Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

Boch, J., Scholze, H., Schornack, S., Landgraf, A., Hahn, S., Kay, S., Lahaye, T., Nickstadt, A., & Bonas, U. (2009) · Science · doi:10.1126/science.1178811 · Cited by 2,470

RNA-programmed genome editing in human cells

Jinek, M., East, A., Cheng, A., Lin, S., Ma, E., & Doudna, J. (2013) · eLife · doi:10.7554/elife.00471 · Cited by 2,098

A Simple Cipher Governs DNA Recognition by TAL Effectors

Moscou, M., & Bogdanove, A. J. (2009) · Science · doi:10.1126/science.1178817 · Cited by 2,050

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

Čermák, T., Doyle, E., Christian, M. L., Wang, L., Zhang, Y., Schmidt, C. L., Baller, J. A., Somia, N. V., Bogdanove, A. J., & Voytas, D. F. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr218 · Cited by 2,034

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,556

High-efficiency TALEN-based gene editing produces disease-resistant rice

Li, T., Liu, B., Spalding, M. H., Weeks, D. P., & Yang, B. (2012) · Nature Biotechnology · doi:10.1038/nbt.2199 · Cited by 1,149

Genome Engineering With Zinc-Finger Nucleases

Carroll, D. (2011) · Genetics · doi:10.1534/genetics.111.131433 · Cited by 1,076

An improved zinc-finger nuclease architecture for highly specific genome editing

Miller, J. C., Holmes, M. C., Wang, J., Guschin, D. Y., Lee, Y.-L., Rupniewski, I., Beausejour, C. M., Waite, A. J., Wang, N. S., Kim, K. A., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1319 · Cited by 1,051

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

Shukla, V. K., Doyon, Y., Miller, J. C., DeKelver, R. C., Moehle, E. A., Worden, S. E., Mitchell, J. C., Arnold, N. L., Gopalan, S. M., Meng, X., et al. (2009) · Nature · doi:10.1038/nature07992 · Cited by 983

Xanthomonas AvrBs3 Family-Type III Effectors: Discovery and Function

Boch, J., & Bonas, U. (2010) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080508-081936 · Cited by 978

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repairPreprint

Nimonkar, A. V., Genschel, J., Kinoshita, E., Polaczek, P., Campbell, J. L., Wyman, C., Modrich, P. L., & Kowalczykowski, S. C. (2011) · Genes & Development · doi:10.1101/gad.2003811 · Cited by 825

High-frequency modification of plant genes using engineered zinc-finger nucleases

Townsend, J. A., Wright, D. A., Winfrey, R. J., Fu, F., Maeder, M. L., Joung, J. K., & Voytas, D. F. (2009) · Nature · doi:10.1038/nature07845 · Cited by 747

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

Maeder, M. L., Thibodeau-Beganny, S., Osiak, A., Wright, D. A., Anthony, R. M., Eichtinger, M., Jiang, T., Foley, J. E., Winfrey, R. J., Townsend, J. A., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.016 · Cited by 727

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

Mussolino, C., Morbitzer, R., Lütge, F., Dannemann, N., Lahaye, T., & Cathomen, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr597 · Cited by 714

Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass

Fu, C., Mielenz, J. R., Xiao, X., Ge, Y., Hamilton, C. Y., Rodríguez, M., Chen, F., Foston, M. B., Ragauskas, A. J., Bouton, J. H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100310108 · Cited by 654

Transcription Activator-Like Effector Nucleases Enable Efficient Plant Genome Engineering

Zhang, Y., Zhang, F., Li, X., Baller, J. A., Qi, Y., Starker, C. G., Bogdanove, A. J., & Voytas, D. F. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.205179 · Cited by 487

Advancing Our Understanding and Capacity to Engineer Nature’s CO2-Sequestering Enzyme, Rubisco

Whitney, S. M., Houtz, R. L., & Alonso, H. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.164814 · Cited by 463

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

Pattanayak, V., Ramirez, C. L., Joung, J. K., & Liu, D. R. (2011) · Nature Methods · doi:10.1038/nmeth.1670 · Cited by 453

