CoChat
Sign Up
Cited by 157

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair

Kusnadi, Anthony, Park, Sung Ho, Yuan, Ruoxi, Pannellini, Tania, Giannopoulou, Eugenia, Oliver, David, Lu, Theresa, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.·2019·Immunity
DOI 10.1016/j.immuni.2019.06.005PMC PMC6709581
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2019.06.005

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Reduced INSIG1 expression activates SREBP2, leading to upregulated expression of inflammatory cytokines in macrophages, such as IL-1β, CXCL10, and CXCL11, independent of the cholesterol synthesis pathway.

    “Moreover, reduced INSIG1 expression activates SREBP2, leading to upregulated expression of inflammatory cytokines in macrophages, such as IL-1β, C-X-C motif chemokine ligand 10 (CXCL10), and CXCL11, independent of the cholesterol synthesis pathway33,34.”

    From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [33]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 65

  1. Akula, 2016, Control of the innate immune response by the mevalonate pathway, Nat. Immunol., 17, 922, 10.1038/ni.3487 · DOI
  2. Ander, 2003, Polyunsaturated fatty acids and their effects on cardiovascular disease, Exp. Clin. Cardiol., 8, 164
  3. Bekkering, 2018, Metabolic induction of trained immunity through the mevalonate pathway, Cell, 172, 135, 10.1016/j.cell.2017.11.025 · DOI
  4. Blanc, 2011, Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis, PLoS Biol., 9, e1000598, 10.1371/journal.pbio.1000598 · DOI
  5. Brown, 1997, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5 · DOI · Paper page
  6. Chen, 2012, An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection, Nat. Med., 18, 260, 10.1038/nm.2628 · DOI
  7. Chia, 2016, Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis, J. Clin. Invest., 126, 4331, 10.1172/JCI85740 · DOI
  8. DeBose-Boyd, 2018, SREBPs in lipid metabolism, insulin signaling, and beyond, Trends Biochem. Sci., 43, 358, 10.1016/j.tibs.2018.01.005 · DOI
  9. Dehelean, 2012, Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation, Chem. Cent. J., 6, 137, 10.1186/1752-153X-6-137 · DOI
  10. Dobin, 2013, STAR: ultrafast universal RNA-seq aligner, Bioinformatics, 29, 15, 10.1093/bioinformatics/bts635 · DOI · Paper page
  11. Eming, 2014, Wound repair and regeneration: mechanisms, signaling, and translation, Sci. Transl. Med., 6, 265sr6, 10.1126/scitranslmed.3009337 · DOI · Paper page
  12. Fessler, 2016, The intracellular cholesterol landscape: dynamic integrator of the immune response, Trends Immunol., 37, 819, 10.1016/j.it.2016.09.001 · DOI
  13. Firestein, 2017, Immunopathogenesis of rheumatoid arthritis, Immunity, 46, 183, 10.1016/j.immuni.2017.02.006 · DOI · Paper page
  14. Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J. Biol. Chem., 226, 497, 10.1016/S0021-9258(18)64849-5 · DOI · Paper page
  15. Ginhoux, 2016, New insights into the multidimensional concept of macrophage ontogeny, activation and function, Nat. Immunol., 17, 34, 10.1038/ni.3324 · DOI
  16. Glass, 2016, Molecular control of activation and priming in macrophages, Nat. Immunol., 17, 26, 10.1038/ni.3306 · DOI
  17. Goren, 2009, A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes, Am. J. Pathol., 175, 132, 10.2353/ajpath.2009.081002 · DOI
  18. Guo, 2018, Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages, Immunity, 49, 842, 10.1016/j.immuni.2018.08.021 · DOI · Paper page
