doi:10.3390/ani12070939 · Cited by 28 · see citing works

AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration

Salminen, A. (2023) · Biogerontology · doi:10.1007/s10522-023-10072-9 · Cited by 25 · see citing works

Oxidative stress bridges the gut microbiota and the occurrence of frailty syndrome

Chen, S.-Y., Wang, T.-Y., Zhao, C., & Wang, H. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i38.5547 · Cited by 25 · see citing works

Methionine restriction alleviates diabetes-associated cognitive impairment via activation of FGF21

Zhang, Y., Wang, Y., Li, Y., Pang, J., Höhn, A., Dong, W., Gao, R. H., Liu, Y., Wang, D., She, Y., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103390 · Cited by 24 · see citing works

Growth signaling and longevity in mouse models

Kim, S.-S., & Lee, C. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.299 · Cited by 23 · see citing works

Engineered ADSCs and doxycycline encapsulated antibacterial, immunomodulatory and proangiogenic hydrogels for infected burn wound healing

Gu, Y., Liang, Z., Wang, Y., Zhou, Y. J., Shi, Y., Luo, J., Xu, X., Fang, K., Wang, H., Guo, B., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158478 · Cited by 22 · see citing works

Potential biomarker of fibroblast growth factor 21 in valproic acid‐treated livers

Xu, X., Guo, C., Liang, X., Li, R., & Chen, J. (2019) · BioFactors · doi:10.1002/biof.1519 · Cited by 21 · see citing works

Senoinflammation: A major mediator underlying age-related metabolic dysregulation

Kim, D. H., Bang, E., Arulkumar, R., Ha, S., Chung, K. W., Park, M. H., Choi, Y. J., Yu, B. P., & Chung, H. Y. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110891 · Cited by 19 · see citing works

FGF21, a modulator of astrocyte reactivity, protects against ischemic brain injury through anti-inflammatory and neurotrophic pathways

Wang, D., Huang, W., Shi, J., Liu, F., Jiang, W., Chen, K., Zhang, S., Li, X., & Lin, L. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01462-x · Cited by 18 · see citing works

RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy

Zhao, Y., Lin, J., Li, J., Bwalya, C., Xu, Y., Niu, Y., Zhang, Y., Wu, J., Xu, Y., Chen, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012466 · Cited by 18 · see citing works

Metabolic remodeling induced by mitokines in heart failure

Duan, J., Chen, Z., Wu, Y., Zhu, B., Yang, L., & Yang, C. (2019) · Aging · doi:10.18632/aging.102247 · Cited by 17 · see citing works

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Mizumoto, T., Yoshizawa, T., Sato, Y., Ito, T., Tsuyama, T., Satoh, A., Araki, S., Tsujita, K., Tamura, M., Oike, Y., et al. (2022) · Cells · doi:10.3390/cells11223609 · Cited by 17 · see citing works

Postprandial dynamics and response of fibroblast growth factor 21 in older adults

Herpich, C., Haß, U., Kochlik, B., Franz, K., Laeger, T., Klaus, S., Bosy‐Westphal, A., & Norman, K. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.037 · Cited by 17 · see citing works

Fibroblast growth factor 8 (FGF8) induces mitochondrial remodeling in chondrocytes via ERK/AMPK signaling pathway

Huang, H.-C., Duan, M., Wei, J.-Y., Liu, Y., Xu, S.-Q., Huang, M., Tu, Y., Xie, J., & Du, W. (2025) · The FASEB Journal · doi:10.1096/fj.202500186r · Cited by 13 · see citing works

Coffee peel extracts ameliorate non-alcoholic fatty liver disease via a fibroblast growth factor 21–adiponectin signaling pathway

Fan, Z., Wang, C., Yang, T., Gao, T., Wang, D., Zhao, X., Guo, X., & Li, D. (2022) · Food & Function · doi:10.1039/d2fo00081d · Cited by 16 · see citing works