TAL effectors: finding plant genes for disease and defense

Bogdanove, A. J., Schornack, S., & Lahaye, T. (2010) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2010.04.010 · Cited by 442

Targeted mutagenesis using zinc-finger nucleases in Arabidopsis

Lloyd, A., Plaisier, C. L., Carroll, D., & Drews, G. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409339102 · Cited by 418

De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

Mahfouz, M. M., Li, L., Shamimuzzaman, M., Wibowo, A. T., Fang, X., & Zhu, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019533108 · Cited by 417

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

Doyon, Y., Vo, T. D., Mendel, M. C., Greenberg, S. G., Wang, J., Xia, D. F., Miller, J. C., Urnov, F. D., Gregory, P. D., & Holmes, M. C. (2011) · Nature Methods · doi:10.1038/nmeth.1539 · Cited by 402

High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases

Zhang, F., Maeder, M. L., Unger‐Wallace, E., Hoshaw, J. P., Reyon, D., Christian, M. L., Li, X., Pierick, C. J., Dobbs, D. L., Peterson, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914991107 · Cited by 385

Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

Stoddard, B. L. (2011) · Structure · doi:10.1016/j.str.2010.12.003 · Cited by 346

Deployment of new biotechnologies in plant breeding

Lusser, M., Parisi, C., Plan, D., & Rodríguez-Cerezo, E. (2012) · Nature Biotechnology · doi:10.1038/nbt.2142 · Cited by 342

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

Gaj, T., Guo, J., Kato, Y., Sirk, S. J., & Barbas, C. F. (2012) · Nature Methods · doi:10.1038/nmeth.2030 · Cited by 306

Site-directed mutagenesis in Arabidopsis using custom-designed zinc finger nucleases

Osakabe, K., Osakabe, Y., & Toki, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000234107 · Cited by 303

Genotoxic stress in plants: Shedding light on DNA damage, repair and DNA repair helicases

Tuteja, N. K., Ahmad, P., Panda, B. B., & Tuteja, R. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.004 · Cited by 261

An Induced Mutation in Tomato eIF4E Leads to Immunity to Two Potyviruses

Piron‐Prunier, F., Nicolaı̈, M., Minoïa, S., Piednoir, E., Moretti, A., Salgues, A., Zamir, D., Caranta, C., & Bendahmane, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011313 · Cited by 245

Heritable targeted mutagenesis in maize using a designed endonuclease

Gao, H., Smith, J., Yang, M., Jones, S., Djukanovic, V., Nicholson, M. G., West, A., Bidney, D. L., Falco, S. C., Jantz, D., et al. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.04041.x · Cited by 241

TILLING - a shortcut in functional genomics

Kurowska, M. M., Daszkowska‐Golec, A., Gruszka, D., Marzec, M., Szurman‐Zubrzycka, M., Szarejko, I., & Małuszyński, M. (2011) · Journal of Applied Genetics · doi:10.1007/s13353-011-0061-1 · Cited by 240

DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases

Cornu, T. I., Thibodeau-Beganny, S., Guhl, E., Alwin, S., Eichtinger, M., Joung, J. K., & Cathomen, T. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300357 · Cited by 228

Targeted transgene integration in plant cells using designed zinc finger nucleases

Cai, C. Q., Doyon, Y., Ainley, W. M., Miller, J. C., DeKelver, R. C., Moehle, E. A., Rock, J. M., Lee, Y.-L., Garrison, R. J., Schulenberg, L. L., et al. (2008) · Plant Molecular Biology · doi:10.1007/s11103-008-9449-7 · Cited by 219

In planta gene targeting

Fauser, F., Roth, N., Pacher, M., Ilg, G., Sánchez‐Fernández, R., Biesgen, C., & Puchta, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202191109 · Cited by 214

Repairing breaks in the plant genome: the importance of keeping it together

Waterworth, W. M., Drury, G. E., Bray, C. M., & West, C. E. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2011.03926.x · Cited by 213

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

Ramirez, C. L., Certo, M. T., Mussolino, C., Goodwin, M. J., Cradick, T. J., McCaffrey, A. P., Cathomen, T., Scharenberg, A. M., & Joung, J. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks179 · Cited by 178

Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleasesPreprint

Lee, H. J., Kweon, J., Kim, E., Kim, S., & Kim, J. (2011) · Genome Research · doi:10.1101/gr.129635.111 · Cited by 169

Recent Advances in Plant Transformation

Barampuram, S., & Zhang, Z. J. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-957-4_1 · Cited by 137

Domain Swapping and Gene Shuffling Identify Sequences Required for Induction of an Avr-Dependent Hypersensitive Response by the Tomato Cf-4 and Cf-9 Proteins

Wulff, B. B. H., Thomas, C. M., Smoker, M., Grant, M., & Jones, J. D. G. (2001) · The Plant Cell · doi:10.1105/tpc.13.2.255 · Cited by 133

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzymePreprint

Wang, J., Friedman, G., Doyon, Y., Wang, N. S., Li, C. J., Miller, J. C., Hua, K. L., Yan, J. J., Babiarz, J., Gregory, P. D., et al. (2012) · Genome Research · doi:10.1101/gr.122879.111 · Cited by 133

Zinc finger nuclease-mediated transgene deletion

Petolino, J. F., Worden, A., Curlee, K., Connell, J., Strange, T. L., Larsen, C., & Russell, S. M. (2010) · Plant Molecular Biology · doi:10.1007/s11103-010-9641-4 · Cited by 129

Homing endonucleases: DNA scissors on a mission

Hafez, M., & Hausner, G. (2012) · Genome · doi:10.1139/g2012-049 · Cited by 125

Genome Engineering of Crops with Designer Nucleases

Curtin, S. J., Voytas, D. F., & Stupar, R. M. (2012) · The Plant Genome · doi:10.3835/plantgenome2012.06.0008 · Cited by 124

Colinearity and Similar Expression Pattern of Rice DREB1s Reveal Their Functional Conservation in the Cold-Responsive Pathway

Mao, D., & Chen, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047275 · Cited by 119

Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other Site‐Directed Nucleases with similar function

(GMO), E. P. O. G. M. O. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2943 · Cited by 117

The I-CreI meganuclease and its engineered derivatives: applications from cell modification to gene therapy

Arnould, S., Delenda, C., Grizot, S., Desseaux, C., Pâques, F., Silva, G. H., & Smith, J. (2010) · Protein Engineering Design and Selection · doi:10.1093/protein/gzq083 · Cited by 116

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion

Şöllü, C., Pars, K., Cornu, T. I., Thibodeau-Beganny, S., Maeder, M. L., Joung, J. K., Heilbronn, R., & Cathomen, T. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq720 · Cited by 110

ZFN‐induced mutagenesis and gene‐targeting in Arabidopsis through Agrobacterium‐mediated floral dip transformation

de Pater, S., Neuteboom, L. W., Pinas, J. E., Hooykaas, P. J. J., & van der Zaal, B. J. (2009) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2009.00446.x · Cited by 105

Homologous recombination: a basis for targeted genome optimization in crop species such as maize

D’Halluin, K., Vanderstraeten, C., Stals, E., Cornelissen, M., & Ruiter, R. K. (2007) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2007.00305.x · Cited by 99

Move over ZFNs

(2011) · Nature Biotechnology · doi:10.1038/nbt.1935 · Cited by 95

Scientific opinion addressing the safety assessment of plants developed using Zinc Finger Nuclease 3 and other site-directed Nucleases with similar function

Arpaia, S., Birch, A. N., Chesson, A., du Jardin, P., Gathmann, A., Gropp, J., Herman, L., Hoen-Sorteberg, H.-G., Jones, H. D., Kiss, J. G., et al. (2012) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-75266 · Cited by 94

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.