  19. Heinz, 2010, Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities, Mol. Cell, 38, 576, 10.1016/j.molcel.2010.05.004 · DOI · Paper page
  20. Helgadottir, 2016, Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease, Nat. Genet., 48, 634, 10.1038/ng.3561 · DOI
  21. Hu, 2017, Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair, JCI Insight, 2, 96260, 10.1172/jci.insight.96260 · DOI
  22. Hu, 2008, Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways, Immunity, 29, 691, 10.1016/j.immuni.2008.08.016 · DOI
  23. Huynh, 2016, Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages, Sci. Rep., 6, 31959, 10.1038/srep31959 · DOI
  24. Im, 2011, Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a, Cell Metab., 13, 540, 10.1016/j.cmet.2011.04.001 · DOI
  25. Kalliolias, 2016, TNF biology, pathogenic mechanisms and emerging therapeutic strategies, Nat. Rev. Rheumatol., 12, 49, 10.1038/nrrheum.2015.169 · DOI
  26. Kim, 1995, Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain, Mol. Cell. Biol., 15, 2582, 10.1128/MCB.15.5.2582 · DOI
  27. Knipper, 2015, Interleukin-4 receptor α signaling in myeloid cells controls collagen fibril assembly in skin repair, Immunity, 43, 803, 10.1016/j.immuni.2015.09.005 · DOI
  28. Kratochvill, 2015, TNF counterbalances the emergence of M2 tumor macrophages, Cell Rep., 12, 1902, 10.1016/j.celrep.2015.08.033 · DOI
  29. Kroner, 2014, TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord, Neuron, 83, 1098, 10.1016/j.neuron.2014.07.027 · DOI · Paper page
  30. Langmead, 2012, Fast gapped-read alignment with Bowtie 2, Nat. Methods, 9, 357, 10.1038/nmeth.1923 · DOI · Paper page
  31. Li, 2013, Cross-talk between TLR4-MyD88-NF-κB and SCAP-SREBP2 pathways mediates macrophage foam cell formation, Am. J. Physiol. Heart Circ. Physiol., 304, H874, 10.1152/ajpheart.00096.2012 · DOI · Paper page
  32. Liu, 2013, Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol, Immunity, 38, 92, 10.1016/j.immuni.2012.11.005 · DOI · Paper page
  33. Marshall, 2018, Cutaneous scarring: basic science, current treatments, and future directions, Adv. Wound Care (New Rochelle), 7, 29, 10.1089/wound.2016.0696 · DOI
  34. Matsuda, 2001, SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation, Genes Dev., 15, 1206, 10.1101/gad.891301 · DOI · Paper page
  35. Minutti, 2017, Tissue-specific contribution of macrophages to wound healing, Semin. Cell Dev. Biol., 61, 3, 10.1016/j.semcdb.2016.08.006 · DOI
  36. Murray, 2017, Macrophage polarization, Annu. Rev. Physiol., 79, 541, 10.1146/annurev-physiol-022516-034339 · DOI · Paper page
  37. Murray, 2014, Macrophage activation and polarization: nomenclature and experimental guidelines, Immunity, 41, 14, 10.1016/j.immuni.2014.06.008 · DOI · Paper page
  38. Nathan, 2010, Nonresolving inflammation, Cell, 140, 871, 10.1016/j.cell.2010.02.029 · DOI · Paper page
  39. O’Neill, 2016, A guide to immunometabolism for immunologists, Nat. Rev. Immunol., 16, 553, 10.1038/nri.2016.70 · DOI · Paper page
  40. Oishi, 2017, SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism, Cell Metab., 25, 412, 10.1016/j.cmet.2016.11.009 · DOI · Paper page
  41. Osborne, 2009, Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it’s been, Genes Dev., 23, 2578, 10.1101/gad.1854309 · DOI · Paper page
  42. Ouyang, 2018, Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages, Exp. Cell Res., 367, 162, 10.1016/j.yexcr.2018.03.032 · DOI · Paper page
  43. Park, 2017, Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation, Nat. Immunol., 18, 1104, 10.1038/ni.3818 · DOI
