The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
Open accessAbstract
SREBPs are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity. In this review, we summarize the recent findings that contribute to the current understanding of the regulation of SREBPs and their physiologic roles in maintenance of lipid homeostasis, insulin signaling, innate immunity, and cancer development.
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Cites
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
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Regulated Intramembrane Proteolysis
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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
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GPX4 at the crossroads of lipid homeostasis and ferroptosis
Forcina, G. C., & Dixon, S. J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800311 · Cited by 1,025
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L.-L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 399
Craft, S., Raman, R., Chow, T. W., Rafii, M. S., Sun, C.-K., Rissman, R. A., Donohue, M. C., Brewer, J. B., Jenkins, C., Harless, K., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1840 · Cited by 389
Acetyl-CoA metabolism in cancer
Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00543-5 · Cited by 303
Kusnadi, A., Park, S. H., Yuan, R., Pannellini, T., Giannopoulou, E., Oliver, D., Lu, T., Park-Min, K.-H., & Ivashkiv, L. B. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.005 · Cited by 157
Metadata
- Authors
- DeBose-Boyd, R. A., & Ye, J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 43
- Issue
- 5
- Pages
- 358-368
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2794383917
- Cited by
- 353
- References
- 78
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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