β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight

Hidalgo‐Gutiérrez, A., Barriocanal‐Casado, E., Díaz-Casado, M. E., González‐García, P., Chiozzi, R. Z., Acuña-Castroviejo, D., & López, L. C. (2021) · Biomedicines · doi:10.3390/biomedicines9101457 · Cited by 16 · see citing works

FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6

Wang, R., Wang, J., Zhang, Z., Ma, B., Sun, S., Gao, L., & Gao, G. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00755-x · Cited by 15 · see citing works

The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice

Mendoza, L. D., & Hyndman, K. A. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00180.2019 · Cited by 15 · see citing works

Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception

Gendron, C. M., Chakraborty, T. S., Chung, B. Y., Harvanek, Z. M., Holme, K. J., Johnson, J. C., Lyu, Y., Munneke, A. S., & Pletcher, S. D. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034440 · Cited by 16 · see citing works

FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity-Matched Nested Case-Control Study

Wang, Z., Yuan, M., Xu, C., Zhang, Y., Ying, C., & Xiao, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.630287 · Cited by 15 · see citing works

The effects of exercise on FGF21 in adults: a systematic review and meta-analysis

Liu, C., Yan, X., Zong, Y., He, Y., Yang, G., Xiao, Y., & Wang, S. (2024) · PeerJ · doi:10.7717/peerj.17615 · Cited by 14 · see citing works

Improvements in Exercise for Alzheimer’s Disease: Highlighting FGF21-Induced Cerebrovascular Protection

Wang, J., Meng, X., Jialun, Y., Tang, Y., Zeng, F., Wang, Y., Chen, Z., Chen, D., Zou, R., & Liu, W. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04350-w · Cited by 13 · see citing works

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

Rodríguez-Hidalgo, M., Luna‐Sánchez, M., Hidalgo‐Gutiérrez, A., Barriocanal‐Casado, E., Mascaraque, C., Acuña-Castroviejo, D., Rivera, M., Escames, G., & López, L. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-32190-y · Cited by 13 · see citing works

Lysine-Specific Demethylase 1 in Energy Metabolism: A Novel Target for Obesity

Wang, D., Kuang, Y., Zhang, G., Xiao, K., & Liu, Y. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac080 · Cited by 12 · see citing works

Focus on Alzheimer’s Disease: The Role of Fibroblast Growth Factor 21 and Autophagy

Yang, L., & Nao, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.11.003 · Cited by 11 · see citing works

Unraveling the multifaceted role of SIRT7 and its therapeutic potential in human diseases

Han, L., Yuan, Z., Wu, J., Lu, J., Wang, Y., & Zhang, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135210 · Cited by 11 · see citing works

Fibroblast growth factor 21 is associated with increased serum total antioxidant capacity and oxidized lipoproteins in humans with different stages of chronic kidney disease

Gómez-Sámano, M. Á., Vargas-Abonce, V. P., Martínez‐Sánchez, F. D., Palacios-Báez, L., Vera-Zertuche, J. M., Navarro-Flores, M. F., Morales-García, M., Fonseca-Correa, J. I., Zuarth-Vázquez, J. M., Vega‐Vega, O., et al. (2021) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188211001160 · Cited by 11 · see citing works

Gender differences in the relationships between housework and metabolic markers: a longitudinal cohort study in China

Wang, X., Ren, X., Kou, W.-J., Li, Y., Hui, Z., Sun, J., & Wang, M. (2022) · BMC Public Health · doi:10.1186/s12889-022-12566-6 · Cited by 11 · see citing works

Myokines as biomarkers of frailty and cardiovascular disease risk in females

Boreskie, K. F., Oldfield, C. J., Hay, J. L., Moffatt, T. L., Hiebert, B. M., Arora, R. C., & Duhamel, T. A. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110859 · Cited by 11 · see citing works

Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse

Cai, L., Li, X., Wang, Y., Chen, Y., Zhu, X., Zuo, Z., Si-Ma, Y.-Q., Lin, Y., Li, X., & Huang, X. (2024) · Inflammation · doi:10.1007/s10753-024-02032-3 · Cited by 10 · see citing works

The Potential Role of Myokines/Hepatokines in the Progression of Neuronal Damage in Streptozotocin and High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

Lee, H., & Lim, Y. (2022) · Biomedicines · doi:10.3390/biomedicines10071521 · Cited by 10 · see citing works

Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection

Mo, Q., Feng, K., Dai, S., Wu, Q., Zhang, Z., Ali, A., Dèng, F., Wáng, H., & Ning, Y. (2022) · Virologica Sinica · doi:10.1016/j.virs.2022.09.002 · Cited by 10 · see citing works

Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage

Chen, K., Huang, W., Wang, J., Xu, H., Ruan, L., Li, Y., Wang, Z., Wang, X. B., Lin, L., & Li, X. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1117057 · Cited by 9 · see citing works

Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria

Wang, J., Li, T., Li, M., Fu, Z., Chen, L., Shi, D., Qiu, F., & Tan, X. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109144 · Cited by 9 · see citing works

Mitochondrial unfolded protein response in ischemia-reperfusion injury

Zhu, M., Ma, X., Niu, X., Fan, G.-B., & Li, Y. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148116 · Cited by 9 · see citing works

Invited review: Adrenocortical function in avian and non-avian reptiles: Insights from dispersed adrenocortical cells

Carsia, R. V., McIlroy, P. J., & John‐Alder, H. B. (2023) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2023.111424 · Cited by 9 · see citing works

Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults

Matsui, M., Kosaki, K., Tanahashi, K., Akazawa, N., Osuka, Y., Tanaka, K., Kuro‐o, M., & Maeda, S. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111081 · Cited by 8 · see citing works

FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway

Chen, W., Shen, Z., Cai, S., Chen, L., & Wang, D. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/133494 · Cited by 8 · see citing works

Adipose Tissue

Eckel, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809518-8.00002-7 · Cited by 8 · see citing works

Fibroblast Growth Factor 21 Protects Against Cerebral Ischemia/Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis

Li, J., Jiang, H., Bai, W., Yang, Y., Zhou, G., Chen, W., & Shao, J. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s504180 · Cited by 7 · see citing works

Serum Fibroblast Growth Factor 21 Level After an Oral Fat Tolerance Test is Related to Postprandial Free Fatty Acid Level

Li, X., Zheng, K., Gu, W., Hou, X., Guan, Y., Liu, L., Hou, L., Geng, J., & Song, G. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s410457 · Cited by 7 · see citing works

Fibroblast growth factor 21 inversely correlates with survival in elderly population – the results of the Polsenior2 study

Handzlik‐Orlik, G., Owczarek, A. J., Więcek, A., Mossakowska, M., Zdrojewski, T. R., Chudek, A., Olszanecka‐Glinianowicz, M., & Chudek, J. T. (2024) · Aging · doi:10.18632/aging.206114 · Cited by 7 · see citing works

Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, Bombyx mori

Song, J., Hao, K., Chen, X., Zhang, Y., Cheng, Z., Mao, S., Tang, Y., Tong, X., & Dai, F. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.01.18 · Cited by 6 · see citing works

Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice

Delgado‐Anglés, A., Blasco‐Roset, A., Godoy-Nieto, F. J., Cairó, M., Villarroya, F., Giralt, M., & Villarroya, J. (2023) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-023-00977-x · Cited by 6 · see citing works

FGF20 promotes spinal cord injury repair by inhibiting the formation of necrotic corpuscle P‐MLKL/P‐RIP1/P‐RIP3 in neurons

Cai, X., Xie, Z., Zhao, J., Lu, W., Zhu, Z., Chen, M., Huang, Z., Ying, Y., Fu, Y., Xu, J., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70109 · Cited by 5 · see citing works

Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF‐21), and insulin‐like growth factor binding protein 2 (IGFBP‐2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum

Dallaire‐Théroux, C., Denis, H. L., Cottez, R. J., Tremblay, C., Provencher, A., Valentin‐Escalera, J., Leclerc, M., Loiselle, A., Tournissac, M., Potvin, O., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71097 · Cited by 5 · see citing works

UPRmt-regulated mitokines: novel strategies for myocardial injury repair

Gao, W., Liu, J., Zhang, W., Liu, B., & Shen, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1652353 · Cited by 4 · see citing works

FGF21 restores metabolic function in Alzheimer’s disease via activation of PI3K/Akt signaling

Zhao, F., Yang, H., Liu, H., Yu, H., & Zhao, Y. (2025) · Neurological Research · doi:10.1080/01616412.2025.2521721 · Cited by 4 · see citing works

Impacts of minimally-processed omnivorous vs lacto-ovo-vegetarian diets on insulin sensitivity, lipid profile, and adiposity in older adults: Secondary findings from a randomized crossover feeding trial

Vaezi, S., Freeling, J., de Vargas, B. O., Weidauer, L. A., Shoemaker, M. E., Sanders, W. M., & Dey, M. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.10.010 · Cited by 4 · see citing works

Stress-CARE: A Chinese music therapeutic model to treat stress and burnout syndromes

Mastnak, W. (2022) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2022.13.2.0103 · Cited by 4 · see citing works

Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice

Fang, Y., Medina, D., Stockwell, R., McFadden, S., Hascup, E. R., Hascup, K. N., & Bartke, A. (2022) · GeroScience · doi:10.1007/s11357-022-00706-0 · Cited by 3 · see citing works

Association of copy number variation in X chromosome-linked PNPLA4 with heterotaxy and congenital heart disease

Gao, H., Huang, X., Chen, W., Feng, Z., Zhao, Z., Li, P., Tan, C., Wang, J., Zhuang, Q., Gao, Y., et al. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003192 · Cited by 3 · see citing works

The stimulatory effects of glucagon on cortisol and GH secretion occur independently from FGF-21

Akkar, I., Karaca, Z., Taheri, S., Ünlühızarcı, K., Hacıoğlu, A., & Keleştimur, F. (2021) · Endocrine · doi:10.1007/s12020-021-02829-4 · Cited by 4 · see citing works

Fibroblast growth factor 21 associating with serotonin and dopamine in the cerebrospinal fluid predicts impulsivity in healthy subjects

Xu, J., Wu, F., Li, Y., Wang, F., Lin, W., Song, Q., Li, H., Fan, Y., Li, H., Chen, L., et al. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00676-7 · Cited by 3 · see citing works

FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway

Chen, L., Zheng, L., Qin, Y. H., Liu, B., Zheng, Y., Tong, X., Dai, M., & Gong, G. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.10.053 · Cited by 2 · see citing works

Hepatic FGF21 Deletion Improves Glucose Metabolism, Alters Lipogenic and Chrna4 Gene Expression, and Enhances Telomere Maintenance in Aged Female Mice

Torres-Oteros, D., Nicola-Llorente, M., Sanz-Lamora, H., Pérez-Martí, A., Marrero, P., Canudas, S., Haro, D., & Relat, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010194 · Cited by 2 · see citing works

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.009 · Cited by 97 · see citing works

FGF21 gene therapy for healthy aging: Great promise, important questions

Kuro‐o, M. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.07.015

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

Kim, K. H., & Lee, M.-S. (2014) · Diabetes &amp; Metabolism Journal · doi:10.4093/dmj.2014.38.4.245 · Cited by 146 · see citing works

FGF21 connects ER stress to sulfide signaling to enhance cellular resilience

Hatem, S., Ponti, A. K., & Hine, C. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.06.009

FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs

Kim, K. H., & Lee, M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0160 · Cited by 63 · see citing works