  44. Park, 2011, Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages, Nat. Immunol., 12, 607, 10.1038/ni.2043 · DOI
  45. Park, 2016, Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS, Nat. Immunol., 17, 914, 10.1038/ni.3457 · DOI
  46. Perretti, 2017, Immune resolution mechanisms in inflammatory arthritis, Nat. Rev. Rheumatol., 13, 87, 10.1038/nrrheum.2016.193 · DOI
  47. Reed, 2008, Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes, PLoS Genet., 4, e1000133, 10.1371/journal.pgen.1000133 · DOI
  48. Robinson, 2010, edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, Bioinformatics, 26, 139, 10.1093/bioinformatics/btp616 · DOI · Paper page
  49. Rong, 2017, Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice, eLife, 6, e25015, 10.7554/eLife.25015 · DOI · Paper page
  50. Satoh, 2010, The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection, Nat. Immunol., 11, 936, 10.1038/ni.1920 · DOI · Paper page
  51. Seo, 2009, Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif, Proc. Natl. Acad. Sci. USA, 106, 13765, 10.1073/pnas.0904246106 · DOI
  52. Seo, 2011, Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy, Cell Metab., 13, 367, 10.1016/j.cmet.2011.03.005 · DOI
  53. Sharif, 2006, Twist mediates suppression of inflammation by type I IFNs and Axl, J. Exp. Med., 203, 1891, 10.1084/jem.20051725 · DOI
  54. Shimano, 1997, Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene, J. Clin. Invest., 100, 2115, 10.1172/JCI119746 · DOI · Paper page
  55. Šošić, 2003, Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity, Cell, 112, 169, 10.1016/S0092-8674(03)00002-3 · DOI
  56. Soyal, 2015, Targeting SREBPs for treatment of the metabolic syndrome, Trends Pharmacol. Sci., 36, 406, 10.1016/j.tips.2015.04.010 · DOI
  57. Spann, 2012, Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses, Cell, 151, 138, 10.1016/j.cell.2012.06.054 · DOI
  58. Teich, 2014, Rapid improvement of refractory pyoderma gangrenosum with infliximab gel in a patient with ulcerative colitis, J. Crohn’s Colitis, 8, 85, 10.1016/j.crohns.2013.06.003 · DOI
  59. Tong, 2016, A stringent systems approach uncovers gene-specific mechanisms regulating inflammation, Cell, 165, 165, 10.1016/j.cell.2016.01.020 · DOI
  60. Toth, 2004, Selective coactivator interactions in gene activation by SREBP-1a and -1c, Mol. Cell. Biol., 24, 8288, 10.1128/MCB.24.18.8288-8300.2004 · DOI
  61. Trapnell, 2013, Differential analysis of gene regulation at transcript resolution with RNA-seq, Nat. Biotechnol., 31, 46, 10.1038/nbt.2450 · DOI · Paper page
  62. Wei, 2016, Ligand activation of ERRα by cholesterol mediates statin and bisphosphonate effects, Cell Metab., 23, 479, 10.1016/j.cmet.2015.12.010 · DOI
  63. Yarilina, 2008, TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes, Nat. Immunol., 9, 378, 10.1038/ni1576 · DOI
  64. York, 2015, Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling, Cell, 163, 1716, 10.1016/j.cell.2015.11.045 · DOI · Paper page
  65. Zhao, 2016, Inflammation in chronic wounds, Int. J. Mol. Sci., 17, E2085, 10.3390/ijms17122085 · DOI

Cited by

Sorted by citations

Metadata

Authors
Kusnadi, A., Park, S. H., Yuan, R., Pannellini, T., Giannopoulou, E., Oliver, D., Lu, T., Park-Min, K.-H., & Ivashkiv, L. B.
Venue
Immunity
Publisher
Elsevier BV
Published
2019-08
Volume
51
Issue
2
Pages
241-257.e9
ISSN
1074-7613
DOI
10.1016/j.immuni.2019.06.005
PMC
PMC6709581
Cited by
157
References
22
Language
en
Licence
Funders
National Institutes of Health

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review