Grabarz, A., Barascu, A., Guirouilh‐Barbat, J., & López, B. S. (2012) · Europe PMC (PubMed Central) · Cited by 93

Identification and characterisation of seed storage protein transcripts from Lupinus angustifolius

Foley, R. C., Gao, L., Spriggs, A., Soo, L. Y. C., Goggin, D. E., Smith, P. M. C., Atkins, C. A., & Singh, K. B. (2011) · BMC Plant Biology · doi:10.1186/1471-2229-11-59 · Cited by 90

Genome-Wide Analysis of Fatty Acid Desaturases in Soybean (Glycine max)

Chi, X., Yang, Q., Lu, Y., Wang, J., Zhang, Q., Pan, L., Chen, M., He, Y., & Yu, S. (2011) · Plant Molecular Biology Reporter · doi:10.1007/s11105-010-0284-z · Cited by 87

Tiptoeing around transgenics

Waltz, E. (2012) · Nature Biotechnology · doi:10.1038/nbt.2143 · Cited by 84

Herbicides, Theory and Applications

(2011) · InTech eBooks · doi:10.5772/1430 · Cited by 84

Lack of starch synthase IIIa and high expression of granule-bound starch synthase I synergistically increase the apparent amylose content in rice endosperm

Crofts, N., Abe, K., Aihara, S., Itoh, R., Nakamura, Y., Itoh, K., & Fujita, N. (2012) · Plant Science · doi:10.1016/j.plantsci.2012.05.006 · Cited by 79

A toolbox and procedural notes for characterizing novel zinc finger nucleases for genome editing in plant cells

Tovkach, A., Zeevi, V., & Tzfira, T. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03718.x · Cited by 76

The requirement for recombination factors differs considerably between different pathways of homologous double‐strand break repair in somatic plant cells

Roth, N., Klimesch, J., Dukowic‐Schulze, S., Pacher, M., Mannuß, A., & Puchta, H. (2012) · The Plant Journal · doi:10.1111/j.1365-313x.2012.05119.x · Cited by 72

Genome modifications in plant cells by custom‐made restriction enzymes

Tzfira, T., Weinthal, D., Marton, I., Zeevi, V., Zuker, A., & Vainstein, A. (2012) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00672.x · Cited by 70

Inside the CBF locus in Poaceae

Tondelli, A., Francia, E., Barabaschi, D., Pasquariello, M., & Pecchioni, N. (2010) · Plant Science · doi:10.1016/j.plantsci.2010.08.012 · Cited by 68

Suitability of Molecular Markers for Selection of Potatoes Resistant to Globodera spp

Milczarek, D., Flis, B., & Przetakiewicz, A. (2011) · American Journal of Potato Research · doi:10.1007/s12230-011-9189-0 · Cited by 68

Localized egg‐cell expression of effector proteins for targeted modification of the Arabidopsis genome

Even‐Faitelson, L., Samach, A., Melamed‐Bessudo, C., Avivi‐Ragolsky, N., & Levy, A. A. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2011.04741.x · Cited by 64

Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds

Grizot, S., Epinat, J.-C., Thomas, S., Duclert, A., Rolland, S., Pâques, F., & Duchateau, P. N. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1171 · Cited by 63

Duplication of a well-conserved homeodomain-leucine zipper transcription factor gene in barley generates a copy with more specific functions

Sakuma, S., Pourkheirandish, M., Matsumoto, T., Koba, T., & Komatsuda, T. (2009) · Functional & Integrative Genomics · doi:10.1007/s10142-009-0134-y · Cited by 54

LAHEDES: the LAGLIDADG homing endonuclease database and engineering server

Taylor, G. K., Petrucci, L. H., Lambert, A. R., Baxter, S. K., Jarjour, J., & Stoddard, B. L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks365 · Cited by 53

The twenty-first century, the century of plant breeding

Stamp, P., & Visser, R. G. F. (2012) · Euphytica · doi:10.1007/s10681-012-0743-8 · Cited by 48

Studies on rice seed quality through analysis of a large-scale T-DNA insertion population

Fu, F., Ye, R., Xu, S., & Xue, H. (2009) · Cell Research · doi:10.1038/cr.2009.15 · Cited by 40

Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases

Fonfara, I., Curth, U., Pingoud, A. M., & Wende, W. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr788 · Cited by 32

Permanent genome modifications in plant cells by transient viral vectors

Vainstein, A., Marton, I., Zuker, A., Danziger, M., & Tzfira, T. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.03.007 · Cited by 29

