Cited by 214CRISPR and Genetic EngineeringGenetically Modified Organisms ResearchPlant Genetic and Mutation Studies

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Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

Podevin, Nancy, Davies, Howard V., Hartung, Frank, Nogué, Fabien, Casacuberta, Josep M.·2013·Trends in biotechnology

DOI 10.1016/j.tibtech.2013.03.004

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Abstract

Conventional plant breeding exploits existing genetic variability and introduces new variability by mutagenesis. This has proven highly successful in securing food supplies for an ever-growing human population. The use of genetically modified plants is a complementary approach but all plant breeding techniques have limitations. Here, we discuss how the recent evolution of targeted mutagenesis and DNA insertion techniques based on tailor-made site-directed nucleases (SDNs) provides opportunities to overcome such limitations. Plant breeding companies are exploiting SDNs to develop a new generation of crops with new and improved traits. Nevertheless, some technical limitations as well as significant uncertainties on the regulatory status of SDNs may challenge their use for commercial plant breeding.

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Authors: Podevin, N., Davies, H. V., Hartung, F., Nogué, F., & Casacuberta, J. M.
Affiliations: European Food Safety Authority (IT)
James Hutton Institute (GB)
Julius Kühn-Institut (DE)
AgroParisTech (FR)
Universitat Autònoma de Barcelona (ES)
Corresponding author: Casacuberta, Josep M.
ORCID: Podevin, Nancy
Hartung, Frank
Nogué, Fabien
Casacuberta, Josep M.
Venue: Trends in biotechnology
Publisher: Elsevier BV
Published: 2013-06
Volume: 31
Issue: 6
Pages: 375-383
ISSN: 0167-7799 (ISSN-L)
DOI: 10.1016/j.tibtech.2013.03.004
OpenAlex: W1992221498
Cited by: 214
References: 83
Citations by year: 2026: 11 · 2025: 20 · 2024: 28 · 2023: 11 · 2022: 34 · 2021: 16 · 2020: 14 · 2019: 14 · 2018: 10 · 2017: 8 · 2016: 17 · 2015: 12 · 2014: 9 · 2013: 9
FWCI: 1.47
Type: journal article
Language: en
Open access: closed
Locations: Trends in biotechnology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
OpenAgrar (submittedVersion)
Funders: European Food Safety Authority
Agence Nationale de la Recherche (ANR-11-BTBR-0001)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Genetic and Mutation Studies
Keywords: targeted mutagenesis, DNA insertion, plant breeding, transgenic plants, regulatory status, crop improvement
MeSH terms: Breeding, Deoxyribonucleases, Humans, Plants, Gene Targeting

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Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding

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