Plant Chromosome Engineering

(2010) · Methods in molecular biology · doi:10.1007/978-1-61737-957-4 · Cited by 18

Functional characterization of the Gentiana lutea zeaxanthin epoxidase (GlZEP) promoter in transgenic tomato plants

Yang, Q., Yuan, D., Shi, L., Capell, T., Bai, C., Nuan, W., Lü, X., Sandmann, G., Christou, P., & Zhu, C. (2012) · Transgenic Research · doi:10.1007/s11248-012-9591-5 · Cited by 15

Analysing patent landscapes in plant biotechnology and new plant breeding techniques

Parisi, C. M., Rodríguez‐Cerezo, E., & Thangaraj, H. S. (2012) · Transgenic Research · doi:10.1007/s11248-012-9641-z · Cited by 14

An Industry Perspective of All-native and Transgenic Potatoes

Toevs, E. A., Guenthner, J. F., Johnson, A. J., McIntosh, C. S., & Thornton, M. K. (2011) · MOspace Institutional Repository (University of Missouri) · Cited by 13

Unusual Case of Apparent Hypermutation in Arabidopsis thaliana

Sasaki, T., Naumann, U., Forai, P., Matzke, A. J. M., & Matzke, M. A. (2012) · Genetics · doi:10.1534/genetics.112.144634 · Cited by 9

Decreasing erucic acid level by RNAi-mediated silencing of fatty acid elongase 1 (BnFAE1.1) in rapeseeds (Brassica napus L.)

Tian, B., Wei, F., Shu, H., Zhang, Q., Zang, X., & Lian, Y. (2011) · AFRICAN JOURNAL OF BIOTECHNOLOGY · Cited by 6

Isolation of fruit ripening genes from Carica papaya var. Eksotika I cDNA libraries.

Yun, S., Johari, S. A., Maheswary, V., & Kalsom, A. (2011) · Simulating the effects of changing planting date towards rice production in MADA area Malaysia · Cited by 4

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

Kim, S., Kim, D., Cho, S. W., Kim, J., & Kim, J.-S. (2014) · Genome Research · doi:10.1101/gr.171322.113 · Cited by 1,856

The CRISPR/Cas9 system for plant genome editing and beyond

Bortesi, L., & Fischer, R. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.12.006 · Cited by 1,289

Editing plant genomes with CRISPR/Cas9

Belhaj, K., Chaparro‐Garcia, A., Kamoun, S., Patron, N. J., & Nekrasov, V. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.11.007 · Cited by 559

Global Regulation of Genetically Modified Crops Amid the Gene Edited Crop Boom – A Review

Turnbull, C., Lillemo, M., & Hvoslef‐Eide, A. K. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.630396 · Cited by 479

The Regulatory Status of Genome‐edited Crops

Wolt, J. D., Wang, K., & Yang, B. (2015) · Plant Biotechnology Journal · doi:10.1111/pbi.12444 · Cited by 292

Targeted Genetic Modification in Crops Using Site-Directed Nucleases

Collonnier, C., Nogué, F., & Casacuberta, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802259-7.00013-0 · Cited by 4

From classical mutagenesis to nuclease‐based breeding – directing natural DNA repair for a natural end‐product

Pacher, M., & Puchta, H. (2016) · The Plant Journal · doi:10.1111/tpj.13469 · Cited by 152

Targeted modification of plant genomes for precision crop breeding

Hilscher, J., Buerstmayr, H., & Stöger, E. (2016) · Biotechnology Journal · doi:10.1002/biot.201600173 · Cited by 79

Re-evaluating the site-directed nuclease classification as a regulatory trigger for genome-edited plant products

Mewett, O., McMurdy, J., Bertho, L., Atanassova, A., Stevens, N., Huber, S., Fedorova, M., Diehl, K., & Zhao, K. T. (2026) · Nature Biotechnology · doi:10.1038/s41587-026-03028-0 · Cited by 5

The Generic Risks and the Potential of SDN-1 Applications in Crop Plants

Kawall, K. (2021) · Plants · doi:10.3390/plants10112259 · Cited by 28